Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury

American Journal of Physiology - Cell Physiology

Volumn 306, Issue 12, 2014, Pages

  Xu, Aijun ^a,c   Szczepanek, Karol ^a   Maceyka, Michael W ^a   Ross, Thomas ^a   Bowler, Elizabeth ^a,d   Hu, Ying ^a   Kenny, Barrett ^a   Mehfoud, Chris ^a   Desai, Pooja N ^a   Baumgarten, Clive M ^a   Chen, Qun ^a   Lesnefsky, Edward J ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

Author keywords

Cytochrome c; Ischemia; Mitochondrial permeability transition pore; Reactive oxygen species

Indexed keywords

ACONITATE HYDRATASE; BUFFER; CALCIUM ION; CITRATE SYNTHASE; LACTATE DEHYDROGENASE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ACIDIFICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART INFARCTION; HEART INJURY; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; MALE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; REPERFUSION;

CYTOCHROME C; ISCHEMIA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN SPECIES;

ACIDS; ANIMALS; CALCIUM; CELL RESPIRATION; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; MICE; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANES; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; ORGAN CULTURE TECHNIQUES; REACTIVE OXYGEN SPECIES;

EID: 84902662047     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00241.2013     Document Type: Article

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