Nanoparticles in Biocatalysis

New and Future Developments in Catalysis: Catalysis by Nanoparticles

Volumn , Issue , 2013, Pages 95-123

  El Boubbou, Kheireddine ^a   Landry, Christopher C ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCATALYSIS;

EID: 84903054375     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-444-53874-1.00004-4     Document Type: Chapter

References (137)

1. Amitai G., Murata H., Andersen J.D., Koepsel R.R., Russell A.J. Decontamination of chemical and biological warfare agents with a single multifunctional material. Biomaterials 2010, 31:4417-4425.
2. Andrews R., Jacques D., Qian D., Rantell T. Multiwall carbon nanotubes: synthesis and application. Acc. Chem. Res. 2002, 35:1008-1017.
3. Aniagyei S.E., DuFort C., Kao C.C., Dragnea B. Self-assembly approaches to nanomaterial encapsulation in viral protein cages. J. Mater. Chem. 2008, 18:3763-3774.
4. Ansari S.A., Husain Q. Potential applications of enzymes immobilized on/in nano materials: a review. Biotechnol. Adv. 2012, 30:512-523.
5. Asuri P., Karajanagi S.S., Sellitto E., Kim D.Y., Kane R.S., Dordick J.S. Water-soluble carbon nanotube-enzyme conjugates as functional biocatalytic formulations. Biotechnol. Bioeng. 2006, 95:804-811.
6. Besteman K., Lee J.O., Wiertz F.G.M., Heering H.A., Dekker C. Enzyme-coated carbon nanotubes as single-molecule biosensors. Nano Lett. 2003, 3:727-730.
7. Betancor L., Luckarift H.R. Bioinspired enzyme encapsulation for biocatalysis. Trends Biotechnol. 2008, 26:566-572.
8. Bi S., Zhou H., Zhang S. Multilayers enzyme-coated carbon nanotubes as biolabel for ultrasensitive chemiluminescence immunoassay of cancer biomarker. Biosens. Bioelectron. 2009, 24:2961-2966.
9. Bode S.A., Minten I.J., Nolte R.J.M., Cornelissen J.J.L.M. Reactions inside nanoscale protein cages. Nanoscale 2011, 3:2376-2389.
10. Cao L. Immobilised enzymes: science or art?. Curr. Opin. Chem. Biol. 2005, 9:217-226.
11. Cao L., Langen L., Sheldon R.A. Immobilised enzymes: carrier-bound or carrier-free?. Curr. Opin. Biotechnol. 2003, 14:387-394.
12. Chen R.J., Zhang Y., Wang D., Dai H. Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J. Am. Chem. Soc. 2001, 123:3838-3839.
13. Chen B.W., Lei C.H., Shin Y.S., Liu J. Probing mechanisms for enzymatic activity enhancement of organophosphorus hydrolase in functionalized mesoporous silica. Biochem. Biophys. Res. Commun. 2009, 390:1177-1181.
14. Comellas-Aragones M., Engelkamp H., Claessen V.I., Sommerdijk N.A.J.M., Rowan A.E., Christianen P.C.M., Maan J.C., Verduin B.J.M., Cornelissen J.J.L.M., Nolte R.J.M. A virus-based single-enzyme nanoreactor. Nat. Nanotechnol. 2007, 2:635-639.
15. Corchero J.L., Cedano J. Self-assembling, protein-based intracellular bacterial organelles: emerging vehicles for encapsulating, targeting and delivering therapeutical cargoes. Microbiol. Cell Factories 2011, 10:92.
16. De Rose R., Zelikin A.N., Johnston A.P.R., Sexton A., Chong S.F., Cortez C., Mulholland W., Caruso F., Kent S.J. Binding, internalization, and antigen presentation of vaccine-loaded nanoengineered capsules in blood. Adv. Mater. 2008, 20:4698-4703.
17. Dinu C.Z., Zhu G., Bale S.S., Anand G., Reeder P.J., Sanford K., Whited G., Kane R.S., Dordick J.S. Enzyme-based nanoscale composites for use as active decontamination surfaces. Adv. Funct. Mater. 2010, 20:392-398.
18. Douglas T., Young M. Viruses: making friends with old foes. Science 2006, 312:873-875.
19. Douglas T. A bright bio-inspired future. Science 2003, 299:1192-1193.
20. Douglas T., Strable E., Willits D., Aitouchen A., Libera M., Young M. Protein engineering of a viral cage for constrained nanomaterials synthesis. Adv. Mater. 2002, 14:415-418.
21. Douglas T., Young M. Host-guest encapsulation of materials by assembled virus protein cages. Nature 1998, 393:152-155.
22. Dumas D.P., Caldwell S.R., Wild J.R., Raushel F.M. Purification and properties of the phosphotriesterase from Pseudomonas-diminuta. J. Biol. Chem. 1989, 264:19659-19665.
23. El-Boubbou K., Schofield D.A., Landry C.C. Enhanced enzymatic activity of OPH in ammonium-functionalized mesoporous silica: surface modifications and pore effects. J. Phys. Chem. C 2012, 116:17501-17506.
24. 31P NMR. Adv. Healthc. Mater. 2012, 1:183-188.
25. El-Boubbou K., Huang X. Glyco-nanomaterials: translating insights from the sugar-code to biomedical applications. Curr. Med. Chem. 2011, 18:2060-2078.
26. El-Boubbou K., Zhu David C., Vasileiou C., Borhan B., Prosperi D., Li W., Huang X. Magnetic glyco-nanoparticles: a tool to detect, differentiate, and unlock the glyco-codes of cancer via magnetic resonance imaging. J. Am. Chem. Soc. 2010, 132:4490-4499.
27. El-Boubbou K., Gruden C., Huang X. Magnetic glyco-nanoparticles: a unique tool for rapid pathogen detection, decontamination, and strain differentiation. J. Am. Chem. Soc. 2007, 129:13392-13393.
28. Eubanks L.M., Dickerson T.J., Janda K.D. Technological advancements for the detection of and protection against biological and chemical warfare agents. Chem. Soc. Rev. 2007, 36:458-470.
29. Fiedler J.D., Brown S.D., Lau J.L., Finn M.G. RNA-directed packaging of enzymes within virus-like particles. Angew. Chem. Int. Ed. 2010, 49:9648-9651.
30. Fitch J.P., Raber E., Imbro D.R. Technology challenges in responding to biological or chemical attacks in the civilian sector. Science 2003, 302:1350-1354.
31. Gao B.J., Li L., Ho P.L., Mak G.C., Gu H., Xu B. Combining fluorescent probes and biofunctional magnetic nanoparticles for rapid detection of bacteria in human blood. Adv. Mater. 2006, 18:3145-3148.
32. Garcia J., Zhang Y., Taylor H., Cespedes O., Webb M.E., Zhou D. Multilayer enzyme-coupled magnetic nanoparticles as efficient, reusable biocatalysts and biosensors. Nanoscale 2011, 3:3721-3730.
33. Gill I., Ballesteros A. Bioencapsulation within synthetic polymers (Part 1): sol-gel encapsulated biologicals. Trends Biotechnol. 2000, 18:282-296.
34. Gomes D.E.B., Lins R.D., Pascutti P.G., Lei C.H., Soares T.A. The role of nonbonded interactions in the conformational dynamics of organophosphorus hydrolase adsorbed onto functionalized mesoporous silica surfaces. J. Phys. Chem. B 2010, 114:531-540.
35. Grimm J., Perez J.M., Josephson L., Weissleder R. Novel nanosensors for rapid analysis of telomerase activity. Cancer Res. 2004, 64:639-643.
36. T.A. Hatton, L.E. Bromberg, Catalytic nanoparticles for nerve-agent destruction, US Patent, 2009, 7598199.
37. Hennebel T., Simoen H., De Windt W., Verloo M., Boon N., Verstraete W. Biocatalytic dechlorination of trichloroethylene with bio-palladium in a pilot-scale membrane reactor. Biotechnol. Bioeng. 2009, 102:995-1002.
38. Hirsch A. Functionalization of single-walled carbon nanotubes. Angew. Chem. Int. Ed. 2002, 41:1853-1859.
39. 2 magnetic nanoparticles. Biotechnol. Lett. 2011, 32:817-821.
40. Ivnitski D., Artyushkova K., Rincon R.A., Atanassov P., Luckarift H.R., Johnson G.R. Entrapment of enzymes and carbon nanotubes in biologically synthesized silica: glucose oxidase-catalyzed direct electron transfer. Small 2008, 4:357-364.
41. Jain T.K., Richey J., Strand M., Leslie-Pelecky D.L., Flask C.A., Labhasetwar V. Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging. Biomaterials 2008, 29:4012-4021.
42. Jang J., Nah H., Lee J.H., Moon S.H., Kim M.G., Cheon J. Critical enhancements of MRI contrast and hyperthermic effects by dopant-controlled magnetic nanoparticles. Angew. Chem. Int. Ed. 2009, 48:1234-1238.
43. Jia C.P., Zhong X.Q., Hua B., Liu M.Y., Jing F.X., Lou X.H., Yao S.H., Xiang J.Q., Jin Q.H., Zhao J.L. Nano-ELISA for highly sensitive protein detection. Biosens. Bioelectron. 2009, 24:2836-2841.
44. Jiang H., Han X., Li Z., Chen X., Hou Y., Gai L., Li D., Lu X., Fu T. Superparamagnetic core-shell structured microspheres carrying carboxyl groups as adsorbents for purification of genomic DNA. Colloids Surf. A 2012, 401:74-80.
45. Jin R. Super robust nanoparticles for biology and biomedicine. Angew. Chem. Int. Ed. 2008, 47:6750-6753.
46. Jin X., Li J.F., Huang P.Y., Dong X.Y., Guo L.L., Yang L., Cao Y.C., Wei F., Zhao Y.D., Chen H. Immobilized protease on the magnetic nanoparticles used for the hydrolysis of rapeseed meals. J. Magn. Magn. Mater. 2010, 322:2031-2037.
47. Jun Y.W., Lee J.H., Cheon J. Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. Angew. Chem. Int. Ed. 2008, 47:5122-5135.
48. Jun Y.W., Huh Y.M., Choi J.S., Lee J.H., Song H.T., Kim S., Yoon S., Kim K.S., Shin J.S., Suh J.S., Cheon J. Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J. Am. Chem. Soc. 2005, 127:5732-5733.
49. Kamat M., El-Boubbou K., Zhu D.C., Lansdell T., Lu X.W., Li W., Huang X.F. Hyaluronic acid immobilized magnetic nanoparticles for active targeting and imaging of macrophages. Bioconjug. Chem. 2010, 21:2128-2135.
50. Kang S., Douglas T. Some enzymes just need a space of their own. Science 2010, 327:42-43.
51. Karajanagi S.S., Vertegel A.A., Kane R.S., Dordick J.S. Structure and function of enzymes adsorbed onto single-walled carbon nanotubes. Langmuir 2004, 20:11594-11599.
52. Kickhoefer V.A., Garcia Y., Mikyas Y., Johansson E., Zhou J.C., Raval-Fernandes S., Minoofar P., Zink J.I., Dunn B., Stewart P.L., Rome L.H. Engineering of vault nanocapsules with enzymatic and fluorescent properties. Proc. Natl. Acad. Sci. USA 2005, 102:4348-4352.
53. Kim J., Piao Y., Hyeon T. Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. Chem. Soc. Rev. 2009, 38:372-390.
54. Kim J., Kim H.S., Lee N., Kim T., Kim H., Yu T., Song I.C., Moon W.K., Hyeon T. Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angew. Chem. Int. Ed. 2008, 47:8438-8441.
55. Kim J., Lee J.E., Lee S.H., Yu J.H., Lee J.H., Park T.G., Hyeon T. Designed fabrication of a multifunctional polymer nanomedical platform for simultaneous cancer-targeted imaging and magnetically guided drug delivery. Adv. Mater. 2008, 20:478-483.
56. Kim J., Grate J.W., Wang P. Nanobiocatalysis and its potential applications. Trends Biotechnol. 2008, 26:639-646.
57. Kim M.I., Kim J., Lee J., Jia H., Na H.B., Youn J.K., Kwak J.H., Dohnalkova A., Grate J.W., Wang P., Hyeon T., Park H.G., Chang H.N. Crosslinked enzyme aggregates in hierarchically-ordered mesoporous silica: a simple and effective method for enzyme stabilization. Biotechnol. Bioeng. 2007, 96:210-218.
58. Kim J., Grate J.W., Wang P. Nanostructures for enzyme stabilization. Chem. Eng. Sci. 2006, 61:1017-1026.
59. Kim J., Lee J., Na H.B., Kim B.C., Youn J.K., Kwak J.H., Moon K., Lee E., Kim J., Park J., Dohnalkova A., Park H.G., Gu M.B., Chang H.N., Grate J.W., Hyeon T. A magnetically separable, highly stable enzyme system based on nanocomposites of enzymes and magnetic nanoparticles shipped in hierarchically ordered, mesocellular, mesoporous silica. Small 2005, 1:1203-1207.
60. Koh I., Hong R., Weissleder R., Josephson L. Sensitive NMR sensors detect antibodies to influenza. Angew. Chem. Int. Ed. 2008, 47:4119-4121.
61. Koskela H. Use of NMR techniques for toxic organophosphorus compound profiling. J. Chromatogr. B 2010, 878:1365-1381.
62. Kreft O., Prevot M., Mohwald H., Sukhorukov G.B. Shell-in-shell microcapsules: a novel tool for integrated, spatially confined enzymatic reactions. Angew. Chem. Int. Ed. 2007, 46:5605-5608.
63. C.C. Landry, T.W. Nassivera, Mesoporous inorganic oxide spheres and method of making same, US Patent, 2009, 20090220791.
64. Laurent S., Forge D., Port M., Roch A., Robic C., Vander Elst L., Muller R.N. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem. Rev. 2008, 108:2064-2110.
65. Lee C.H., Lin T.S., Mou C.Y. Mesoporous materials for encapsulating enzymes. Nano Today 2009, 4:165-179.
66. Lee J., Lee Y., Youn J.K., Na H.B., Yu T., Kim H., Lee S.M., Koo Y.M., Kwak J.H., Park H.G., Chang H.N., Hwang M., Park J.G., Kim J., Hyeon T. Simple synthesis of functionalized superparamagnetic magnetite/silica core/shell nanoparticles and their application as magnetically separable high-performance biocatalysts. Small 2008, 4:143-152.
67. Lee J., Kim J., Kim J., Jia H., Kim M.I., Kwak J.H., Jin S., Dohnalkova A., Park H.G., Chang H.N., Wang P., Grate J.W., Hyeon T. Simple synthesis of hierarchically ordered mesocellular mesoporous silica materials hosting crosslinked enzyme aggregates. Small 2005, 1:744-753.
68. Lee J.E., Lee N., Kim H., Kim J., Choi S.H., Kim J.H., Kim T., Song I.C., Park S.P., Moon W.K., Hyeon T. Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery. J. Am. Chem. Soc. 2010, 132:552-557.
69. Lee J.H., Huh Y.M., Jun Y.W., Seo J.W., Jang J.T., Song H.T., Kim S., Cho E.J., Yoon H.G., Suh J.S., Cheon J. Artificially engineered magnetic particles for ultra-sensitive molecular imaging. Nat. Med. 2007, 13:95-99.
70. Lee S.Y., Lee S., Kho H., Lee J.H., Kim J.H., Chang J.H. Enzyme-magnetic nanoparticle conjugates as a rigid biocatalyst for the elimination of toxic aromatic hydrocarbons. Chem. Commun. 2011, 47:9989-9991.
71. Lei C.H., Soares T.A., Shin Y.S., Liu J., Ackerman E.J. Enzyme specific activity in functionalized nanoporous supports. Nanotechnology 2008, 19:1-9.
72. Lei C.H., Shin Y., Magnuson J.K., Fryxell G., Lasure L.L., Elliott D.C., Liu J., Ackerman E.J. Characterization of functionalized nanoporous supports for protein confinement. Nanotechnology 2006, 17:5531-5538.
73. Lei C.H., Shin Y.S., Liu J., Ackerman E.J. Entrapping enzyme in a functionalized nanoporous support. J. Am. Chem. Soc. 2002, 124:11242-11243.
74. LeJeune K.E., Wild J.R., Russell A.J. Nerve agents degraded by enzymatic foams. Nature 1998, 395:27-28.
75. LeJeune K.E., Dravis B.C., Yang F.X., Doctor B.P., Russell A.J. Fighting nerve agent chemical weapons with enzyme technology. Ann. N.Y. Acad. Sci. 1998, 864:153-170.
76. Lewis S.R., Datta S., Gui M., Coker E.L., Huggins F.E., Daunert S., Bachas L., Bhattacharyya D. Reactive nanostructured membranes for water purification. Proc. Natl. Acad. Sci. USA 2011, 108:8577-8582.
77. Lin P.C., Tseng M.C., Su A.K., Chen Y.J., Lin C.C. Functionalized magnetic nanoparticles for small-molecule isolation, identification, and quantification. Anal. Chem. 2007, 3401-3408.
78. Liu Y., Yao Z., Adronov A. Functionalization of single-walled carbon nanotubes with well-defined polymers by radical coupling. Macromolecules 2005, 38:1172-1179.
79. Luckarift H.R., Spain J.C., Naik R.R., Stone M.O. Enzyme immobilization in a biomimetic silica support. Nat. Biotechnol. 2004, 22:211-213.
80. Mitchell D.T., Lee S.B., Trofin L., Li N., Nevanen T.K., Soderlund H., Martin C.R. Smart nanotubes for bioseparations and biocatalysis. J. Am. Chem. Soc. 2002, 124:11864-11865.
81. Murugavel R., Choudhury A., Walawalkar M.G., Pothiraja R., Rao C.N.R. Metal complexes of organophosphate esters and open-framework metal phosphates: synthesis, structure, transformations, and applications. Chem. Rev. 2008, 108:3549-3655.
82. Na H.B., Song I.C., Hyeon T. Inorganic nanoparticles for MRI contrast agents. Adv. Mater. 2009, 21:2133-2148.
83. Nahrendorf M., Jaffer F.A., Kelly K.A., Sosnovik D.E., Aikawa E., Libby P., Weissleder R. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation 2006, 114:1504-1511.
84. Nahrendorf M., Waterman P., Thurber G., Groves K., Rajopadhye M., Panizzi P., Marinelli B., Aikawa E., Pittet M.J., Swirski F.K., Weissleder R. Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors. Arterioscler. Thromb. Vasc. Biol. 2009, 29:1444-1451.
85. Nepal D., Geckeler K.E. pH-sensitive dispersion and debundling of single-walled carbon nanotubes: lysozyme as a tool. Small 2006, 2:406-412.
86. Nieba L., Nieba-Axmann S.E., Persson A., Hämäläinen M., Edebratt F., Hansson A., Lidholm J., Magnusson K., Karlsson A.F., Plückthun A. BIACORE analysis of Histidine-Tagged proteins using a chelating NTA sensor chip. Anal. Biochem. 1997, 252:217-228.
87. Niide T., Gotoab M., Kamiya N. Biocatalytic synthesis of gold nanoparticles with cofactor regeneration in recombinant Escherichia coli cells. Chem. Commun. 2011, 47:7350-7352.
88. Niyogi S., Hamon M.A., Hu H., Zhao B., Bhowmik P., Sen R., Itkis M.E., Haddon R.C. Chemistry of single-walled carbon nanotubes. Acc. Chem. Res. 2002, 35:1105-1113.
89. O'Neil A., Reichhardt C., Johnson B., Prevelige P.E., Douglas T. Genetically programmed in vivo packaging of protein cargo and its controlled release from bacteriophage P22. Angew. Chem. Int. Ed. 2011, 50:7425-7428.
90. Orosco M.M., Pacholski C., Sailor M.J. Real-time monitoring of enzyme activity in a mesoporous silicon double layer. Nat. Nanotechnol. 2009, 4:255-258.
91. Pavlidis I.V., Vorhaben T., Tsoufis T., Rudolf P., Bornscheuer U.T., Gournis D., Stamatis H. Development of effective nanobiocatalytic systems through the immobilization of hydrolases on functionalized carbon-based nanomaterials. Bioresour. Technol. 2012, 115:164-171.
92. Pedrosa V.A., Paliwal S., Balasubramanian S., Nepal D., Davis V., Wild J., Ramanculov E., Simonian A. Enhanced stability of enzyme organophosphate hydrolase interfaced on the carbon nanotubes. Colloids Surf. B 2010, 77:69-74.
93. Peng X.H., Qian X., Mao H., Wang A.Y., Chen Z., Nie S., Shin D.M. Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy. Int. J. Nanomed. 2008, 3:311-321.
94. Perez J.M., Josephson L., Weissleder R. Use of magnetic nanoparticles as nanosensors to probe for molecular interactions. ChemBioChem 2004, 5:261-264.
95. Perez J.M., Josephson L., O'Loughlin T., Hogemann D., Weissleder R. Magnetic relaxation switches capable of sensing molecular interactions. Nat. Biotechnol. 2002, 20:816-820.
96. Piao Y., Lee D., Lee J., Hyeon T., Kim J., Kim H.S. Multiplexed immunoassay using the stabilized enzymes in mesoporous silica. Biosens. Bioelectron. 2009, 25:906-912.
97. Palankar R., Skirtach A.G., Kreft O., Bedard M., Garstka M., Gould K., Mohwald H., Sukhorukov G.B., Winterhalter M., Springer S. Controlled intracellular release of peptides from microcapsules enhances antigen presentation on MHC class I molecules. Small 2009, 5:2168-2176.
98. Raushel F.M. Catalytic detoxification. Nature 2011, 469:310-311.
99. Rege K., Raravikar N.R., Kim D.Y., Schadler L.S., Ajayan P.M., Dordick J.S. Enzyme-polymer-single walled carbon nanotube composites as biocatalytic films. Nano Lett. 2003, 3:829-832.
100. 3 nanoparticles with tailored functionality for protein separation. Chem. Commun. 2007, 4677-4679.
101. Slowing I.I., Vivero-Escoto J.L., Trewyn B.G., Lin V.S.-Y. Mesoporous silica nanoparticles: structural design and applications. J. Mater. Chem. 2010, 20:7924-7937.
102. Sperling R.A., Parak W.J. Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Philos. Trans. R. Soc. 2010, 368:1333-1383.
103. Sun E.Y., Weissleder R., Josephson L. Continuous analyte sensing with magnetic nanoswitches. Small 2006, 2:1144-1147.
104. Tan H., Feng W., Ji P. Lipase immobilized on magnetic multi-walled carbon nanotubes. Bioresour. Technol. 2012, 115:172-176.
105. Tasis D., Tagmatarchis N., Bianco A., Prato M. Chemistry of carbon nanotubes. Chem. Rev. 2006, 106:1105-1136.
106. Taft B.R., Lazareck A.D., Withey G.D., Yin A., Xu J.M., Kelley S.O. Site-specific assembly of DNA and appended cargo on arrayed carbon nanotubes. J. Am. Chem. Soc. 2004, 126:12750-12751.
107. Teschke C.M., McGough A., Thuman-Commike P.A. Penton release from P22 heat-expanded capsids suggests importance of stabilizing penton-hexon interactions during capsid maturation. Biophys. J. 2003, 84:2585-2592.
108. Thorek D.L.J., Chen A.K., Czupryna J., Tsourkas A. Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Ann. Biomed. Eng. 2006, 34:23-38.
109. Tischer W., Kasche V. Immobilized enzymes: crystals or carriers?. Trends Biotechnol. 1999, 17:326-335.
110. Tischer W., Wedekind F. Immobilized enzymes: methods and applications. Top. Curr. Chem. 1999, 200:96-126.
111. Uchida M., Klem M.T., Allen M., Suci P., Flenniken M., Gillitzer E., Varpness Z., Liepold L.O., Young M., Douglas T. Biological containers: protein cages as multifunctional nanoplatforms. Adv. Mater. 2007, 19:1025-1042.
112. Vestergaard M., Kerman K., Tamiya E. An overview of label-free electrochemical protein sensors. Sensors 2007, 7:3442-3458.
113. Wang J., Liu G., Jan M.R. Ultrasensitive electrical biosensing of proteins and DNA: carbon-nanotube derived amplification of the recognition and transduction events. J. Am. Chem. Soc. 2004, 126:3010-3011.
114. Wang L., Wei L., Chen Y., Jiang R. Specific and reversible immobilization of NADH oxidase on functionalized carbon nanotubes. J. Biotechnol. 2010, 150:57-63.
115. Wang P. Nanoscale biocatalyst systems. Curr. Opin. Biotechnol. 2006, 17:574-579.
116. Wang W., Xu Y., Wang D.I.C., Li Z. Recyclable nanobiocatalyst for enantioselective sulfoxidation: facile fabrication and high performance of chloroperoxidase-coated magnetic nanoparticles with iron oxide core and polymer shell. J. Am. Chem. Soc. 2009, 131:12892-12893.
117. Wang Y.J., Caruso F. Mesoporous silica spheres as supports for enzyme immobilization and encapsulation. Chem. Mater. 2005, 17:953-961.
118. Waysbort D., McGarvey D.J., Creasy W.R., Morrissey K.M., Hendrickson D.M., Durst H.D. A decontamination system for chemical weapons agents using a liquid solution on a solid sorbent. J. Hazard. Mater. 2009, 161:1114-1121.
119. Weissleder R., Kelly K., Sun E.Y., Shtatland T., Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat. Biotechnol. 2005, 23:1418-1423.
120. Willner I., Baron R., Willner B. Integrated nanoparticle-biomolecule systems for biosensing and bioelectronics. Biosens. Bioelectron. 2007, 22:1841-1852.
121. Willner I., Baron R., Willner B. Growing metal nanoparticles by enzymes. Adv. Mater. 2006, 18:1109-1120.
122. Withey G.D., Kim J.H., Xu J. DNA-programmable multiplexing for scalable, renewable redox protein bio-nanoelectronics. Bioelectrochemistry 2008, 74:111-117.
123. Xiao Y., Pavlov V., Levine S., Niazov T., Markovitch G., Willner I. Angew. Chem. Int. Ed. 2004, 43:4519.
124. 4 nanoparticles as biocatalyst for biodiesel production. Energy Fuels 2009, 23:1347-1353.
125. Yan Y., Yehezkeli O., Willner I. Integrated, electrically contacted NAD(P)+-dependent enzyme-carbon nanotube electrodes for biosensors and biofuel cell applications. Chem. Eur. J. 2007, 13:10168-10175.
126. Yan Y., Tel-Vered R., Yehezkeli O., Cheglakov Z., Willner I. Biocatalytic growth of Au nanoparticles immobilized on glucose oxidase enhances the ferrocene-mediated bioelectrocatalytic oxidation of glucose. Adv. Mater. 2008, 20:2365-2370.
127. Yang Y.C. Chemical detoxification of nerve agent VX. Acc. Chem. Res. 1999, 32:109-115.
128. 3 particles upon ultrasound disruption of attached substrate-filled liposomes. Angew. Chem. Int. Ed. 2010, 49:8116-8120.
129. Yehezkeli O., Raichlin S., Tel-Vered R., Kesselman E., Danino D., Willner I. Biocatalytic implant of Pt nanoclusters into glucose oxidase: a method to electrically wire the enzyme and to transform it from an oxidase to a hydrogenase. J. Phys. Chem. Lett. 2010, 1:2816-2819.
130. Yiu H.H.P., Wright P.A. Enzymes supported on ordered mesoporous solids: a special case of an inorganic-organic hybrid. J. Mater. Chem. 2005, 15:3690-3700.
131. Yu C.M., Yen M.J., Chen L.C. A bioanode based on MWCNT/protein-assisted coimmobilization of glucose oxidase and 2,5-dihydroxybenzaldehyde for glucose fuel cells. Biosens. Bioelectron. 2010, 25:2515-2521.
132. Yu H.C., Kuo Y.Y., Liang C.F., Chien W.T., Wu H.T., Chang T.C., Jan F.D., Lin C.C. Site-specific immobilization of enzymes on magnetic nanoparticles and their use in organic synthesis. Bioconj. Chem. 2012, 23:714-724.
133. Yu M.K., Jeong Y.Y., Park J., Park S., Kim J.W., Min J.J., Kim K., Jon S. Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. Angew. Chem. Int. Ed. 2008, 47:5362-5365.
134. Yu X., Munge B., Patel V., Jensen G., Bhirde A., Gong J.D., Kim S.N., Gillespie J., Gutkind J.S., Papadimitrakopoulos F., Rusling J.F. Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. J. Am. Chem. Soc. 2006, 128:11199-11205.
135. Zayats M., Baron R., Popov I., Willner I. Nano Lett. 2005, 5:21.
136. Zhao W., Schafer S., Choi J., Yamanaka Y.J., Lombardi M.L., Bose S., Carlson A.L., Phillips J.A., Teo W., Droujinine I.A., Cui C.H., Jain R.K., Lammerding J., Love J.C., Lin C.P., Sarkar D., Karnik R., Karp J.M. Cell-surface sensors for real-time probing of cellular environments. Nat. Nanotechnol. 2011, 6:524-531.
137. Feng W., Ji P. Enzymes immobilized on carbon nanotubes. Biotechnol. Adv. 2011, 29:889-895.