Multistep molecular mechanism for bone morphogenetic protein extracellular transport in the Drosophila embryo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 28, 2012, Pages 11222-11227

  Sawala, Annick ^a   Sutcliffe, Catherine ^a   Ashe, Hilary L ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; COLLAGEN TYPE 4; DECAPENTAPLEGIC PROTEIN; MEMBRANE PROTEIN; SCW PROTEIN; SOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL TRANSPORT; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EXTRACELLULAR MATRIX; EXTRACELLULAR TRANSPORT; GASTRULATION; IN VIVO STUDY; MOLECULAR MECHANICS; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BONE MORPHOGENETIC PROTEINS; COLLAGEN TYPE IV; DIMERIZATION; DROSOPHILA; DROSOPHILA PROTEINS; EXTRACELLULAR MATRIX; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTATHIONE TRANSFERASE; LIGANDS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84863895016     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1202781109     Document Type: Article

References (31)

1. Little SC, Mullins MC (2006) Extracellular modulation of BMP activity in patterning the dorsoventral axis. Birth Defects Res C Embryo Today 78:224-242. (Pubitemid 44704440)
2. Umulis D, O'Connor MB, Blair SS (2009) The extracellular regulation of bone morphogenetic protein signaling. Development 136:3715-3728.
3. Ferguson EL, Anderson KV (1992) Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71:451-461.
4. O'Connor MB, Umulis D, Othmer HG, Blair SS (2006) Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing. Development 133:183-193. (Pubitemid 43210708)
5. Holley SA, et al. (1996) The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell 86:607-617. (Pubitemid 26299492)
6. Ashe HL, Levine M (1999) Local inhibition and long-range enhancement of Dpp signal transduction by Sog. Nature 398:427-431. (Pubitemid 29180375)
7. Eldar A, et al. (2002) Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature 419:304-308.
8. Wang YC, Ferguson EL (2005) Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning. Nature 434:229-234.
9. Shimmi O, Umulis D, Othmer H, O'Connor MB (2005) Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo. Cell 120:873-886. (Pubitemid 40568802)
10. Marqués G, et al. (1997) Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins. Cell 91:417-426. (Pubitemid 27467972)
11. Wang XM, Harris RE, Bayston LJ, Ashe HL (2008) Type IV collagens regulate BMP signalling in Drosophila. Nature 455:72-77.
12. Umulis DM, Shimmi O, O'Connor MB, Othmer HG (2010) Organism-scale modeling of early Drosophila patterning via bone morphogenetic proteins. Dev Cell 18:260-274.
13. Künnapuu J, Björkgren I, Shimmi O (2009) The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites. Proc Natl Acad Sci USA 106:8501-8506.
14. Fritsch C, et al. (2012) Different requirements for proteolytic processing of bone morphogenetic protein 5/6/7/8 ligands in Drosophila melanogaster. J Biol Chem287:5942-5953.
15. Zhang JL, Huang Y, Qiu LY, Nickel J, Sebald W (2007) von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms. J Biol Chem 282:20002-20014. (Pubitemid 47100074)
16. Fujisawa T, Huang Y, Sebald W, Zhang J-L (2009) The binding of von Willebrand factor type C domains of Chordin family proteins to BMP-2 and Tsg is mediated by their SD1 subdomain. Biochem Biophys Res Commun 385:215-219.
17. Ashe HL, Mannervik M, Levine M (2000) Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo. Development 127:3305-3312. (Pubitemid 30649542)
18. Mizutani CM, et al. (2005) Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell 8:915-924. (Pubitemid 40754062)
19. Yu K, et al. (2000) Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity. Development 127:2143-2154. (Pubitemid 30386678)
20. Ohkawara B, Iemura S, ten Dijke P, Ueno N (2002) Action range of BMP is defined by its N-terminal basic amino acid core. Curr Biol 12:205-209. (Pubitemid 34122375)
21. Akiyama T, et al. (2008) Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface. Dev Biol 313:408-419. (Pubitemid 350298327)
22. Bornemann DJ, Park S, Phin S, Warrior R (2008) A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo. Development 135: 1039-1047. (Pubitemid 351578132)
23. Kirkpatrick CA, et al. (2006) The function of a Drosophila glypican does not depend entirely on heparan sulfate modification. Dev Biol 300:570-582. (Pubitemid 44914138)
24. Ben-Zvi D, Shilo BZ, Fainsod A, Barkai N (2008) Scaling of the BMP activation gradient in Xenopus embryos. Nature 453:1205-1211. (Pubitemid 351913602)
25. Zakin L, Chang EY, Plouhinec J-L, De Robertis EM (2010) Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos. Dev Biol 347:204-215.
26. Shimmi O, Ralston A, Blair SS, O'Connor MB (2005) The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing. Dev Biol 282:70-83. (Pubitemid 40779929)
27. Matsuda S, Shimmi O (2012) Directional transport and active retention of Dpp/BMP create wing vein patterns in Drosophila. Dev Biol 366:153-162.
28. Bunt S, et al. (2010) Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila. Dev Cell 19:296-306.
29. Paralkar VM, et al. (1990) Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type-IV collagen. J Biol Chem 265:17281-17284.
30. Kosman D, Small S (1997) Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps. Development 124:1343-1354. (Pubitemid 27190107)
31. Sopory S, Kwon S, Wehrli M, Christian JL (2010) Regulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain. Dev Biol 346:102-112.