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Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice
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This elegant experimental study demonstrated that inhibition of IL6 trans-signaling with an sgp130Fc fusion protein can dramatically reduce, and even reverse, atherosclerosis in mice. Importantly, sgp130FC did not increase serum lipid levels, a common occurrence with tocilizumab treatment
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.• Schuett H, Oestreich R, Waetzig GH, Annema W, Luchtefeld M, Hillmer A, et al. Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2011;32(2):281-90. This elegant experimental study demonstrated that inhibition of IL6 trans-signaling with an sgp130Fc fusion protein can dramatically reduce, and even reverse, atherosclerosis in mice. Importantly, sgp130FC did not increase serum lipid levels, a common occurrence with tocilizumab treatment.
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(2011)
Arterioscler Thromb Vasc Biol
, vol.32
, Issue.2
, pp. 281-290
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Schuett, H.1
Oestreich, R.2
Waetzig, G.H.3
Annema, W.4
Luchtefeld, M.5
Hillmer, A.6
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