Effects of insulin on glucose turnover rates in vivo: Isotope dilution versus constant specific activity technique

Metabolism: Clinical and Experimental

Volumn 45, Issue 1, 1996, Pages 82-91

  Hother Nielsen, Ole ^a   Henriksen, Jan Erick ^b   Holst, Jens Juul ^b   Beck Nielsen, Henning ^b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; MALE; METABOLIC RATE; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

EID: 0029920988     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90204-8     Document Type: Article

References (44)

1. Vranic M: Banting Lecture: Glucose turnover. A key to understanding the pathogenesis of diabetes (indirect effects of insulin). Diabetes 41:1188-1206, 1992
2. Wolfe RR: Tracers in metabolic research: Radioisotope and stable isotope/mass spectrometry methods. Lab Res Methods Biol Med 9:1-287, 1984
3. Steele R: Influence of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82:420-430, 1959
4. Kolterman OG, Insel J, Saekow M, et al: Mechanisms of insulin resistance in human obesity: Evidence for receptor and postreceptor defects. J Clin Invest 65:1272-1284, 1980
5. DeFronzo RA, Ferrannini E, Hendler R, et al: Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32:35-45, 1983
6. Revers RR, Fink R, Griffin J, et al: Influence of hyperglycemia on insulin's in vivo effects in type II diabetes. J Clin Invest 73:664-672, 1984
7. Rizza RA, Mandarino LJ, Gerich JE: Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol 240:E630-E639, 1981
8. Campbell PJ, Mandarino LJ, Gerich JE: Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus. Metabolism 37:15-21, 1988
9. Groop LC, Bonadonna RC, DelPrato S, et al: Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest 84:205-213, 1989
10. Prager R, Wallace P, Olefsky JM: Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 36:607-611, 1987
11. Brown PM, Tompkins CV, Juul S, et al: Mechanism of action of insulin in diabetic patients: A dose-related effect on glucose production and utilisation. Br Med J 1:1239-1242, 1978
12. Allsop JR, Wolfe RR, Burke JF: The reliability of rates of glucose appearance in vivo calculated from constant tracer infusions. Biochem J 172:407-416, 1978
13. Radziuk J, Norwich KH, Vranic M: Experimental validation of measurements of glucose turnover in nonsteady state. Am J Physiol 234:E84-E93, 1978
14. Bergman RN, Finegood DT, Ader M: Assessment of insulin sensitivity in vivo. Endocr Rev 6:45-86, 1985
15. Rizza RA, Cryer PE, Haymond MW, et al: Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. J Clin Invest 65:682-689, 1980
16. Hother-Nielsen O, Schmitz O, Andersen PH, et al: In vivo action of glibenclamide in obese subjects with mild type 2 (non-insulin dependent) diabetes. Diabetes Res 8:63-70, 1988
17. Hother-Nielsen O, Schmitz O, Andersen PH, et al: Metformin improves peripheral but not hepatic insulin action in obese patients with type II diabetes. Acta Endocrinol (Copenh) 120:257-265, 1989
18. Hother-Nielsen O, Beck-Nielsen H: Insulin resistance, but normal basal rates of glucose production in patients with newly diagnosed mild diabetes mellitus. Acta Endocrinol (Copenh) 124:637-645, 1991
19. Lager I, Attvall S, Eriksson BM, et al: Studies on the insulin-antagonistic effect of catecholamines in normal man. Evidence for the importance of beta 2-receptors. Diabetologia 29:409-416, 1986
20. Argoud GM, Schade DS, Eaton RP: Underestimation of hepatic glucose production by radioactive and stable tracers. Am J Physiol 252:E606-E615, 1987
21. Bergman RN, Steil GM, Bradley DC, et al: Modeling of insulin action in vivo. Annu Rev Physiol 54:861-883, 1992
22. Cobelli C, Mari A, Ferrannini E: Non-steady state: Error analysis of Steele's model and developments for glucose kinetics. Am J Physiol 252:E679-E689, 1987
23. Norwich KH: Measuring rates of appearance in systems which are not in steady state. Can J Physiol Pharmacol 51:91-101, 1973
24. Finegood DT, Bergman RN, Vranic M: Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36:914-924, 1987
25. Levy JC, Brown G, Matthews DR, et al: Hepatic glucose output in humans measured with labeled glucose to reduce negative errors. Am J Physiol 257:E531-E540, 1989
26. Molina JM, Baron AD, Edelman SV, et al: Use of a variable tracer infusion method to determine glucose turnover in humans. Am J Physiol 258:E16-E23, 1990
27. 3H]-glucose infusion and labelled or unlabelled glucose infusates. Diabetic Med 9:840-849, 1992
28. Hother-Nielsen O, Vaag A, Skøtt P, et al: Effect of hyperglycemia per se on glucose turnover rates in patients with insulin-dependent diabetes. Metabolism 42:86-93, 1993
29. Butler PC, Caumo A, Zerman A, et al: Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans. Am J Physiol 264:E548-E560, 1993
30. Katz H, Butler P, Homan M, et al: Hepatic and extrahepatic insulin action in humans: Measurement in the absence of non-steady-state error. Am J Physiol 264:E561-E566, 1993
31. Katz H, Homan M, Jensen M, et al: Assessment of insulin action in NIDDM in the presence of dynamic changes in insulin and glucose concentration. Diabetes 43:289-296, 1994
32. Finegood DT, Bergman RN, Vranic M: Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes 37:1025-1034, 1988
33. Bradley DC, Poulin RA, Bergman RN: Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo. Diabetes 42:296-306, 1993
34. Hother-Nielsen O, Schmitz O, Bak J, et al: Enhanced hepatic insulin sensitivity, but peripheral insulin resistance, in patients with type 1 (insulin-dependent) diabetes. Diabetologia 30:834-840, 1987
35. 3H-glucose infusion. Diabetologia 33:603-610, 1990
36. Pedersen B, Møller N, Hother-Nielsen O, et al: Contamination of tritiated glucose tracers. Diabete Metab 15:102-103, 1989
37. Cowan JS, Hetenyi GJ: Glucoregulatory responses in normal and diabetic dogs recorded by a new tracer method. Metabolism 20:360-372, 1971
38. Insel PA, Liljenquist JE, Tobin JD, et al: Insulin control of glucose metabolism in man. A new kinetic analysis. J Clin Invest 55:1057-1066, 1975
39. 3H]glucose. Am J Physiol 258: E228-E233, 1990
40. Koivisto VA, Yki Jarvinen H, Puhakainen I, et al: No evidence for isotope discrimination of tritiated glucose tracers in measurements of glucose turnover rates in man. Diabetologia 33:168-173, 1990
41. Yki Jarvinen H, Consoli A, Nurjhan N, et al: Mechanism for underestimation of isotopically determined glucose disposal. Diabetes 38:744-751, 1989
42. Wall JS, Steele R, DeBodo RC, et al: Effect of insulin on utilization and production of circulating glucose. Am J Physiol 189:43-50, 1957
43. Pigon J: Aspects of the pathogenesis of low insulin response in man. Doctoral thesis, Karolinska Institute, Stockholm, Sweden, 1994, pp 1-40
44. Stæhr P, Hother-Nielsen O, Levin K, et al: Is hepatic insulin resistance a major feature of NIDDM patients with peripheral insulin resistance? Diabetologia 37:A136, 1994 (abstr)