CCR2 acts as scavenger for CCL2 during monocyte chemotaxis

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Volpe, Silvia ^a,c   Cameroni, Elisabetta ^a   Moepps, Barbara ^b   Thelen, Sylvia ^a   Apuzzo, Tiziana ^a,c   Thelen, Marcus ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1; DIAGNOSTIC AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOTOPROTEIN; RED FLUORESCENT PROTEIN;

ARTICLE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; ENDOCYTOSIS; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; INTERNALIZATION; MONOCYTE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROCESS MONITORING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; TIME-LAPSE VIDEO MICROSCOPY; CELL MOTION; CELL POLARITY; DRUG POTENTIATION; METABOLISM; PHYSIOLOGY;

CELL MOVEMENT; CELL POLARITY; CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; HUMANS; LUMINESCENT PROTEINS; MONOCYTES; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, CCR2;

EID: 84861205858     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037208     Document Type: Article

References (50)

1. Thelen M, Stein JV, (2008) How chemokines invite leukocytes to dance. Nat Immunol 9: 953-959.
2. Murphy PM, Baggiolini M, Charo IF, Hebert CA, Horuk R, et al. (2000) International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 52: 145-176.
3. Thelen M, (2001) Dancing to the tune of chemokines. Nat Immunol 2: 129-134.
4. Pollok-Kopp B, Schwarze K, Baradari VK, Oppermann M, (2003) Analysis of ligand-stimulated CC Chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. J Biol Chem 278: 2190-2198.
5. Zhang N, Yang D, Dong H, Chen Q, Dimitrova DI, et al. (2006) Adenosine A2a receptors induce heterologous desensitization of chemokine receptors. Blood 108: 38-44.
6. Oppermann M, Mack M, Proudfoot AE, Olbrich H, (1999) Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. J Biol Chem 274: 8875-8885.
7. Neel NF, Schutyser E, Sai J, Fan GH, Richmond A, (2005) Chemokine receptor internalization and intracellular trafficking. Cytokine Growth Factor Rev 16: 637-658.
8. Tobin AB, Butcher AJ, Kong KC, (2008) Location, location, location. Site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling. Trends Pharmacol Sci 29: 413-420.
9. Signoret N, Hewlett L, Wavre S, Pelchen-Matthews A, Oppermann M, et al. (2005) Agonist-induced endocytosis of CC chemokine receptor 5 is clathrin dependent. Mol Biol Cell 16: 902-917.
10. Venkatesan S, Rose JJ, Lodge R, Murphy PM, Foley JF, (2003) Distinct mechanisms of agonist-induced endocytosis for human chemokine receptors CCR5 and CXCR4. Mol Biol Cell 14: 3305-3324.
11. Garcia Lopez MA, Aguado MA, Lamaze C, Martinez A, Fischer T, (2009) Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2. Cell Signal 21: 1748-1757.
12. Borroni EM, Mantovani A, Locati M, Bonecchi R, (2010) Chemokine receptors intracellular trafficking. Pharmacol Ther 127: 1-8.
13. Moser B, Wolf M, Walz A, Loetscher P, (2004) Chemokines: multiple levels of leukocyte migration control. Trends Immunol 25: 75-84.
14. Charo IF, Myers SJ, Herman A, Franci C, Connolly AJ, et al. (1994) Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci USA 91: 2752-2756.
15. Franci C, Wong LM, Van Damme J, Proost P, Charo IF, (1995) Monocyte chemoattractant protein-3, but not monocyte chemoattractant protein-2, is a functional ligand of the human monocyte chemoattractant protein-1 receptor. J Immunol 154: 6511-6517.
16. Godiska R, Chantry D, Raport CJ, Schweickart VL, Trong HL, et al. (1997) Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. J Leukoc Biol 61: 353-360.
17. Dubois PM, Palmer D, Webb ML, Ledbetter JA, Shapiro RA, (1996) Early signal transduction by the receptor to the chemokine monocyte chemotactic protein-1 in a murine T cell hybrid. J Immunol 156: 1356-1361.
18. Sozzani S, Zhou D, Locati M, Rieppi M, Proost P, et al. (1994) Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3: Similarities and differences with MCP-1. J Immunol 152: 3615-3622.
19. Berchiche YA, Gravel S, Pelletier ME, St-Onge G, Heveker N, (2011) Different effects of the different natural CC chemokine receptor 2b ligands on beta-arrestin recruitment, Galphai signaling, and receptor internalization. Mol Pharmacol 79: 488-498.
20. Handel TM, Johnson Z, Rodrigues DH, Dos Santos AC, Cirillo R, et al. (2008) An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo. J Leukoc Biol 84: 1101-1108.
21. Franci C, Gosling J, Tsou CL, Coughlin SR, Charo IF, (1996) Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. J Immunol 157: 5606-5612.
22. Arai H, Monteclaro FS, Tsou CL, Franci C, Charo IF, (1997) Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B- Evidence that directed migration does not require rapid modulation of signaling at the receptor level. J Biol Chem 272: 25037-25042.
23. Nieto M, Frade JMR, Sancho D, Mellado M, Martinez C, et al. (1997) Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis. J Exp Med 186: 153-158.
24. Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR, (1999) Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10: 1163-1178.
25. Volpe S, Thelen S, Pertel T, Lohse MJ, Thelen M, (2010) Polarization of migrating monocytic cells is independent of PI 3-kinase activity. PLoS ONE 5: e10159.
26. Shaner NC, Campbell RE, Steinbach PA, Giepmans BN, Palmer AE, et al. (2004) Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol 22: 1567-1572.
27. Garotta G, Thelen M, Delia D, Kamber M, Baggiolini M, (1991) GM-1, a clone of the monoblastic phagocyte U937 that expresses a large respiratory burst capacity upon activation with interferon-gamma. J Leukocyte Biol 49: 294-301.
28. Shaner NC, Steinbach PA, Tsien RY, (2005) A guide to choosing fluorescent proteins. Nat Methods 2: 905-909.
29. Nibbs RJB, Wylie SM, Pragnell IB, Graham GJ, (1997) Cloning and characterization of a novel murine b chemokine receptor, D6- Comparison to three other related macrophage inflammatory protein-1a receptors, CCR-1, CCR-3, and CCR- 5. J Biol Chem 272: 12495-12504.
30. Graham GJ, (2009) D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes. Eur J Immunol 39: 342-351.
31. Savino B, Borroni EM, Machado TN, Proost P, Struyf S, et al. (2009) Recognition versus adaptive upregulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence. J Biol Chem 284: 26207-26215.
32. Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M, (2001) Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood 97: 1920-1924.
33. Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, et al. (1997) Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J Exp Med 185: 1595-1604.
34. Cherney RJ, Mo R, Meyer DT, Nelson DJ, Lo YC, et al. (2008) Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J Med Chem 51: 721-724.
35. Spiro DJ, Boll W, Kirchhausen T, Wessling-Resnick M, (1996) Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro. Mol Biol Cell 7: 355-367.
36. Naga Prasad SV, Jayatilleke A, Madamanchi A, Rockman HA, (2005) Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. Nat Cell Biol 7: 785-796.
37. Sauty A, Colvin RA, Wagner L, Rochat S, Spertini F, et al. (2001) CXCR3 internalization following T cell-endothelial cell contact: preferential role of IFN-inducible T cell alpha chemoattractant (CXCL11). J Immunol 167: 7084-7093.
38. Thelen M, Wymann MP, Langen H, (1994) Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein- coupled receptor signaling in neutrophil leukocytes. Proc Natl Acad Sci USA 91: 4960-4964.
39. Turner SJ, Domin J, Waterfield MD, Ward SG, Westwick J, (1998) The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K- C2alpha. J Biol Chem 273: 25987-25995.
40. Hoeller O, Kay RR, (2007) Chemotaxis in the absence of PIP3 gradients. Curr Biol 17: 813-817.
41. Ferguson GJ, Milne L, Kulkarni S, Sasaki T, Walker S, et al. (2007) PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat Cell Biol 9: 86-91.
42. Wang JM, Hishinuma A, Oppenheim JJ, Matsushima K, (1993) Studies of binding and internalization of human recombinant monocyte chemotactic and activating factor (MCAF) by monocytic cells. Cytokine 5: 264-275.
43. Yoshimura T, Leonard EJ, (1990) Identification of high affinity receptors for human monocyte chemoattractant protein-1 on human monocytes. J Immunol 145: 292-297.
44. Valente AJ, Rozek MM, Schwartz CJ, Graves DT, (1991) Characterization of monocyte chemotactic protein-1 binding to human monocytes. Biochem Biophys Res Commun 176: 309-314.
45. Sohy D, Parmentier M, Springael JY, (2007) Allosteric trans-inhibition by specific antagonists in CCR2/CXCR4 heterodimers. J Biol Chem 282: 30062-30069.
46. Maus UA, Wellmann S, Hampl C, Kuziel WA, Srivastava M, et al. (2005) CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels. Am J Physiol Lung Cell Mol Physiol 288: L350-L358.
47. Gong J-H, Clark-Lewis I, (1995) Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues. J Exp Med 181: 631-640.
48. Baggiolini M, Dewald B, Moser B, (1994) Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv Immunol 55: 97-179.
49. Panzer U, Uguccioni M, (2004) Prostaglandin E2 modulates the functional responsiveness of human monocytes to chemokines. Eur J Immunol 34: 3682-3689.
50. Arai H, Tsou CL, Charo IF, (1997) Chemotaxis in a lymphocyte cell line transfected with C- C chemokine receptor 2B: Evidence that directed migration is mediated by bgamma dimers released by activation of Gai- coupled receptors. Proc Natl Acad Sci USA 94: 14495-14499.