Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure

Heart and Vessels

Volumn 19, Issue 5, 2004, Pages 237-241

  Hirota, Hisao ^a   Izumi, Masahiro ^a   Hamaguchi, Tomoyuki ^b   Sugiyama, Shoko ^b   Murakami, Eiki ^c   Kunisada, Keita ^a   Fujio, Yasushi ^a   Oshima, Yuichi ^a   Nakaoka, Yoshikazu ^a   Yamauchi Takihara, Keiko ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA PREFECTURAL MEDICAL CENTER FOR RESPIRATORY AND ALLERGIC DISEASES   (Japan)

^c Kinki Central Hospital of Mutual Association of Public School Teachers   (Japan)

Author keywords

Cardiomyopathy; Cytokine; gp130; Heart failure

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

AGED; ARTICLE; BLOOD LEVEL; CONGESTIVE CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; VALVULAR HEART DISEASE;

AGED; ANTIGENS, CD; CARDIOMYOPATHY, DILATED; CYTOKINE RECEPTOR GP130; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART FAILURE, CONGESTIVE; HUMANS; INTERLEUKIN-11; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; MALE; MEMBRANE GLYCOPROTEINS; NATRIURETIC PEPTIDE, BRAIN; RECEPTORS, INTERLEUKIN-6;

EID: 5044225420     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00380-004-0770-z     Document Type: Article

References (16)

1. Yamauchi-Takihara K, Kishimoto T (2000) Cytokines and their receptors in cardiovascular diseases - role of gp130 signaling pathway in cardiac myocyte growth and maintenance. Int J Exp Pathol 81:1-16
2. Pan J, Fukuda K, Kodama H, Sano M, Takahashi T, Makino S, Kato T, Manabe T, Hori S, Ogawa S (1998) Involvement of gp130-mediated signaling in pressure overload-induced activation of the JAK/STAT pathway in rodent heart. Heart Vessels 13:199-208
3. Hirota H, Chen J, Betz UAK, Rajewsky K, Gu Y, Ross J Jr, Muller W, Chien K (1999) Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell 97:189-198
4. Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D, Mabuchi N, Sawaki M, Kinoshita M (1998) Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 31:391-398
5. Talwar S, Downie PF, Squire IB, Barnett DB, Davies JD, Ng LL (1999) An immunoluminometric assay for cardiotrophin-1: a newly identified cytokine is present in normal human plasma and is increased in heart failure. Biochem Biophys Res Commun 261:567-571
6. Tsutamoto T, Wada A, Maeda K, Mabuchi N, Hayashi M, Tsutsui T, Ohnishi M, Fujii M, Matsumoto T, Yamamoto T, Wang X, Asai S, Tsuji T, Tanaka H, Saito Y, Kuwahara K, Nakao K, Kinoshita M (2001) Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy. J Am Coll Cardiol 38:1485-1490
7. Jougasaki M, Tachibana I, Luchner A, Leskinen H, Redfield MM, Burnett JC Jr (2000) Augmented cardiac cardiotrophin-1 in experimental congestive heart failure. Circulation 101:14-17
8. Wang F, Seta Y, Baumgarten G, Engel DJ, Sivasubramanian N, Mann DL (2001) Functional significance of hemodynamic overload-induced expression of leukemia inhibitory factor in the adult mammalian heart. Circulation 103:1296-1302
9. Eiken HG, Oie E, Damas JK, Yndestad A, Bjerkeli V, Aass H, Simonsen S, Geiran OR, Tonnessen T, Christensen G, Froland SS, Gullestad L, Attramadal H, Aukrust P (2001) Myocardial gene expression of leukemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure. Eur J Clin Invest 31:389-397
10. Zolk O, Ng LL, O'Brien RJ, Weyand M, Eschenhagen T (2002) Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance. Circulation 106:1442-1446
11. Aukrust P, Ueland T, Lien E, Bendtzen K, Muller F, Andreassen AK, Nordoy I, Aass H, Espevik T, Simonsen S, Froland SS, Gullestad L (1999) Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 83:376-382
12. Geisterfer M, Richards CD, Gauldie J (1995) Cytokines oncostatin M and interleukin 1 regulate the expression of the IL-6 receptor (gp80, gp130). Cytokine 7:503-509
13. Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, Yancopoulos GD, Taga T, Kishimoto T (1993) Soluble forms of the interleukin-6 signal transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 82:1120-1126
14. Matsui H, Fujio Y, Kunisada K, Hirota H, Yamauchi-Takihara K (1996) Leukemia inhibitory factor induces a hypertrophic response mediated by gp130 in murine cardiac myocytes. Res Commun Mol Pathol Pharmacol 93:149-162
15. Pennica D, Shaw KJ, Swanson TA, Moore MW, Shelton DL, Zioncheck KA, Rosenthal A, Taga T, Paoni NF, Wood WI (1995) Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J Biol Chem 270:10915-10922
16. Yamaoka M, Yamaguchi S, Okuyama M, Tomoike H (1999) Anti-inflammatory cytokine profile in human heart failure: behavior of interleukin-10 in association with tumor necrosis factor-alpha. Jpn Circ J 63:951-956