메뉴 건너뛰기




Volumn 14, Issue 7, 2014, Pages 1481-1487

The role of hypoxia-inducible factors in organ donation and transplantation: The current perspective and future opportunities

Author keywords

HIF; hypoxia; ischemia; ischemia reperfusion injury; transplant

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1;

EID: 84903184456     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12737     Document Type: Review
Times cited : (43)

References (45)
  • 1
    • 0027461553 scopus 로고
    • Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism
    • Maxwell PH, Pugh CW, Ratcliffe PJ., Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism. Proc Natl Acad Sci U S A 1993; 90: 2423-2427.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 2423-2427
    • Maxwell, P.H.1    Pugh, C.W.2    Ratcliffe, P.J.3
  • 2
    • 0025885693 scopus 로고
    • Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene
    • Pugh CW, Tan CC, Jones RW, Ratcliffe PJ., Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene. Proc Natl Acad Sci U S A 1991; 88: 10553-10557.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10553-10557
    • Pugh, C.W.1    Tan, C.C.2    Jones, R.W.3    Ratcliffe, P.J.4
  • 3
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    • Wang GL, Semenza GL., General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A 1993; 90: 4304-4308.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 4304-4308
    • Wang, G.L.1    Semenza, G.L.2
  • 4
    • 17944375360 scopus 로고    scopus 로고
    • C. Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001; 107: 43-54.
    • (2001) Cell , vol.107 , pp. 43-54
    • Epstein, A.C.1    Gleadle, J.M.2    McNeill, L.A.3
  • 5
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML., Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 2002; 295: 858-861.
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 6
    • 84863982836 scopus 로고    scopus 로고
    • Molecular oxygen sensing: Implications for visceral surgery
    • Kiss J, Kirchberg J, Schneider M., Molecular oxygen sensing: Implications for visceral surgery. Langenbecks Arch Surg 2012; 397: 603-610.
    • (2012) Langenbecks Arch Surg , vol.397 , pp. 603-610
    • Kiss, J.1    Kirchberg, J.2    Schneider, M.3
  • 7
    • 0034904751 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: Nucleus or cytoplasm
    • Berra E, Roux D, Richard DE, Pouysségur J., Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: Nucleus or cytoplasm. EMBO Rep 2001; 2: 615-620.
    • (2001) EMBO Rep , vol.2 , pp. 615-620
    • Berra, E.1    Roux, D.2    Richard, D.E.3    Pouysségur, J.4
  • 8
    • 30944437448 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible transcription factors in developing human and rat kidneys
    • Bernhardt WM, Schmitt R, Rosenberger C, et al. Expression of hypoxia-inducible transcription factors in developing human and rat kidneys. Kidney Int 2006; 69: 114-122.
    • (2006) Kidney Int , vol.69 , pp. 114-122
    • Bernhardt, W.M.1    Schmitt, R.2    Rosenberger, C.3
  • 9
    • 77956805884 scopus 로고    scopus 로고
    • Feedback regulators of hypoxia-inducible factors and their role in cancer biology
    • Henze AT, Acker T., Feedback regulators of hypoxia-inducible factors and their role in cancer biology. Cell Cycle 2010; 9: 2749-2763.
    • (2010) Cell Cycle , vol.9 , pp. 2749-2763
    • Henze, A.T.1    Acker, T.2
  • 10
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3' enhancer
    • Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ., Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3' enhancer. Proc Natl Acad Sci U S A 1994; 91: 6496-6500.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6496-6500
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 11
    • 84882263722 scopus 로고    scopus 로고
    • Novel approaches to preventing ischemia-reperfusion injury during liver transplantation
    • Akhtar MZ, Henderson T, Sutherland A, Vogel T, Friend PJ., Novel approaches to preventing ischemia-reperfusion injury during liver transplantation. Transplant Proc 2013; 45: 2083-2092.
    • (2013) Transplant Proc , vol.45 , pp. 2083-2092
    • Akhtar, M.Z.1    Henderson, T.2    Sutherland, A.3    Vogel, T.4    Friend, P.J.5
  • 12
    • 4944246547 scopus 로고    scopus 로고
    • The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
    • Greijer AE, van der Wall E., The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 2004; 57: 1009-1014.
    • (2004) J Clin Pathol , vol.57 , pp. 1009-1014
    • Greijer, A.E.1    Van Der Wall, E.2
  • 13
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ., Regulation of angiogenesis by hypoxia: Role of the HIF system. Nat Med 2003; 9: 677-684.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 14
  • 15
    • 70350373671 scopus 로고    scopus 로고
    • The role of NF-kappaB in hypoxia-induced gene expression
    • Taylor CT, Cummins EP., The role of NF-kappaB in hypoxia-induced gene expression. Ann N Y Acad Sci 2009; 1177: 178-184.
    • (2009) Ann N y Acad Sci , vol.1177 , pp. 178-184
    • Taylor, C.T.1    Cummins, E.P.2
  • 16
    • 84876713228 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species in the renal ischemia/reperfusion injury
    • Rodriguez F, Bonacasa B, Fenoy FJ, Salom MG., Reactive oxygen and nitrogen species in the renal ischemia/reperfusion injury. Curr Pharm Des 2013; 19: 2776-2794.
    • (2013) Curr Pharm des , vol.19 , pp. 2776-2794
    • Rodriguez, F.1    Bonacasa, B.2    Fenoy, F.J.3    Salom, M.G.4
  • 17
    • 4644318828 scopus 로고    scopus 로고
    • Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    • Appelhoff RJ, Tian YM, Raval RR, et al. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 2004; 279: 38458-38465.
    • (2004) J Biol Chem , vol.279 , pp. 38458-38465
    • Appelhoff, R.J.1    Tian, Y.M.2    Raval, R.R.3
  • 18
    • 58249089430 scopus 로고    scopus 로고
    • Machine perfusion or cold storage in deceased-donor kidney transplantation
    • Moers C, Smits JM, Maathuis MH, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009; 360: 7-19.
    • (2009) N Engl J Med , vol.360 , pp. 7-19
    • Moers, C.1    Smits, J.M.2    Maathuis, M.H.3
  • 19
    • 84858204846 scopus 로고    scopus 로고
    • Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival
    • Conde E, Alegre L, Blanco-Sánchez I, et al. Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival. PLoS ONE 2012; 7: e33258.
    • (2012) PLoS ONE , vol.7
    • Conde, E.1    Alegre, L.2    Blanco-Sánchez, I.3
  • 20
    • 84879792763 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase
    • Zhang XL, Yan ZW, Sheng WW, Xiao J, Zhang ZX, Ye ZB., Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase. Mol Cell Biochem 2011; 358: 287-295.
    • (2011) Mol Cell Biochem , vol.358 , pp. 287-295
    • Zhang, X.L.1    Yan, Z.W.2    Sheng, W.W.3    Xiao, J.4    Zhang, Z.X.5    Ye, Z.B.6
  • 21
    • 38149075003 scopus 로고    scopus 로고
    • Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury
    • Hill P, Shukla D, Tran MG, et al. Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. J Am Soc Nephrol 2008; 19: 39-46.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 39-46
    • Hill, P.1    Shukla, D.2    Tran, M.G.3
  • 22
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
    • Hu CJ, Wang LY, Chodosh LA, Brian K, Simon MC., Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol Cell Biol 2003; 23: 9361-9374.
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Brian, K.4    Simon, M.C.5
  • 23
    • 84875190487 scopus 로고    scopus 로고
    • Renoprotective role of fenoldopam pretreatment through hypoxia-inducible factor-1alpha and heme oxygenase-1 expressions in rat kidney transplantation
    • Yi X, Zhang G, Yuan J., Renoprotective role of fenoldopam pretreatment through hypoxia-inducible factor-1alpha and heme oxygenase-1 expressions in rat kidney transplantation. Transplant Proc 2013; 45: 517-522.
    • (2013) Transplant Proc , vol.45 , pp. 517-522
    • Yi, X.1    Zhang, G.2    Yuan, J.3
  • 24
    • 73349131437 scopus 로고    scopus 로고
    • Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling
    • Yang CC, Lin LC, Wu MS, Chien CT, Lai MK., Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling. Transplantation 2009; 88: 1251-1260.
    • (2009) Transplantation , vol.88 , pp. 1251-1260
    • Yang, C.C.1    Lin, L.C.2    Wu, M.S.3    Chien, C.T.4    Lai, M.K.5
  • 25
    • 75849163295 scopus 로고    scopus 로고
    • Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
    • Bernhardt WM, Gottmann U, Doyon F, et al. Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A 2009; 106: 21276-21281.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21276-21281
    • Bernhardt, W.M.1    Gottmann, U.2    Doyon, F.3
  • 26
    • 0037468501 scopus 로고    scopus 로고
    • Living kidney donors and hypoxia-inducible factor-1alpha
    • Baan C, van Gelder T, Peeters A, et al. Living kidney donors and hypoxia-inducible factor-1alpha. Transplantation 2003; 75: 570-571.
    • (2003) Transplantation , vol.75 , pp. 570-571
    • Baan, C.1    Van Gelder, T.2    Peeters, A.3
  • 27
    • 33748913696 scopus 로고    scopus 로고
    • Renal parenchymal oxygenation and hypoxia adaptation in acute kidney injury
    • Rosenberger C, Rosen S, Heyman SN., Renal parenchymal oxygenation and hypoxia adaptation in acute kidney injury. Clin Exp Pharmacol Physiol 2006; 33: 980-988.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 980-988
    • Rosenberger, C.1    Rosen, S.2    Heyman, S.N.3
  • 28
    • 84858989214 scopus 로고    scopus 로고
    • The role of normothermic extracorporeal perfusion in minimizing ischemia reperfusion injury
    • Vogel T, Brockmann JG, Coussios C, Friend PJ., The role of normothermic extracorporeal perfusion in minimizing ischemia reperfusion injury. Transplant Rev (Orlando) 2012; 26: 156-162.
    • (2012) Transplant Rev (Orlando) , vol.26 , pp. 156-162
    • Vogel, T.1    Brockmann, J.G.2    Coussios, C.3    Friend, P.J.4
  • 29
    • 84870612137 scopus 로고    scopus 로고
    • Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat
    • Ben Mosbah I, Mouchel Y, Pajaud J, et al. Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat. PLoS ONE 2012; 7: e50235.
    • (2012) PLoS ONE , vol.7
    • Ben Mosbah, I.1    Mouchel, Y.2    Pajaud, J.3
  • 30
    • 77449090208 scopus 로고    scopus 로고
    • Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury
    • Schneider M, Van Geyte K, Fraisl P, et al. Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury. Gastroenterology 2010; 138: 1143-1154.e1-2.
    • (2010) Gastroenterology , vol.138
    • Schneider, M.1    Van Geyte, K.2    Fraisl, P.3
  • 31
    • 57349173945 scopus 로고    scopus 로고
    • Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion
    • Zhong Z, Ramshesh VK, Rehman H, et al. Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol 2008; 295: G823-G832.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295
    • Zhong, Z.1    Ramshesh, V.K.2    Rehman, H.3
  • 32
    • 34547838835 scopus 로고    scopus 로고
    • Ischemic pre-conditioning in deceased donor liver transplantation: A prospective randomized clinical trial
    • Amador A, Grande L, Martí J, et al. Ischemic pre-conditioning in deceased donor liver transplantation: A prospective randomized clinical trial. Am J Transplant 2007; 7: 2180-2189.
    • (2007) Am J Transplant , vol.7 , pp. 2180-2189
    • Amador, A.1    Grande, L.2    Martí, J.3
  • 33
    • 34548252551 scopus 로고    scopus 로고
    • Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver
    • Plock J, Frese S, Keogh A, et al. Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver. J Hepatol 2007; 47: 538-545.
    • (2007) J Hepatol , vol.47 , pp. 538-545
    • Plock, J.1    Frese, S.2    Keogh, A.3
  • 34
    • 84870055358 scopus 로고    scopus 로고
    • Remote ischemic preconditioning regulates HIF-1α levels, apoptosis and inflammation in heart tissue of cardiosurgical patients: A pilot experimental study
    • Albrecht M, Zitta K, Bein B, et al. Remote ischemic preconditioning regulates HIF-1α levels, apoptosis and inflammation in heart tissue of cardiosurgical patients: A pilot experimental study. Basic Res Cardiol 2013; 108: 314.
    • (2013) Basic Res Cardiol , vol.108 , pp. 314
    • Albrecht, M.1    Zitta, K.2    Bein, B.3
  • 35
    • 84865610131 scopus 로고    scopus 로고
    • Hypoxia-inducible factor as a therapeutic target for cardioprotection
    • Ong SG, Hausenloy DJ., Hypoxia-inducible factor as a therapeutic target for cardioprotection. Pharmacol Ther 2012; 136: 69-81.
    • (2012) Pharmacol Ther , vol.136 , pp. 69-81
    • Ong, S.G.1    Hausenloy, D.J.2
  • 36
    • 0038163900 scopus 로고    scopus 로고
    • Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
    • Cai Z, Manalo DJ, Wei G, et al. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation 2003; 108: 79-85.
    • (2003) Circulation , vol.108 , pp. 79-85
    • Cai, Z.1    Manalo, D.J.2    Wei, G.3
  • 37
    • 0035975982 scopus 로고    scopus 로고
    • Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction
    • Nwogu JI, Geenen D, Bean M, Brenner MC, Huang X, Buttrick PM., Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction. Circulation 2001; 104: 2216-2221.
    • (2001) Circulation , vol.104 , pp. 2216-2221
    • Nwogu, J.I.1    Geenen, D.2    Bean, M.3    Brenner, M.C.4    Huang, X.5    Buttrick, P.M.6
  • 38
    • 84874399670 scopus 로고    scopus 로고
    • Differential effects of pharmacological HIF preconditioning of donors versus recipients in rat cardiac allografts
    • Keränen MA, Tuuminen R, Syrjälä S, et al. Differential effects of pharmacological HIF preconditioning of donors versus recipients in rat cardiac allografts. Am J Transplant 2013; 13: 600-610.
    • (2013) Am J Transplant , vol.13 , pp. 600-610
    • Keränen, M.A.1    Tuuminen, R.2    Syrjälä, S.3
  • 39
    • 0036014523 scopus 로고    scopus 로고
    • Endothelial response to hypoxia: Physiologic adaptation and pathologic dysfunction
    • Ten VS, Pinsky DJ., Endothelial response to hypoxia: Physiologic adaptation and pathologic dysfunction. Curr Opin Crit Care 2002; 8: 242-250.
    • (2002) Curr Opin Crit Care , vol.8 , pp. 242-250
    • Ten, V.S.1    Pinsky, D.J.2
  • 40
    • 84862665618 scopus 로고    scopus 로고
    • Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat
    • Paulus P, Ockelmann P, Tacke S, et al. Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat. PLoS ONE 2012; 7: e39265.
    • (2012) PLoS ONE , vol.7
    • Paulus, P.1    Ockelmann, P.2    Tacke, S.3
  • 41
    • 34247571886 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning
    • Chin BY, Jiang G, Wegiel B, et al. Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning. Proc Natl Acad Sci U S A 2007; 104: 5109-5114.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5109-5114
    • Chin, B.Y.1    Jiang, G.2    Wegiel, B.3
  • 43
    • 84867381718 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    • Clambey ET, McNamee EN, Westrich JA, et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A 2012; 109: E2784-E2793.
    • (2012) Proc Natl Acad Sci U S A , vol.109
    • Clambey, E.T.1    McNamee, E.N.2    Westrich, J.A.3
  • 44
    • 79955562849 scopus 로고    scopus 로고
    • Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury
    • Kannan KB, Colorado I, Reino D, et al. Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2011; 300: G853-G861.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300
    • Kannan, K.B.1    Colorado, I.2    Reino, D.3
  • 45
    • 48749125421 scopus 로고    scopus 로고
    • Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury
    • Hart ML, Henn M, Köhler D, et al. Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury. FASEB J 2008; 22: 2784-2797.
    • (2008) FASEB J , vol.22 , pp. 2784-2797
    • Hart, M.L.1    Henn, M.2    Köhler, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.