N-acetylcysteine reverses cardiac myocyte dysfunction in a rodent model of behavioral stress

Journal of Applied Physiology

Volumn 115, Issue 4, 2013, Pages 514-524

  Chen, Fangping ^a   Hadfield, Jessalyn M ^a   Berzingi, Chalak ^a   Hollander, John M ^a   Miller, Diane B ^b   Nichols, Cody E ^a   Finkel, Mitchell S ^a,b,c  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^c Louis A Johnson Veterans Affairs Medical Center   (United States)

Author keywords

Heart function; N acetylcysteine; Prenatal stress

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ADRENALIN; CALCIUM; CATALASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; ISOPRENALINE; NORADRENALIN;

ANIMAL; ARTICLE; BLOOD; CALCIUM SIGNALING; CARDIOMYOPATHY; DISEASE MODEL; DRUG EFFECT; FEMALE; HEART FUNCTION; HEART MUSCLE; HEART MUSCLE CELL; MALE; METABOLISM; N-ACETYLCYSTEINE; OXIDATIVE STRESS; PRENATAL STRESS; RAT; SPRAGUE DAWLEY RAT;

HEART FUNCTION; N-ACETYLCYSTEINE; PRENATAL STRESS;

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CALCIUM SIGNALING; CARDIOMYOPATHIES; CATALASE; DISEASE MODELS, ANIMAL; EPINEPHRINE; FEMALE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; ISOPROTERENOL; MALE; MYOCARDIUM; MYOCYTES, CARDIAC; NOREPINEPHRINE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84882605035     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01471.2012     Document Type: Article

References (48)

1. Akashi YJ, Goldstein DS, Barbaro G, Ueyama T. Takotsubo cardiomyopathy: A new form of acute, reversible heart failure. Circulation 118: 2754-2762, 2008.
2. Akki A, Zhang M, Murdoch C, Brewer A, Shah AM. NADPH oxidase signaling and cardiac myocyte function. J Mol Cell Cardiol 47: 15-22, 2009.
3. Atkuri KR, Mantovani JJ, Herzenberg LA. N-acetylcysteine-a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol 7: 355-359, 2007.
4. Borges-Santos MD, Moreto F, Pereira PC, Ming-Yu Y, Burini RC. Plasma glutathione of HIV( ) patients responded positively and differently to dietary supplementation with cysteine or glutamine. Nutrition 28: 753-756, 2012.
5. Bybee KA, Prasad A. Stress-related cardiomyopathy syndromes. Circulation 118: 397-409, 2008.
6. Chen F, Kan H, Hobbs G, Finkel MS. p38 MAP kinase inhibitor reverses stress-induced myocardial dysfunction in vivo. J Appl Physiol 106: 1132-1141, 2009.
7. Chen F, Lewis W, Hollander JM, Baseler WA, Finkel MS. N-acetylcysteine reverses cardiac myocyte dysfunction in HIV-Tat proteinopathy. J Appl Physiol 113: 105-113, 2012.
8. Choy KH, Dean O, Berk M, Bush AI, Buuse MV. Effects of N-acetylcysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats. Eur J Pharmacol 649: 224-228, 2010.
9. Cratty MS, Ward HS, Johnson EA, Azzaro AJ, Birkle DL. Prenatal stress increases corticotropin-releasing factor (CRF) content and release in rat amygdala minces. Brain Res 675: 297-302, 1995.
10. Dash R, Schmidt AG, Pathak A, Gerst MJ, Biniakiewicz D, Kadambi VJ, Hoit BD, Abraham WT, Kranias EG. Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy. Cardiovasc Res 57: 704-714, 2003.
11. De Rosa SC, Zaretsky MD, Dubs JG, Roederer M, Anderson M, Green A, Mitra D, Watanabe N, Nakamura H, Tjioe I, Deresinski SC, Moore WA, Ela SW, Parks D, Herzenberg LA. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 30: 915-929, 2000.
12. Finkel MS, Shen L, Oddis CV, Romeo RC, Salama G. Positive inotropic effect of acetylcysteine in cardiomyopathic Syrian hamsters. J Cardiovasc Pharmacol 21: 29-34, 1993.
13. Fride E, Weinstock M. Prenatal stress increases anxiety related behavior and alters cerebral lateralization of dopamine activity. Life Sci 42: 1059-1065, 1988.
14. Gaburjakova J, Gaburjakova M. Comparison of the effects exerted by luminal Ca2 on the sensitivity of the cardiac ryanodine receptor to caffeine and cytosolic Ca2 . J Membr Biol 212: 17-28, 2006.
15. Goldhaber JI, Qayyum MS. Oxygen free radicals and excitation-contraction coupling. Antioxid Redox Signal 2: 55-64, 2000.
16. Han YH, Yang YM, Kim SZ, Park WH. Attenuation of MG132-induced HeLa cell death by N-acetyl cysteine via reducing reactive oxygen species and preventing glutathione depletion. Anticancer Res 30: 2107-2112, 2010.
17. Harada D, Anraku M, Fukuda H, Naito S, Harada H, Suenaga A, Otagiri M. Kinetic studies of covalent binding between N-acetyl-Lcysteine and human serum albumin through a mixed-disulfide using an N-methylpyridinium polymer-based column. Drug Metab Pharmacokinet 19: 297-302, 2004.
18. Hasenfuss G, Pieske B. Calcium cycling in congestive heart failure. J Mol Cell Cardiol 34: 951-969, 2002.
19. Hobai IA, O?Rourke B. Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation 103: 1577-1584, 2001.
20. Holdiness MR. Clinical pharmacokinetics of N-acetylcysteine. Clin Pharmacokinet 20: 123-134, 1991.
21. Hollander J, Gore M, Fiebig R, Mazzeo R, Ohishi S, Ohno H, Ji LL. Spaceflight downregulates antioxidant defense systems in rat liver. Free Radic Biol Med 24: 385-390, 1998.
22. Jones DP. Radical-free biology of oxidative stress. Am J Physiol Cell Physiol 295: C849-C868, 2008.
23. Kan H, Birkle D, Jain AC, Failinger C,Xie S, Finkel MS. p38 MAP kinase inhibitor reverses stress-induced cardiac myocyte dysfunction. J Appl Physiol 98: 77-82, 2005.
24. Kan H, Failinger CF, Fang Q, Finkel MS. Reversible myocardial dysfunction in sepsis and ischemia. Crit Care Med 33: 2845-2847, 2005.
25. Kan H, Finkel MS. Inflammatory mediators and reversible myocardial dysfunction. J Cell Physiol 195: 1-11, 2003.
26. Kelly GS. Clinical applications of N-acetylcysteine. Altern Med Rev 3: 114-127, 1998.
27. Kerksick C, Willoughby D. The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stress. J Int Soc Sports Nutr 2: 38-44, 2005.
28. Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, Sadoshima J. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A 107: 15565-15570, 2010.
29. Kushnir A, Marks AR. The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol 59: 1-30, 2010.
30. Leeuwenburgh C, Hollander J, Leichtweis S, Griffiths M, Gore M, Ji LL. Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific. Am J Physiol Regul Integr Comp Physiol 272: R363-R369, 1997.
31. Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts. Cell 101: 365-376, 2000.
32. Masood A, Nadeem A, Mustafa SJ, O?Donnell JM. Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice. J Pharmacol Exp Ther 326: 369-379, 2008.
33. Mastorci F, Vicentini M, Viltart O, Manghi M, Graiani G, Quaini F, Meerlo P, Nalivaiko E, Maccari S, Sgoifo A. Long-term effects of prenatal stress: changes in adult cardiovascular regulation and sensitivity to stress. Neurosci Biobehav Rev 33: 191-203, 2009.
34. Prabhu SD, Salama G. Reactive disulfide compounds induce Ca2 release from cardiac sarcoplasmic reticulum. Arch Biochem Biophys 282: 275-283, 1990.
35. Prosser BL, Ward CW, Lederer WJ. Subcellular Ca2 signaling in the heart: The role of ryanodine receptor sensitivity. J Gen Physiol 136: 135-142, 2010.
36. Richard C. Stress-related cardiomyopathies. Ann Intensive Care 1: 39, 2011.
37. Saitoh S, Kiyooka T, Rocic P, Rogers PA, Zhang C, Swafford A, Dick DM, Viswanathan C, Park Y, Chilian WM. Redox-dependent coronary metabolic dilation. Am J Physiol Heart Circ Physiol 293: H3720-H3725, 2007.
38. Sakamoto A, Ono K, Abe M, Jasmin G, Eki T, Murakami Y, Masaki T, Toyo-oka T, Hanaoka F. Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, delta-sarcoglycan, in hamster: An animal model of disrupted dystrophin-associated glycoprotein complex. Proc Natl Acad Sci U S A 94: 13873-13878, 1997.
39. Salama G, Abramson JJ, Pike GK. Sulphydryl reagents trigger Ca2 release from the sarcoplasmic reticulum of skinned rabbit psoas fibres. J Physiol 454: 389-420, 1992.
40. Sawyer DB, Siwik DA, Xiao L, Pimentel DR, Singh K, Colucci WS. Role of oxidative stress in myocardial hypertrophy and failure. J Mol Cell Cardiol 34: 379-388, 2002.
41. Takahashi LK, Baker Ew Kalin NH. Ontogeny of behavioral and hormonal responses to stress in prenatally stressed male rat pups. Physiol Behav 47: 357-364, 1990.
42. Terentyev D, Györke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y, Blanco EC, Khanna S, Sen CK, Cardounel AJ, Carnes CA, Györke S. Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2 leak in chronic heart failure. Circ Res 103: 1466-1472, 2008.
43. Ward HE, Johnson EA, Salm AK, Birkle DL. Effects of prenatal stress on defensive withdrawal behavior and corticotropin releasing factor systems in rat brain. Physiol Behav 70: 359-366, 2000.
44. Williams IA, Allen DG. The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice. Am J Physiol Heart Circ Physiol 293: H1969-H1977, 2007.
45. Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352: 539-548, 2005.
46. Zafarullah M, Li WQ, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60: 6-20, 2003.
47. Zalk R, Lehnart SE, Marks AR. Modulation of the ryanodine receptor and intracellular calcium. Annu Rev Biochem 76: 367-385, 2007.
48. Zima AV, Blatter LA. Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 71: 310-321, 2006.