The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: Potential implication in osteoporosis

Osteoporosis International

Volumn 24, Issue 5, 2013, Pages 1647-1661

  Casado Diaz A ^a   Santiago Mora, R ^a   Dorado, G ^b   Quesada Gomez J M ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Adipocyte differentiation; Mesenchymal stem cell; Osteoblast differentiation; Osteoporosis; Polyunsaturated fatty acid

Indexed keywords

ALKALINE PHOSPHATASE; ARACHIDONIC ACID; BONE SIALOPROTEIN; CELL MARKER; COLLAGEN TYPE 1; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; LIPOXYGENASE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; BONE ATROPHY; BONE MASS; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DIETARY INTAKE; GENE EXPRESSION; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; OSTEOBLAST; OSTEOBLASTOGENESIS; OSTEOCLAST; OSTEOPOROSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION;

ADIPOCYTES; ADIPOGENESIS; ADOLESCENT; ADULT; ARACHIDONIC ACID; CELL DIFFERENTIATION; CELLS, CULTURED; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPOXYGENASE; MALE; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS; RANK LIGAND; YOUNG ADULT;

EID: 84880345247     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-012-2138-z     Document Type: Article

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