Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Singhal, Vibha ^a   Lawson, Elizabeth A ^a   Ackerman, Kathryn E ^a,b   Fazeli, Pouneh K ^a   Clarke, Hannah ^a   Lee, Hang ^a   Eddy, Kamryn ^a   Marengi, Dean A ^a   Derrico, Nicholas P ^a   Bouxsein, Mary L ^a,c   Misra, Madhusmita ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; HORMONE; IRISIN; UNCLASSIFIED DRUG; FIBROBLAST GROWTH FACTOR; FIBRONECTIN; FNDC5 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AMENORRHEIC ATHLETE; ARTICLE; ATHLETE; BODY COMPOSITION; BONE DENSITY; BONE STRENGTH; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENERGY EXPENDITURE; EUMENORRHEIC ATHLETE; FAT MASS; FEMALE; FINITE ELEMENT ANALYSIS; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; NON ATHLETE; NORMAL HUMAN; QUANTITATIVE ANALYSIS; RESTING ENERGY EXPENDITURE; YOUNG ADULT; AMENORRHEA; ANATOMY AND HISTOLOGY; BLOOD; BONE; CASE CONTROL STUDY; MENSTRUATION; PHOTON ABSORPTIOMETRY; PHYSIOLOGY;

ABSORPTIOMETRY, PHOTON; ADOLESCENT; ADULT; AMENORRHEA; ATHLETES; BONE AND BONES; BONE DENSITY; CASE-CONTROL STUDIES; FEMALE; FIBROBLAST GROWTH FACTORS; FIBRONECTINS; HUMANS; MENSTRUATION; YOUNG ADULT;

EID: 84902825375     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100218     Document Type: Article

References (43)

1. Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, et al. (2014) Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab 19: 302-309.
2. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481: 463-468.
3. Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61: 1725-1738.
4. Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 26: 271-281.
5. Lee P, Brychta RJ, Linderman J, Smith S, Chen KY, et al. Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis. J Clin Endocrinol Metab 98: E98-102.
6. Cuevas-Ramos D, Almeda-Valdes P, Gomez-Perez FJ, Meza-Arana CE, Cruz-Bautista I, et al. Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels. Eur J Endocrinol 163: 469-477.
7. Cuevas-Ramos D, Almeda-Valdes P, Meza-Arana CE, Brito-Cordova G, Gomez-Perez FJ, et al. Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PLoS One 7: e38022.
8. Lee P, Brychta RJ, Collins MT, Linderman J, Smith S, et al. (2012) Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women. Osteoporos Int 24: 1513-1518.
9. Ponrartana S, Aggabao PC, Hu HH, Aldrovandi GM, Wren TA, et al. (2012) Brown adipose tissue and its relationship to bone structure in pediatric patients. J Clin Endocrinol Metab 97: 2693-2698.
10. Zhang J, Cheng J, Tu Q, Chen J (2013) Effects of Irisin on Bone Metabolism and its Signal Transduction ASBMR 2013 Book of Abstracts.
11. Wei W, Dutchak PA, Wang X, Ding X, Bookout AL, et al. (2012) Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor gamma. Proc Natl Acad Sci U S A 109: 3143-3148.
12. Lee P, Linderman J, Smith S, Brychta RJ, Perron R, et al. (2013) Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans? Osteoporos Int.
13. Ishida K, Haudenschild DR (2013) Interactions between FGF21 and BMP-2 in osteogenesis. Biochem Biophys Res Commun 432: 677-682.
14. Ackerman KE, Nazem T, Chapko D, Russell M, Mendes N, et al. (2011) Bone microarchitecture is impaired in adolescent amenorrheic athletes compared with eumenorrheic athletes and nonathletic controls. J Clin Endocrinol Metab 96: 3123-3133.
15. Ackerman K, Putman M, Guereca G, Taylor A, Pierce L, et al. (2012) Cortical Microstructure and Estimated Bone Strength in Young Amenorrheic Athletes, Eumenorrheic Athletes and Non-Athletes. Bone In Press.
16. Lawson EA, Ackerman KE, Estella NM, Guereca G, Pierce L, et al. (2013) Nocturnal oxytocin secretion is lower in amenorrheic athletes than nonathletes and associated with bone microarchitecture and finite element analysis parameters. Eur J Endocrinol 168: 457-464.
17. Fazeli PK, Ackerman KE, Pierce L, Guereca G, Bouxsein M, et al. (2013) Sclerostin and Pref-1 have differential effects on bone mineral density and strength parameters in adolescent athletes compared with non-athletes. Osteoporos Int 24: 2433-2440.
18. Harris JA, Benedict FG (1918) A Biometric Study of Human Basal Metabolism. Proc Natl Acad Sci U S A 4: 370-373.
19. Weir JB (1949) New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109: 1-9.
20. Peter PR, Park KH, Huh JY, Wedick NM, Mantzoros CS (2014) Circulating irisin levels are not affected by coffee intake: a randomized controlled trial. PLoS One 9: e94463.
21. Hecksteden A, Wegmann M, Steffen A, Kraushaar J, Morsch A, et al. (2013) Irisin and exercise training in humans - results from a randomized controlled training trial. BMC Med 11: 235.
22. Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, et al. (2012) FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61: 1725-1738.
23. Miller KK, Rosner W, Lee H, Hier J, Sesmilo G, et al. (2004) Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods. J Clin Endocrinol Metab 89: 525-533. (Pubitemid 38269853)
24. Dostalova I, Kavalkova P, Haluzikova D, Lacinova Z, Mraz M, et al. (2008) Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. J Clin Endocrinol Metab 93: 3627-3632.
25. Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, et al. (2013) Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity-correlation with body mass index. Peptides 39: 125-130.
26. Norheim F, Langleite TM, Hjorth M, Holen T, Kielland A, et al. (2014) The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans. FEBS J 281: 739-749.
27. Park KH, Zaichenko L, Brinkoetter M, Thakkar B, Sahin-Efe A, et al. (2013) Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab 98: 4899-4907.
28. Bredella MA, Fazeli PK, Freedman LM, Calder G, Lee H, et al. (2012) Young women with cold-activated brown adipose tissue have higher bone mineral density and lower Pref-1 than women without brown adipose tissue: a study in women with anorexia nervosa, women recovered from anorexia nervosa, and normal-weight women. J Clin Endocrinol Metab 97: E584-590.
29. Hofmann T, Elbelt U, Ahnis A, Kobelt P, Rose M, et al. (2014) Irisin Levels are Not Affected by Physical Activity in Patients with Anorexia Nervosa. Front Endocrinol (Lausanne) 4: 202.
30. Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, et al. (2014) Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol 592: 1091-1107.
31. Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, et al. (2013) Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab 98: E769-778.
32. Bluher S, Panagiotou G, Petroff D, Markert J, Wagner A, et al. (2014) Effects of a 1-year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children. Obesity (Silver Spring).
33. Anastasilakis AD, Polyzos SA, Makras P, Gkiomisi A, Bisbinas I, et al. (2014) Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months. Osteoporos Int 25: 1633-1642.
34. Colaianni G, Cuscito C, Mongelli T, Oranger A, Mori G, et al. (2014) Irisin enhances osteoblast differentiation in vitro. Int J Endocrinol 2014: 902186.
35. Kim KH, Kim SH, Min YK, Yang HM, Lee JB, et al. (2013) Acute exercise induces FGF21 expression in mice and in healthy humans. PLoS One 8: e63517.
36. Cuevas-Ramos D, Almeda-Valdes P, Meza-Arana CE, Brito-Cordova G, Gomez-Perez FJ, et al. (2012) Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PLoS One 7: e38022.
37. Fletcher JA, Meers GM, Laughlin MH, Ibdah JA, Thyfault JP, et al. (2012) Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction. Appl Physiol Nutr Metab 37: 1054-1062.
38. Yang SJ, Hong HC, Choi HY, Yoo HJ, Cho GJ, et al. (2011) Effects of a three-month combined exercise programme on fibroblast growth factor 21 and fetuin-A levels and arterial stiffness in obese women. Clin Endocrinol (Oxf) 75: 464-469.
39. Reinehr T, Woelfle J, Wunsch R, Roth CL Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis. J Clin Endocrinol Metab 97: 2143-2150.
40. Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 57: 1246-1253.
41. Shen Y, Ma X, Zhou J, Pan X, Hao Y, et al. (2013) Additive relationship between serum fibroblast growth factor 21 level and coronary artery disease. Cardiovasc Diabetol 12: 124.
42. Gorar S, Culha C, Uc ZA, Dellal FD, Serter R, et al. (2010) Serum fibroblast growth factor 21 levels in polycystic ovary syndrome. Gynecol Endocrinol 26: 819-826.
43. Sahin SB, Ayaz T, Cure MC, Sezgin H, Ural UM, et al. (2014) Fibroblast growth factor 21 and its relation to metabolic parameters in women with polycystic ovary syndrome. Scand J Clin Lab Invest.