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Volumn 20, Issue 12, 2014, Pages 3159-3173

Autophagy inhibition augments the anticancer effects of epirubicin treatment in anthracycline-sensitive and -resistant triple-negative breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE DERIVATIVE; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; CELL PROTEIN; DOXORUBICIN; EPIRUBICIN; HYDROXYCHLOROQUINE; MITOXANTRONE; UNCLASSIFIED DRUG; ANTHRACYCLINE; ANTINEOPLASTIC ANTIBIOTIC;

EID: 84902652254     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-2060     Document Type: Article
Times cited : (127)

References (47)
  • 1
    • 28344454000 scopus 로고    scopus 로고
    • Molecular classification and molecular forecasting of breast cancer: Ready for clinical application?
    • DOI 10.1200/JCO.2005.03.3845
    • Brenton JD, Carey LA, Ahmed AA, Caldas C. Molecular classification and molecular forecasting of breast cancer: ready for clinical application? J Clin Oncol 2005;23:7350-60. (Pubitemid 46202348)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.29 , pp. 7350-7360
    • Brenton, J.D.1    Carey, L.A.2    Ahmed, A.3    Caldas, C.4
  • 2
    • 79959503213 scopus 로고    scopus 로고
    • Triple-negative breast cancer: An unmet medical need
    • Suppl 1
    • Hudis CA, Gianni L. Triple-negative breast cancer: an unmet medical need. Oncologist 2011;16(Suppl 1):1-11.
    • (2011) Oncologist , vol.16 , pp. 1-11
    • Hudis, C.A.1    Gianni, L.2
  • 3
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011;121:2750-67.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3    Sanders, M.E.4    Chakravarthy, A.B.5    Shyr, Y.6
  • 4
    • 84862526929 scopus 로고    scopus 로고
    • The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    • Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 2012;486:395-9.
    • (2012) Nature , vol.486 , pp. 395-399
    • Shah, S.P.1    Roth, A.2    Goya, R.3    Oloumi, A.4    Ha, G.5    Zhao, Y.6
  • 6
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008;132:27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 7
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation: Core machinery and adaptations
    • DOI 10.1038/ncb1007-1102, PII NCB1007-1102
    • Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007;9:1102-9. (Pubitemid 47500484)
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 8
    • 27644466759 scopus 로고    scopus 로고
    • Autophagy and signaling: Their role in cell survival and cell death
    • DOI 10.1038/sj.cdd.4401751, PII 4401751
    • Codogno P, Meijer AJ. Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 2005;12(Suppl 2):1509-18. (Pubitemid 41553987)
    • (2005) Cell Death and Differentiation , vol.12 , Issue.SUPPL. 2 , pp. 1509-1518
    • Codogno, P.1    Meijer, A.J.2
  • 10
    • 0017697151 scopus 로고
    • Induction of autophagy by amino-acid deprivation in perfused rat liver
    • DOI 10.1038/270174a0
    • Mortimore GE, Schworer CM. Induction of autophagy by amino-acid deprivation in perfused rat liver. Nature 1977;270:174-6. (Pubitemid 8209074)
    • (1977) Nature , vol.270 , Issue.5633 , pp. 174-176
    • Mortimore, G.E.1    Schworer, C.M.2
  • 11
    • 40449086885 scopus 로고    scopus 로고
    • Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
    • DOI 10.1158/0008-5472.CAN-07-0562
    • Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008;68:1485-94. (Pubitemid 351346857)
    • (2008) Cancer Research , vol.68 , Issue.5 , pp. 1485-1494
    • Apel, A.1    Herr, I.2    Schwarz, H.3    Rodemann, H.P.4    Mayer, A.5
  • 12
    • 56549116658 scopus 로고    scopus 로고
    • Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization
    • Qadir MA, Kwok B, Dragowska WH, To KH, Le D, Bally MB, et al. Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization. Breast Cancer Res Treat 2008;112:389-403.
    • (2008) Breast Cancer Res Treat , vol.112 , pp. 389-403
    • Qadir, M.A.1    Kwok, B.2    Dragowska, W.H.3    To, K.H.4    Le, D.5    Bally, M.B.6
  • 13
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • DOI 10.1038/sj.emboj.7601623, PII 7601623
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007;26:1749-60. (Pubitemid 46624042)
    • (2007) EMBO Journal , vol.26 , Issue.7 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 14
    • 80755132255 scopus 로고    scopus 로고
    • Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study
    • Shen S, Kepp O, Michaud M, Martins I, Minoux H, Métivier D, et al. Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study. Oncogene 2011;30:4544-56.
    • (2011) Oncogene , vol.30 , pp. 4544-4556
    • Shen, S.1    Kepp, O.2    Michaud, M.3    Martins, I.4    Minoux, H.5    Métivier, D.6
  • 15
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009;15:5308-16.
    • (2009) Clin Cancer Res , vol.15 , pp. 5308-5316
    • White, E.1    DiPaola, R.S.2
  • 16
    • 34248549830 scopus 로고    scopus 로고
    • Autophagy as a mechanism of radiation sensitization in breast tumor cells
    • Gewirtz DA. Autophagy as a mechanism of radiation sensitization in breast tumor cells. Autophagy 2007;3:249-50. (Pubitemid 46752688)
    • (2007) Autophagy , vol.3 , Issue.3 , pp. 249-250
    • Gewirtz, D.A.1
  • 17
    • 54049151248 scopus 로고    scopus 로고
    • A role for macroautophagy in protection against 4-hydroxytamoxifen- induced cell death and the development of antiestrogen resistance
    • Samaddar JS, Gaddy VT, Duplantier J, Thandavan SP, Shah M, Smith MJ, et al. A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance. Mol Cancer Ther 2008;7:2977-87.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2977-2987
    • Samaddar, J.S.1    Gaddy, V.T.2    Duplantier, J.3    Thandavan, S.P.4    Shah, M.5    Smith, M.J.6
  • 19
    • 84861961464 scopus 로고    scopus 로고
    • Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells
    • Rao R, Balusu R, Fiskus W, Mudunuru U, Venkannagari S, Chauhan L, et al. Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells. Mol Cancer Ther 2012;11:973-83.
    • (2012) Mol Cancer Ther , vol.11 , pp. 973-983
    • Rao, R.1    Balusu, R.2    Fiskus, W.3    Mudunuru, U.4    Venkannagari, S.5    Chauhan, L.6
  • 21
    • 66449122303 scopus 로고    scopus 로고
    • Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
    • Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009;119:1109-23.
    • (2009) J Clin Invest , vol.119 , pp. 1109-1123
    • Bellodi, C.1    Lidonnici, M.R.2    Hamilton, A.3    Helgason, G.V.4    Soliera, A.R.5    Ronchetti, M.6
  • 22
    • 84869475093 scopus 로고    scopus 로고
    • Breast cancer and autophagy
    • Romero ME, Dashek LM, editors. New York: Nova Science Publishers Inc.
    • Armstrong LJ, Gorski SM. Breast cancer and autophagy. In:Romero ME, Dashek LM, editors. In breast cancer: causes, diagnosis and treatment. New York: Nova Science Publishers Inc.; 2010. p. 53-88.
    • (2010) In Breast Cancer: Causes, Diagnosis and Treatment , pp. 53-88
    • Armstrong, L.J.1    Gorski, S.M.2
  • 23
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010;140:313-26.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 24
    • 78751556979 scopus 로고    scopus 로고
    • Autophagy as a therapeutic target in cancer
    • Chen N, Karantza V. Autophagy as a therapeutic target in cancer. Cancer Biol Ther 2011;11:157-68.
    • (2011) Cancer Biol Ther , vol.11 , pp. 157-168
    • Chen, N.1    Karantza, V.2
  • 25
    • 78650215702 scopus 로고    scopus 로고
    • Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes
    • Al-Ejeh F, Kumar R, Wiegmans A, Lakhani SR, Brown MP, Khanna KK. Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene 2010;29:6085-98.
    • (2010) Oncogene , vol.29 , pp. 6085-6098
    • Al-Ejeh, F.1    Kumar, R.2    Wiegmans, A.3    Lakhani, S.R.4    Brown, M.P.5    Khanna, K.K.6
  • 26
    • 54249107573 scopus 로고    scopus 로고
    • Regulation of estrogenic effects by beclin 1 in breast cancer cells
    • John S, Nayvelt I, Hsu H-C, Yang P, Liu W, Das GM, et al. Regulation of estrogenic effects by beclin 1 in breast cancer cells. Cancer Res 2008;68:7855-63.
    • (2008) Cancer Res , vol.68 , pp. 7855-7863
    • John, S.1    Nayvelt, I.2    Hsu, H.-C.3    Yang, P.4    Liu, W.5    Das, G.M.6
  • 28
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007;3:452-60. (Pubitemid 47293726)
    • (2007) Autophagy , vol.3 , Issue.5 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 29
    • 0038783150 scopus 로고    scopus 로고
    • Epirubicin versus doxorubicin: Which is the anthracycline of choice for the treatment of breast cancer?
    • Kaklamani VG, Gradishar WJ. Epirubicin versus doxorubicin: which is the anthracycline of choice for the treatment of breast cancer? Clin Breast Cancer 2003;4(Suppl 1):S26-33. (Pubitemid 36621613)
    • (2003) Clinical Breast Cancer , vol.4 , Issue.SUPPL. 1
    • Kaklamani, V.G.1    Gradishar, W.J.2
  • 30
    • 80052306066 scopus 로고    scopus 로고
    • Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development
    • Sun W-L, Chen J, Wang Y-P, Zheng H. Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development. Autophagy 2011;7:1035-44.
    • (2011) Autophagy , vol.7 , pp. 1035-1044
    • Sun, W.-L.1    Chen, J.2    Wang, Y.-P.3    Zheng, H.4
  • 31
    • 0023158838 scopus 로고
    • Epirubicin treatment of advanced breast carcinoma with the weekly low-dose regimen
    • Beretta G, Locatelli C, Tabiadon D, Labianca R, Fraschini P, Luporini G. Epirubicin treatment of advanced breast carcinoma with the weekly low-dose regimen. Oncology 1987;44:6-12. (Pubitemid 17028384)
    • (1987) Oncology , vol.44 , Issue.1 , pp. 6-12
    • Beretta, G.1    Locatelli, C.2    Tabiadon, D.3
  • 34
    • 67650885510 scopus 로고    scopus 로고
    • Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab
    • Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS ONE 2009;4:e6251.
    • (2009) PLoS ONE , vol.4
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Menendez, J.A.3
  • 36
    • 84871122319 scopus 로고    scopus 로고
    • Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer
    • Choi J, Jung W, Koo JS. Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer. Histopathology 2013;62:275-86.
    • (2013) Histopathology , vol.62 , pp. 275-286
    • Choi, J.1    Jung, W.2    Koo, J.S.3
  • 37
    • 84880630413 scopus 로고    scopus 로고
    • High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer
    • Zhao H, Yang M, Zhao J, Wang J, Zhang Y, Zhang Q. High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer. Med Oncol 2013;30:475.
    • (2013) Med Oncol , vol.30 , pp. 475
    • Zhao, H.1    Yang, M.2    Zhao, J.3    Wang, J.4    Zhang, Y.5    Zhang, Q.6
  • 38
    • 84865300412 scopus 로고    scopus 로고
    • Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors
    • Thomas S, Sharma N, Golden EB, Cho H, Agarwal P, Gaffney KJ, et al. Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. Cancer Lett 2012;325:63-71.
    • (2012) Cancer Lett , vol.325 , pp. 63-71
    • Thomas, S.1    Sharma, N.2    Golden, E.B.3    Cho, H.4    Agarwal, P.5    Gaffney, K.J.6
  • 40
    • 63849308518 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells
    • Oh S-H, Lim S-C. Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells. J Pharmacol Exp Ther 2009;329:112-22.
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 112-122
    • Oh, S.-H.1    Lim, S.-C.2
  • 41
    • 80053634368 scopus 로고    scopus 로고
    • The dynamic nature of autophagy in cancer
    • Kimmelman AC. The dynamic nature of autophagy in cancer. Genes Dev 2011;25:1999-2010.
    • (2011) Genes Dev , vol.25 , pp. 1999-2010
    • Kimmelman, A.C.1
  • 42
    • 78751511180 scopus 로고    scopus 로고
    • Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
    • Lock R, Roy S, Kenific CM, Su JS, Salas E, Ronen SM, et al. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell 2011;22:165-78.
    • (2011) Mol Biol Cell , vol.22 , pp. 165-178
    • Lock, R.1    Roy, S.2    Kenific, C.M.3    Su, J.S.4    Salas, E.5    Ronen, S.M.6
  • 43
    • 84879777723 scopus 로고    scopus 로고
    • Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomasand maintains lipid homeostasis
    • Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomasand maintains lipid homeostasis. Genes Dev 2013;27:1447-61.
    • (2013) Genes Dev , vol.27 , pp. 1447-1461
    • Guo, J.Y.1    Karsli-Uzunbas, G.2    Mathew, R.3    Aisner, S.C.4    Kamphorst, J.J.5    Strohecker, A.M.6
  • 44
  • 45
    • 0027434905 scopus 로고
    • Mechanism of action of hydroxychloroquine as an antirheumatic drug
    • Fox RI. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Semin Arthritis Rheum 1993;23:82-91.
    • (1993) Semin Arthritis Rheum , vol.23 , pp. 82-91
    • Fox, R.I.1
  • 46
    • 0037442806 scopus 로고    scopus 로고
    • +-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells
    • +-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells. Biochem J 2003;370:185-93.
    • (2003) Biochem J , vol.370 , pp. 185-193
    • Ouar, Z.1    Bens, M.2    Vignes, C.3    Paulais, M.4    Pringel, C.5    Fleury, J.6
  • 47
    • 84861434652 scopus 로고    scopus 로고
    • Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
    • McAfee Q, Zhang Z, Samanta A, Levi SM, Ma X-H, Piao S, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A. 2012;109:8253-8.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 8253-8258
    • McAfee, Q.1    Zhang, Z.2    Samanta, A.3    Levi, S.M.4    Ma, X.-H.5    Piao, S.6


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