메뉴 건너뛰기




Volumn 171, Issue 1, 2014, Pages 77-88

Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; MITOCHONDRIAL DNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PLACEBO; TESTOSTERONE;

EID: 84903532634     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-14-0006     Document Type: Article
Times cited : (30)

References (46)
  • 1
    • 79961243360 scopus 로고    scopus 로고
    • Low testosterone in men with type 2 diabetes: Significance and treatment
    • doi:10.1210/jc.2011-0118
    • Grossmann M. Low testosterone in men with type 2 diabetes: significance and treatment. Journal of Clinical Endocrinology and Metabolism 2011 96 2341-2353. (doi:10.1210/jc.2011-0118)
    • (2011) Journal of Clinical Endocrinology and Metabolism , vol.96 , pp. 2341-2353
    • Grossmann, M.1
  • 2
    • 70849117428 scopus 로고    scopus 로고
    • Testosterone deficiency, insulin resistance and the metabolic syndrome
    • doi:10.1038/nrendo.2009.212
    • Zitzmann M. Testosterone deficiency, insulin resistance and the metabolic syndrome. Nature Reviews. Endocrinology 2009 5 673-681. (doi:10.1038/nrendo. 2009.212)
    • (2009) Nature Reviews. Endocrinology , vol.5 , pp. 673-681
    • Zitzmann, M.1
  • 3
    • 84863561473 scopus 로고    scopus 로고
    • Androgens and skeletal muscle: Cellular and molecular action mechanisms underlying the anabolic actions
    • doi:10.1007/s00018-011-0883-3
    • Dubois V, Laurent M, Boonen S, Vanderschueren D & Claessens F. Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions. Cellular and Molecular Life Sciences 2012 69 1651-1667. (doi:10.1007/s00018-011-0883-3)
    • (2012) Cellular and Molecular Life Sciences , vol.69 , pp. 1651-1667
    • Dubois, V.1    Laurent, M.2    Boonen, S.3    Vanderschueren, D.4    Claessens, F.5
  • 4
    • 84862326636 scopus 로고    scopus 로고
    • Testosterone therapy increased muscle mass and lipid oxidation in aging men
    • doi:10.1007/s11357-011-9213-9
    • Frederiksen L, Hojlund K, Hougaard DM, Brixen K & Andersen M. Testosterone therapy increased muscle mass and lipid oxidation in aging men. Age 2012 34 145-156. (doi:10.1007/s11357-011-9213-9)
    • (2012) Age , vol.34 , pp. 145-156
    • Frederiksen, L.1    Hojlund, K.2    Hougaard, D.M.3    Brixen, K.4    Andersen, M.5
  • 6
    • 33750932543 scopus 로고    scopus 로고
    • Impaired glycogen synthase activity and mitochondrial dysfunction in skeletal muscle: Markers or mediators of insulin resistance in type 2 diabetes?
    • doi:10.2174/1573399810602040375
    • Hojlund K & Beck-Nielsen H. Impaired glycogen synthase activity and mitochondrial dysfunction in skeletal muscle: markers or mediators of insulin resistance in type 2 diabetes? Current Diabetes Reviews 2006 2 375-395. (doi:10.2174/1573399810602040375)
    • (2006) Current Diabetes Reviews , vol.2 , pp. 375-395
    • Hojlund, K.1    Beck-Nielsen, H.2
  • 8
    • 34249720640 scopus 로고    scopus 로고
    • Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes
    • doi:10.2337/db06-0981
    • Mogensen M, Sahlin K, Fernstrom M, Glintborg D, Vind BF, Beck-Nielsen H & Hojlund K. Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes 2007 56 1592-1599. (doi:10.2337/db06- 0981)
    • (2007) Diabetes , vol.56 , pp. 1592-1599
    • Mogensen, M.1    Sahlin, K.2    Fernstrom, M.3    Glintborg, D.4    Vind, B.F.5    Beck-Nielsen, H.6    Hojlund, K.7
  • 10
    • 84856415487 scopus 로고    scopus 로고
    • The role of mitochondria in insulin resistance and type 2 diabetes mellitus
    • doi:10.1038/nrendo.2011.138
    • Szendroedi J, Phielix E & Roden M. The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nature Reviews. Endocrinology 2012 8 92-103. (doi:10.1038/nrendo.2011.138)
    • (2012) Nature Reviews. Endocrinology , vol.8 , pp. 92-103
    • Szendroedi, J.1    Phielix, E.2    Roden, M.3
  • 14
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • doi:10.1073/pnas.1032913100
    • Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. PNAS 2003 100 8466-8471. (doi:10.1073/pnas.1032913100)
    • (2003) PNAS , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3    Cusi, K.4    Berria, R.5    Kashyap, S.6    Miyazaki, Y.7    Kohane, I.8    Costello, M.9    Saccone, R.10
  • 15
    • 12344305124 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and type 2 diabetes
    • doi:10.1126/science.1104343
    • Lowell BB & Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science 2005 307 384-387. (doi:10.1126/science.1104343)
    • (2005) Science , vol.307 , pp. 384-387
    • Lowell, B.B.1    Shulman, G.I.2
  • 17
    • 20044389885 scopus 로고    scopus 로고
    • Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects
    • doi:10.2337/diabetes.54.6.1692
    • Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE & Wallberg-Henriksson H. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes 2005 54 1692-1697. (doi:10.2337/diabetes.54.6.1692)
    • (2005) Diabetes , vol.54 , pp. 1692-1697
    • Karlsson, H.K.1    Zierath, J.R.2    Kane, S.3    Krook, A.4    Lienhard, G.E.5    Wallberg-Henriksson, H.6
  • 18
    • 79953767747 scopus 로고    scopus 로고
    • Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training
    • doi:10.1007/s00125-010-1924-4
    • Vind BF, Pehmoller C, Treebak JT, Birk JB, Hey-Mogensen M, Beck-Nielsen H, Zierath JR, Wojtaszewski JF & Hojlund K. Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training. Diabetologia 2011 54 157-167. (doi:10.1007/s00125-010-1924-4)
    • (2011) Diabetologia , vol.54 , pp. 157-167
    • Vind, B.F.1    Pehmoller, C.2    Treebak, J.T.3    Birk, J.B.4    Hey-Mogensen, M.5    Beck-Nielsen, H.6    Zierath, J.R.7    Wojtaszewski, J.F.8    Hojlund, K.9
  • 20
    • 70349665186 scopus 로고    scopus 로고
    • Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): Comparison of oral and transdermal testosterone administration in hypopituitary men
    • doi:10.1111/j.1365-2265.2009.03524.x
    • Birzniece V, Meinhardt UJ, Handelsman DJ & Ho KK. Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): comparison of oral and transdermal testosterone administration in hypopituitary men. Clinical Endocrinology 2009 71 715-721. (doi:10.1111/j.1365-2265.2009.03524.x)
    • (2009) Clinical Endocrinology , vol.71 , pp. 715-721
    • Birzniece, V.1    Meinhardt, U.J.2    Handelsman, D.J.3    Ho, K.K.4
  • 23
    • 79251538909 scopus 로고    scopus 로고
    • Voluntary running, skeletal muscle gene expression, and signaling inversely regulated by orchidectomy and testosterone replacement
    • doi:10.1152/ajpendo.00402.2010
    • Ibebunjo C, Eash JK, Li C,Ma Q & Glass DJ. Voluntary running, skeletal muscle gene expression, and signaling inversely regulated by orchidectomy and testosterone replacement. American Journal of Physiology. Endocrinology and Metabolism 2011 300 E327-E340. (doi:10.1152/ajpendo.00402. 2010)
    • (2011) American Journal of Physiology. Endocrinology and Metabolism , vol.300
    • Ibebunjo, C.1    Eash, J.K.2    Li, C.3    Ma, Q.4    Glass, D.J.5
  • 24
    • 80052564156 scopus 로고    scopus 로고
    • Testosterone or 17β-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes
    • doi:10.1530/JOE-10-0497
    • Salehzadeh F, Rune A, Osler M & Al-Khalili L. Testosterone or 17β-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. Journal of Endocrinology 2011 210 219-229. (doi:10.1530/JOE-10-0497)
    • (2011) Journal of Endocrinology , vol.210 , pp. 219-229
    • Salehzadeh, F.1    Rune, A.2    Osler, M.3    Al-Khalili, L.4
  • 25
    • 67651159365 scopus 로고    scopus 로고
    • Transcriptional control of mitochondrial biogenesis and function
    • doi:10.1146/annurev.physiol.010908.163119
    • Hock MB & Kralli A. Transcriptional control of mitochondrial biogenesis and function. Annual Review of Physiology 2009 71 177-203. (doi:10.1146/annurev.physiol.010908.163119)
    • (2009) Annual Review of Physiology , vol.71 , pp. 177-203
    • Hock, M.B.1    Kralli, A.2
  • 26
    • 34447131545 scopus 로고    scopus 로고
    • Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men
    • doi:10.1210/jc.2006-1847
    • Nielsen TL, Hagen C,Wraae K, Brixen K, Petersen PH, Haug E, Larsen R & Andersen M. Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men. Journal of Clinical Endocrinology and Metabolism 2007 92 2696-2705. (doi:10.1210/jc.2006-1847)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 2696-2705
    • Nielsen, T.L.1    Hagen Cwraae, K.2    Brixen, K.3    Petersen, P.H.4    Haug, E.5    Larsen, R.6    Andersen, M.7
  • 28
    • 0029920988 scopus 로고    scopus 로고
    • Effects of insulin on glucose turnover rates in vivo: Isotope dilution versus constant specific activity technique
    • doi:10.1016/S0026-0495(96)90204-8
    • Hother-Nielsen O, Henriksen JE, Holst JJ & Beck-Nielsen H. Effects of insulin on glucose turnover rates in vivo: isotope dilution versus constant specific activity technique. Metabolism 1996 45 82-91. (doi:10.1016/S0026- 0495(96)90204-8)
    • (1996) Metabolism , vol.45 , pp. 82-91
    • Hother-Nielsen, O.1    Henriksen, J.E.2    Holst, J.J.3    Beck-Nielsen, H.4
  • 29
    • 33646504856 scopus 로고    scopus 로고
    • Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes
    • doi:10.1007/s00125-006-0240-5
    • Hojlund K, Frystyk J, Levin K, Flyvbjerg A, Wojtaszewski JF & Beck-Nielsen H. Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes. Diabetologia 2006 49 1283-1291. (doi:10.1007/s00125-006- 0240-5)
    • (2006) Diabetologia , vol.49 , pp. 1283-1291
    • Hojlund, K.1    Frystyk, J.2    Levin, K.3    Flyvbjerg, A.4    Wojtaszewski, J.F.5    Beck-Nielsen, H.6
  • 31
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • doi:10.1210/jcem.84.10.6079
    • Vermeulen A, Verdonck L & Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism 1999 84 3666-3672. (doi:10.1210/jcem.84.10.6079)
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 32
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • RESEARCH0034 doi:10.1186/gb-2002-3-7-research0034
    • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van RoyN,De Paepe A& Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology 2002 3. RESEARCH0034. (doi:10.1186/gb-2002-3-7-research0034)
    • (2002) Genome Biology , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roynde Paepe, A.5    Speleman, F.6
  • 33
    • 45449087921 scopus 로고    scopus 로고
    • QBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data
    • doi:10.1186/gb-2007-8-2-r19
    • Hellemans J, Mortier G, De Paepe A, Speleman F & Vandesompele J. qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biology 2007 8 R19. (doi:10.1186/gb-2007-8-2-r19)
    • (2007) Genome Biology , vol.8
    • Hellemans, J.1    Mortier, G.2    De Paepe, A.3    Speleman, F.4    Vandesompele, J.5
  • 34
    • 0030592623 scopus 로고    scopus 로고
    • The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro
    • doi:10.1016/S0014-5793(96)01209-4
    • Woods A, Salt I, Scott J, Hardie DG & Carling D. The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. FEBS Letters 1996 397 347-351. (doi:10.1016/S0014-5793(96)01209-4)
    • (1996) FEBS Letters , vol.397 , pp. 347-351
    • Woods, A.1    Salt, I.2    Scott, J.3    Hardie, D.G.4    Carling, D.5
  • 35
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • doi:10.1038/nrm3311
    • Hardie DG, Ross FA & Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature Reviews. Molecular Cell Biology 2012 13 251-262. (doi:10.1038/nrm3311)
    • (2012) Nature Reviews. Molecular Cell Biology , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 37
    • 0037059013 scopus 로고    scopus 로고
    • Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMPactivated protein kinase activation
    • doi:10.1073/pnas.222657499
    • Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang CC, Itani SI, Lodish HF & Ruderman NB. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMPactivated protein kinase activation. PNAS 2002 99 16309-16313. (doi:10.1073/pnas.222657499)
    • (2002) PNAS , vol.99 , pp. 16309-16313
    • Tomas, E.1    Tsao, T.S.2    Saha, A.K.3    Murrey, H.E.4    Zhang, C.C.5    Itani, S.I.6    Lodish, H.F.7    Ruderman, N.B.8
  • 38
    • 33750578279 scopus 로고    scopus 로고
    • Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha
    • doi:10.2337/db05-1322
    • Yoon MJ, Lee GY, Chung JJ, Ahn YH, Hong SH & Kim JB. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 2006 55 2562-2570. (doi:10.2337/db05-1322)
    • (2006) Diabetes , vol.55 , pp. 2562-2570
    • Yoon, M.J.1    Lee, G.Y.2    Chung, J.J.3    Ahn, Y.H.4    Hong, S.H.5    Kim, J.B.6
  • 40
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • doi:10.1210/er.2005-0005
    • Kadowaki T & Yamauchi T. Adiponectin and adiponectin receptors. Endocrine Reviews 2005 26 439-451. (doi:10.1210/er.2005-0005)
    • (2005) Endocrine Reviews , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 43
    • 33846991956 scopus 로고    scopus 로고
    • Position statement: Utility, limitations, and pitfalls in measuring testosterone: An Endocrine Society position statement
    • doi:10.1210/jc.2006-1864
    • Rosner W, Auchus RJ, Azziz R, Sluss PM & Raff H. Position statement: utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. Journal of Clinical Endocrinology and Metabolism 2007 92 405-413. (doi:10.1210/jc.2006-1864)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 405-413
    • Rosner, W.1    Auchus, R.J.2    Azziz, R.3    Sluss, P.M.4    Raff, H.5
  • 44
    • 34249103249 scopus 로고    scopus 로고
    • The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes
    • doi:10.1530/EJE-06-0737
    • Kapoor D, Clarke S, Stanworth R, Channer KS & Jones TH. The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes. European Journal of Endocrinology 2007 156 595-602. (doi:10.1530/EJE-06-0737)
    • (2007) European Journal of Endocrinology , vol.156 , pp. 595-602
    • Kapoor, D.1    Clarke, S.2    Stanworth, R.3    Channer, K.S.4    Jones, T.H.5
  • 46
    • 15944404290 scopus 로고    scopus 로고
    • Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    • doi:10.1210/jc.2004-1933
    • Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ & Tenover JL. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. Journal of Clinical Endocrinology and Metabolism 2005 90 1502-1510. (doi:10.1210/jc.2004-1933)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , pp. 1502-1510
    • Page, S.T.1    Amory, J.K.2    Bowman, F.D.3    Anawalt, B.D.4    Matsumoto, A.M.5    Bremner, W.J.6    Tenover, J.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.