Ovariectomy-induced hyperphagia does not modulate bone mineral density or bone strength in rats

Journal of Nutrition

Volumn 138, Issue 11, 2008, Pages 2106-2110

  Jiang, Jessica M Y ^a   Sacco, Sandra M ^a   Ward, Wendy E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BIOMECHANICS; BODY COMPOSITION; BODY FAT; BODY REGIONS; BODY WEIGHT; BONE DENSITY; BONE STRENGTH; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR TUMOR; FOOD INTAKE; HYPERPHAGIA; LUMBAR VERTEBRA; NONHUMAN; NUTRITIONAL ASSESSMENT; OUTCOME ASSESSMENT; OVARIECTOMY; RAT; UTERUS WEIGHT; WEIGHT GAIN;

ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; FEEDING BEHAVIOR; FEMALE; HYPERPHAGIA; ORGAN SIZE; OSTEOPOROSIS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; UTERUS;

ANIMALIA; RATTUS;

EID: 55949100839     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.093781     Document Type: Article

References (44)

1. NIH. NIH consensus development panel on osteoporosis prevention, diagnosis, and treatment. JAMA. 2001;285:785-95.
2. Brown JP, Josse RG. 2002 Clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ. 2002;167:S1-34.
3. Bonjour JP, Ammann P, Rizzoli R. Importance of preclinical studies in the development of drugs for the treatment of osteoporosis: a review related to the 1998 WHO Guidelines. Osteoporos Int. 1999;9:379-93.
4. Egermann M, Goldhahn J, Schneider E. Animal models for fracture treatment in osteoporosis. Osteoporos Int. 2005;16:S129-38.
5. Jee WSS, Yao W. Overview: animal models of osteopenia and osteoporosis. J Musculoskelet Neuronal Interact. 2001;1:193-207.
6. FDA. Guidelines for preclinical and clinical evaluation of agents used in the prevention or treatment of postmenopausal osteoporosis. Rockville Division of Metabolism and Endocrine Drug Products, FDA, April, 1994.
7. McElroy JF, Wade GN. Short-and long-term effects of ovariectomy on food intake, body weight, carcass composition, and brown adipose tissue in rats. Physiol Behav. 1987;39:361-5.
8. Liang YQ, Akishta M, Kim S, Ako J, Hashimoto M, Iijima K, Ohike Y, Watanabe T, Sudoh N, et al. Estrogen receptor β is involved in the anorectic action of estrogen. Int J Obes Relat Metab Disord. 2002;26:1103-9.
9. Asarian L, Geary N. Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats. Horm Behav. 2002;42:461-71.
10. Toth MJ, Poehlman ET, Matthews DE, Tchernof A, MacCoss MJ. Effects of estradiol and progesterone on body composition, protein synthesis, and lipoprotein lipase in rats. Am J Physiol Endocrinol Metab. 2001;280:E496-501.
11. Eckel LA, Houpt TA, Geary N. Estradiol treatment increases CCK-induced c-Fos expression in the brains of ovariectomized rats. Am J Physiol Regul Integr Comp Physiol. 2002;283:R1378-85.
12. Geary N, Asarian L. Estradiol increases glucagon's satiating potency in ovariectomized rats. Am J Physiol Regul Integr Comp Physiol. 2001;281:R1290-4.
13. Torto R, Boghossian S, Dube MG, Kalra PS, Kalra SP. Central leptin gene therapy blocks ovariectomy-induced adiposity. Obesity (Silver Spring). 2006;14:1312-9.
14. Chen Y, Heiman ML. Increased weight gain after ovariectomy is not a consequence of leptin resistance. Am J Physiol Endocrinol Metab. 2001;280:E315-22.
15. Shimomura K, Shimizu H, Tsuchiya T, Abe Y, Uehara Y, Mori M. Is leptin a key factor which develops obesity by ovariectomy? Endocr J. 2002;49:417-23.
16. Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, et al. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med. 2007;13:89-94.
17. Glauber HS, Vollmer WM, Nevitt MC, Ensrud KE, Orwoll ES. Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density. J Clin Endocrinol Metab. 1995;80:1118-23.
18. Crepaldi G, Romanato G, Tonin P, Maggi S. Osteoporosis and body composition. J Endocrinol Invest. 2007;30:42-7.
19. Zhao LJ, Jiang H, Papasian CJ, Maulik D, Drees B, Hamilton J, Deng HW. Correlation of obesity and osteoporosis: effects of fat mass on the determination of osteoporosis. J Bone Miner Res. 2008;23:17-29.
20. Fisher JS, Kohrt WM, Borwn M. Food restriction suppresses muscle growth and augments osteopenia in ovariectomized rats. J Appl Physiol. 2000;88:265-71.
21. McCormick KM, Burns KL, Piccone CM, Gosselini LE, Brazeau GA. Effects of ovariectomy and estrogen on skeletal muscle function in growing rats. J Muscle Res Cell Motil. 2004;25:21-7.
22. McMillan J, Kinney RC, Ranly DM, Fatehi-Sedeh S, Schwartz Z, Boyan BD. Osteoinductivity of demineralized bone matrix in immunocompromised mice and rats is decreased by ovariectomy and restored by estrogen replacement. Bone. 2007;40:111-21.
23. Morohashi T, Sano T, Harai K, Yamada S. Effects of strontium on calcium metabolism in rats II. Strontium prevents the increased rate of bone turnover in ovariectomized rats. Jpn J Pharmacol. 1995;68:153-9.
24. Melhus G, Solberg LB, Dimmen S, Madsen JE, Nordsletten L, Reinholt FP. Experimental osteoporosis induced by ovariectomy and vitamin D deficiency does not markedly affect fracture healing in rats. Acta Orthop. 2007;78:393-403.
25. Picherit C, Bennetau-Pelissero C, Chanteranne B, Lebecque P, Davicco MJ, Barlet JP, Coxam V. Soybean isoflavones dose-dependently reduce bone turnover but do not reverse established osteopenia in adult ovariectomized rats. J Nutr. 2001;131:723-8.
26. Toba Y, Kajita Y, Masuyama R, Takada Y, Suzuki K, Aoe S. Dietary magnesium supplementation affects bone metabolism and dynamic strength of bone in ovariectomized rats. J Nutr. 2000;130:216-20.
27. Kim HJ, Bae YC, Park RW, Choi SW, Cho SH, Choi YS, Lee WJ. Bone-protecting effects of safflower seeds in ovariectomized rats. Calcif Tissue Int. 2002;71:88-94.
28. Om AS, Shim JY. Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats. Acta Biochim Pol. 2007;54:641-6.
29. Fuchs RK, Shea M, Durski SL, Winters-Stone KM, Widrick J, Snow CM. Individual and combined effects of exercise and alendronate on bone mass and strength in ovariectomized rats. Bone. 2007;41:290-6.
30. Nian H, Qin LP, Chen WS, Zhang QY, Zheng HC, Wang Y. Protective effect of steroidal saponins from rhizome of Anemarrhena asphodeloides on ovariectomy-induced bone loss in rats. Acta Pharmacol Sin. 2006;27:728-34.
31. Hertrampf T, Gruca MJ, Seibel J, Laudenbach U, Fritzemeier KH, Diel P. The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity. Bone. 2007;40:1529-35.
32. Tsuchita H, Goto T, Shimizu T, Yonehara Y, Kuwata T. Dietary casein phosphopeptides prevent bone loss in aged ovariectomized rats. J Nutr. 1996;126:86-93.
33. Goda T, Suruga K, Takase S, Ezawa I, Hosoya N. Dietary maltitol increases calcium content and breaking force of femoral bone in ovariectomized rats. J Nutr. 1995;125:2869-73.
34. Zafar TA, Weaver CM, Zhao Y, Martin BR, Wastney ME. Non-digestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. J Nutr. 2004;134:399-402.
35. Olfert ED, Cross BM, McWilliam AA, editors. Guide to the care and use of experimental animals. 1st vol. 2nd ed. Ottawa: Canadian Council on Animal Care; 1993. p. 1-211.
36. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
37. Breitman PL, Fonseca D, Cheung AM, Ward WE. Isoflavones with supplemental calcium provide greater protection against the loss of bone mass and strength after ovariectomy compared to isoflavones alone. Bone. 2003;33:597-605.
38. Roy EJ, Wade GN. Role of food intake in estradiol-induced body weight changes in female rats. Horm Behav. 1977;8:265-74.
39. Landau IT, Zucker I. Estrogenic regulation of body weight in the female rat. Horm Behav. 1976;7:29-39.
40. Ainslie DA, Morris MJ, Wittert G, Turnbull H, Proietto J, Thornburn AW. Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y. Int J Obes Relat Metab Disord. 2001;25:1680-8.
41. Thomas DK, Storlien LH, Bellingham WP, Gillette K. Ovarian hormone effects on activity, glucoregulation, and thyroid hormone in the rat. Physiol Behav. 1986;36:567-73.
42. Zhang Y, Lai WP, Leung PC, Wu CF, Wong MS. Short- to mid-term effects of ovariectomy on bone turnover, bone mass and bone strength in rats. Biol Pharm Bull. 2007;30:898-903.
43. Peng ZQ, Väänänen HK, Zhang HX, Tuukkanen J. Long-term effects of ovariectomy on the mechanical properties and chemical composition of rat bone. Bone. 1997;20:207-12.
44. Wronski TJ, Schenck PA, Cintrón M, Walsh CC. Effect of body weight on osteopenia in ovariectomized rats. Calcif Tissue Int. 1987;40:155-9.