Reduced amino acid specificity of mammalian tyrosyl-tRNA synthetase is associated with elevated mistranslation of Tyr codons

Journal of Biological Chemistry

Volumn 289, Issue 25, 2014, Pages 17780-17790

  Raina, Medha ^a   Moghal, Adil ^a   Kano, Amanda ^b   Jerums, Mathew ^b   Schnier, Paul D ^b   Luo, Shun ^b   Deshpande, Rohini ^b   Bondarenko, Pavel V ^b   Lin, Henry ^b   Ibba, Michael ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; MAMMALS; QUALITY CONTROL;

BACTERIAL ENZYMES; CELLULAR VIABILITY; CHINESE HAMSTER OVARY CELLS; GROWTH CONDITIONS; PROTEIN SYNTHESIS; RECOMBINANT ANTIBODY; STEADY-STATE KINETICS; TRANSLATION QUALITY;

AMINO ACIDS;

TYROSINE; TYROSINE TRANSFER RNA LIGASE;

AMINO ACID ANALYSIS; AMINOACYLATION; ANIMAL CELL; ARTICLE; CELL VIABILITY; CHO CELL LINE; CODON; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; FEMALE; GEOBACILLUS STEAROTHERMOPHILUS; HYDROGEN BOND; MISTRANSLATION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; QUALITY CONTROL; SPECIES DIFFERENCE; STEADY STATE; TRANSLATION REGULATION;

AMINOACYL TRNA SYNTHESIS; AMINOACYL TRNA SYNTHETASE; PROTEIN SYNTHESIS; TRANSFER RNA (TRNA); TRANSLATION;

AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CODON; CRICETINAE; CRICETULUS; PROTEIN BIOSYNTHESIS; TYROSINE-TRNA LIGASE;

EID: 84903449324     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.564609     Document Type: Article

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