메뉴 건너뛰기




Volumn 39, Issue 7, 2014, Pages 801-810

Flaxseed enhances the beneficial effect of low-dose estrogen therapy at reducing bone turnover and preserving bone microarchitecture in ovariectomized rats

Author keywords

Bone histology; Bone microarchitecture; Bone turnover; Flaxseed; Low dose estrogen therapy; Lumbar vertebra; Ovariectomized rats

Indexed keywords

ESTRADIOL; ESTROGEN;

EID: 84903445796     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2013-0417     Document Type: Article
Times cited : (11)

References (55)
  • 1
    • 79953713687 scopus 로고    scopus 로고
    • Manipulation of flaxseed inhibits tumor necrosis factor-alpha and interleukin-6 production in ovarian-induced osteoporosis
    • PMID: 21483995
    • Abdelkarem, H.M., Abd El-Kader, M.M., and Kasem, S.A. 2011. Manipulation of flaxseed inhibits tumor necrosis factor-alpha and interleukin-6 production in ovarian-induced osteoporosis. Saudi Med. J. 32(4): 369-375. PMID: 21483995.
    • (2011) Saudi Med. J , vol.32 , Issue.4 , pp. 369-375
    • Abdelkarem, H.M.1    Abd El-Kader, M.M.2    Kasem, S.A.3
  • 2
    • 0031915998 scopus 로고    scopus 로고
    • Prognostic and predictive factors in breast cancer by immunohistochemical analysis
    • PMID:9504686
    • Allred, D.C., Harvey, J.M., Berardo, M., and Clark, G.M. 1998. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod. Pathol. 11(2): 155-168. PMID:9504686.
    • (1998) Mod. Pathol , vol.11 , Issue.2 , pp. 155-168
    • Allred, D.C.1    Harvey, J.M.2    Berardo, M.3    Clark, G.M.4
  • 3
    • 0034053276 scopus 로고    scopus 로고
    • Nutritional and hematological impact of dietary flaxseed and defatted flaxseed meal in rats
    • doi:10.1080/ 096374800100804. PMID:10953754
    • Babu, U.S., Mitchell, G.V., Wiesenfeld, P., Jenkins, M.Y., and Gowda, H. 2000. Nutritional and hematological impact of dietary flaxseed and defatted flaxseed meal in rats. Int. J. Food Sci. Nutr. 51(2): 109-117. doi:10.1080/ 096374800100804. PMID:10953754.
    • (2000) Int. J. Food Sci. Nutr , vol.51 , Issue.2 , pp. 109-117
    • Babu, U.S.1    Mitchell, G.V.2    Wiesenfeld, P.3    Jenkins, M.Y.4    Gowda, H.5
  • 4
    • 34548454049 scopus 로고    scopus 로고
    • Biology of RANK, RANKL, and osteoprotegerin
    • doi:10.1186/ar2165. PMID:17634140
    • Boyce, B.F., and Xing, L. 2007. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 9(Suppl. 1): S1. doi:10.1186/ar2165. PMID:17634140.
    • (2007) Arthritis Res. Ther , vol.9 , Issue.SUPPL. 1
    • Boyce, B.F.1    Xing, L.2
  • 5
    • 1342286100 scopus 로고    scopus 로고
    • Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy
    • PMID: 14749240
    • Brooks, J.D., Ward, W.E., Lewis, J.E., Hilditch, J., Nickell, L., Wong, E., and Thompson, L.U. 2004. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am. J. Clin. Nutr. 79(2): 318-325. PMID: 14749240.
    • (2004) Am. J. Clin. Nutr , vol.79 , Issue.2 , pp. 318-325
    • Brooks, J.D.1    Ward, W.E.2    Lewis, J.E.3    Hilditch, J.4    Nickell, L.5    Wong, E.6    Thompson, L.U.7
  • 6
    • 0003616161 scopus 로고
    • Canadian Council on Animal Care, Edited by ErnestD.Olfert, Brenda M. Cross, and A. Ann McWilliam, Accessed 15 August 2013
    • Canadian Council on Animal Care. 1993. Guide to the Care and Use of Experimental Animals. Canadian Council on Animal Care. Edited by ErnestD.Olfert, Brenda M. Cross, and A. Ann McWilliam. Available from http://www.ccac.ca/Documents/Standards/Guidelines/Experimental_Animals_Vol1.pdf. [Accessed 15 August 2013.]
    • (1993) Guide to The Care and Use of Experimental Animals. Canadian Council On Animal Care
  • 7
    • 84880345247 scopus 로고    scopus 로고
    • The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: Potential implication in osteoporosis
    • doi:10.1007/s00198-012-2138-z. PMID:23104199
    • Casado-Diaz, A., Santiago-Mora, R., Dorado, G., and Quesada-Gomez, J.M. 2013. The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis. Osteoporos. Int. 24(5): 1647-1661. doi:10.1007/s00198-012-2138-z. PMID:23104199.
    • (2013) Osteoporos. Int , vol.24 , Issue.5 , pp. 1647-1661
    • Casado-Diaz, A.1    Santiago-Mora, R.2    Dorado, G.3    Quesada-Gomez, J.M.4
  • 8
    • 0031454578 scopus 로고    scopus 로고
    • Ovariectomy in the rat induces a rapid increase in the urinary excretion of hydroxylysine glycosides and non-reducible crosslink residues
    • doi:10.1007/BF02652559. PMID:9604049
    • Casari, E., Alfano, M., Valente, M., Clarke, G.D., Ferni, G., and Grazioli, B. 1997. Ovariectomy in the rat induces a rapid increase in the urinary excretion of hydroxylysine glycosides and non-reducible crosslink residues. Osteoporos. Int. 7(6): 539-543. doi:10.1007/BF02652559. PMID:9604049.
    • (1997) Osteoporos. Int , vol.7 , Issue.6 , pp. 539-543
    • Casari, E.1    Alfano, M.2    Valente, M.3    Clarke, G.D.4    Ferni, G.5    Grazioli, B.6
  • 9
    • 34548443813 scopus 로고    scopus 로고
    • Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen
    • doi:10.3181/0702-RM-36. PMID: 17720953
    • Chen, J., Power, K.A., Mann, J., Cheng, A., and Thompson, L.U. 2007. Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen. Exp. Biol. Med. (Maywood), 232(8): 1071-1080. doi:10.3181/0702-RM-36. PMID: 17720953.
    • (2007) Exp. Biol. Med. (Maywood) , vol.232 , Issue.8 , pp. 1071-1080
    • Chen, J.1    Power, K.A.2    Mann, J.3    Cheng, A.4    Thompson, L.U.5
  • 10
    • 20144371603 scopus 로고    scopus 로고
    • Flaxseed oil and inflammation-associated bone abnormalities in interleukin-10 knockout mice
    • doi:10.1016/j.jnutbio.2005.01.008. PMID:15936649
    • Cohen, S.L., Moore, A.M., and Ward, W.E. 2005. Flaxseed oil and inflammation-associated bone abnormalities in interleukin-10 knockout mice. J. Nutr. Biochem. 16(6): 368-374. doi:10.1016/j.jnutbio.2005.01.008. PMID:15936649.
    • (2005) J. Nutr. Biochem , vol.16 , Issue.6 , pp. 368-374
    • Cohen, S.L.1    Moore, A.M.2    Ward, W.E.3
  • 11
    • 2542441543 scopus 로고    scopus 로고
    • Prevention of postmenopausal bone loss by pulsed estrogen therapy: Comparison with transdermal route
    • doi:10.1016/j.maturitas.2004.01.012. PMID:15172082
    • Delmas, P.D., Marianowski, L., Perez Ade, C., Ribot, C., Pornel, B., Palacios, S., and Lopes, P. 2004. Prevention of postmenopausal bone loss by pulsed estrogen therapy: comparison with transdermal route. Maturitas, 48(2): 85-96. doi:10.1016/j.maturitas.2004.01.012. PMID:15172082.
    • (2004) Maturitas , vol.48 , Issue.2 , pp. 85-96
    • Delmas, P.D.1    Marianowski, L.2    Perez Ade, C.3    Ribot, C.4    Pornel, B.5    Palacios, S.6    Lopes, P.7
  • 12
    • 15944405724 scopus 로고    scopus 로고
    • The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: A randomized, double-blind, wheat germ placebo-controlled clinical trial
    • doi:10.1210/jc.2004-1148. PMID:15613422
    • Dodin, S., Lemay, A., Jacques, H., Légaré, F., Forest, J.C., and Mâsse, B. 2005. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J. Clin. Endocrinol. Metab. 90(3): 1390-1397. doi:10.1210/jc.2004-1148. PMID:15613422.
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , Issue.3 , pp. 1390-1397
    • Dodin, S.1    Lemay, A.2    Jacques, H.3    Légaré, F.4    Forest, J.C.5    Mâsse, B.6
  • 13
    • 35348970851 scopus 로고    scopus 로고
    • Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions
    • doi:10.1152/ajpheart.01104.2006. PMID:17616740
    • Dupasquier, C.M., Dibrov, E., Kneesh, A.L., Cheung, P.K., Lee, K.G., Alexander, H.K., et al. 2007. Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions. Am. J. Physiol. Heart Circ. Physiol. 293(4): H2394-H2402. doi:10.1152/ajpheart.01104.2006. PMID:17616740.
    • (2007) Am. J. Physiol. Heart Circ. Physiol , vol.293 , Issue.4
    • Dupasquier, C.M.1    Dibrov, E.2    Kneesh, A.L.3    Cheung, P.K.4    Lee, K.G.5    Alexander, H.K.6
  • 14
    • 34547241574 scopus 로고    scopus 로고
    • Effects of dietary supplementation with flax during prepuberty on fatty acid profile, mammo-genesis, and bone resorption in gilts
    • doi:10. 2527/jas.2007-0022. PMID:17400971
    • Farmer, C., Petit, H.V., Weiler, H., and Capuco, A.V. 2007. Effects of dietary supplementation with flax during prepuberty on fatty acid profile, mammo-genesis, and bone resorption in gilts. J. Anim. Sci. 85(7): 1675-1686. doi:10. 2527/jas.2007-0022. PMID:17400971.
    • (2007) J. Anim. Sci , vol.85 , Issue.7 , pp. 1675-1686
    • Farmer, C.1    Petit, H.V.2    Weiler, H.3    Capuco, A.V.4
  • 15
    • 0038293003 scopus 로고    scopus 로고
    • Effects of estradiol and progesterone on vertebral collagen, glycosami-noglycans and phosphatases in ovariectomized adult rats
    • doi:10.1055/s-2003-39073. PMID:12734772
    • Gopala Krishnan, V., Arunakaran, J., Govindarajulu, P., and Srinivasan, N. 2003. Effects of estradiol and progesterone on vertebral collagen, glycosami-noglycans and phosphatases in ovariectomized adult rats. Horm. Metab. Res. 35(3): 137-141. doi:10.1055/s-2003-39073. PMID:12734772.
    • (2003) Horm. Metab. Res , vol.35 , Issue.3 , pp. 137-141
    • Gopala Krishnan, V.1    Arunakaran, J.2    Govindarajulu, P.3    Srinivasan, N.4
  • 16
    • 33846795696 scopus 로고    scopus 로고
    • An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
    • doi:10.1186/1475-2891-6-2. PMID: 17227589
    • Griel, A.E., Kris-Etherton, P.M., Hilpert, K.F., Zhao, G., West, S.G., and Corwin, R.L. 2007. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. Nutr. J. 6(2): 1-8. doi:10.1186/1475-2891-6-2. PMID: 17227589.
    • (2007) Nutr. J , vol.6 , Issue.2 , pp. 1-8
    • Griel, A.E.1    Kris-Etherton, P.M.2    Hilpert, K.F.3    Zhao, G.4    West, S.G.5    Corwin, R.L.6
  • 17
    • 0346599193 scopus 로고    scopus 로고
    • National use of postmeno-pausal hormone therapy: Annual trends and response to recent evidence
    • doi:10.1001/jama.291.1.47. PMID:14709575
    • Hersh, A.L., Stefanick, M.L., and Stafford, R.S. 2004. National use of postmeno-pausal hormone therapy: annual trends and response to recent evidence. JAMA, 291(1): 47-53. doi:10.1001/jama.291.1.47. PMID:14709575.
    • (2004) JAMA , vol.291 , Issue.1 , pp. 47-53
    • Hersh, A.L.1    Stefanick, M.L.2    Stafford, R.S.3
  • 18
    • 0031735152 scopus 로고    scopus 로고
    • Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprote-gerin in osteoblastic stromal cells
    • doi:10. 1210/endo.139.11.6433, PMID:9794488
    • Horwood, N.J., Elliott, J., Martin, T.J., and Gillespie, M.T. 1998. Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprote-gerin in osteoblastic stromal cells. Endocrinology, 139(11): 4743-4746. doi:10. 1210/endo.139.11.6433. PMID:9794488.
    • (1998) Endocrinology , vol.139 , Issue.11 , pp. 4743-4746
    • Horwood, N.J.1    Elliott, J.2    Martin, T.J.3    Gillespie, M.T.4
  • 19
    • 38449089068 scopus 로고    scopus 로고
    • Endogenous estrogen levels and the effects of ultra-low-dose transdermal estradiol therapy on bone turnover and BMD in post-menopausal women
    • doi:10.1359/jbmr. 070707. PMID:17620054
    • Huang, A.J., Ettinger, B., Vittinghoff, E., Ensrud, K.E., Johnson, K.C., and Cummings, S.R. 2007. Endogenous estrogen levels and the effects of ultra-low-dose transdermal estradiol therapy on bone turnover and BMD in post-menopausal women. J. Bone Miner. Res. 22(11): 1791-1797. doi:10.1359/jbmr. 070707. PMID:17620054.
    • (2007) J. Bone Miner. Res , vol.22 , Issue.11 , pp. 1791-1797
    • Huang, A.J.1    Ettinger, B.2    Vittinghoff, E.3    Ensrud, K.E.4    Johnson, K.C.5    Cummings, S.R.6
  • 20
    • 84878150618 scopus 로고    scopus 로고
    • Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: A randomized study
    • doi:10.1016/j.nutres.2013.02.012. PMID:23684438
    • Hutchins, A.M., Brown, B.D., Cunnane, S.C., Domitrovich, S.G., Adams, E.R., and Bobowiec, C.E. 2013. Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. Nutr. Res. 33(5): 367-375. doi:10.1016/j.nutres.2013.02.012. PMID:23684438.
    • (2013) Nutr. Res , vol.33 , Issue.5 , pp. 367-375
    • Hutchins, A.M.1    Brown, B.D.2    Cunnane, S.C.3    Domitrovich, S.G.4    Adams, E.R.5    Bobowiec, C.E.6
  • 21
    • 55949100839 scopus 로고    scopus 로고
    • Ovariectomy-induced hyperphagia does not modulate bone mineral density or bone strength in rats
    • doi:10.3945/jn.108.093781. PMID:18936205
    • Jiang, J.M., Sacco, S.M., and Ward, W.E. 2008. Ovariectomy-induced hyperphagia does not modulate bone mineral density or bone strength in rats. J. Nutr. 138(11): 2106-2110. doi:10.3945/jn.108.093781. PMID:18936205.
    • (2008) J. Nutr , vol.138 , Issue.11 , pp. 2106-2110
    • Jiang, J.M.1    Sacco, S.M.2    Ward, W.E.3
  • 22
    • 0035206443 scopus 로고    scopus 로고
    • Minireview: The OPG/RANKL/RANK system
    • doi:10.1210/endo.142.12.8536. PMID:11713196
    • Khosla, S. 2001. Minireview: the OPG/RANKL/RANK system. Endocrinology, 142(12): 5050-5055. doi:10.1210/endo.142.12.8536. PMID:11713196.
    • (2001) Endocrinology , vol.142 , Issue.12 , pp. 5050-5055
    • Khosla, S.1
  • 24
    • 56549098575 scopus 로고    scopus 로고
    • RANK/RANKL: Regulators of immune responses and bone physiology
    • doi:10. 1196/annals.1443.016. PMID:19076348
    • Leibbrandt, A., and Penninger, J.M. 2008. RANK/RANKL: regulators of immune responses and bone physiology. Ann. N.Y. Acad. Sci. 1143: 123-150. doi:10. 1196/annals.1443.016. PMID:19076348.
    • (2008) Ann. N.Y. Acad. Sci , vol.1143 , pp. 123-150
    • Leibbrandt, A.1    Penninger, J.M.2
  • 25
    • 78651398665 scopus 로고    scopus 로고
    • Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer
    • doi:10.1158/0008-5472.CAN-10-2289. PMID:21097717
    • Lindahl, G., Saarinen, N., Abrahamsson, A., and Dabrosin, C. 2011. Tamoxifen, flaxseed, and the lignan enterolactone increase stroma- and cancer cell-derived IL-1Ra and decrease tumor angiogenesis in estrogen-dependent breast cancer. Cancer Res. 71(1): 51-60. doi:10.1158/0008-5472.CAN-10-2289. PMID:21097717.
    • (2011) Cancer Res , vol.71 , Issue.1 , pp. 51-60
    • Lindahl, G.1    Saarinen, N.2    Abrahamsson, A.3    Dabrosin, C.4
  • 26
    • 84876497206 scopus 로고    scopus 로고
    • Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk
    • doi:10.1007/s10552-013-0155-7. PMID:23354422
    • Lowcock, E.C., Cotterchio, M., and Boucher, B.A. 2013. Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk. Cancer Causes Control, 24(4): 813-816. doi:10.1007/s10552-013-0155-7. PMID:23354422.
    • (2013) Cancer Causes Control , vol.24 , Issue.4 , pp. 813-816
    • Lowcock, E.C.1    Cotterchio, M.2    Boucher, B.A.3
  • 27
    • 0036277731 scopus 로고    scopus 로고
    • Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women
    • doi:10.1210/jcem.87.4.8374. PMID:11932276
    • Lucas, E.A., Wild, R.D., Hammond, L.J., Khalil, D.A., Juma, S., Daggy, B.P., et al. 2002. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J. Clin. Endocrinol. Metab. 87(4): 1527-1532. doi:10.1210/jcem.87.4.8374. PMID:11932276.
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , Issue.4 , pp. 1527-1532
    • Lucas, E.A.1    Wild, R.D.2    Hammond, L.J.3    Khalil, D.A.4    Juma, S.5    Daggy, B.P.6
  • 28
    • 79960568885 scopus 로고    scopus 로고
    • Consumption of different sources of omega-3 polyunsaturated fatty acids by growing female rats affects long bone mass and microarchitecture
    • doi:10.1016/j.bone.2011.05.029. PMID:21672645
    • Lukas, R., Gigliotti, J.C., Smith, B.J., Altman, S., and Tou, J.C. 2011. Consumption of different sources of omega-3 polyunsaturated fatty acids by growing female rats affects long bone mass and microarchitecture. Bone, 49(3): 455-462. doi:10.1016/j.bone.2011.05.029. PMID:21672645.
    • (2011) Bone , vol.49 , Issue.3 , pp. 455-462
    • Lukas, R.1    Gigliotti, J.C.2    Smith, B.J.3    Altman, S.4    Tou, J.C.5
  • 29
    • 0038521433 scopus 로고    scopus 로고
    • Botanical dietary supplement use in peri- and postmenopausal women
    • doi:10.1097/00042192-200310010-00011. PMID:12544679
    • Mahady, G.B., Parrot, J., Lee, C., Yun, G.S., and Dan, A. 2003. Botanical dietary supplement use in peri- and postmenopausal women. Menopause, 10(1): 65-72. doi:10.1097/00042192-200310010-00011. PMID:12544679.
    • (2003) Menopause , vol.10 , Issue.1 , pp. 65-72
    • Mahady, G.B.1    Parrot, J.2    Lee, C.3    Yun, G.S.4    Dan, A.5
  • 30
    • 31644445124 scopus 로고    scopus 로고
    • Effects of garlic oil on postmenopausal osteoporosis using ovariectomized rats: Comparison with the effects of lovastatin and 17beta-estradiol
    • doi:10.1002/ptr.1795. PMID:16397916
    • Mukherjee, M., Das, A.S., Das, D., Mukherjee, S., Mitra, S., and Mitra, C. 2006. Effects of garlic oil on postmenopausal osteoporosis using ovariectomized rats: comparison with the effects of lovastatin and 17beta-estradiol. Phyto-ther. Res. 20(1): 21-27. doi:10.1002/ptr.1795. PMID:16397916.
    • (2006) Phyto-ther. Res , vol.20 , Issue.1 , pp. 21-27
    • Mukherjee, M.1    Das, A.S.2    Das, D.3    Mukherjee, S.4    Mitra, S.5    Mitra, C.6
  • 31
    • 0035165337 scopus 로고    scopus 로고
    • Metabolism and functions of highly unsaturated fatty acids: An update
    • doi:10.1007/s11745-001-0806-5. PMID:11724468
    • Nakamura, M.T., Cho, H.P., Xu, J., Tang, Z., and Clarke, S.D. 2001. Metabolism and functions of highly unsaturated fatty acids: an update. Lipids, 36(9): 961-964. doi:10.1007/s11745-001-0806-5. PMID:11724468.
    • (2001) Lipids , vol.36 , Issue.9 , pp. 961-964
    • Nakamura, M.T.1    Cho, H.P.2    Xu, J.3    Tang, Z.4    Clarke, S.D.5
  • 32
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • doi:10.1016/S0092-8674(01)00622-5. PMID:11792318
    • Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J.M., Behringer, R.R., and de Crombrugghe, B. 2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell, 108(1): 17-29. doi:10.1016/S0092-8674(01)00622-5. PMID:11792318.
    • (2002) Cell , vol.108 , Issue.1 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    de Crombrugghe, B.7
  • 33
    • 77957884561 scopus 로고    scopus 로고
    • Comparison of active vitamin D compounds and a calcimimetic in mineral ho-meostasis
    • doi:10.1681/ASN.2009050531. PMID:20651168
    • Nguyen-Yamamoto, L., Bolivar, I., Strugnell, S.A., and Goltzman, D. 2010. Comparison of active vitamin D compounds and a calcimimetic in mineral ho-meostasis.J.Am. Soc. Nephrol. 21(10): 1713-1723. doi:10.1681/ASN.2009050531. PMID:20651168.
    • (2010) J.Am. Soc. Nephrol , vol.21 , Issue.10 , pp. 1713-1723
    • Nguyen-Yamamoto, L.1    Bolivar, I.2    Strugnell, S.A.3    Goltzman, D.4
  • 34
    • 0035857351 scopus 로고    scopus 로고
    • Osteoporosis Prevention, Diagnosis, and Therapy
    • NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, doi:10.1001/jama.285.6.785. PMID:11176917
    • NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. 2001. Osteoporosis Prevention, Diagnosis, and Therapy. JAMA, 285: 785-795. doi:10.1001/jama.285.6.785. PMID:11176917.
    • (2001) JAMA , vol.285 , pp. 785-795
  • 36
    • 84903457266 scopus 로고    scopus 로고
    • Osteoporosis Canada, Accessed 16 December 2013
    • Osteoporosis Canada. 2013. Osteoporosis at-a-glance. Available from http://www.osteoporosis.ca/osteoporosis-and-you/. [Accessed 16 December 2013.]
    • (2013) Osteoporosis At-a-glance
  • 37
    • 67949109601 scopus 로고    scopus 로고
    • Meta-analysis of the effects of flaxseed interventions on blood lipids
    • doi:10.3945/ajcn.2009.27469. PMID:19515737
    • Pan, A., Yu, D., Demark-Wahnefried, W., Franco, O.H., and Lin, X. 2009. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am. J. Clin. Nutr. 90(2): 288-297. doi:10.3945/ajcn.2009.27469. PMID:19515737.
    • (2009) Am. J. Clin. Nutr , vol.90 , Issue.2 , pp. 288-297
    • Pan, A.1    Yu, D.2    Demark-Wahnefried, W.3    Franco, O.H.4    Lin, X.5
  • 38
    • 34748891664 scopus 로고    scopus 로고
    • Diet-derived polyphenol metabolite enterolac-tone is a tissue-specific estrogen receptor activator
    • doi:10.1210/en.2007-0289. PMID:17628008
    • Penttinen, P., Jaehrling, J., Damdimopoulos, A.E., Inzunza, J., Lemmen, J.G., van der Saag, P., et al. 2007. Diet-derived polyphenol metabolite enterolac-tone is a tissue-specific estrogen receptor activator. Endocrinology, 148(10): 4875-4886. doi:10.1210/en.2007-0289. PMID:17628008.
    • (2007) Endocrinology , vol.148 , Issue.10 , pp. 4875-4886
    • Penttinen, P.1    Jaehrling, J.2    Damdimopoulos, A.E.3    Inzunza, J.4    Lemmen, J.G.5    van der Saag, P.6
  • 39
    • 69149098470 scopus 로고    scopus 로고
    • Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice
    • doi:10.1002/mnfr.200800487. PMID: 19603405
    • Penttinen-Damdimopoulou, P.E., Power, K.A., Hurmerinta, T.T., Nurmi, T., van der Saag, P.T., and Mäkelä, S.I. 2009. Dietary sources of lignans and isoflavones modulate responses to estradiol in estrogen reporter mice. Mol. Nutr. Food Res. 53(8): 996-1006. doi:10.1002/mnfr.200800487. PMID: 19603405.
    • (2009) Mol. Nutr. Food Res , vol.53 , Issue.8 , pp. 996-1006
    • Penttinen-Damdimopoulou, P.E.1    Power, K.A.2    Hurmerinta, T.T.3    Nurmi, T.4    van der Saag, P.T.5    Mäkelä, S.I.6
  • 40
    • 0032866653 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover after surgical menopause and hormone replacement therapy
    • doi:10.1016/S8756-3282 (99)00175-1. PMID:10495139
    • Peris, P., Alvarez, L., Monegal, A., Guañabens, N., Durán, M., Pons, F., et al. 1999. Biochemical markers of bone turnover after surgical menopause and hormone replacement therapy. Bone, 25(3): 349-353. doi:10.1016/S8756-3282 (99)00175-1. PMID:10495139.
    • (1999) Bone , vol.25 , Issue.3 , pp. 349-353
    • Peris, P.1    Alvarez, L.2    Monegal, A.3    Guañabens, N.4    Durán, M.5    Pons, F.6
  • 41
    • 43249085529 scopus 로고    scopus 로고
    • Docosahexaenoic acid and 17 beta-estradiol co-treatment is more effective than 17 beta-estradiol alone in maintaining bone post-ovariectomy
    • doi:10.3181/0709-RM-259. PMID:18375826
    • Poulsen, R.C., Moughan, P.J., and Kruger, M.C. 2008. Docosahexaenoic acid and 17 beta-estradiol co-treatment is more effective than 17 beta-estradiol alone in maintaining bone post-ovariectomy. Exp. Biol. Med. (Maywood), 233(5): 592-602. doi:10.3181/0709-RM-259. PMID:18375826.
    • (2008) Exp. Biol. Med. (Maywood) , vol.233 , Issue.5 , pp. 592-602
    • Poulsen, R.C.1    Moughan, P.J.2    Kruger, M.C.3
  • 42
    • 72949087988 scopus 로고    scopus 로고
    • Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis
    • doi:10.1111/j. 1582-4934.2008.00649.x. PMID:20141608
    • Rahman, M.M., Bhattacharya, A., Banu, J., Kang, J.X., and Fernandes, G. 2009. Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis. J. Cell. Mol. Med. 13(8B): 1833-1844. doi:10.1111/j. 1582-4934.2008.00649.x. PMID:20141608.
    • (2009) J. Cell. Mol. Med , vol.13 , Issue.8 B , pp. 1833-1844
    • Rahman, M.M.1    Bhattacharya, A.2    Banu, J.3    Kang, J.X.4    Fernandes, G.5
  • 43
    • 0030912476 scopus 로고    scopus 로고
    • Components of the AIN-93 diets as improvements in the AIN-76A diet
    • PMID:9164249
    • Reeves, P.G. 1997. Components of the AIN-93 diets as improvements in the AIN-76A diet. J. Nutr. 127(5): S838-S841. PMID:9164249.
    • (1997) J. Nutr , vol.127 , Issue.5
    • Reeves, P.G.1
  • 44
    • 80054055322 scopus 로고    scopus 로고
    • Revisiting estrogen: Efficacy and safety for postmenopausal bone health
    • doi:10.4061/2010/708931. PMID:20981150
    • Sacco, S.M., and Ward, W.E. 2010. Revisiting estrogen: efficacy and safety for postmenopausal bone health. J. Osteoporos. 708931. doi:10.4061/2010/708931. PMID:20981150.
    • (2010) J. Osteoporos , pp. 708931
    • Sacco, S.M.1    Ward, W.E.2
  • 45
    • 67649884790 scopus 로고    scopus 로고
    • Flaxseed combined with low-dose estrogen therapy preserves bone tissue in ovariectomized rats
    • doi:10. 1097/gme.0b013e31818fc00a. PMID:19182694
    • Sacco, S.M., Jiang, J.M., Reza-Lopez, S., Ma, D.W., Thompson, L.U., and Ward, W.E. 2009. Flaxseed combined with low-dose estrogen therapy preserves bone tissue in ovariectomized rats. Menopause, 16(3): 545-554. doi:10. 1097/gme.0b013e31818fc00a. PMID:19182694.
    • (2009) Menopause , vol.16 , Issue.3 , pp. 545-554
    • Sacco, S.M.1    Jiang, J.M.2    Reza-Lopez, S.3    Ma, D.W.4    Thompson, L.U.5    Ward, W.E.6
  • 46
    • 0033298505 scopus 로고    scopus 로고
    • Oestrogen and essential fatty acid supplementation corrects bone loss due toovariectomy in the female Sprague Dawley rat
    • doi:10.1054/plef.1999.0116. PMID:10718112
    • Schlemmer, C.K., Coetzer, H., Claassen, N., and Kruger, M.C. 1999. Oestrogen and essential fatty acid supplementation corrects bone loss due toovariectomy in the female Sprague Dawley rat. Prostaglandins Leukot. Essent. Fatty Acids, 61(6): 381-390. doi:10.1054/plef.1999.0116. PMID:10718112.
    • (1999) Prostaglandins Leukot. Essent. Fatty Acids , vol.61 , Issue.6 , pp. 381-390
    • Schlemmer, C.K.1    Coetzer, H.2    Claassen, N.3    Kruger, M.C.4
  • 47
    • 0034526233 scopus 로고    scopus 로고
    • Molecular markers of bone turnover: Biochemical, technical and analytical aspects
    • doi:10.1007/s001980070003. PMID:11193236
    • Seibel, M.J. 2000. Molecular markers of bone turnover: biochemical, technical and analytical aspects. Osteoporos. Int. 11(Suppl. 6): S18-S29. doi:10.1007/s001980070003. PMID:11193236.
    • (2000) Osteoporos. Int , vol.11 , Issue.SUPPL. 6
    • Seibel, M.J.1
  • 48
    • 33748787156 scopus 로고    scopus 로고
    • Natural health product use in Canada: Analysis of the National Population Health Survey
    • PMID:16921199
    • Singh, S.R., and Levine, M.A. 2006. Natural health product use in Canada: analysis of the National Population Health Survey. Can. J. Clin. Pharmacol. 13(2): e240-e250. PMID:16921199.
    • (2006) Can. J. Clin. Pharmacol , vol.13 , Issue.2
    • Singh, S.R.1    Levine, M.A.2
  • 49
    • 0028785711 scopus 로고
    • FDA Guidelines and animal models for osteoporosis
    • doi:10. 1016/8756-3282(95)00285-L. PMID:8579908
    • Thompson, D.D., Simmons, H.A., Pirie, C.M., and Ke, H.Z. 1995. FDA Guidelines and animal models for osteoporosis. Bone, 17(4 Suppl.): 125S-133S. doi:10. 1016/8756-3282(95)00285-L. PMID:8579908.
    • (1995) Bone , vol.17 , Issue.4 SUPPL.
    • Thompson, D.D.1    Simmons, H.A.2    Pirie, C.M.3    Ke, H.Z.4
  • 50
    • 18844389202 scopus 로고    scopus 로고
    • Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer
    • doi:10.1158/1078-0432.CCR-04-2326. PMID:15897583
    • Thompson, L.U., Chen, J.M., Li, T., Strasser-Weippl, K., and Goss, P.E. 2005. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin. Cancer Res. 11(10): 3828-3835. doi:10.1158/1078-0432.CCR-04-2326. PMID:15897583.
    • (2005) Clin. Cancer Res , vol.11 , Issue.10 , pp. 3828-3835
    • Thompson, L.U.1    Chen, J.M.2    Li, T.3    Strasser-Weippl, K.4    Goss, P.E.5
  • 51
    • 84903481666 scopus 로고    scopus 로고
    • Flaxseed and bone health in animal models of menopause
    • Edited by C.J. Hollins Martin, R.R. Watson, and V.R. Preedy. Humana Press, London, UK, doi:10.1007/978-1-62703-373-2_31
    • Ward, W.E., and Thompson, L.U. 2013. Flaxseed and bone health in animal models of menopause. In Nutrition and Diet in Menopause. Edited by C.J. Hollins Martin, R.R. Watson, and V.R. Preedy. Humana Press, London, UK. pp. 419-426. doi:10.1007/978-1-62703-373-2_31.
    • (2013) Nutrition and Diet In Menopause , pp. 419-426
    • Ward, W.E.1    Thompson, L.U.2
  • 52
    • 0034767830 scopus 로고    scopus 로고
    • Exposure to purified lignan from flaxseed (Linum usitatissimum) alters bone development in female rats
    • doi:10.1079/BJN2001429. PMID: 11591237
    • Ward, W.E., Yuan, Y.V., Cheung, A.M., and Thompson, L.U. 2001. Exposure to purified lignan from flaxseed (Linum usitatissimum) alters bone development in female rats. Br. J. Nutr. 86(4): 499-505. doi:10.1079/BJN2001429. PMID: 11591237.
    • (2001) Br. J. Nutr , vol.86 , Issue.4 , pp. 499-505
    • Ward, W.E.1    Yuan, Y.V.2    Cheung, A.M.3    Thompson, L.U.4
  • 53
    • 0035844065 scopus 로고    scopus 로고
    • Exposure to flaxseed and its purified lignan reduces bone strength in young but not older male rats
    • doi:10.1080/ 152873901750128362. PMID:11346133
    • Ward, W.E., Yuan, Y.V., Cheung, A.M., and Thompson, L.U. 2001. Exposure to flaxseed and its purified lignan reduces bone strength in young but not older male rats. J. Toxicol. Environ. Health A, 63(1): 53-65. doi:10.1080/ 152873901750128362. PMID:11346133.
    • (2001) J. Toxicol. Environ. Health A , vol.63 , Issue.1 , pp. 53-65
    • Ward, W.E.1    Yuan, Y.V.2    Cheung, A.M.3    Thompson, L.U.4
  • 54
    • 0023803311 scopus 로고
    • Temporal relationship between bone loss and increased bone turnover in ovariectomized rats
    • doi:10.1007/BF02571317. PMID:3141020
    • Wronski, T.J., Cintron, M., and Dann, L.M. 1988. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif. Tissue Int. 43(3): 179-183. doi:10.1007/BF02571317. PMID:3141020.
    • (1988) Calcif. Tissue Int , vol.43 , Issue.3 , pp. 179-183
    • Wronski, T.J.1    Cintron, M.2    Dann, L.M.3
  • 55
    • 34248178937 scopus 로고    scopus 로고
    • Short- to midterm effects of ovariectomy on bone turnover, bone mass and bone strength in rats
    • doi:10.1248/bpb.30.898. PMID: 17473432
    • Zhang, Y., Lai, W.P., Leung, P.C., Wu, C.F., and Wong, M.S. 2007. Short- to midterm effects of ovariectomy on bone turnover, bone mass and bone strength in rats. Biol. Pharm. Bull. 30(5): 898-903. doi:10.1248/bpb.30.898. PMID: 17473432.
    • (2007) Biol. Pharm. Bull , vol.30 , Issue.5 , pp. 898-903
    • Zhang, Y.1    Lai, W.P.2    Leung, P.C.3    Wu, C.F.4    Wong, M.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.