Alcohol dependence: Molecular and behavioral evidence

Trends in Pharmacological Sciences

Volumn 35, Issue 7, 2014, Pages 317-323

  Trudell, James R ^a   Messing, Robert O ^b   Mayfield, Jody ^b   Harris, R Adron ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

behavior; chronic alcohol consumption; crystal structures; ethanol; gene expression; GLIC; glycine; knockin mice; knockout; LGICs; NMDA; PKC; trafficking

Indexed keywords

ALCOHOL;

ALCOHOLISM; BEHAVIORAL RESEARCH; BINDING SITE; GENE DELETION; GENETIC ASSOCIATION; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

BEHAVIOR; CHRONIC ALCOHOL CONSUMPTION; CRYSTAL STRUCTURES; ETHANOL; GABA(A); GENE EXPRESSION; GLIC; GLYCINE; KNOCKIN MICE; KNOCKOUT; LGICS; NMDA; PKC; TRAFFICKING;

ALCOHOLISM; ANIMALS; ETHANOL; HUMANS; ION CHANNELS; MICE;

EID: 84903383551     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.04.009     Document Type: Review

References (66)

1. R.A. Harris et al. Ethanol's molecular targets Sci. Signal. 1 2008 re7
2. R.J. Howard et al. Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics Pharmacol. Rev. 66 2014 396 412
3. D.I. Perkins et al. Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors J. Pharmacol. Exp. Ther. 341 2012 543 551
4. D. Ron, and R.O. Messing Signaling pathways mediating alcohol effects Curr. Top. Behav. Neurosci. 13 2013 87 126
5. I. Ponomarev et al. Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence J. Neurosci. 32 2012 1884 1897
6. G. Gorini et al. Proteomic approaches and identification of novel therapeutic targets for alcoholism Neuropsychopharmacology 39 2014 104 130
7. C.M. Borghese et al. Characterization of two mutations, M287L and Q266I, in the alpha1 glycine receptor subunit that modify sensitivity to alcohols J. Pharmacol. Exp. Ther. 340 2012 304 316
8. R.J. Howard et al. Structural basis for alcohol modulation of a pentameric ligand-gated ion channel Proc. Natl. Acad. Sci. U.S.A. 108 2011 12149 12154
9. R.J. Howard et al. Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution Alcohol. Clin. Exp. Res. 35 2011 1561 1573
10. K. Bodhinathan, and P.A. Slesinger Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels Proc. Natl. Acad. Sci. U.S.A. 110 2013 18309 18314
11. G. Weber Biological specificity and ligand binding. Biological specificity in ligand binding Protein Interactions 1992 Chapman and Hall 271 273
12. J.R. Trudell, and W.L. Hubbell Localization of molecular halothane in phospholipid bilayer model nerve membranes Anesthesiology 44 1976 202 205
13. Y. Xu et al. NMR study of volatile anesthetic binding to nicotinic acetylcholine receptors Biophys. J. 78 2000 746 751 (Pubitemid 30211832)
14. S. Murail et al. Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor Biophys. J. 100 2011 1642 1650
15. T.W. Schwartz, and W.L. Hubbell Structural biology: a moving story of receptors Nature 455 2008 473 474
16. E.J. Bertaccini et al. Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein J. Chem. Inf. Model. 48 2008 855 860 (Pubitemid 351757750)
17. R.W. Olsen et al. Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol Alcohol. Clin. Exp. Res. 38 2014 595 603
18. J.R. Trudell et al. Teaching an old GABA receptor new tricks Anesth. Analg. 115 2012 270 273
19. L. Sauguet et al. Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel Nat. Commun. 4 2013 1697
20. S.W. Kruse et al. Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster Nat. Struct. Biol. 10 2003 694 700 (Pubitemid 37052406)
21. E.J. Bertaccini et al. Normal-mode analysis of the glycine alpha1 receptor by three separate methods J. Chem. Inf. Model. 47 2007 1572 1579 (Pubitemid 47210060)
22. E.J. Bertaccini et al. Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4 J. Chem. Inf. Model. 50 2010 2248 2255
23. A receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication Neuropharmacology 67 2013 46 56
24. Y.A. Blednov et al. Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data Genes Brain Behav. 11 2012 424 435
25. A receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake Proc. Natl. Acad. Sci. U.S.A. 108 2011 4459 4464
26. A receptors in the nucleus accumbens mediate moderate intake of alcohol J. Neurosci. 29 2009 543 549
27. A receptors J. Pharmacol. Exp. Ther. 336 2011 145 154
28. C.R. den Hartog et al. Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors PLoS ONE 8 2013 e80541
29. Q.M. Anstee et al. Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition Nat. Commun. 4 2013 2816
30. Y.A. Blednov et al. Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor alpha1 subunit J. Pharmacol. Exp. Ther. 340 2012 317 329
31. A receptors in the development of alcoholism Pharmacol. Biochem. Behav. 90 2008 95 104
32. D. Li et al. Association of γ-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder Neuropsychopharmacology 39 2014 907 918
33. S. Han et al. Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans Hum. Genet. 132 2013 397 403
34. B. Soderpalm, and M. Ericson Neurocircuitry involved in the development of alcohol addiction: the dopamine system and its access points Curr. Top. Behav. Neurosci. 13 2013 127 161
35. R.I. Aroeira et al. Age-related changes of glycine receptor at the rat hippocampus: from the embryo to the adult J. Neurochem. 118 2011 339 353
36. E. Muller et al. Despite GABAergic neurotransmission, GABAergic innervation does not compensate for the defect in glycine receptor postsynaptic aggregation in spastic mice Eur. J. Neurosci. 27 2008 2529 2541 (Pubitemid 351781661)
37. K.A. Badanich et al. Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism Neuropsychopharmacology 38 2013 1176 1188
38. E.P. Maguire et al. Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol Neuropsychopharmacology 39 2014 1232 1244
39. X. Xuei et al. GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence Am. J. Med. Genet. B: Neuropsychiatr. Genet. 153B 2010 418 427
40. A receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice PLoS ONE 9 2014 e85525
41. T.K. Clarke et al. KCNJ6 is associated with adult alcohol dependence and involved in gene × early life stress interactions in adolescent alcohol drinking Neuropsychopharmacology 36 2011 1142 1148
42. S.J. Kang et al. Family-based genome-wide association study of frontal theta oscillations identifies potassium channel gene KCNJ6 Genes Brain Behav. 11 2012 712 719
43. Y.A. Blednov et al. A pervasive mechanism for analgesia: activation of GIRK2 channels Proc. Natl. Acad. Sci. U.S.A. 100 2003 277 282 (Pubitemid 36078065)
44. M.W. Salter, and L.V. Kalia Src kinases: a hub for NMDA receptor regulation Nat. Rev. Neurosci. 5 2004 317 328 (Pubitemid 38478658)
45. N. Suvarna et al. Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras J. Biol. Chem. 280 2005 31450 31459 (Pubitemid 41291887)
46. R. Yaka et al. Scaffolding of fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol J. Neurosci. 23 2003 3623 3632 (Pubitemid 36958470)
47. J. Wang et al. Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior J. Neurosci. 27 2007 3593 3602 (Pubitemid 46515141)
48. J. Wang et al. Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse J. Neurosci. 30 2010 10187 10198
49. S. Ben Hamida et al. Protein tyrosine phosphatase alpha in the dorsomedial striatum promotes excessive ethanol-drinking behaviors J. Neurosci. 33 2013 14369 14378
50. A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma 2 subunits J. Biol. Chem. 282 2007 33052 33063
51. A receptor modulators and alcohol in mice lacking PKC Nat. Neurosci. 2 1999 997 1002 (Pubitemid 30599563)
52. A receptors by diazepam binding inhibitor Neuron 78 2013 1063 1074
53. K.R. Tan et al. GABA neurons of the VTA drive conditioned place aversion Neuron 73 2012 1173 1183
54. P.M. Newton, and R.O. Messing Increased sensitivity to the aversive effects of ethanol in PKC null mice revealed by place conditioning Behav. Neurosci. 121 2007 439 442 (Pubitemid 47445096)
55. M. Bajo et al. Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala Proc. Natl. Acad. Sci. U.S.A. 105 2008 8410 8415 (Pubitemid 351904770)
56. D.S. Choi et al. Protein kinase Cδ regulates ethanol intoxication and enhancement of GABA-stimulated tonic current J. Neurosci. 28 2008 11890 11899
57. A receptor plasticity after ethanol intoxication J. Neurosci. 27 2007 12367 12377 (Pubitemid 350085483)
58. A receptors after ethanol pre-exposure in cultured hippocampal neurons Mol. Pharmacol. 79 2011 432 442
59. M.R. Diaz et al. Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses J. Pharmacol. Exp. Ther. 337 2011 162 170
60. K.R. Tan et al. Neural bases for addictive properties of benzodiazepines Nature 463 2010 769 774
61. A receptors J. Neurosci. 32 2012 17874 17881
62. A receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption J. Neurochem. 82 2002 110 117 (Pubitemid 34755255)
63. A receptor α4 subunit expression in cultured cerebral cortical neurons J. Neurochem. 116 2011 554 563
64. M. Kimura, and S. Higuchi Genetics of alcohol dependence Psychiatry Clin. Neurosci. 65 2011 213 225
65. Y.O. Nunez, and R.D. Mayfield Understanding alcoholism through microRNA signatures in brains of human alcoholics Front. Genet. 3 2012 43
66. R.A. Harris, and Y.A. Blednov Neuroimmune genes and alcohol drinking behavior C. Cui, Neural-Immune Interactions in Brain Function and Alcohol Related Disorders 2013 Springer 425 440