Flaxseed and bone health in animal models of menopause

Nutrition and Diet in Menopause

Volumn , Issue , 2013, Pages 419-426

  Ward, Wendy Elizabeth ^a   Thompson, Lilian U ^b  

^a BROCK UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alpha linolenic acid; Bone mineral density; Bone strength; Bone structure; Estrogen; Flaxseed; Lignans; Ovariectomy

Indexed keywords

EID: 84903481666     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-62703-373-2_31     Document Type: Chapter

References (21)

1. Singh SR, Levine MAH. Natural health product use in Canada: analysis of the national population health survey. Can J Clin Pharmacol. 2006;13:e240-50.
2. Verhoef MJ, Balneaves LG, Boon HS, Vroegindewey A. Reasons for and characteristics associated with complementary and alternative medicine use among adult cancer patients: a systematic review. Integr Cancer Ther. 2005;4:274-86.
3. Pacifici R. Role of T cells in ovariectomy induced bone loss-revisited. J Bone Miner Res. 2012;27:231-9.
4. Brooks JD, Ward WE, Lewis JE, Hilditch J, Nickell L, Wong E, et al. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr. 2004;79:318-25.
5. Dodin S, Lemary A, Jacques H, Legare F, Forest JC, Masse B. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo- controlled clinical trial. J Clin Endocrinol Metab. 2005;90:1390-7.
6. Griel AE, Kris-Etherton PM, Hilpert KF, Zhao G, West SG, Corwin RL. An increase in dietary n-3 fatty acids decrease a marker of bone resorption in humans. Nutr J. 2007;6:1-8.
7. Lucas EA, Wild RD, Hammond LJ, Khalil DA, Juma S, Daggy BP, et al. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinol Metab. 2002;87:1527-32.
8. Weiss LA, Barrett-Connor E, Von Muhlen D. Ratio of n-6 to n-3 fatty acids and bone mineral density in older adults:the Rancho Bernardo Study. Am J Clin Nutr. 2005;81:934-8.
9. Jiang JM, Sacco SM, Ward WE. Ovariectomy-induced hyperphagia does not modulate bone mineral density or bone strength in rats. J Nutr. 2008;138:2106-10.
10. Kavanaugh CJ, Desai KV, Calvo A, et al. Pre-clinical applications of transgenic mouse mammary cancer models. Transgenic Res. 2002;11:617-33.
11. Sacco SM, Jiang JMY, Reza-Lopez S, Ma DWL, Thompson LU, Ward WE. Flaxseed combined with low-dose estrogen therapy preserves bone tissue in ovariectomized rats. Menopause. 2009;16:545-54.
12. Sacco SM, Jiang JMY, Reza-Lopez S, Ma DWL, Thompson LU, Ward WE. Flaxseed does not antagonize the effect of ultra-low-dose estrogen therapy on bone mineral density and biomechanical bone strength in ovariectomized rats. J Toxicol Environ Health A. 2009;72:1209-16.
13. Sacco SM, Thompson LU, Ganss B, Ward WE. Accessibility of 3H-secoisolariciresinol diglycoside lignan metabolites in skeletal tissue of ovariectomized rats. J Med Food. 2011;14:1208-14.
14. Sacco SM, Ward WE. Revisiting estrogen: efficacy and safety for postmenopausal bone health. J Osteoporos. 2010;708931:8. doi:10.4061/2010/708931.
15. Sacco SM. Flaxseed and lower-dose estrogen: studies on their protective actions and mechanisms in bone using the ovariectomized rat model. Ph.D. Thesis. University of Toronto. 2011.
16. Power KA, Ward WE, Chen JM, Saarinen N, Thompson LU. Flaxseed and soy protein isolate, alone and in combination, differ in their effect on bone mass, biomechanical bone strength, and uterus in ovariectomized nude mice with MCF-7 human breast tumor xenografts. J Toxicol Environ Health A. 2007;70:1088-896.
17. Power KA, Ward WE, Chen JM, Saarinen N, Thompson LU. Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model. Bone. 2006;39:117-24.
18. Chen J, Saggar JK, Ward WE, Thompson LU. Effects of flaxseed lignan and oil on bone health of breast-tumorbearing mice treated with or without tamoxifen. J Toxicol Environ Health A. 2011;74:756-68.
19. Saarinen NM, Power K, Chen J, Thompson LU. Flaxseed attenuates the tumor growth stimulating effect of soy protein in ovariectomized athymic mice with MCF-7 human breast cancer xenografts. Int J Cancer. 2006;119:925-31.
20. Saggar JK, Chen J, Corey P, Thompson LU. The effect of secoisolariciresinol diglycoside and flaxseed oil, alone and in combination, on MCF-7 tumor growth and signaling pathways. Nutr Cancer. 2010;62:532-42.
21. Eastell R, Hannon RA, Cuzick J, Dowsett M, Clack G, Adams JE, et al. Effect of an aromatase inhibitor on BMD and bone turnover markers: 2 year results of the Anastrozole, Tamoxifen, alone or in combination (ATAC) trial. J Bone Miner Res. 2006;21:1215-23.