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Volumn 10, Issue 2, 2014, Pages 615-624

N-acetylcysteine reduces oxidative stress, nuclear factor-κB activity and cardiomyocyte apoptosis in heart failure

Author keywords

Apoptosis; Heart failure; N acetylcysteine; Nuclear factor B; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; DOXORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; 8-EPI-PROSTAGLANDIN F2ALPHA; GLUTATHIONE; I KAPPA B; NF-KAPPAB INHIBITOR ALPHA; PROSTAGLANDIN F2 ALPHA; PROTEIN BAX; PROTEIN BCL 2; TRANSCRIPTION FACTOR RELA;

EID: 84903310262     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2292     Document Type: Article
Times cited : (59)

References (50)
  • 1
    • 77649126524 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2010 update: A report from the American Heart Association
    • Lloyd-Jones D, Adams RJ, Brown TM, et al: Heart disease and stroke statistics - 2010 update: a report from the American Heart Association. Circulation 121: e46-e215, 2010.
    • (2010) Circulation , vol.121
    • Lloyd-Jones, D.1    Adams, R.J.2    Brown, T.M.3
  • 2
    • 84855353573 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2012 update: A report from the American Heart Association
    • Roger VL, Go AS, Lloyd-Jones DM, et al: Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation 125: e2-e220, 2012.
    • (2012) Circulation , vol.125
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 3
    • 21244440204 scopus 로고    scopus 로고
    • Epidemiology of diastolic heart failure
    • DOI 10.1016/j.pcad.2005.02.010, PII S0033062005000150
    • Owan TE and Redfield MM: Epidemiology of diastolic heart failure. Progr Cardiovasc Dis 47: 320-332, 2005. (Pubitemid 40884561)
    • (2005) Progress in Cardiovascular Diseases , vol.47 , Issue.5 , pp. 320-332
    • Owan, T.E.1    Redfield, M.M.2
  • 4
    • 84888040487 scopus 로고    scopus 로고
    • Heart failure and tachycardia-induced cardiomyopathy
    • Ellis ER and Josephson ME: Heart failure and tachycardia-induced cardiomyopathy. Curr Heart Fail Rep 10: 296-306, 2013.
    • (2013) Curr Heart Fail Rep , vol.10 , pp. 296-306
    • Ellis, E.R.1    Josephson, M.E.2
  • 5
    • 26444562493 scopus 로고    scopus 로고
    • Heart failure in African Americans
    • Yancy CW: Heart failure in African Americans. Am J Cardiol 96: 3i-12i, 2005.
    • (2005) Am J Cardiol , vol.96
    • Yancy, C.W.1
  • 6
    • 84891670705 scopus 로고    scopus 로고
    • Racial differences in the prevalence and outcomes of atrial fibrillation among patients hospitalized with heart failure
    • Thomas KL, Piccini JP, Liang L, et al: Racial differences in the prevalence and outcomes of atrial fibrillation among patients hospitalized with heart failure. J Am Heart Assoc 2: e000200, 2013.
    • (2013) J Am Heart Assoc , vol.2
    • Thomas, K.L.1    Piccini, J.P.2    Liang, L.3
  • 7
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart-an engine out of fuel
    • Neubauer S: The failing heart-an engine out of fuel. N Engl J Med 356: 1140-1151, 2007.
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 8
    • 14644442283 scopus 로고    scopus 로고
    • Oxygen, oxidative stress, hypoxia, and heart failure
    • Giordano FJ: Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115: 500-508, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 500-508
    • Giordano, F.J.1
  • 9
    • 33645562485 scopus 로고    scopus 로고
    • Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: Improvement after short-term inotropic support
    • White M, Ducharme A, Ibrahim R, et al: Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support. Clin Sci (Lond) 110: 483-489, 2006.
    • (2006) Clin Sci (Lond) , vol.110 , pp. 483-489
    • White, M.1    Ducharme, A.2    Ibrahim, R.3
  • 10
    • 0035800885 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis in heart failure progression
    • Hare JM: Oxidative stress and apoptosis in heart failure progression. Circ Res 89: 198-200, 2001.
    • (2001) Circ Res , vol.89 , pp. 198-200
    • Hare, J.M.1
  • 13
    • 80051721082 scopus 로고    scopus 로고
    • Toll-like receptor 4/nuclear factor-kappa B pathway is involved in myocardial injury in a rat chronic stress model
    • Wang RP, Yao Q, Xiao YB, et al: Toll-like receptor 4/nuclear factor-kappa B pathway is involved in myocardial injury in a rat chronic stress model. Stress 14: 567-575, 2011.
    • (2011) Stress , vol.14 , pp. 567-575
    • Wang, R.P.1    Yao, Q.2    Xiao, Y.B.3
  • 14
    • 79955605472 scopus 로고    scopus 로고
    • Multiple facets of NF-κB in the heart: To be or not to NF-κB
    • Gordon JW, Shaw JA and Kirshenbaum LA: Multiple facets of NF-κB in the heart: to be or not to NF-κB. Circ Res 108: 1122-1132, 2011.
    • (2011) Circ Res , vol.108 , pp. 1122-1132
    • Gordon, J.W.1    Shaw, J.A.2    Kirshenbaum, L.A.3
  • 15
    • 33748648140 scopus 로고    scopus 로고
    • Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction
    • Frantz S, Hu K, Bayer B, et al: Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction. FASEB 20: 1918-1920, 2006.
    • (2006) FASEB , vol.20 , pp. 1918-1920
    • Frantz, S.1    Hu, K.2    Bayer, B.3
  • 16
    • 0034617956 scopus 로고    scopus 로고
    • Apoptotic cell death during ischemia/reperfusion and its attenuation by antioxidant therapy
    • DOI 10.1016/S0300-483X(00)00201-8, PII S0300483X00002018
    • Galang N, Sasaki H and Maulik N: Apoptotic cell death during ischemia/reperfusion and its attenuation by antioxidant therapy. Toxicology 148: 111-118, 2000. (Pubitemid 30621350)
    • (2000) Toxicology , vol.148 , Issue.2-3 , pp. 111-118
    • Galang, N.1    Sasaki, H.2    Maulik, N.3
  • 18
    • 84874068388 scopus 로고    scopus 로고
    • Subendocardial increase in reactive oxygen species production affects regional contractile function in ischemic heart failure
    • Andre L, Fauconnier J, Reboul C, et al: Subendocardial increase in reactive oxygen species production affects regional contractile function in ischemic heart failure. Antioxid Redox Signal 18: 1009-1020, 2013.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1009-1020
    • Andre, L.1    Fauconnier, J.2    Reboul, C.3
  • 19
    • 80052044499 scopus 로고    scopus 로고
    • Cardioprotective interventions for cancer patients receiving anthracyclines
    • van Dalen EC, Caron HN, Dickinson HO, et al: Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst Rev 15: CD003917, 2011.
    • (2011) Cochrane Database Syst Rev , vol.15
    • Van Dalen, E.C.1    Caron, H.N.2    Dickinson, H.O.3
  • 20
    • 84894765443 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiotoxicity: From bioenergetic failure and cell death to cardiomyopathy
    • Carvalho FS, Burgeiro A, Garcia R, et al: Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy. Med Res Rev 34: 106-135, 2014.
    • (2014) Med Res Rev , vol.34 , pp. 106-135
    • Carvalho, F.S.1    Burgeiro, A.2    Garcia, R.3
  • 21
    • 84880166032 scopus 로고    scopus 로고
    • Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice
    • Dolinsky VW, Rogan KJ, Sung MM, et al: Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. Am J Physiol Endocrinol Metab 305: E243-E253, 2013.
    • (2013) Am J Physiol Endocrinol Metab , vol.305
    • Dolinsky, V.W.1    Rogan, K.J.2    Sung, M.M.3
  • 22
    • 85047680307 scopus 로고
    • Cardiovascular responses to graded treadmill exercise during the development of doxorubicin induced heart failure in rabbits
    • Langton D, Jover B, McGrath BP, et al: Cardiovascular responses to graded treadmill exercise during the development of doxorubicin induced heart failure in rabbits. Cardiovasc Res 24: 959-968, 1990.
    • (1990) Cardiovasc Res , vol.24 , pp. 959-968
    • Langton, D.1    Jover, B.2    McGrath, B.P.3
  • 23
    • 33947726165 scopus 로고    scopus 로고
    • Major depressive disorder is accompanied with oxidative stress: Short-term antidepressant treatment does not alter oxidative - Antioxidative systems
    • DOI 10.1002/hup.829
    • Sarandol A, Sarandol E, Eker SS, et al: Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems. Hum Psychopharmacol 22: 67-73, 2007. (Pubitemid 46505714)
    • (2007) Human Psychopharmacology , vol.22 , Issue.2 , pp. 67-73
    • Sarandol, A.1    Sarandol, E.2    Eker, S.S.3    Erdinc, S.4    Vatansever, E.5    Kirli, S.6
  • 24
    • 0346023040 scopus 로고    scopus 로고
    • A novel automated method to measure total antioxidant response against potent free radical reactions
    • Erel O: A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 37: 112-119, 2004.
    • (2004) Clin Biochem , vol.37 , pp. 112-119
    • Erel, O.1
  • 25
    • 0033960220 scopus 로고    scopus 로고
    • On the role of hydroxyl radical and the effect of tetrandrine on nuclear factor-κB activation by phorbol 12-myristate 13-acetate
    • Ye J, Ding M, Zhang X, et al: On the role of hydroxyl radical and the effect of tetrandrine on nuclear factor-κB activation by phorbol 12-myristate 13-acetate. Ann Clin Lab Sci 30: 65-71, 2000. (Pubitemid 30078306)
    • (2000) Annals of Clinical and Laboratory Science , vol.30 , Issue.1 , pp. 65-71
    • Ye, J.1    Ding, M.2    Zhang, X.3    Rojanasakul, Y.4    Shi, X.5
  • 27
    • 79953700537 scopus 로고    scopus 로고
    • Role of reactive oxygen species in the regulation of cardiac contractility
    • Kubin AM, Skoumal R, Tavi P, et al: Role of reactive oxygen species in the regulation of cardiac contractility. J Mol Cell Cardiol 50: 884-893, 2011.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 884-893
    • Kubin, A.M.1    Skoumal, R.2    Tavi, P.3
  • 28
    • 84855711033 scopus 로고    scopus 로고
    • Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells
    • Finn NA and Kemp ML: Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells. Mol Biosyst 8: 650-662, 2012.
    • (2012) Mol Biosyst , vol.8 , pp. 650-662
    • Finn, N.A.1    Kemp, M.L.2
  • 29
    • 0036521856 scopus 로고    scopus 로고
    • Antioxidant and pro-oxidant effect of the thiolic compounds N-acetyl-L-cysteine and glutathione against free radical-induced lipid peroxidation
    • DOI 10.1080/10715760290019354
    • Sagristá ML, García AE, Africa De Madariaga M, et al: Antioxidant and pro-oxidant effect of the thiolic compounds N-acetyl-L-cysteine and glutathione against free radical-induced lipid peroxidation. Free Radic Res 36: 329-340, 2002. (Pubitemid 35154078)
    • (2002) Free Radical Research , vol.36 , Issue.3 , pp. 329-340
    • Sagrista, M.L.1    Garcacia, A.F.2    Africa, D.M.M.3    Mora, M.4
  • 31
    • 31144456169 scopus 로고    scopus 로고
    • Panax ginseng reduces adriamycin-induced heart failure in rats
    • You JS, Huang HF and Chang YL: Panax ginseng reduces adriamycin-induced heart failure in rats. Phytother Res 19: 1018-1022, 2005.
    • (2005) Phytother Res , vol.19 , pp. 1018-1022
    • You, J.S.1    Huang, H.F.2    Chang, Y.L.3
  • 32
    • 2342554921 scopus 로고    scopus 로고
    • Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression
    • Dong JW, Zhu HF, Zhu WZ, et al: Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression. Cell Res 13: 385-391, 2003.
    • (2003) Cell Res , vol.13 , pp. 385-391
    • Dong, J.W.1    Zhu, H.F.2    Zhu, W.Z.3
  • 33
    • 0034332916 scopus 로고    scopus 로고
    • Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure
    • Sabbah HN, Sharov VG, Gupata RC, et al: Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure. J Am Coll Cardiol 36: 1698-1705, 2000.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 1698-1705
    • Sabbah, H.N.1    Sharov, V.G.2    Gupata, R.C.3
  • 34
    • 0142027806 scopus 로고    scopus 로고
    • Targeting I kappa B kinase for the treatment of inflammatory and other disorders
    • Burke JR: Targeting I kappa B kinase for the treatment of inflammatory and other disorders. Curr Opin Drug Discov Devel 6: 720-728, 2003.
    • (2003) Curr Opin Drug Discov Devel , vol.6 , pp. 720-728
    • Burke, J.R.1
  • 35
    • 0043236476 scopus 로고    scopus 로고
    • Gene transfer of IkappaBalpha limit infarct ischemia-reperfusion injury
    • Squadrito F, Deodato B, Squadrito G, et al: Gene transfer of IkappaBalpha limit infarct ischemia-reperfusion injury. Lab Invest 83: 1097-1104, 2003.
    • (2003) Lab Invest , vol.83 , pp. 1097-1104
    • Squadrito, F.1    Deodato, B.2    Squadrito, G.3
  • 37
    • 1342345219 scopus 로고    scopus 로고
    • Nuclear factor κB: A potential therapeutic target in atherosclerosis and thrombosis
    • DOI 10.1016/j.cardiores.2003.11.038
    • Monaco C and Paleolog E: Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis. Cardiovasc Res 61: 671-682, 2004. (Pubitemid 38249466)
    • (2004) Cardiovascular Research , vol.61 , Issue.4 , pp. 671-682
    • Monaco, C.1    Paleolog, E.2
  • 38
    • 84863946664 scopus 로고    scopus 로고
    • Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure
    • Maier HJ, Schips TG, Wietelmann A, et al: Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure. Proc Natl Acad Sci USA 109: 11794-11799, 2012.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 11794-11799
    • Maier, H.J.1    Schips, T.G.2    Wietelmann, A.3
  • 39
    • 33748557190 scopus 로고    scopus 로고
    • Regulating the regulator: NF-κB signaling in heart
    • DOI 10.1016/j.yjmcc.2006.07.006, PII S002228280600719X
    • Hall G, Hasday JD and Rogers TB: Regulating the regulator: NF-kappaB signaling in heart. J Mol Cell Cardiol 41: 580-591, 2006. (Pubitemid 44374539)
    • (2006) Journal of Molecular and Cellular Cardiology , vol.41 , Issue.4 , pp. 580-591
    • Hall, G.1    Hasday, J.D.2    Rogers, T.B.3
  • 43
    • 79960191783 scopus 로고    scopus 로고
    • Chronic treatment with N-acetylcysteine improves cardiac function but does not prevent progression of cardiomyopathy in Syrian cardiomyopathic hamsters
    • Crespo MJ, Cruz N, Altieri PI, et al: Chronic treatment with N-acetylcysteine improves cardiac function but does not prevent progression of cardiomyopathy in Syrian cardiomyopathic hamsters. J Cardiovasc Pharmacol Ther 16: 197-204, 2011.
    • (2011) J Cardiovasc Pharmacol Ther , vol.16 , pp. 197-204
    • Crespo, M.J.1    Cruz, N.2    Altieri, P.I.3
  • 44
    • 80455173975 scopus 로고    scopus 로고
    • N-acetylcysteine offers cardioprotection by decreasing cardiac lipid hydroperoxides and 8-isoprostane level in isoproterenol-induced cardiotoxicity in rats
    • Haleagrahara N, Julian V and Chakravarthi S: N-acetylcysteine offers cardioprotection by decreasing cardiac lipid hydroperoxides and 8-isoprostane level in isoproterenol-induced cardiotoxicity in rats. Cardiovasc Toxicol 11: 373-381, 2011.
    • (2011) Cardiovasc Toxicol , vol.11 , pp. 373-381
    • Haleagrahara, N.1    Julian, V.2    Chakravarthi, S.3
  • 45
    • 84870253172 scopus 로고    scopus 로고
    • An in vivo and in vitro study on the protective effects of N-acetylcysteine on mitochondrial dysfunction in isoproterenol treated myocardial infarcted rats
    • Basha RH and Priscilla DH: An in vivo and in vitro study on the protective effects of N-acetylcysteine on mitochondrial dysfunction in isoproterenol treated myocardial infarcted rats. Exp Toxicol Pathol 65: 7-14, 2013.
    • (2013) Exp Toxicol Pathol , vol.65 , pp. 7-14
    • Basha, R.H.1    Priscilla, D.H.2
  • 46
    • 33644689606 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and glutathione interplay in chronic heart failure
    • Adamy C, Le Corvoisier P, Candiani G, et al: Tumor necrosis factor alpha and glutathione interplay in chronic heart failure. Arch Mal Coeur Vaiss 98: 906-912, 2005.
    • (2005) Arch Mal Coeur Vaiss , vol.98 , pp. 906-912
    • Adamy, C.1    Le Corvoisier, P.2    Candiani, G.3
  • 47
    • 84882605035 scopus 로고    scopus 로고
    • N-acetylcysteine reverses cardiac myocyte dysfunction in a rodent model of behavioral stress
    • 1985
    • Chen F, Hadfield JM, Berzingi C, et al: N-acetylcysteine reverses cardiac myocyte dysfunction in a rodent model of behavioral stress. J Appl Physiol (1985) 115: 514-524, 2013.
    • (2013) J Appl Physiol , vol.115 , pp. 514-524
    • Chen, F.1    Hadfield, J.M.2    Berzingi, C.3
  • 48
    • 80052290747 scopus 로고    scopus 로고
    • N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats
    • Wang T, Qiao S, Lei S, et al: N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats. PLoS One 6: e23967, 2011.
    • (2011) PLoS One , vol.6
    • Wang, T.1    Qiao, S.2    Lei, S.3
  • 50
    • 84876722465 scopus 로고    scopus 로고
    • Evaluation of short-term use of N-acetylcysteine as a strategy for prevention of anthracycline-induced cardiomyopathy: EPOCH trial-a prospective randomized study
    • Jo SH, Kim LS, Kim SA, et al: Evaluation of short-term use of N-acetylcysteine as a strategy for prevention of anthracycline-induced cardiomyopathy: EPOCH trial-a prospective randomized study. Korean Circ J 43: 174-181, 2013.
    • (2013) Korean Circ J , vol.43 , pp. 174-181
    • Jo, S.H.1    Kim, L.S.2    Kim, S.A.3


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