Serum Levels of Interleukin-6 and Its Soluble Receptors in Patients with Hepatitis C Virus Infection

Human Immunology

Volumn 67, Issue 1-2, 2006, Pages 27-32

  Migita, Kiyoshi ^a   Abiru, Seigo ^a   Maeda, Yumi ^a   Daikoku, Manabu ^a   Ohata, Kazuyuki ^a   Nakamura, Minoru ^a   Komori, Atsumasa ^a   Yano, Koji ^a   Yatsuhashi, Hiroshi ^a   Eguchi, Katsumi ^b   Ishibashi, Hiromi ^a  

^a NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hepatitis C virus; Interleukin 6; Liver cirrhosis; Soluble interleukin 6 receptor

Indexed keywords

BILIRUBIN; CHOLINESTERASE; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; PROTHROMBIN; SOLUBLE INTERLEUKIN 6 RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BILIRUBIN BLOOD LEVEL; CHRONIC HEPATITIS; CHRONIC LIVER DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; LIVER CIRRHOSIS; LIVER DYSFUNCTION; LIVER FIBROSIS; LIVER FUNCTION; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; STATISTICAL SIGNIFICANCE; VIRUS INFECTION;

AGED; CHRONIC DISEASE; CYTOKINE RECEPTOR GP130; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; INTERLEUKIN-6; LIVER DISEASES; LIVER REGENERATION; MALE; MIDDLE AGED; PROGNOSIS; RECEPTORS, INTERLEUKIN-6;

EID: 33646485510     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2006.02.025     Document Type: Article

References (31)

1. Hirano T., Akira S., Taga T., and Kishimoto T. Biological and clinical aspects of interleukin 6. Immunol Today 11 (1990) 443
2. Akira S., Taga T., and Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol 54 (1993) 1
3. Barton B.E. IL-6. insights into novel biological activities. Clin Immunol Immunopathol 85 (1997) 16
4. Heinrich P.C., Castell J.V., and Andus T. Interleukin-6 and the acute phase response. Biochem J 265 (1990) 621
5. Akira S., and Kishimoto T. IL-6 and NF-IL6 in acute-phase response and viral infection. Immunol Rev 127 (1992) 25
6. Michalopoulos G.K., and DeFrances M.C. Liver regeneration. Science 276 (1997) 60
7. Streetz K.L., Luedde T., Manns M.P., and Trautwein C. Interleukin 6 and liver regeneration. Gut 47 (2000) 309
8. Blindenbacher A., Wang X., Langer I., Savino R., Terracciano L., and Heim M.H. Interleukin 6 is important for survival after partial hepatectomy in mice. Hepatology 38 (2003) 674
9. Galun E., and Axelrod J.H. The role of cytokines in liver failure and regeneration. potential new molecular therapies. Biochim Biophys Acta 1592 (2002) 345
10. Genesca J., Gonzalez A., Segura R., Catalan R., Marti R., Varela E., Cadelina G., Martinez M., Lopez-Talavera J.C., Esteban R., Groszmann R.J., and Guardia J. Interleukin-6, nitric oxide, and the clinical and hemodynamic alterations of patients with liver cirrhosis. Am J Gastroenterol 94 (1999) 169
11. Kakumu S., Shinagawa T., Ishikawa T., Yoshioka K., Wakita T., Ito Y., Takayanagi M., and Ida N. Serum interleukin 6 levels in patients with chronic hepatitis B. Am J Gastroenterol 86 (1991) 1804
12. Taga T., and Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 15 (1997) 797
13. Jones S.A., and Rose-John S. The role of soluble receptors in cytokine biology. the agonistic properties of the sIL-6R/IL-6 complex. Biochim Biophys Acta 1592 (2002) 251
14. Heinrich P.C., Graeve L., Rose-John S., Schneider-Mergener J., Dittrich E., Erren A., Gerhartz C., Hemann U., Lutticken C., and Wegenka U. Membrane-bound and soluble interleukin-6 receptor. studies on structure, regulation of expression, and signal transduction. Ann N Y Acad Sci 762 (1995) 222
15. Jones S.A., Horiuchi S., Topley N., Yamamoto N., and Fuller G.M. The soluble interleukin 6 receptor. mechanisms of production and implications in disease. FASEB J 15 (2001) 43
16. Kallen K.J. The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases. Biochim Biophys Acta 1592 (2002) 323
17. Jostock T., Mullberg J., Ozbek S., Atreya R., Blinn G., Voltz N., Fischer M., Neurath M.F., and Rose-John S. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem 268 (2001) 160
18. Rehermann B., Trautwein C., Boker K.H., and Manns M.P. Interleukin-6 in liver diseases. J Hepatol 15 (1992) 277
19. Bedossa P., Poynard T., and The METAVIR Cooperative Study Group. An algorithm for the grading of activity in chronic hepatitis C. Hepatology 24 (1996) 289
20. Yamada Y., Kirillova I., Peschon J.J., and Fausto N. Initiation of liver growth by tumor necrosis factor. deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 94 (1997) 1441
21. Fausto N. Liver regeneration. J Hepatol 32 1 Suppl (2000) 19
22. Lapinski T.W. The levels of IL-1beta, IL-4 and IL-6 in the serum and the liver tissue of chronic HCV-infected patients. Arch Immunol Ther Exp 49 (2001) 311
23. Malaguarnera M., Di Fazio I., Romeo M.A., Restuccia S., Laurino A., and Trovato B.A. Elevation of interleukin 6 levels in patients with chronic hepatitis due to hepatitis C virus. J Gastroenterol 32 (1997) 211
24. Frieling J.T., van Hamersvelt H.W., Wijdenes J., Hendriks T., Sauerwein R.W., and van Der Linden C.J. Circulating concentrations of soluble interleukin 6 receptors gp80 and gp130 in chronic renal failure and effects of renal replacement therapy. Am J Nephrol 19 (1999) 571
25. Dandona P., Aljada A., and Bandyopadhyay A. Inflammation. the link between insulin resistance, obesity and diabetes. Trends Immunol 25 (2004) 4
26. Genesca J., Marti R., Gonzalez A., Torregrosa M., and Segura R. Soluble interleukin-6 receptor levels in liver cirrhosis. Am J Gastroenterol 94 (1999) 3074
27. Rose-John S. Interleukin-6 biology is coordinated by membrane bound and soluble receptors. Acta Biochim Pol 50 (2003) 603
28. Montero-Julian F.A. The soluble IL-6 receptors. serum levels and biological function. Cell Mol Biol 47 (2001) 583
29. Cressman D.E., Greenbaum L.E., DeAngelis R.A., Ciliberto G., Furth E.E., Poli V., and Taub R. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274 (1996) 1379
30. Maione D., Di Carlo E., Li W., Musiani P., Modesti A., Peters M., Rose-John S., Della Rocca C., Tripodi M., Lazzaro D., Taub R., Savino R., and Ciliberto G. Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver. EMBO J 17 (1998) 5588
31. Schirmacher P., Peters M., Ciliberto G., Blessing M., Lotz J., Meyer zum Buschenfelde K.H., and Rose-John S. Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice. Am J Pathol 153 (1998) 639