Dual roles of cripto as a ligand and coreceptor in the nodal signaling pathway

Molecular and Cellular Biology

Volumn 22, Issue 13, 2002, Pages 4439-4449

  Yan, Yu Ting ^a   Liu, Jan Jan ^a   Luo, Yi ^a   Chaosu, E ^a   Haltiwanger, Robert S ^a   Abate Shen, Cory ^a   Shen, Michael M ^a  

^a CABM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRIPTO PROTEIN; CYSTEINE; EPIDERMAL GROWTH FACTOR; FUCOSE; MONOSACCHARIDE; PROTEIN; PROTEIN NODAL; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; FUCOSYLATION; GASTRULATION; GLYCOSYLATION; MAMMAL CELL; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS, TYPE I; AMINO ACID MOTIFS; CELLS, CULTURED; CROSS-LINKING REAGENTS; EPIDERMAL GROWTH FACTOR; GLYCOSYLATION; HUMANS; LUCIFERASES; MEMBRANE GLYCOPROTEINS; MUTATION; NEOPLASM PROTEINS; PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; ANURA; MAMMALIA; VERTEBRATA;

EID: 0036275653     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.13.4439-4449.2002     Document Type: Article

References (68)

1. Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer
2. Activation of signalling by the activin receptor complex
3. Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects
4. Cripto-1 indirectly stimulates the tyrosine phosphorylation of erbB-4 through a novel receptor
5. Identification and biological characterization of an epidermal growth factor-related protein: Cripto-1
6. Nodal signalling in the epiblast patterns the early mouse embryo
7. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
8. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin
9. Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex
10. A transcriptional partner for MAD proteins in TGF-beta signalling
11. Smad4 and FAST-1 in the assembly of activin-responsive factor
12. The zebrafish Nodal signal Squint functions as a morphogen
13. Expression of cripto, a novel gene of the epidermal growth factor gene family, leads to in vitro transformation of a normal mouse mammary epithelial cell line
14. Differential expression of epidermal growth factor-related proteins in human colorectal tumors
15. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
16. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases
17. Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses
18. Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
19. A knock-out model of paroxysmal nocturnal hemoglobinuria: Pig-a(-) hematopoiesis is reconstituted following intercellular transfer of GPI-anchored proteins
20. Cripto, a member of the epidermal growth factor family, is over-expressed in human pancreatic cancer and chronic pancreatitis
21. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
22. O-linked fucose and other post-translational modifications unique to EGF modules
23. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
24. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
25. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
26. Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells
27. In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium
28. Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads
29. Expression of cripto, a novel gene of the epidermal growth factor family, in human gastrointestinal carcinomas
30. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
31. Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
32. Human type II receptor for bone morphogenic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
33. TGF-β signal transduction
34. Controlling TGF-beta signaling
35. Structure-function analysis of the EGF-CFC family member Cripto identifies residues essential for nodal signalling
36. Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development
37. The O-linked fucose glycosylation pathway: Identification and characterization of a uridine diphosphoglucose: Fucose-betal,3-glucosyltransferase activity from Chinese hamster ovary cells
38. Fringe is a glycosyltransferase that modifies Notch
39. Mammalian Notchl is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules
40. i2) produced by gene targeting of both alleles
41. Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements
42. Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1
43. Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts
44. The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation
45. Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas
46. Structural requirements for the growth factor activity of the amino-terminal domain of urokinase
47. The orphan receptor ALK7 and the activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development
48. Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors
49. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
50. Cripto: A novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia
51. The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail
52. Nodal signalling in vertebrate development
53. Fucosylation of Cripto is required for its ability to facilitate nodal signaling
54. The EGF-CFC gene family in vertebrate development
55. A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation
56. Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation
57. Fast1 is required for the development of dorsal axial structures in zebrafish
58. One-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube
59. Characterization of a multicomponent receptor for GDNF
60. Nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
61. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase
62. FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo
63. Nodal signaling in early vertebrate embryos. Themes and variations
64. Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes
65. The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
66. Nodal signals to Smads through Criptodependent and Cripto-independent mechanisms
67. Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation
68. Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation