Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation

Journal of Biological Chemistry

Volumn 289, Issue 25, 2014, Pages 17854-17871

  Fuerer, Christophe ^a   Nostro, M Cristina ^b   Constam, Daniel B ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BODY FLUIDS; MOLECULAR WEIGHT; SIGNALING; STEM CELLS;

ENDODERMAL MARKERS; EXTRACELLULAR DOMAINS; HETERODIMERIZATION; LOW MOLECULAR WEIGHT; PLURIPOTENT STEM CELLS; SIGNALING RECEPTOR; SPECIFIC ACTIVITY; STEM CELL DIFFERENTIATION;

CELL SIGNALING;

ACTIVIN RECEPTOR; ACTIVIN RECEPTOR 2; FC RECEPTOR; GROWTH DIFFERENTIATION FACTOR 1; HETERODIMER; PROTEIN NODAL;

ARTICLE; CELL DIFFERENTIATION; CELL FATE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIMERIZATION; ENDODERM; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOLECULAR WEIGHT; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; STEM CELL RESEARCH;

EMBRYONIC STEM CELL; GROWTH AND DIFFERENTIATION FACTOR 1 (GDF1); NODAL; PRODOMAINS; PROPROTEIN CONVERTASE; PROTEIN PURIFICATION; SERUM; SIGNALING; STEM CELL DIFFERENTIATION; TRANSFORMING GROWTH FACTOR Β (TGFΒ);

ACTIVIN RECEPTORS, TYPE II; ANIMALS; CELL DIFFERENTIATION; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; ENDODERM; GROWTH DIFFERENTIATION FACTOR 1; HEK293 CELLS; HEP G2 CELLS; HUMANS; MICE; MICE, KNOCKOUT; NODAL PROTEIN; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 84903444925     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.550301     Document Type: Article

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