Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands

FEBS Letters

Volumn 587, Issue 7, 2013, Pages 957-963

  Asano, Lisa ^a,d   Ito, Ichiaki ^b   Kuwabara, Naoyuki ^a,d   Waku, Tsuyoshi ^a   Yanagisawa, Junn ^b   Miyachi, Hiroyuki ^c   Shimizu, Toshiyuki ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d RIKEN SPring 8 Center   (Japan)

Author keywords

Agonism; Crystal structure; Non secosteroidal ligand; Vitamin D receptor

Indexed keywords

HYDROGEN; LIGAND; SECOSTEROID; SECOSTEROIDAL LIGAND; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; HYDROGEN BOND; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; RAT;

ANIMALS; BINDING, COMPETITIVE; CALCITRIOL; CRYSTALLOGRAPHY, X-RAY; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; ORGANIC CHEMICALS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, CALCITRIOL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875269056     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.02.028     Document Type: Article

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