Insulin receptor substrate (IRS) proteins IRS-1 and IRS-2 differential signaling in the insulin/insulin-like growth factor-I pathways in fetal brown adipocytes

Molecular Endocrinology

Volumn 12, Issue 5, 1998, Pages 688-697

  Valverde, A M ^a   Lorenzo, M ^a   Pons, S ^a   White, M F ^a   Benito, M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TYROSINE;

ANIMAL CELL; ARTICLE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; FETUS; HORMONE ACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

EID: 0032230293     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.5.0106     Document Type: Article

References (34)

1. Insulin action and the insulin signaling network
2. Insulin-like growth factors and their binding proteins: Biological actions
3. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
4. Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
5. The phosphatidylinositol 3-kinase is activated by association with IRS-1 during insulin stimulation
6. The function of GRB2 in linking the insulin receptor to Ras signaling pathways
7. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
8. The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp
9. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene
10. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
11. Role of IRS-2 in insulin and cytokine signaling
12. The IRS-2 gene on Murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action
13. Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells
14. Proliferation of fetal brown adipocyte primary cultures: Relationship with the genetic expression of glucose 6-phosphate dehydrogenase
15. IGF-I is a mitogen also involved in differentiation-related gene expression in fetal rat brown adipocytes
16. cAMP inhibits IGF-I-induced mitogenesis in fetal rat brown adipocytes: Role of p21 ras
17. Hormonal regulation of malic enzyme and glucose 6-phosphate dehydrogenase in fetal brown adipocyte primary cultures
18. Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes
19. Differentiation of rat brown adipocytes during late foetal development: Role of insulin-like growth factor I
20. Insulin-like growth factor I and insulin induce adipogenic-related gene expression in foetal brown adipocyte primary cultures
21. Involvement of Raf-1 kinase and protein kinase C ζ in insulin-like growth factor I-induced brown adipocyte mitogenic signaling cascades: Inhibition by cyclic adenosine 3,5-monophosphate
22. Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes
23. 4PS/Insulin receptor substrate-1 is the alternative substrate of the insulin receptor in IRS-1 deficient mice
24. Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1
25. Insulin signaling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate1-deficient mice
26. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1 deficient cells
27. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS-1 and Shc: Implications for insulin control of ras signaling
28. The insulin signalling system and the IRS proteins
29. Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor
30. Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21 ras-GTP formation
31. Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking
32. Divergent regulation of phosphatidylinositol 3-kinase P85α and P85β isoforms upon T cell activation
33. The 60 kDa insulin receptor substrate functions like an IRS protein (pp60(IRS3)) in adipose cells
34. A rapid and sensitive method for the quantitation of microgram quantities utilizing the principle of protein dye binding