Structure-activity relationship of nonsecosteroidal vitamin D receptor modulators

Trends in Pharmacological Sciences

Volumn 35, Issue 7, 2014, Pages 324-337

  Yamada, Sachiko ^a   Makishima, Makoto ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

cancer; crystal structures; hypercalcemia; nuclear receptors; selective VDR modulators; vitamin D receptor

Indexed keywords

ANTINEOPLASTIC AGENT; AROMATIC COMPOUND; CALCITRIOL; CARBORANE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; LG 190178; PENTANE; PHENYL PYRROLYL PENTANE; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CELL DIFFERENTIATION; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG EFFECT; ENTROPY; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; HYPERCALCEMIA; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SOLVATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRANSACTIVATION; X RAY ANALYSIS;

CANCER; CRYSTAL STRUCTURES; HYPERCALCEMIA; NUCLEAR RECEPTORS; SELECTIVE VDR MODULATORS; VITAMIN D RECEPTOR;

ACETATES; ANIMALS; ARYLSULFONATES; BENZENE DERIVATIVES; BIPHENYL COMPOUNDS; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MODELS, MOLECULAR; RECEPTORS, CALCITRIOL; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84903388444     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.04.008     Document Type: Review

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