Cognitive ability, intraindividual variability, and common genetic variants of Catechol-O-Methyltransferase and Brain-Derived Neurotrophic Factor: A longitudinal study in a population-based sample of older adults

Psychology and Aging

Volumn 29, Issue 2, 2014, Pages 393-403

  Das, Debjani ^a   Tan, Xiaoyun ^a   Bielak, Allison A M ^b   Cherbuin, Nicolas ^c   Easteal, Simon ^a   Anstey, Kaarin J ^c  

^a Biology and Environment   (Australia)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

BDNF; Cognitive decline; COMT; Intraindividual variability; Reaction time

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; DOPAMINE; METHIONINE; VALINE;

ADULT; ALLELE; ARTICLE; ATTENTION; COGNITION; EDUCATION; EPISODIC MEMORY; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENOTYPE; HUMAN; HUMAN EXPERIMENT; LONGITUDINAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NORMAL HUMAN; PREFRONTAL CORTEX; PROTEIN SECRETION; PSYCHOMETRY; REACTION TIME; SINGLE NUCLEOTIDE POLYMORPHISM; VERBAL MEMORY; WORKING MEMORY; AGED; AGING; GENETIC POLYMORPHISM; GENETICS; INDIVIDUALITY; MIDDLE AGED; PHYSIOLOGY; PSYCHOLOGY; YOUNG ADULT;

ADULT; AGED; AGING; ALLELES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATECHOL O-METHYLTRANSFERASE; COGNITION; FEMALE; GENOTYPE; HUMANS; INDIVIDUALITY; LONGITUDINAL STUDIES; MALE; METHIONINE; MIDDLE AGED; POLYMORPHISM, GENETIC; REACTION TIME; VALINE; YOUNG ADULT;

EID: 84902960436     PISSN: 08827974     EISSN: 19391498     Source Type: Journal    
DOI: 10.1037/a0035702     Document Type: Article

References (72)

1. Anstey, K. J., Christensen, H., Butterworth, P., Easteal, S., Mackinnon, A., Jacomb, T., . . . Jorm, A. F. (2012). Cohort profile: The PATH through life project. International Journal of Epidemiology, 41, 951-960.
2. Bäckman, L., Lindenberger, U., Li, S.-C.,&Nyberg, L. (2010). Linking cognitive aging to alterations in dopamine neurotransmitter functioning: Recent data and future avenues. Neuroscience and Biobehavioral Reviews, 34, 670-677.
3. Bäckman, L., Nyberg, L., Lindenberger, U., Li, S.-C.,&Farde, L. (2006). The correlative triad among aging, dopamine, and cognition: Current status and future prospects. Neuroscience and Biobehavioral Reviews, 30, 791-807.
4. Baddeley, A., Emslie, H.,&Nimmo-Smith, I. (1993). The Spot-the-Word test: A robust estimate of verbal intelligence based on lexical decision. British Journal of Clinical Psychology, 32, 55-65.
5. Barde, Y. A., Edgar, D.,&Thoenen, H. (1982). Purification of a new neurotrophic factor from mammalian brain. The EMBO Journal, 1, 549-553.
6. Barnett, J. H., Scoriels, L.,&Munafò, M. R. (2008). Meta-analysis of the cognitive effects of the catechol-o-methyltransferase gene val158/108met polymorphism. Biological Psychiatry, 64, 137-144.
7. Bielak, A. A. M., Anstey, K. J., Christensen, H.,&Windsor, T. D. (2012). Activity engagement is related to level, but not change in cognitive ability across adulthood. Psychology and Aging, 27, 219-228.
8. Bielak, A. A. M., Cherbuin, N., Bunce, D.,&Anstey, K. J.(2013, April 15). Intraindividual variability is a fundamental phenomenon of aging: Evidence from an 8-year longitudinal study across young, middle, and older adulthood. Developmental Psychology, no pagination specified.
9. Binder, D. K.,&Scharfman, H. E. (2004). Brain-derived neurotrophic factor. Growth Factors, 22, 123-131.
10. Boger, H. A., Mannangatti, P., Samuvel, D. J., Saylor, A. J., Bender, T. S., McGinty, J. F., . . . Ramamoorthy, S. (2011). Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes, Brain and Behavior, 10, 186-198.
11. Bosse, K. E., Maina, F. K., Birbeck, J. A., France, M. M., Roberts, J. J. P., Colombo, M. L.,&Mathews, T. A. (2012). Aberrant striatal dopamine transmitter dynamics in brain-derived neurotrophic factor-deficient mice. Journal of Neurochemistry, 120, 385-395.
12. Callicott, J. H., Bertolino, A., Mattay, V. S., Langheim, F. J., Duyn, J., Coppola, R., . . . Weinberger, D. R. (2000). Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex, 10, 1078-1092.
13. Chen, Z.-Y., Patel, P. D., Sant, G., Meng, C.-X., Teng, K. K., Hempstead, B. L.,&Lee, F. S. (2004). Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activitydependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. The Journal of Neuroscience, 24, 4401-4411.
14. Chourbaji, S., Hellweg, R., Brandis, D., Zörner, B., Zacher, C., Lang, U. E., . . . Gass, P. (2004). Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Molecular Brain Research, 121, 28-36.
15. Conner, J. M., Lauterborn, J. C., Yan, Q., Gall, C. M.,&Varon, S. (1997). Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: Evidence for anterograde axonal transport. The Journal of Neuroscience, 17, 2295-2313.
16. Davies, G., Harris, S. E., Reynolds, C. A., Payton, A., Knight, H. M., Liewald, D. C., . . . Deary, I. J. (2012). A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. Molecular Psychiatry.
17. Davies, G., Tenesa, A., Payton, A., Yang, J., Harris, S. E., Liewald, D., . . . Deary, I. J. (2011). Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Molecular Psychiatry, 16, 996-1005.
18. Deary, I. J., Corley, J., Gow, A. J., Harris, S. E., Houlihan, L. M., Marioni, R. E., . . . Starr, J. M. (2009). Age-associated cognitive decline. British Medical Bulletin, 92, 135-152.
19. Deary, I. J., Johnson, W.,&Houlihan, L. M. (2009). Genetic foundations of human intelligence. Human Genetics, 126, 215-232.
20. Deary, I. J., Spinath, F. M.,&Bates, T. C. (2006). Genetics of intelligence. European Journal of Human Genetics, 14, 690-700.
21. De Frias, C. M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., & Nilsson, L.-G. (2004). COMT gene polymorphism is associated with declarative memory in adulthood and old age. Behavior Genetics, 34, 533-539.
22. De Frias, C. M., Annerbrink, K., Westberg, L., Eriksson, E., Adolfsson, R., & Nilsson, L.-G. (2005). Catechol-o-methyltransferase val158met polymorphism is associated with cognitive performance in nondemented adults. Journal of Cognitive Neuroscience, 17, 1018-1025.
23. De Frias, C. M., Lövdén, M., Lindenberger, U.,&Nilsson, L.-G. (2007). Revisiting the dedifferentiation hypothesis with longitudinal multicohort data. Intelligence, 35, 381-392.
24. Delis, D. C., Kramer, J. H., Kaplan, E.,&Ober, B. A. (1987). California Verbal Learning Test: Adult Version. San Antonio, TX: The Psychological Corporation.
25. Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., . . . Weinberger, D. R. (2001). Effect of COMT val108/158 met genotype on frontal lobe function and risk for schizophrenia. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 98, 6917-6922.
26. Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., . . . Weinberger, D. R. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257-269.
27. Erickson, K. I., Kim, J. S., Suever, B. L., Voss, M. W., Francis, B. M., & Kramer, A. F. (2008). Genetic contributions to age-related decline in executive function: A 10-year longitudinal study of COMT and BDNF polymorphisms. Frontiers in Human Neuroscience, 2, 11.
28. Fiocco, A. J., Lindquist, K., Ferrell, R., Li, R., Simonsick, E. M., Nalls, M., . . . Yaffe, K. (2010). COMT genotype and cognitive function: An 8-year longitudinal study in white and black elders. Neurology, 74, 1296-1302.
29. Folstein, M. F. (1983). The Mini-Mental State Examination. Archives of General Psychiatry, 40, 812.
30. Frielingsdorf, H., Bath, K. G., Soliman, F., Difede, J., Casey, B. J.,&Lee, F. S. (2010). Variant brain-derived neurotrophic factor val66met endophenotypes: Implications for posttraumatic stress disorder. Annals of the New York Academy of Sciences, 1208, 150-157.
31. Gajewski, P. D., Hengstler, J. G., Golka, K., Falkenstein, M.,&Beste, C. (2011). The met-allele of the BDNF val66met polymorphism enhances task switching in elderly. Neurobiology of Aging, 32, 2327.e7-2327.e19.
32. Goldman, D., Weinberger, D. R., Malhotra, A. K.,&Goldberg, T. E. (2009). The role of COMT val158met in cognition and Author reply. Biological Psychiatry, 65, e1-e4.
33. Hariri, A. R., Goldberg, T. E., Mattay, V. S., Kolachana, B. S., Callicott, J. H., Egan, M. F.,&Weinberger, D. R. (2003). Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of Neuroscience, 23, 6690-6694.
34. Harris, S. E.,&Deary, I. J. (2011). The genetics of cognitive ability and cognitive ageing in healthy older people. Trends in Cognitive Sciences, 15, 388-394.
35. Harris, S. E., Fox, H., Wright, A. F., Hayward, C., Starr, J. M., Whalley, L. J.,&Deary, I. J. (2006). The brain-derived neurotrophic factor val66met polymorphism is associated with age-related change in reasoning skills. Molecular Psychiatry, 11, 505-513.
36. Ho, B.-C., Milev, P., O'Leary, D. S., Librant, A., Andreasen, N. C., & Wassink, T. H. (2006). Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor val66met gene polymorphism in patients with schizophrenia and healthy volunteers. Archives of General Psychiatry, 63, 731-740.
37. Horn, J. L. (1982). The theory of fluid and crystallized intelligence in relation to concepts of cognitive psychology and aging in adulthood. In F. I. M. Craik,&S. Trehub (Eds.), Aging and cognitive processes (pp. 237-278). New York, NY: Plenum Press.
38. Houlihan, L. M., Harris, S. E., Luciano, M., Gow, A. J., Starr, J. M., Visscher, P. M.,&Deary, I. J. (2009). Replication study of candidate genes for cognitive abilities: The Lothian Birth Cohort 1936. Genes, Brain and Behavior, 8, 238-247.
39. Hultsch, D. F., MacDonald, S. W. S., Hunter, M. A., Levy-Bencheton, J., & Strauss, E. (2000). Intraindividual variability in cognitive performance in older adults: Comparison of adults with mild dementia, adults with arthritis, and healthy adults. Neuropsychology, 14, 588-598.
40. Hultsch, D. F., Strauss, E., Hunter, M. A.,&MacDonald, S. W. S. (2008). Intraindividual variability, cognition, and aging. In F. I. M. Craik, & T. A. Salthouse (Eds.), The handbook of aging and cognition (3rd ed., pp. 491-556). New York, NY: Psychology Press.
41. Hyman, C., Hofer, M., Barde, Y. A., Juhasz, M., Yancopoulos, G. D., Squinto, S. P.,&Lindsay, R. M. (1991). BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature, 350, 230-232.
42. Jorm, A. F., Mather, K. A., Butterworth, P., Anstey, K. J., Christensen, H., & Easteal, S. (2007). APOE genotype and cognitive functioning in a large age-stratified population sample. Neuropsychology, 21, 1-8.
43. Kang, J. I., Song, D.-H., Namkoong, K.,&Kim, S. J. (2010). Interaction effects between COMT and BDNF polymorphisms on boredom susceptibility of sensation seeking traits. Psychiatry Research, 178, 132-136.
44. Laing, K. R., Mitchell, D., Wersching, H., Czira, M. E., Berger, K., & Baune, B. T. (2012). Brain-derived neurotrophic factor (BDNF) gene: A gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study? AGE, 34, 1011-1022.
45. Laukka, E. J., Lövdén, M., Herlitz, A., Karlsson, S., Ferencz, B., Pantzar, A., . . . Bäckman, L. (2013). Genetic effects on old-age cognitive functioning: A population-based study. Psychology and Aging, 28, 262-274.
46. Li, S.-C.,&Lindenberger, U. (1999). Cross-level unification: A computational exploration of the link between deterioration of neurotransmitter systems and dedifferentiation of cognitive abilities in old age. In L.-G. Nilsson,&H. J. Markowitsch (Eds.), Cognitive neuroscience of memory (pp. 103-146). Ashland, OH: Hogrefe&Huber.
47. Lindenberger, U., Nagel, I. E., Chicherio, C., Li, S.-C., Heekeren, H. R., & Bäckman, L. (2008). Age-related decline in brain resources modulates genetic effects on cognitive functioning. Frontiers in Neuroscience, 2, 234-244.
48. Lotta, T., Vidgren, J., Tilgmann, C., Ulmanen, I., Melén, K., Julkunen, I., & Taskinen, J. (1995). Kinetics of human soluble and membrane-bound catechol-o-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry, 34, 4202-4210.
49. Lövdén, M., Li, S.-C., Shing, Y. L.,&Lindenberger, U. (2007). Withinperson trial-to-trial variability precedes and predicts cognitive decline in old and very old age: Longitudinal data from the Berlin Aging Study. Neuropsychologia, 45, 2827-2838.
50. Lu, B. (2003). BDNF and activity-dependent synaptic modulation. Learning & Memory, 10, 86-98.
51. Luciano, M., Batty, G. D., McGilchrist, M., Linksted, P., Fitzpatrick, B., Jackson, C., . . . Deary, I. J. (2010). Shared genetic aetiology between cognitive ability and cardiovascular disease risk factors: Generation Scotland's Scottish family health study. Intelligence, 38, 304-313.
52. MacDonald, S. W. S., Karlsson, S., Rieckmann, A., Nyberg, L.,&Bäckman, L. (2012). Aging-related increases in behavioral variability: Relations to losses of dopamine D1 receptors. The Journal of Neuroscience, 32, 8186-8191.
53. MacDonald, S. W. S., Li, S.-C.,&Bäckman, L. (2009). Neural underpinnings of within-person variability in cognitive functioning. Psychology and Aging, 24, 792-808.
54. MacDonald, S. W. S., Nyberg, L.,&Bäckman, L. (2006). Intra-individual variability in behavior: Links to brain structure, neurotransmission and neuronal activity. Trends in Neurosciences, 29, 474-480.
55. Mandelman, S. D.,&Grigorenko, E. L. (2012). BDNF val66met and cognition: All, none, or some? A meta-analysis of the genetic association. Genes, Brain and Behavior, 11, 127-136.
56. McClearn, G. E., Johansson, B., Berg, S., Pedersen, N. L., Ahern, F., Petrill, S. A.,&Plomin, R. (1997). Substantial genetic influence on cognitive abilities in twins 80 or more years old. Science, 276, 1560-1563.
57. McGue, M.,&Christensen, K. (2001). The heritability of cognitive functioning in very old adults: Evidence from Danish twins aged 75 years and older. Psychology and Aging, 16, 272-280.
58. Miyajima, F., Ollier, W., Mayes, A., Jackson, A., Thacker, N., Rabbitt, P., . . . Payton, A. (2008). Brain-derived neurotrophic factor polymorphism val66met influences cognitive abilities in the elderly. Genes, Brain and Behavior, 7, 411-417.
59. Nagel, I. E., Chicherio, C., Li, S.-C., von Oertzen, T., Sander, T., Villringer, A., . . . Lindenberger, U. (2008). Human aging magnifies genetic effects on executive functioning and working memory. Frontiers in Human Neuroscience, 2, 1.
60. Papaleo, F., Crawley, J. N., Song, J., Lipska, B. K., Pickel, J., Weinberger, D. R.,&Chen, J. (2008). Genetic dissection of the role of catechol-omethyltransferase in cognition and stress reactivity in mice. The Journal of Neuroscience, 28, 8709-8723.
61. Raz, N., Rodrigue, K. M., Kennedy, K. M.,&Land, S. (2009). Genetic and vascular modifiers of age-sensitive cognitive skills: Effects of COMT, BDNF, APOE, and hypertension. Neuropsychology, 23, 105-116.
62. Smith, A. (1982). Symbol Digit Modality Test manual. Los Angeles, CA: Western Psychological Services.
63. Soliman, F., Glatt, C. E., Bath, K. G., Levita, L., Jones, R. M., Pattwell, S. S., . . . Casey, B. J. (2010). A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science, 327, 863-866.
64. Spina, M. B., Squinto, S. P., Miller, J., Lindsay, R. M.,&Hyman, C. (1992). Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and n-methyl-4-phenylpyridinium ion toxicity: Involvement of the glutathione system. Journal of Neurochemistry, 59, 99-106.
65. Starr, J. M., Fox, H., Harris, S. E., Deary, I. J.,&Whalley, L. J. (2007). COMT genotype and cognitive ability: A longitudinal aging study. Neuroscience Letters, 421, 57-61.
66. Stefanis, N. C., van Os, J., Avramopoulos, D., Smyrnis, N., Evdokimidis, I.,&Stefanis, C. N. (2005). Effect of COMT val158met polymorphism on the Continuous Performance Test, Identical Pairs version: Tuning rather than improving performance. The American Journal of Psychiatry, 162, 1752-1754.
67. Swan, G. E.,&Carmelli, D. (2002). Evidence for genetic mediation of executive control: A study of aging male twins. The Journals of Gerontology: Series B. Psychological Sciences and Social Sciences, 57, P133-P143.
68. Webster, M. J., Herman, M. M., Kleinman, J. E.,&Shannon Weickert, C. (2006). BDNF and trkB mRNA expression in the hippocampus and temporal cortex during the human lifespan. Gene Expression Patterns, 6, 941-951.
69. Wechsler, D. (1945). Wechsler Memory Scale manual. New York, NY: The Psychological Corporation.
70. Witte, A. V.,&Flöel, A. (2012). Effects of COMT polymorphisms on brain function and behavior in health and disease. Brain Research Bulletin, 88, 418-428.
71. Witte, A. V., Kürten, J., Jansen, S., Schirmacher, A., Brand, E., Sommer, J.,&Flöel, A. (2012). Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity. The Journal of Neuroscience, 32, 4553-4561.
72. Yavich, L., Forsberg, M. M., Karayiorgou, M., Gogos, J. A.,&Männistö, P. T. (2007). Site-specific role of catechol-o-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. The Journal of Neuroscience, 27, 10196-10209.