메뉴 건너뛰기




Volumn 166, Issue 3, 2012, Pages 469-476

Testosterone therapy decreases subcutaneous fat and adiponectin in aging men

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; INSULIN; PLACEBO; TESTOSTERONE;

EID: 84857933573     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-11-0565     Document Type: Article
Times cited : (78)

References (45)
  • 1
    • 79955604878 scopus 로고    scopus 로고
    • Do androgens play any role in the physical frailty of ageing men?
    • doi:10.1111/j.1365-2605.2010.01093.x
    • O'Connell MD, Tajar A, Roberts SA & Wu FC. Do androgens play any role in the physical frailty of ageing men? International Journal of Andrology 2010 34 195-211. (doi:10.1111/j.1365-2605.2010.01093.x)
    • (2010) International Journal of Andrology , vol.34 , pp. 195-211
    • O'Connell, M.D.1    Tajar, A.2    Roberts, S.A.3    Wu, F.C.4
  • 2
    • 84862326636 scopus 로고    scopus 로고
    • Testosterone therapy increased muscle mass and lipid oxidation in aging men
    • In Press. (doi:10.1007/s11357-011-9213-9)
    • Frederiksen L, Hojlund K, Hougaard DM, Brixen K & Andersen M. Testosterone therapy increased muscle mass and lipid oxidation in aging men. Age, 2012. In Press. (doi:10.1007/s11357-011-9213-9)
    • (2012) Age
    • Frederiksen, L.1    Hojlund, K.2    Hougaard, D.M.3    Brixen, K.4    Andersen, M.5
  • 3
    • 77953612080 scopus 로고    scopus 로고
    • Gluteofemoral body fat as a determinant of metabolic health
    • doi:10.1038/ijo.2009.286
    • Manolopoulos KN, Karpe F & Frayn KN. Gluteofemoral body fat as a determinant of metabolic health. International Journal of Obesity 2010 34 949-959. (doi:10.1038/ijo.2009.286)
    • (2010) International Journal of Obesity , vol.34 , pp. 949-959
    • Manolopoulos, K.N.1    Karpe, F.2    Frayn, K.N.3
  • 10
    • 48349144149 scopus 로고    scopus 로고
    • Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip
    • doi:10.1038/ijir.2008.19
    • Svartberg J, Agledahl I, Figenschau Y, Sildnes T, Waterloo K &Jorde R. Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip. International Journal of Impotence Research 2008 20 378-387. (doi:10.1038/ijir.2008.19)
    • (2008) International Journal of Impotence Research , vol.20 , pp. 378-387
    • Svartberg, J.1    Agledahl, I.2    Figenschau, Y.3    Sildnes, T.4    Waterloo, K.5    Jorde, R.6
  • 12
    • 34249103249 scopus 로고    scopus 로고
    • The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes
    • doi:10.1530/EJE-06-0737
    • Kapoor D, Clarke S, Stanworth R, Channer KS & Jones TH. The effect of testosterone replacement therapy on adipocytokines and C-reactive protein in hypogonadal men with type 2 diabetes. European Journal of Endocrinology 2007 156 595-602. (doi:10.1530/EJE-06-0737)
    • (2007) European Journal of Endocrinology , vol.156 , pp. 595-602
    • Kapoor, D.1    Clarke, S.2    Stanworth, R.3    Channer, K.S.4    Jones, T.H.5
  • 14
    • 15944404290 scopus 로고    scopus 로고
    • Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    • doi:10.1210/jc.2004-1933
    • Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ & Tenover JL. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. Journal of Clinical Endocrinology and Metabolism 2005 90 1502-1510. (doi:10.1210/jc.2004-1933)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , pp. 1502-1510
    • Page, S.T.1    Amory, J.K.2    Bowman, F.D.3    Anawalt, B.D.4    Matsumoto, A.M.5    Bremner, W.J.6    Tenover, J.L.7
  • 15
    • 34447131545 scopus 로고    scopus 로고
    • Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men
    • doi:10.1210/jc.2006-1847
    • Nielsen TL, Hagen C, Wraae K, Brixen K, Petersen PH, Haug E, Larsen R & Andersen M. Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men. Journal of Clinical Endocrinology and Metabolism 2007 92 2696-2705. (doi:10.1210/jc.2006-1847)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 2696-2705
    • Nielsen, T.L.1    Hagen, C.2    Wraae, K.3    Brixen, K.4    Petersen, P.H.5    Haug, E.6    Larsen, R.7    Andersen, M.8
  • 16
    • 79957505759 scopus 로고    scopus 로고
    • Automatic segmentation of abdominal adipose tissue in MRI
    • Proceedings of the 17th Scandinavian Conference on Image Analysis 1-1
    • Mosbech TM, Larsen R & Vaag A. Automatic segmentation of abdominal adipose tissue in MRI. Lecture Notes in Computer Science, Proceedings of the 17th Scandinavian Conference on Image Analysis 1-1-2011.
    • (2011) Lecture Notes in Computer Science
    • Mosbech, T.M.1    Larsen, R.2    Vaag, A.3
  • 17
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • doi:10.1210/jc.84.10.3666
    • Vermeulen A, Verdonck L & Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. Journal of Clinical Endocrinology and Metabolism 1999 84 3666-3672. (doi:10.1210/jc.84.10.3666)
    • (1999) Journal of Clinical Endocrinology and Metabolism , vol.84 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 18
    • 24944545643 scopus 로고    scopus 로고
    • Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications
    • doi:10.1007/s00125-005-1850-z
    • Frystyk J, Tarnow L, Hansen TK, Parving HH & Flyvbjerg A. Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Diabetologia 2005 48 1911-1918. (doi:10.1007/s00125-005-1850-z)
    • (2005) Diabetologia , vol.48 , pp. 1911-1918
    • Frystyk, J.1    Tarnow, L.2    Hansen, T.K.3    Parving, H.H.4    Flyvbjerg, A.5
  • 19
    • 0029920988 scopus 로고    scopus 로고
    • Effects of insulin on glucose turnover rates in vivo: Isotope dilution versus constant specific activity technique
    • doi:10.1016/S0026-0495(96)90204-8
    • Hother-Nielsen O, Henriksen JE, Holst JJ & Beck-Nielsen H. Effects of insulin on glucose turnover rates in vivo: isotope dilution versus constant specific activity technique. Metabolism 1996 45 82-91. (doi:10.1016/S0026- 0495(96)90204-8)
    • (1996) Metabolism , vol.45 , pp. 82-91
    • Hother-Nielsen, O.1    Henriksen, J.E.2    Holst, J.J.3    Beck-Nielsen, H.4
  • 20
    • 0035841813 scopus 로고    scopus 로고
    • Statistics notes: Analysing controlled trials with baseline and follow up measurements
    • doi:10.1136/bmj.323.7321.1123
    • Vickers AJ & Altman DG. Statistics notes: analysing controlled trials with baseline and follow up measurements. BMJ 2001 323 1123-1124. (doi:10.1136/bmj.323.7321.1123)
    • (2001) BMJ , vol.323 , pp. 1123-1124
    • Vickers, A.J.1    Altman, D.G.2
  • 22
    • 1442327856 scopus 로고    scopus 로고
    • Measurement of total serum testosterone in adult men: Comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry
    • doi:10.1210/jc.2003-031287
    • Wang C, Catlin DH, Demers LM, Starcevic B & Swerdloff RS. Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry. Journal of Clinical Endocrinology and Metabolism 2004 89 534-543. (doi:10.1210/jc.2003- 031287)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , pp. 534-543
    • Wang, C.1    Catlin, D.H.2    Demers, L.M.3    Starcevic, B.4    Swerdloff, R.S.5
  • 23
    • 24144489427 scopus 로고    scopus 로고
    • Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: A meta-analysis
    • doi:10.1111/j.1365-2265.2005.02339.x
    • Isidori AM, Giannetta E, Greco EA, Gianfrilli D, Bonifacio V, Isidori A, Lenzi A & Fabbri A. Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clinical Endocrinology 2005 63 280-293. (doi:10.1111/j.1365-2265.2005.02339.x)
    • (2005) Clinical Endocrinology , vol.63 , pp. 280-293
    • Isidori, A.M.1    Giannetta, E.2    Greco, E.A.3    Gianfrilli, D.4    Bonifacio, V.5    Isidori, A.6    Lenzi, A.7    Fabbri, A.8
  • 24
    • 38149032364 scopus 로고    scopus 로고
    • Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men
    • doi:10.1210/jc.2007-1291
    • Allan CA, Strauss BJ, Burger HG, Forbes EA & McLachlan RI. Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging men. Journal of Clinical Endocrinology and Metabolism 2008 93 139-146. (doi:10.1210/jc.2007-1291)
    • (2008) Journal of Clinical Endocrinology and Metabolism , vol.93 , pp. 139-146
    • Allan, C.A.1    Strauss, B.J.2    Burger, H.G.3    Forbes, E.A.4    McLachlan, R.I.5
  • 25
    • 0027366138 scopus 로고
    • Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy
    • doi:10.1038/ng1093-184
    • Mhatre AN, Trifiro MA, Kaufman M, Kazemi-Esfarjani P, Figlewicz D, Rouleau G & Pinsky L. Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy. Nature Genetics 1993 5 184-188. (doi:10.1038/ng1093-184)
    • (1993) Nature Genetics , vol.5 , pp. 184-188
    • Mhatre, A.N.1    Trifiro, M.A.2    Kaufman, M.3    Kazemi-Esfarjani, P.4    Figlewicz, D.5    Rouleau, G.6    Pinsky, L.7
  • 26
    • 0030694396 scopus 로고    scopus 로고
    • Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility
    • doi:10.1210/jc.82.11.3777
    • Tut TG, Ghadessy FJ, Trifiro MA, Pinsky L & Yong EL. Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility. Journal of Clinical Endocrinology and Metabolism 1997 82 3777-3782. (doi:10.1210/jc.82.11. 3777)
    • (1997) Journal of Clinical Endocrinology and Metabolism , vol.82 , pp. 3777-3782
    • Tut, T.G.1    Ghadessy, F.J.2    Trifiro, M.A.3    Pinsky, L.4    Yong, E.L.5
  • 27
    • 77950320120 scopus 로고    scopus 로고
    • The impact of the CAG repeat polymorphism of the androgen receptor gene on muscle and adipose tissues in 20-29-year-old Danish men: Odense Androgen Study
    • doi:10.1530/EJE-09-0763
    • Nielsen TL, Hagen C, Wraae K, Bathum L, Larsen R, Brixen K &Andersen M. The impact of the CAG repeat polymorphism of the androgen receptor gene on muscle and adipose tissues in 20-29-year-old Danish men: Odense Androgen Study. European Journal of Endocrinology 2010 162 795-804. (doi:10.1530/EJE-09-0763)
    • (2010) European Journal of Endocrinology , vol.162 , pp. 795-804
    • Nielsen, T.L.1    Hagen, C.2    Wraae, K.3    Bathum, L.4    Larsen, R.5    Brixen, K.6    Andersen, M.7
  • 28
    • 44449111714 scopus 로고    scopus 로고
    • Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans
    • doi:10.1089/met.2007.0029
    • Swarbrick MM & Havel PJ. Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. Metabolic Syndrome and Related Disorders 2008 6 87-102. (doi:10.1089/met.2007. 0029)
    • (2008) Metabolic Syndrome and Related Disorders , vol.6 , pp. 87-102
    • Swarbrick, M.M.1    Havel, P.J.2
  • 29
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • doi:10.1172/JCI29126
    • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K & Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Journal of Clinical Investigation 2006 116 1784-1792. (doi:10.1172/JCI29126)
    • (2006) Journal of Clinical Investigation , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 30
    • 2042480671 scopus 로고    scopus 로고
    • Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans
    • doi:10.1210/en.2003-1336
    • Fain JN, Madan AK, Hiler ML, Cheema P & Bahouth SW. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 2004 145 2273-2282. (doi:10.1210/en.2003-1336)
    • (2004) Endocrinology , vol.145 , pp. 2273-2282
    • Fain, J.N.1    Madan, A.K.2    Hiler, M.L.3    Cheema, P.4    Bahouth, S.W.5
  • 31
    • 39849088585 scopus 로고    scopus 로고
    • Is there any association between subcutaneous adipose tissue area and plasma total and high molecular weight adiponectin levels?
    • doi:10.1016/j.metabol.2007.11.012
    • Fujikawa R, Ito C, Nakashima R, Orita Y & Ohashi N. Is there any association between subcutaneous adipose tissue area and plasma total and high molecular weight adiponectin levels? Metabolism 2008 57 506-510. (doi:10.1016/j.metabol.2007.11.012)
    • (2008) Metabolism , vol.57 , pp. 506-510
    • Fujikawa, R.1    Ito, C.2    Nakashima, R.3    Orita, Y.4    Ohashi, N.5
  • 32
    • 1842684155 scopus 로고    scopus 로고
    • Serum adiponectin levels in hypogonadal males: Influence of testosterone replacement therapy
    • doi:10.1111/j.1365-2265.2004.02007.x
    • Lanfranco F, Zitzmann M, Simoni M & Nieschlag E. Serum adiponectin levels in hypogonadal males: influence of testosterone replacement therapy. Clinical Endocrinology 2004 60 500-507. (doi:10.1111/j.1365-2265.2004.02007.x)
    • (2004) Clinical Endocrinology , vol.60 , pp. 500-507
    • Lanfranco, F.1    Zitzmann, M.2    Simoni, M.3    Nieschlag, E.4
  • 33
    • 0025062622 scopus 로고
    • The effects of androgens on the regulation of lipolysis in adipose precursor cells
    • doi:10.1210/endo-126-2-1229
    • Xu X, De PG & Bjorntorp P. The effects of androgens on the regulation of lipolysis in adipose precursor cells. Endocrinology 1990 126 1229-1234. (doi:10.1210/endo-126-2-1229)
    • (1990) Endocrinology , vol.126 , pp. 1229-1234
    • Xu, X.1    De, P.G.2    Bjorntorp, P.3
  • 35
    • 70350162530 scopus 로고    scopus 로고
    • The influence of sex, body composition, and nonesterified fatty acids on serum adipokine concentrations
    • doi:10.1016/j.metabol.2009.04.038
    • Plaisance EP, Grandjean PW, Judd RL, Jones KW & Taylor JK. The influence of sex, body composition, and nonesterified fatty acids on serum adipokine concentrations. Metabolism 2009 58 1557-1563. (doi:10.1016/j.metabol. 2009.04.038)
    • (2009) Metabolism , vol.58 , pp. 1557-1563
    • Plaisance, E.P.1    Grandjean, P.W.2    Judd, R.L.3    Jones, K.W.4    Taylor, J.K.5
  • 36
    • 0035955453 scopus 로고    scopus 로고
    • Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes
    • doi:10.1016/S0014-5793(01)02960-X
    • Fasshauer M, Klein J, Neumann S, Eszlinger M & Paschke R. Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Letters 2001 507 142-146. (doi:10.1016/S0014- 5793(01)02960-X)
    • (2001) FEBS Letters , vol.507 , pp. 142-146
    • Fasshauer, M.1    Klein, J.2    Neumann, S.3    Eszlinger, M.4    Paschke, R.5
  • 37
    • 38949125405 scopus 로고    scopus 로고
    • Post-translational modifications of adiponectin: Mechanisms and functional implications
    • doi:10.1042/BJ20071492
    • Wang Y, Lam KS, Yau MH & Xu A. Post-translational modifications of adiponectin: mechanisms and functional implications. Biochemical Journal 2008 409 623-633. (doi:10.1042/BJ20071492)
    • (2008) Biochemical Journal , vol.409 , pp. 623-633
    • Wang, Y.1    Lam, K.S.2    Yau, M.H.3    Xu, A.4
  • 38
    • 34249861029 scopus 로고    scopus 로고
    • Gender differences of oligomers and total adiponectin during puberty: A cross-sectional study of 859 Danish school children
    • doi:10.1210/jc.2006-2310
    • AndersenKK, Frystyk J,WolthersOD,HeuckC&FlyvbjergA.Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children. Journal of Clinical Endocrinology and Metabolism 2007 92 1857-1862. (doi:10.1210/jc.2006-2310)
    • (2007) Journal of Clinical Endocrinology and Metabolism , vol.92 , pp. 1857-1862
    • Andersen, K.K.1    Frystyk, J.2    Wolthers, O.D.3    Heuck, C.4    Flyvbjerg, A.5
  • 40
    • 0034819462 scopus 로고    scopus 로고
    • Intramuscular testosterone esters and plasma lipids in hypogonadal men: A meta-analysis
    • doi:10.1016/S0002-9343(01)00833-6
    • Whitsel EA, Boyko EJ, Matsumoto AM, Anawalt BD &Siscovick DS. Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis. American Journal of Medicine 2001 111 261-269. (doi:10.1016/S0002-9343(01)00833-6)
    • (2001) American Journal of Medicine , vol.111 , pp. 261-269
    • Whitsel, E.A.1    Boyko, E.J.2    Matsumoto, A.M.3    Anawalt, B.D.4    Siscovick, D.S.5
  • 43
    • 78449294931 scopus 로고    scopus 로고
    • Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: The double-blinded placebo-controlled Moscow study
    • doi:10.1111/j.1365-2265.2010.03845.x
    • Kalinchenko SY, Tishova YA, Mskhalaya GJ, Gooren LJ, Giltay EJ &Saad F. Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study. Clinical Endocrinology 2010 73 602-612. (doi:10.1111/j.1365-2265.2010.03845.x)
    • (2010) Clinical Endocrinology , vol.73 , pp. 602-612
    • Kalinchenko, S.Y.1    Tishova, Y.A.2    Mskhalaya, G.J.3    Gooren, L.J.4    Giltay, E.J.5    Saad, F.6
  • 45
    • 33745684473 scopus 로고    scopus 로고
    • Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    • DOI 10.1530/eje.1.02166
    • Kapoor D, Goodwin E, Channer KS & Jones TH. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol 2006 154 899-906. (Pubitemid 43997730)
    • (2006) European Journal of Endocrinology , vol.154 , Issue.6 , pp. 899-906
    • Kapoor, D.1    Goodwin, E.2    Channer, K.S.3    Jones, T.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.