Brain-derived neurotrophic factor (BDNF) gene: A gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?

Age

Volumn 34, Issue 4, 2012, Pages 1011-1022

  Laing, Katharine R ^a   Mitchell, David ^a   Wersching, Heike ^b   Czira, Maria E ^b,d   Berger, Klaus ^b   Baune, Bernhard T ^c  

^a JAMES COOK UNIVERSITY   (Australia)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

BDNF; BDNF gene; Elderly; Gender; Memory; Motor function; Perceptual speed

Indexed keywords

APOLIPOPROTEIN E4; BRAIN DERIVED NEUROTROPHIC FACTOR;

AGED; AGING; APOLIPOPROTEIN E4 GENE; ARTICLE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; COGNITION; CONTROLLED STUDY; FEMALE; GENE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENOTYPING TECHNIQUE; HUMAN; MALE; MEMORY; MENTAL PERFORMANCE; MOTOR PERFORMANCE; OUTCOME ASSESSMENT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TASK PERFORMANCE;

AGED; AGING; ANALYSIS OF VARIANCE; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; COGNITION DISORDERS; COHORT STUDIES; CONFIDENCE INTERVALS; FEMALE; GERIATRIC ASSESSMENT; HUMANS; LINEAR MODELS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SEX FACTORS;

EID: 84866488076     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9275-8     Document Type: Article

References (51)

1. Baune BT, Suslow T, Engelien A, Arolt V, Berger K (2006) The association between depressive mood and cognitive performance in an elderly general population -the MEMO Study. Dement Geriatr Cogn Disord 22(2):142-149 (Pubitemid 44253210)
2. Baune B, Ponath G, Rothermundt M, Riess O, Funke H, Berger K (2008) Association between genetic variants of IL-1 [beta], IL-6 and TNF-[alpha] cytokines and cognitive performance in the elderly general population of the MEMO-Study. Psychoneuroendocrinology 33:68-76
3. Beckman L, Nilsson L (1996) Semantic memory functioning across the adult life span. Eur Psychol 1:27-33
4. Cheng S, Grow M, Pallaud C, Klitz W, Erlich H, Visvikis S, Chen J, Pullinger C, Malloy M, Siest G (1999) A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 9:936
5. Chiang MC, Barysheva M, Toga AW, Medland SE, Hansell NK, James MR, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Thompson PM (2011) BDNF gene effects on brain circuitry replicated in 455 twins. NeuroImage 55:448-454
6. Costa L, Vaughan H Jr, Levita E, Farber N (1963) Purdue Pegboard as a predictor of the presence and laterality of cerebral lesions. J Consult Psychol 27:133-137
7. Desrosiers J, Hebert R, Bravo G, Dutil E (1995) The Purdue Pegboard Test: Normative data for people aged 60 and over. Disabil Rehabil 17:217-224
8. Egan M, Kojima M, Callicott J, Goldberg T, Kolachana B, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-269 (Pubitemid 36144114)
9. Ferrer I, Marin C, Rey M, Ribalta T, Goutan E, Blanco R, Tolosa E, Marti E (1999) BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J Neuropathol Exp Neurol 58:729
10. Foltynie T, Lewis S, Goldberg T, Blackwell A, Kolachana B, Weinberger D, Robbins T, Barker R (2005) The BDNF Val 66 Met polymorphism has a gender specific influence on planning ability in Parkinson's disease. J Neurol 252:833-838 (Pubitemid 40984861)
11. Foltynie T, Cheeran B, Williams-Gray C, Edwards M, Schneider S, Weinberger D, Rothwell J, Barker R, Bhatia K (2009) BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease. J Neurol Neurosurg Psychiatry 80:141
12. Forlenza OV, Diniz BS, Teixeira AL, Ojopi EB, Talib LL, Mendonca VA, Izzo G, Gattaz WF (2010) Effect of brainderived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment. World J Biol Psychiatry 11:774-780
13. Guerini FR, Beghi E, Riboldazzi G, Zangaglia R, Pianezzola C, Bono G, Casali C, Di Lorenzo C, Agliardi C, Nappi G, Clerici M, Martignoni E (2009) BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease. Eur J Neurol 16:1240-1245
14. Hariri A, Goldberg T, Mattay V, Kolachana B, Callicott J, Egan M, Weinberger D (2003) Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23:6690
15. Harris S, Fox H, Wright A, Hayward C, Starr J, Whalley L, Deary I (2006) The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills. Mol Psychiatry 11:505-513
16. Hayashi M, Yamashita A, Shimizu K (1997) Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: Decreased levels of mRNAs during aging. Brain Res 749:283-289 (Pubitemid 27104209)
17. Hayashi M, Mistunaga F, Ohira K, Shimizu K (2001) Changes in BDNF-immunoreactive structures in the hippocampal formation of the agedmacaquemonkey. Brain Res 918:191-196 (Pubitemid 33001506)
18. Hock C, Heese K, Hulette C, Rosenberg C, Otten U (2000) Region-specific neurotrophin imbalances in Alzheimer disease: Decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch Neurol 57:846
19. Howells D, Porritt M, Wong J, Batchelor P, Kalnins R, Hughes A, Donnan G (2000) Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra. Exp Neurol 166:127-135
20. Huang R, Huang J, Cathcart H, Smith S, Poduslo SE (2007) Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. J Med Genet 44:e66
21. Jones K, Reichardt L (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc Natl Acad Sci 87:8060
22. Keil U, Liese A, Hense H, Filipiak B, Doring A, Stieber J, Lowel H (1998) Classical risk factors and their impact on incident non-fatal and fatal myocardial infarction and all-cause mortality in southern Germany: results from the MONICA Augsburg Cohort Study 1984-1992. Eur Heart J 19:1197
23. Komulainen P, Pedersen M, Hanninen T, Bruunsgaard H, Lakka T, Kivipelto M, Hassinen M, Rauramaa T, Pedersen B, Rauramaa R (2008) BDNF is a novel marker of cognitive function in ageing women: The DR's EXTRA Study. Neurobiol Learn Mem 90:596-603
24. Korte M, Carroll P, Wolf E, Brem G, Thoenen H, Bonhoeffer T (1995) Hippocampal long-Term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci 92:8856
25. Korte M, Griesbeck O, Gravel C, Carroll P, Staiger V, Thoenen H, Bonhoeffer T (1996) Virus-mediated gene transfer into hippocampal CA1 region restores long-Term potentiation in brain-derived neurotrophic factor mutant mice. Proc Natl Acad Sci USA 93:12547
26. Korte M, Kang H, Bonhoeffer T, Schuman E (1998) A role for BDNF in the late-phase of hippocampal long-Term potentiation. Neuropharmacology 37:553-559 (Pubitemid 28306944)
27. Linnarsson S, Bjorklund A, Ernfors P (1997) Learning deficit in BDNF mutant mice. Eur J Neurosci 9:2581-2587 (Pubitemid 28082947)
28. Lynch MA (2004) Long-Term potentiation and memory. Physiol Rev 84:87-136 (Pubitemid 38049877)
29. Mattson M, Maudsley S, Martin B (2004) A neural signaling triumvirate that influences ageing and age-related disease: Insulin/IGF-1, BDNF and serotonin. Ageing Res Rev 3:445-464 (Pubitemid 39487900)
30. Mercader J, Ribasés M, Gratacòs M, González J, Bayés M, de Cid R, Badía A, Fernández-Aranda F, Estivill X (2007) Altered brain-derived neurotrophic factor blood levels and gene variability are associated with anorexia and bulimia. Genes Brain Behav 6:706-716 (Pubitemid 350043942)
31. Miyajima F, Ollier W, Mayes A, Jackson A, Thacker N, Rabbitt P, Pendleton N, Horan M, Payton A (2008) Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly. Genes Brain Behav 7:411-417 (Pubitemid 351590926)
32. Morris R (1989) Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-Term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J Neurosci 9:3040
33. Narisawa-Saito M, Wakabayashi K, Tsuji S, Takahashi H, Nawa H (1996) Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neuroreport 7:2925
34. Nilsson L, Söderlund H, Berger K, Breteler M, de Ridder M, Dufouil C, Fuhrer R, Giampaoli S, Hofman A, Pajak A (2005) Cognitive test battery of CASCADE: Tasks and data. Aging Neuropsychol Cogn 12:32-56 (Pubitemid 40524496)
35. Nyberg L, Maitland S, Ronnlund M, Backman L, Dixon R, Wahhn A, Nilsson L (2003) Selective adult age differences in an age-invariant multifactor model of declarative memory. Psychol Aging 18:149-160 (Pubitemid 36293052)
36. Oeth P, Beaulieu M, Park C, Kosman D, del Mistro G, van den Boom D, Jurinke C (2007) iPLEX™ assay: Increased plexing efficiency and flexibility for MassARRAY system through single base primer extension with mass-modified terminators. Online access: http://www.agrf.org.au/docstore/snp/ iPlex.pdf
37. Oroszi G, Lapteva L, Davis E, Yarboro C, Weickert T, Roebuck-Spencer T, Bleiberg J, Rosenstein D, Pao M, Lipsky P (2006) The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus. Ann Rheum Dis 65:1330
38. Parain K, Murer M, Yan Q, Faucheux B, Agid Y, Hirsch E, Raisman-Vozari R (1999) Reduced expression of brainderived neurotrophic factor protein in Parkinson's disease substantia nigra. Neuroreport 10:557
39. Perneger TV (1998) What's wrong with Bonferroni adjustments. BMJ 316:1236-1238 (Pubitemid 28171344)
40. Phillips H, Hains J, Armanini M, Laramee G, Johnson S, Winslow J (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7:695-702
41. Raz N, Rodrigue K, Kennedy K, Land S (2009) Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE and hypertension. Neuropsychology 23:105
42. Rybakowski JK, Borkowska A, Czerski PM, Skibiska M, Hauser J (2003) Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord 5:468-472 (Pubitemid 38072252)
43. Rybakowski J, Borkowska A, Skibinska M, Szczepankiewicz A, Kapelski P, Leszczynska-Rodziewicz A, Czerski P, Hauser J (2006) Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor gene. Psychiatry Clin Neurosci 60:70-76
44. Salthouse T (1978) The role of memory in the age decline in digit-symbol substitution performance. J Gerontol 33:232
45. Schmidt W, Roesler A, Kretzschmar K, Ladwig K, Junker R, Berger K (2004) Functional and cognitive consequences of silent stroke discovered using brain magnetic resonance imaging in an elderly population. J Am Geriatr Soc 52:1045-1050 (Pubitemid 38869061)
46. Stroop J (1935) Studies of interference in serial verbal reactions. J Exp Psychol 18:643-662
47. Tang YP,Wang H, Feng R, Kyin M, Tsien JZ (2001) Differential effects of enrichment on learning and memory function in NR2B transgenic mice. Neuropharmacology 41:779-790 (Pubitemid 32972196)
48. Tiffin J (1948) Manual for the Purdue Pegboard. Science Research Associates, Chicago (IL).
49. Tsai SJ, Gau YT, Liu ME, Hsieh CH, Liou YJ, Hong CJ (2008) Association study of brain-derived neurotrophic factor and apolipoprotein E polymorphisms and cognitive function in aged males without dementia. Neurosci Lett 433:158-162
50. Xiromerisiou G, Hadjigeorgiou G, Eerola J, Fernandez H, Tsimourtou V, Mandel R, Hellström O, Gwinn-Hardy K, Okun M, Tienari P (2007) BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups. Neurosci Lett 415:59-63 (Pubitemid 46380268)
51. Zivadinov R,Weinstock-Guttman B, Benedict R, Tamaño-Blanco M, Hussein S, Abdelrahman N, Durfee J, Ramanathan M (2007) Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor. Hum Mol Genet 16:2659