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Volumn 9, Issue 6, 2014, Pages

Mechanisms of U87 astrocytoma cell uptake and trafficking of monomeric versus protofibril Alzheimer's disease amyloid-β proteins

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; DYNAMIN II; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MONOMER; OLIGOMER; AMYLOID BETA PROTEIN; CHOLESTEROL; DYNAMIN; FLUORESCENT DYE; LRP1 PROTEIN, HUMAN; PEPTIDE;

EID: 84903310597     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099939     Document Type: Article
Times cited : (41)

References (52)
  • 1
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 2
    • 80052790704 scopus 로고    scopus 로고
    • The p75NTR extracellular domain: A potential molecule regulating the solubility and removal of amyloid-beta
    • Zhou XF, Wang YJ (2011) The p75NTR extracellular domain: a potential molecule regulating the solubility and removal of amyloid-beta. Prion 5: 161-163.
    • (2011) Prion , vol.5 , pp. 161-163
    • Zhou, X.F.1    Wang, Y.J.2
  • 3
    • 33748753481 scopus 로고    scopus 로고
    • Clearance of amyloid-beta in Alzheimer's disease: Progress, problems and perspectives
    • Wang YJ, Zhou HD, Zhou XF (2006) Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today 11: 931-938.
    • (2006) Drug Discov Today , vol.11 , pp. 931-938
    • Wang, Y.J.1    Zhou, H.D.2    Zhou, X.F.3
  • 6
    • 52049088941 scopus 로고    scopus 로고
    • Abeta(1-42) reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: A quantitative analysis
    • Evans NA, Facci L, Owen DE, Soden PE, Burbidge SA, et al. (2008) Abeta(1-42) reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: a quantitative analysis. J Neurosci Methods 175: 96-103.
    • (2008) J Neurosci Methods , vol.175 , pp. 96-103
    • Evans, N.A.1    Facci, L.2    Owen, D.E.3    Soden, P.E.4    Burbidge, S.A.5
  • 7
    • 84855373098 scopus 로고    scopus 로고
    • Natural amyloid-beta oligomers acutely impair the formation of a contextual fear memory in mice
    • Kittelberger KA, Piazza F, Tesco G, Reijmers LG (2012) Natural amyloid-beta oligomers acutely impair the formation of a contextual fear memory in mice. PLoS One 7: e29940.
    • (2012) PLoS One , vol.7
    • Kittelberger, K.A.1    Piazza, F.2    Tesco, G.3    Reijmers, L.G.4
  • 8
    • 34250819839 scopus 로고    scopus 로고
    • Intracellular amyloid-beta in Alzheimer's disease
    • LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 8: 499-509.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 499-509
    • LaFerla, F.M.1    Green, K.N.2    Oddo, S.3
  • 9
    • 7744235869 scopus 로고    scopus 로고
    • 1 integrin-dependent mechanism
    • DOI 10.1523/JNEUROSCI.2557-04.2004
    • Koenigsknecht J, Landreth G (2004) Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism. J Neurosci 24: 9838-9846. (Pubitemid 39463564)
    • (2004) Journal of Neuroscience , vol.24 , Issue.44 , pp. 9838-9846
    • Koenigsknecht, J.1    Landreth, G.2
  • 10
    • 77956238695 scopus 로고    scopus 로고
    • Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme
    • Kong Y, Ruan L, Qian L, Liu X, Le Y (2010) Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme. J Neurosci 30: 11848-11857.
    • (2010) J Neurosci , vol.30 , pp. 11848-11857
    • Kong, Y.1    Ruan, L.2    Qian, L.3    Liu, X.L.Y.4
  • 11
    • 65249170245 scopus 로고    scopus 로고
    • Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis
    • Mandrekar S, Jiang Q, Lee CY, Koenigsknecht-Talboo J, Holtzman DM, et al. (2009) Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J Neurosci 29: 4252-4262.
    • (2009) J Neurosci , vol.29 , pp. 4252-4262
    • Mandrekar, S.1    Jiang, Q.2    Lee, C.Y.3    Koenigsknecht-Talboo, J.4    Holtzman, D.M.5
  • 13
    • 0033527637 scopus 로고    scopus 로고
    • Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells
    • Chung H, Brazil MI, Soe TT, Maxfield FR (1999) Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells. J Biol Chem 274: 32301-32308.
    • (1999) J Biol Chem , vol.274 , pp. 32301-32308
    • Chung, H.1    Brazil, M.I.2    Soe, T.T.3    Maxfield, F.R.4
  • 14
    • 67650741983 scopus 로고    scopus 로고
    • Binding and uptake of A beta1-42 by primary human astrocytes in vitro
    • Nielsen HM, Veerhuis R, Holmqvist B, Janciauskiene S (2009) Binding and uptake of A beta1-42 by primary human astrocytes in vitro. Glia 57: 978-988.
    • (2009) Glia , vol.57 , pp. 978-988
    • Nielsen, H.M.1    Veerhuis, R.2    Holmqvist, B.3    Janciauskiene, S.4
  • 15
    • 77954375412 scopus 로고    scopus 로고
    • Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteins
    • Nielsen HM, Mulder SD, Belien JA, Musters RJ, Eikelenboom P, et al. (2010) Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteins. Glia 58: 1235-1246.
    • (2010) Glia , vol.58 , pp. 1235-1246
    • Nielsen, H.M.1    Mulder, S.D.2    Belien, J.A.3    Musters, R.J.4    Eikelenboom, P.5
  • 16
    • 84856221835 scopus 로고    scopus 로고
    • The effect of amyloid associated proteins on the expression of genes involved in amyloid-beta clearance by adult human astrocytes
    • Mulder SD, Veerhuis R, Blankenstein MA, Nielsen HM (2012) The effect of amyloid associated proteins on the expression of genes involved in amyloid-beta clearance by adult human astrocytes. Exp Neurol 233: 373-379.
    • (2012) Exp Neurol , vol.233 , pp. 373-379
    • Mulder, S.D.1    Veerhuis, R.2    Blankenstein, M.A.3    Nielsen, H.M.4
  • 17
    • 84655162704 scopus 로고    scopus 로고
    • Soluble Abeta oligomer production and toxicity
    • Larson ME, Lesne SE (2012) Soluble Abeta oligomer production and toxicity. J Neurochem 120 Suppl 1: 125-139.
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. 1 , pp. 125-139
    • Larson, M.E.1    Lesne, S.E.2
  • 18
    • 0036550597 scopus 로고    scopus 로고
    • Significance of intracellular Abeta42 accumulation in Alzheimer's disease
    • Tabira T, Chui DH, Kuroda S (2002) Significance of intracellular Abeta42 accumulation in Alzheimer's disease. Front Biosci 7: a44-49.
    • (2002) Front Biosci , vol.7
    • Tabira, T.1    Chui, D.H.2    Kuroda, S.3
  • 19
    • 49949083479 scopus 로고    scopus 로고
    • Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain
    • Aoki M, Volkmann I, Tjernberg LO, Winblad B, Bogdanovic N (2008) Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain. Neuroreport 19: 1085-1089.
    • (2008) Neuroreport , vol.19 , pp. 1085-1089
    • Aoki, M.1    Volkmann, I.2    Tjernberg, L.O.3    Winblad, B.4    Bogdanovic, N.5
  • 20
    • 0345303669 scopus 로고    scopus 로고
    • Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration
    • DOI 10.1016/S0014-5793(03)01272-9
    • Li Y, Lu W, Bu G (2003) Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration. FEBS Lett 555: 346-350. (Pubitemid 37486053)
    • (2003) FEBS Letters , vol.555 , Issue.2 , pp. 346-350
    • Li, Y.1    Lu, W.2    Bu, G.3
  • 21
    • 33748286734 scopus 로고    scopus 로고
    • Oleic Acid Inhibits Amyloid Formation of the Intermediate of alpha-Lactalbumin at Moderately Acidic pH
    • DOI 10.1016/j.jmb.2006.07.059, PII S0022283606009375
    • Yang F Jr, Zhang M, Zhou BR, Chen J, Liang Y (2006) Oleic acid inhibits amyloid formation of the intermediate of alpha-lactalbumin at moderately acidic pH. J Mol Biol 362: 821-834. (Pubitemid 44332426)
    • (2006) Journal of Molecular Biology , vol.362 , Issue.4 , pp. 821-834
    • Yang Jr., F.1    Zhang, M.2    Zhou, B.-R.3    Chen, J.4    Liang, Y.5
  • 23
    • 77956317803 scopus 로고    scopus 로고
    • Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols
    • Wang P, Henning SM, Heber D (2010) Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols. PLoS One 5: e10202.
    • (2010) PLoS One , vol.5
    • Wang, P.1    Henning, S.M.2    Heber, D.3
  • 24
    • 84890550550 scopus 로고    scopus 로고
    • In vitroOligomerization and Fibrillogenesis of Amyloid-beta Peptides
    • Benseny-Cases N, Klementieva O, Cladera J (2012) In vitroOligomerization and Fibrillogenesis of Amyloid-beta Peptides. Subcell Biochem 65: 53-74.
    • (2012) Subcell Biochem , vol.65 , pp. 53-74
    • Benseny-Cases, N.1    Klementieva, O.2    Cladera, J.3
  • 25
    • 84934439037 scopus 로고    scopus 로고
    • Preparing synthetic Abeta in different aggregation states
    • Stine WB, Jungbauer L, Yu C, LaDu MJ (2011) Preparing synthetic Abeta in different aggregation states. Methods Mol Biol 670: 13-32.
    • (2011) Methods Mol Biol , vol.670 , pp. 13-32
    • Stine, W.B.1    Jungbauer, L.2    Yu, C.3    LaDu, M.J.4
  • 26
    • 0033570337 scopus 로고    scopus 로고
    • Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
    • Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, et al. (1999) Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci 19: 8876-8884. (Pubitemid 30226709)
    • (1999) Journal of Neuroscience , vol.19 , Issue.20 , pp. 8876-8884
    • Hartley, D.M.1    Walsh, D.M.2    Ye, C.P.3    Diehl, T.4    Vasquez, S.5    Vassilev, P.M.6    Teplow, D.B.7    Selkoe, D.J.8
  • 28
    • 70450273117 scopus 로고    scopus 로고
    • Receptor-associated protein interacts with amyloidbeta peptide and promotes its cellular uptake
    • Kanekiyo T, Bu G (2009) Receptor-associated protein interacts with amyloidbeta peptide and promotes its cellular uptake. J Biol Chem 284: 33352-33359.
    • (2009) J Biol Chem , vol.284 , pp. 33352-33359
    • Kanekiyo, T.1    Bu, G.2
  • 29
    • 84862911656 scopus 로고    scopus 로고
    • Apolipoprotein E promotes beta-amyloid trafficking and degradation by modulating microglial cholesterol levels
    • Lee CY, Tse W, Smith JD, Landreth GE (2012) Apolipoprotein E promotes beta-amyloid trafficking and degradation by modulating microglial cholesterol levels. J Biol Chem 287: 2032-2044.
    • (2012) J Biol Chem , vol.287 , pp. 2032-2044
    • Lee, C.Y.1    Tse, W.2    Smith, J.D.3    Landreth, G.E.4
  • 30
    • 7044260932 scopus 로고    scopus 로고
    • Where sterols are required for endocytosis
    • DOI 10.1016/j.bbamem.2004.05.011, PII S0005273604001580, Lipid-Protein Interactions
    • Pichler H, Riezman H (2004) Where sterols are required for endocytosis. Biochim Biophys Acta 1666: 51-61. (Pubitemid 39425198)
    • (2004) Biochimica et Biophysica Acta - Biomembranes , vol.1666 , Issue.1-2 , pp. 51-61
    • Pichler, H.1    Riezman, H.2
  • 31
    • 59449088311 scopus 로고    scopus 로고
    • Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells
    • Liu YW, Surka MC, Schroeter T, Lukiyanchuk V, Schmid SL (2008) Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol Biol Cell 19: 5347-5359.
    • (2008) Mol Biol Cell , vol.19 , pp. 5347-5359
    • Liu, Y.W.1    Surka, M.C.2    Schroeter, T.3    Lukiyanchuk, V.4    Schmid, S.L.5
  • 34
    • 0035997373 scopus 로고    scopus 로고
    • Lipoprotein receptors in the nervous system
    • DOI 10.1146/annurev.biochem.71.110601.135342
    • Herz J, Bock HH (2002) Lipoprotein receptors in the nervous system. Annu Rev Biochem 71: 405-434. (Pubitemid 34800226)
    • (2002) Annual Review of Biochemistry , vol.71 , pp. 405-434
    • Herz, J.1    Bock, H.H.2
  • 35
    • 79952007060 scopus 로고    scopus 로고
    • Inhibition of beta-amyloid 1-42 internalization attenuates neuronal death by stabilizing the endosomal-lysosomal system in rat cortical cultured neurons
    • Song MS, Baker GB, Todd KG, Kar S (2011) Inhibition of beta-amyloid 1-42 internalization attenuates neuronal death by stabilizing the endosomal-lysosomal system in rat cortical cultured neurons. Neuroscience 178: 181-188.
    • (2011) Neuroscience , vol.178 , pp. 181-188
    • Song, M.S.1    Baker, G.B.2    Todd, K.G.3    Kar, S.4
  • 36
    • 77957335213 scopus 로고    scopus 로고
    • Amyloid-beta1-42 induces reactive oxygen species-mediated autophagic cell death in U87 and SHSY5Y cells
    • Wang H, Ma J, Tan Y, Wang Z, Sheng C, et al. (2010) Amyloid-beta1-42 induces reactive oxygen species-mediated autophagic cell death in U87 and SHSY5Y cells. J Alzheimers Dis 21: 597-610.
    • (2010) J Alzheimers Dis , vol.21 , pp. 597-610
    • Wang, H.1    Ma, J.2    Tan, Y.3    Wang, Z.4    Sheng, C.5
  • 37
    • 60549112186 scopus 로고    scopus 로고
    • Immunization in Alzheimer's disease: Naive hope or realistic clinical potential?
    • Foster JK, Verdile G, Bates KA, Martins RN (2009) Immunization in Alzheimer's disease: naive hope or realistic clinical potential? Mol Psychiatry 14: 239-251.
    • (2009) Mol Psychiatry , vol.14 , pp. 239-251
    • Foster, J.K.1    Verdile, G.2    Bates, K.A.3    Martins, R.N.4
  • 39
    • 77955604553 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking
    • Fuentealba RA, Liu Q, Zhang J, Kanekiyo T, Hu X, et al. (2010) Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. PLoS One 5: e11884.
    • (2010) PLoS One , vol.5
    • Fuentealba, R.A.1    Liu, Q.2    Zhang, J.3    Kanekiyo, T.4    Hu, X.5
  • 40
    • 84863306256 scopus 로고    scopus 로고
    • Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: Ramifications for the Alzheimer's drug discovery
    • Omtri RS, Davidson MW, Arumugam B, Poduslo JF, Kandimalla KK (2012) Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: ramifications for the Alzheimer's drug discovery. Mol Pharm 9: 1887-1897.
    • (2012) Mol Pharm , vol.9 , pp. 1887-1897
    • Omtri, R.S.1    Davidson, M.W.2    Arumugam, B.3    Poduslo, J.F.4    Kandimalla, K.K.5
  • 41
    • 37249062072 scopus 로고    scopus 로고
    • Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E
    • DOI 10.1074/jbc.M701823200
    • Saavedra L, Mohamed A, Ma V, Kar S, de Chaves EP (2007) Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E. J Biol Chem 282: 35722-35732. (Pubitemid 350277136)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.49 , pp. 35722-35732
    • Saavedra, L.1    Mohamed, A.2    Ma, V.3    Kar, S.4    De Chaves, E.P.5
  • 43
    • 67649371201 scopus 로고    scopus 로고
    • Ca2+ regulation of dynamin-independent endocytosis in cortical astrocytes
    • Jiang M, Chen G (2009) Ca2+ regulation of dynamin-independent endocytosis in cortical astrocytes. J Neurosci 29: 8063-8074.
    • (2009) J Neurosci , vol.29 , pp. 8063-8074
    • Jiang, M.1    Chen, G.2
  • 44
    • 77956955758 scopus 로고    scopus 로고
    • The role of microglia in amyloid clearance from the AD brain
    • Lee CY, Landreth GE (2010) The role of microglia in amyloid clearance from the AD brain. J Neural Transm 117: 949-960.
    • (2010) J Neural Transm , vol.117 , pp. 949-960
    • Lee, C.Y.1    Landreth, G.E.2
  • 45
    • 84859980871 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes
    • Basak JM, Verghese PB, Yoon H, Kim J, Holtzman DM (2012) Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes. J Biol Chem 287: 13959-13971.
    • (2012) J Biol Chem , vol.287 , pp. 13959-13971
    • Basak, J.M.1    Verghese, P.B.2    Yoon, H.3    Kim, J.4    Holtzman, D.M.5
  • 46
    • 84869037441 scopus 로고    scopus 로고
    • LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-beta
    • Kanekiyo T, Liu CC, Shinohara M, Li J, Bu G (2012) LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-beta. J Neurosci 32: 16458-16465.
    • (2012) J Neurosci , vol.32 , pp. 16458-16465
    • Kanekiyo, T.1    Liu, C.C.2    Shinohara, M.3    Li, J.4    Bu, G.5
  • 47
    • 84857782207 scopus 로고    scopus 로고
    • AP-2beta regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes
    • Rossello XS, Igbavboa U, Weisman GA, Sun GY, Wood WG (2012) AP-2beta regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes. Brain Res 1444: 87-95.
    • (2012) Brain Res , vol.1444 , pp. 87-95
    • Rossello, X.S.1    Igbavboa, U.2    Weisman, G.A.3    Sun, G.Y.4    Wood, W.G.5
  • 48
    • 84859709003 scopus 로고    scopus 로고
    • Mitochondriaspecific accumulation of amyloid beta induces mitochondrial dysfunction leading to apoptotic cell death
    • Cha MY, Han SH, Son SM, Hong HS, Choi YJ, et al. (2012) Mitochondriaspecific accumulation of amyloid beta induces mitochondrial dysfunction leading to apoptotic cell death. PLoS One 7: e34929.
    • (2012) PLoS One , vol.7
    • Cha, M.Y.1    Han, S.H.2    Son, S.M.3    Hong, H.S.4    Choi, Y.J.5
  • 49
    • 65249161745 scopus 로고    scopus 로고
    • Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta
    • Pigino G, Morfini G, Atagi Y, Deshpande A, Yu C, et al. (2009) Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta. Proc Natl Acad Sci U S A 106: 5907-5912.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 5907-5912
    • Pigino, G.1    Morfini, G.2    Atagi, Y.3    Deshpande, A.4    Yu, C.5
  • 50
    • 1242316263 scopus 로고    scopus 로고
    • Intracellular Accumulation of Amyloidogenic Fragments of Amyloid-beta Precursor Protein in Neurons with Niemann-Pick Type C Defects Is Associated with Endosomal Abnormalities
    • Jin LW, Shie FS, Maezawa I, Vincent I, Bird T (2004) Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol 164: 975-985. (Pubitemid 38235479)
    • (2004) American Journal of Pathology , vol.164 , Issue.3 , pp. 975-985
    • Jin, L.-W.1    Maezawa, I.2    Vincent, I.3    Bird, T.4
  • 51
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • DOI 10.1038/416535a
    • Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, et al. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal longterm potentiation in vivo. Nature 416: 535-539. (Pubitemid 34288854)
    • (2002) Nature , vol.416 , Issue.6880 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 52
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, et al. (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14: 837-842.
    • (2008) Nat Med , vol.14 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5


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