Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Tian, Zongwen ^a,c   Wang, Changhua ^a   Hu, Chengjun ^a,c   Tian, Yihao ^a,c   Liu, Jinbao ^b   Wang, Xuejun ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; BAFILOMYCIN A1; FLUORESCENT DYE; MESSENGER RNA; PROTEASOME; PROTEIN P62; RAB7 PROTEIN; RED FLUORESCENCE PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; 3-METHYLADENINE; ADENINE; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; BORTEZOMIB; HEAT SHOCK PROTEIN; PROTEASOME INHIBITOR; PYRAZINE DERIVATIVE; SQSTM1 PROTEIN, RAT; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVITY; HEART CELL CULTURE; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; UBIQUITINATION; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; GENETICS; LYSOSOME; METABOLISM; TRANSGENIC MOUSE;

ADENINE; ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; BORONIC ACIDS; HEAT-SHOCK PROTEINS; LYSOSOMES; MICE; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEOLYSIS; PYRAZINES; RATS; UBIQUITIN;

EID: 84903520218     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100715     Document Type: Article

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