Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 536-544

  Alipour, Masoumeh ^a   Khoobi, Mehdi ^a   Moradi, Alireza ^b   Nadri, Hamid ^b   Homayouni Moghadam, Farshad ^b   Emami, Saeed ^c   Hasanpour, Zeinab ^a   Foroumadi, Alireza ^a   Shafiee, Abbas ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Coumarins; Docking study

Indexed keywords

4 METHYL 7 [4 OXO 4 (4 PHENYLPIPERAZIN 1 YL)BUTOXY] 2H CHROMEN 2 ONE; 7 [2 (4 BENZYLPIPERIDIN 1 YL) 2 OXOETHOXY] 2H CHROMEN 2 ONE; 7 [2 OXO 2 (4 PHENYLPIPERAZIN 1 YL)ETHOXY] 2H CHROMEN 2 ONE; 7 [2 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHOXY] 2H CHROMEN 2 ONE; 7 [2 [4 (3,4 DICHLOROPHENYL)PIPERAZIN 1 YL] 2 OXOETHOXY] 2H CHROMEN 2 ONE; 7 [4 (4 BENZYLPIPERIDIN 1 YL) 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 7 [4 OXO 4 (4 PHENYLPIPERAZIN 1 YL)BUTOXY] 2H CHROMEN 2 ONE; 7 [4 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 7 [4 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 4 METHYL 2H CHROMEN 2 ONE; 7 [4 [4 (2 HYDROXYPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 7 [4 [4 (2 HYDROXYPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 4 METHYL 2H CHROMEN 2 ONE; 7 [4 [4 (3,4 DICHLOROPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 7 [4 [4 (3,4 DICHLOROPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 4 METHYL 2H CHROMEN 2 ONE; 7 [4 [4 (4 BROMOPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 7 [4 [4 (4 BROMOPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 4 OXOBUTOXY] 4 METHYL 2H CHROMEN 2 ONE; 7 [4 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 2H CHROMEN 2 ONE; 7 [4 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 4 OXOBUTOXY] 4 METHYL 2H CHROMEN 2 ONE; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; LIGAND; N (1 BENZYLPIPERIDIN 4 YL) 2 [(2 OXO 2H CHROMEN 7 YL) OXY]ACETAMIDE; N (3,4 DIMETHOXYPHENETHYL) 2 [(2 OXO 2H CHROMEN 7 YL) OXY]ACETAMIDE; UMBELLIFERONE DERIVATIVE; UNCLASSIFIED DRUG; 7-HYDROXYCOUMARIN; HYDROGEN PEROXIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CHOLINESTERASE INHIBITION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; MOLECULAR MODEL; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PH; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ELECTROPHORUS; HORSE; METABOLISM; PC12 CELL LINE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CELL DEATH; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORUS; HORSES; HYDROGEN PEROXIDE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PC12 CELLS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; UMBELLIFERONES;

EID: 84902660803     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.056     Document Type: Article

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