The roles of regulatory B cells in cancer

Journal of Immunology Research

Volumn 2014, Issue , 2014, Pages

  He, Yan ^a   Qian, Hongyan ^a   Liu, Yuan ^a   Duan, Lihua ^a   Li, Yan ^a   Shi, Guixiu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ADAPTIVE IMMUNITY; ALLERGIC AIRWAY INFLAMMATION; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BONE MARROW CELL; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG INFILTRATE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; NEOPLASM; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY B CELL; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; TUMOR IMMUNITY; ANIMAL; IMMUNOLOGY; METABOLISM;

ANIMALS; B-LYMPHOCYTES, REGULATORY; HUMANS; NEOPLASMS;

EID: 84903643054     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2014/215471     Document Type: Review

References (62)

1. Disis M. L., Immune regulation of cancer. Journal of Clinical Oncology 2010 28 29 4531 4538 2-s2.0-78149432308 10.1200/JCO.2009.27.2146
2. Swann J. B., Smyth M. J., Immune surveillance of tumors. Journal of Clinical Investigation 2007 117 5 1137 1146 2-s2.0-34248193253 10.1172/JCI31405 (Pubitemid 46718398)
3. Kim R., Emi M., Tanabe K., Cancer immunoediting from immune surveillance to immune escape. Immunology 2007 121 1 1 14 2-s2.0-34047220868 10.1111/j.1365-2567.2007.02587.x (Pubitemid 46537674)
4. Mizoguchi A., Mizoguchi E., Takedatsu H., Blumberg R. S., Bhan A. K., Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002 16 2 219 230 2-s2.0-0036197923 10.1016/S1074-7613(02)00274-1 (Pubitemid 34211962)
5. + phenotype controls T cell-dependent inflammatory responses. Immunity 2008 28 5 639 650 2-s2.0-43049156086 10.1016/j.immuni.2008.03.017 (Pubitemid 351636247)
6. Amu S., Saunders S. P., Kronenberg M., Mangan N. E., Atzberger A., Fallon P. G., Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. Journal of Allergy and Clinical Immunology 2010 125 5 1114.e8 1124.e8 2-s2.0-77951667958 10.1016/j.jaci.2010.01.018
7. Matsushita T., Yanaba K., Bouaziz J.-D., Fujimoto M., Tedder T. F., Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. Journal of Clinical Investigation 2008 118 10 3420 3430 2-s2.0-54949141219 10.1172/JCI36030
8. Watanabe R., Ishiura N., Nakashima H., Kuwano Y., Okochi H., Tamaki K., Sato S., Tedder T. F., Fujimoto M., Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. Journal of Immunology 2010 184 9 4801 4809 2-s2.0-77954505663 10.4049/jimmunol.0902385
9. Fillatreau S., Sweenie C. H., McGeachy M. J., Gray D., Anderton S. M., B cells regulate autoimmunity by provision of IL-10. Nature Immunology 2002 3 10 944 950 2-s2.0-0036795531 10.1038/ni833 (Pubitemid 35154008)
10. Evans J. G., Chavez-Rueda K. A., Eddaoudi A., Meyer-Bahlburg A., Rawlings D. J., Ehrenstein M. R., Mauri C., Novel suppressive function of transitional 2 B cells in experimental arthritis. Journal of Immunology 2007 178 12 7868 7878 2-s2.0-34250179766 (Pubitemid 46898059)
11. Blair P. A., Chavez-Rueda K. A., Evans J. G., Shlomchik M. J., Eddaoudi A., Isenberg D. A., Ehrenstein M. R., Mauri C., Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. Journal of Immunology 2009 182 6 3492 3502 2-s2.0-65449188259 10.4049/jimmunol.0803052
12. Di Caro V., Phillips B., Engman C., Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice. PLoS ONE 2014 9 1 e83575
13. Mauri C., Bosma A., Immune regulatory function of B cells. Annual Review of Immunology 2012 30 221 241 2-s2.0-84859385739 10.1146/annurev-immunol-020711- 074934
14. Ding Q., Yeung M., Camirand G., Zeng Q., Akiba H., Yagita H., Chalasani G., Sayegh M. H., Najafian N., Rothstein D. M., Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. Journal of Clinical Investigation 2011 121 9 3645 3656 2-s2.0-80052382391 10.1172/JCI46274
15. Rafei M., Hsieh J., Zehntner S., Li M., Forner K., Birman E., Boivin M.-N., Young Y. K., Perreault C., Galipeau J., A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties. Nature Medicine 2009 15 9 1038 1045 2-s2.0-69949153114 10.1038/nm.2003
16. Nishimura S., Manabe I., Takaki S., Adipose natural regulatory B cells negatively control adipose tissue inflammation. Cell Metabolism 2013 18 5 759 766
17. Iwata Y., Matsushita T., Horikawa M., DiLillo D. J., Yanaba K., Venturi G. M., Szabolcs P. M., Bernstein S. H., Magro C. M., Williams A. D., Hall R. P., St Clair E. W., Tedder T. F., Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011 117 2 530 541 2-s2.0-78751469622 10.1182/blood-2010-07-294249
18. hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010 32 1 129 140 2-s2.0-74649083783 10.1016/j.immuni.2009. 11.009
19. + T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells. Autoimmunity Reviews 2012 11 9 670 677 2-s2.0-84861724649 10.1016/j.autrev.2011.11.018
20. Kalampokis I., Yoshizaki A., Tedder T. F., IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Research and Therapy 2013 15 1, article S1 2-s2.0-84873601139 10.1186/ar3907
21. Byrne S. N., Halliday G. M., B cells activated in lymph nodes in response to ultraviolet irradiation or by interleukin-10 inhibit dendritic cell induction of immunity. Journal of Investigative Dermatology 2005 124 3 570 578 2-s2.0-15044340074 10.1111/j.0022-202X.2005.23615.x (Pubitemid 40381580)
22. Miles K., Heaney J., Sibinska Z., Salter D., Savill J., Gray D., Gray M., A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells. Proceedings of the National Academy of Sciences of the United States of America 2012 109 3 887 892 2-s2.0-84856373688 10.1073/pnas.1109173109
23. Yoshizaki A., Miyagaki T., Dilillo D. J., Matsushita T., Horikawa M., Kountikov E. I., Spolski R., Poe J. C., Leonard W. J., Tedder T. F., Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 2012 491 7423 264 268 2-s2.0-84868619716 10.1038/nature11501
24. Lindner S., Dahlke K., Sontheimer K., Hagn M., Kaltenmeier C., Barth T. F. E., Beyer T., Reister F., Fabricius D., Lotfi R., Lunov O., Nienhaus G. U., Simmet T., Kreienberg R., Moller P., Schrezenmeier H., Jahrsdorfer B., Interleukin 21-induced granzyme b-expressing b cells infiltrate tumors and regulate t cells. Cancer Research 2013 73 8 2468 2479 2-s2.0-84876991334 10.1158/0008-5472.CAN-12-3450
25. Jin G., Hamaguchi Y., Matsushita T., Hasegawa M., Le Huu D., Ishiura N., Naka K., Hirao A., Takehara K., Fujimoto M., B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells. Journal of Allergy and Clinical Immunology 2013 131 6 1674.e9 1682.e9 2-s2.0-84878544671 10.1016/j.jaci.2013.01.044
26. Yang X., Yang J., Chu Y., Wang J., Guan M., Zhu X., Xue Y., Zou H., T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-Prone MRL/lpr mice. PLoS ONE 2013 8 4 2-s2.0-84876513517 10.1371/journal.pone.0062855 e62855
27. Matsumoto M., Fujii Y., Baba A., Hikida M., Kurosaki T., Baba Y., The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production. Immunity 2011 34 5 703 714 2-s2.0-79956303933 10.1016/j.immuni.2011.03.016
28. Matsushita T., Horikawa M., Iwata Y., Tedder T. F., Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. Journal of Immunology 2010 185 4 2240 2252 2-s2.0-77956895769 10.4049/jimmunol.1001307
29. Wong S.-C., Puaux A.-L., Chittezhath M., Shalova I., Kajiji T. S., Wang X., Abastado J.-P., Lam K.-P., Biswas S. K., Macrophage polarization to a unique phenotype driven by B cells. European Journal of Immunology 2010 40 8 2296 2307 2-s2.0-77956114905 10.1002/eji.200940288
30. Tian J., Zekzer D., Hanssen L., Lu Y., Olcott A., Kaufman D. L., Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. Journal of Immunology 2001 167 2 1081 1089 2-s2.0-0035879105 (Pubitemid 32660868)
31. Liu Y., Chen Y., Li Z., Role of IL-10-producing regulatory B cells in control of cerebral malaria in Plasmodium berghei infected mice. European Journal of Immunology 2013 43 11 2907 2918
32. Carter N. A., Rosser E. C., Mauri C., Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis. Arthritis Research and Therapy 2012 14 1, article R32 2-s2.0-84856616941 10.1186/ar3736
33. Carter N. A., Vasconcellos R., Rosser E. C., Tulone C., Muñoz-Suano A., Kamanaka M., Ehrenstein M. R., Flavell R. A., Mauri C., Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells. Journal of Immunology 2011 186 10 5569 5579 2-s2.0-79956224216 10.4049/jimmunol.1100284
34. hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation. Science Translational Medicine 2013 5 173 2-s2.0-84874720574 10.1126/scitranslmed. 3005407 173ra23
35. Ray A., Basu S., Williams C. B., Salzman N. H., Dittel B. N., A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. Journal of Immunology 2012 188 7 3188 3198 2-s2.0-84859376769 10.4049/jimmunol.1103354
36. Sorrentino R., Morello S., Forte G., Montinaro A., De Vita G., Luciano A., Palma G., Arra C., Maiolino P., Adcock I. M., Pinto A., B cells contribute to the antitumor activity of CpG-oligodeoxynucleotide in a mouse model of metastatic lung carcinoma. The American Journal of Respiratory and Critical Care Medicine 2011 183 10 1369 1379 2-s2.0-79956207159 10.1164/rccm.201010-1738OC
37. + T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice. Journal of Immunology 2010 184 7 4006 4016 2-s2.0-77951629658 10.4049/jimmunol.0903009
38. Li Q., Teitz-Tennenbaum S., Donald E. J., Li M., Chang A. E., In vivo sensitized and in vitro activated B cells mediate tumor regression in cancer adoptive immunotherapy. Journal of Immunology 2009 183 5 3195 3203 2-s2.0-70349240438 10.4049/jimmunol.0803773
39. Shah S., Divekar A. A., Hilchey S. P., Cho H.-M., Newman C. L., Shin S.-U., Nechustan H., Challita-Eid P. M., Segal B. M., Yi K. H., Rosenblatt J. D., Increased rejection of primary tumors in mice lacking B cells: inhibition of anti-tumor CTL and TH1 cytokine responses by B cells. International Journal of Cancer 2005 117 4 574 586 2-s2.0-27144471717 10.1002/ijc.21177 (Pubitemid 41504545)
40. Qin Z., Richter G., Schüler T., Ibe S., Cao X., Blankenstein T., B cells inhibit induction of T cell-dependent tumor immunity. Nature Medicine 1998 4 5 627 630 2-s2.0-0031863680 10.1038/nm0598-627 (Pubitemid 28237366)
41. Inoue S., Leitner W. W., Golding B., Scott D., Inhibitory effects of B cells on antitumor immunity. Cancer Research 2006 66 15 7741 7747 2-s2.0-33747880415 10.1158/0008-5472.CAN-05-3766 (Pubitemid 44289234)
42. Zhang Y., Eliav Y., Shin S.-U., Schreiber T. H., Podack E. R., Tadmor T., Rosenblatt J. D., B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion. Cancer Immunology, Immunotherapy 2013 62 1 87 99 2-s2.0-84872489363 10.1007/s00262-012-1313-6
43. Olkhanud P. B., Baatar D., Bodogai M., Hakim F., Gress R., Anderson R. L., Deng J., Xu M., Briest S., Biragyn A., Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells. Cancer Research 2009 69 14 5996 6004 2-s2.0-67650995905 10.1158/0008-5472.CAN-08-4619
44. De Visser K. E., Korets L. V., Coussens L. M., De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 2005 7 5 411 423 2-s2.0-19344365408 10.1016/j.ccr.2005.04.014 (Pubitemid 40719125)
45. Houghton A. N., Uchi H., Wolchok J. D., The role of the immune system in early epithelial carcinogenesis: B-ware the double-edged sword. Cancer Cell 2005 7 5 403 405 2-s2.0-19344368041 10.1016/j.ccr.2005.04.026 (Pubitemid 40719122)
46. Schreiber H., Wu T. H., Nachman J., Rowley D. A., Immunological enhancement of primary tumor development and its prevention. Seminars in Cancer Biology 2000 10 5 351 357 2-s2.0-0033756657 10.1006/scbi.2000.0331
47. Ammirante M., Luo J.-L., Grivennikov S., Nedospasov S., Karin M., B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 2010 464 7286 302 305 2-s2.0-77949379050 10.1038/nature08782
48. Andreu P., Johansson M., Affara N. I., Pucci F., Tan T., Junankar S., Korets L., Lam J., Tawfik D., DeNardo D. G., Naldini L., de Visser K. E., De Palma M., Coussens L. M., FcR γ Activation regulates inflammation- associated squamous carcinogenesis. Cancer Cell 2010 17 2 121 134 2-s2.0-76349088502 10.1016/j.ccr.2009.12.019
49. Barbera-Guillem E., Nelson M. B., Barr B., Nyhus J. K., May K. F. Jr., Feng L., Sampsel J. W., B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion. Cancer Immunology Immunotherapy 2000 48 10 541 549 2-s2.0-0033988580 (Pubitemid 30004488)
50. Berthelot J.-M., Jamin C., Amrouche K., Le Goff B., Maugars Y., Youinou P., Regulatory B cells play a key role in immune system balance. Joint Bone Spine 2013 80 1 18 22 2-s2.0-84872867376 10.1016/j.jbspin.2012.04.010
51. Fiorentino D. F., Zlotnik A., Mosmann T. R., Howard M., O'Garra A., IL-10 inhibits cytokine production by activated macrophages. Journal of Immunology 1991 147 11 3815 3822 2-s2.0-0025889028
52. Townsend M. J., Monroe J. G., Chan A. C., B-cell targeted therapies in human autoimmune diseases: an updated perspective. Immunological Reviews 2010 237 1 264 283 2-s2.0-77955895130 10.1111/j.1600-065X.2010.00945.x
53. + T cells to T-regulatory cells. Cancer Research 2011 71 10 3505 3515 2-s2.0-79956131523 10.1158/0008-5472.CAN-10-4316
54. Olkhanud P. B., Rochman Y., Bodogai M., Malchinkhuu E., Wejksza K., Xu M., Gress R. E., Hesdorffer C., Leonard W. J., Biragyn A., Thymic stromal lymphopoietin is a key mediator of breast cancer progression. Journal of Immunology 2011 186 10 5656 5662 2-s2.0-79956194490 10.4049/jimmunol.1100463
55. Lelekakis M., Moseley J. M., Martin T. J., Hards D., Williams E., Ho P., Lowen D., Javni J., Miller F. R., Slavin J., Anderson R. L., A novel orthotopic model of breast cancer metastasis to bone. Clinical and Experimental Metastasis 1999 17 2 163 170 2-s2.0-0032768313 10.1023/A:1006689719505 (Pubitemid 29335443)
56. + regulatory T cells and for expansion of these cells. Journal of Immunology 2007 178 4 2018 2027 2-s2.0-33846923124 (Pubitemid 46233398)
57. Wejksza K., Catalina L.-C., Bodogai M., Bonzo J., Gonzalez F. J., Lehrmann E., Becker K., Biragyn A., Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked regulatory B Cells via peroxisome proliferator-activated receptor Journal of Immunology 2013 190 6 2575 2584 2-s2.0-84874853858 10.4049/jimmunol.1201920
58. Horikawa M., Minard-Colin V., Matsushita T., Tedder T. F., Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. Journal of Clinical Investigation 2011 121 11 4268 4280 2-s2.0-80555124922 10.1172/JCI59266
59. Bodogai M., Chang C. L., Wejksza K., Lai J., Merino M., Wersto R. P., Gress R. E., Chan A. C., Hesdorffer C., Biragyn A., Anti-CD20 antibody promotes cancer escape via enrichment of tumor-evoked regulatory B cells expressing low levels of CD20 and CD137L. Cancer Research 2013 73 7 2127 2138 2-s2.0-84876008718 10.1158/0008-5472.CAN-12-4184
60. Minard-Colin V., Xiu Y., Poe J. C., Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood 2008 112 4 1205 1213
61. Schioppa T., Moore R., Thompson R. G., Rosser E. C., Kulbe H., Nedospasov S., Mauri C., Coussens L. M., Balkwill F. R., B regulatory cells and the tumor-promoting actions of TNF- during squamous carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America 2011 108 26 10662 10667 2-s2.0-79960605654 10.1073/pnas.1100994108
62. Lebien T. W., Tedder T. F., B lymphocytes: how they develop and function. Blood 2008 112 5 1570 1580 2-s2.0-47249099558 10.1182/blood-2008-02-078071