Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells

Journal of Immunology

Volumn 186, Issue 10, 2011, Pages 5569-5579

  Carter, Natalie A ^a   Vasconcellos, Rita ^a,b   Rosser, Elizabeth C ^a   Tulone, Calogero ^a   Muñoz Suano, Alba ^c   Kamanaka, Masahito ^d,e   Ehrenstein, Michael R ^a   Flavell, Richard A ^d   Mauri, Claudia ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Arai Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; B LYMPHOCYTE; CD4+ CD25- T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL INTERACTION; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; IMMUNOREGULATION; IN VITRO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY B LYMPHOCYTE; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; UPREGULATION; WILD TYPE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD4; ARTHRITIS; AUTOIMMUNITY; B-LYMPHOCYTE SUBSETS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-17; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PRECURSOR CELLS, B-LYMPHOID; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS;

EID: 79956224216     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100284     Document Type: Article

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