β2-Adrenoceptor involved in smoking-induced airway mucus hypersecretion through β-arrestin-dependent signaling

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Zhou, Yujiao ^a,b   Zhang, Yuan ^a,b   Guo, Yang ^c   Zhang, Youyi ^a,b   Xu, Ming ^a,b   He, Bei ^a,b  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b Beijing Key Laboratory of Cardiovascular Receptors Research Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides   (China)

^c Department of Respiratory Medicine Changji Renmin Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ARRESTIN; CIGARETTE SMOKE; PROPRANOLOL; SMALL INTERFERING RNA;

AIRWAY MUCUS HYPERSECRETION; AIRWAY PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GOBLET CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTERNALIZATION; LUNG FUNCTION TEST; MALE; MUCUS SECRETION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOKING;

EID: 84902596935     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097788     Document Type: Article

References (50)

1. Chakravorty I, Chahal K, Austin G (2011) A pilot study of the impact of high-frequency chest wall oscillation in chronic obstructive pulmonary disease patients with mucus hypersecretion. Int J Chron Obstruct Pulmon Dis 6: 693-699.
2. Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, et al. (2008) Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol 38: 446-454. (Pubitemid 351758691)
3. Kim ST, Ye MK, Shin SH (2011) Effects of Asian sand dust on mucin gene expression and activation of nasal polyp epithelial cells. Am J Rhinol Allergy 25: 303-306.
4. Di YP, Zhao J, Harper R (2012) Cigarette smoke induces MUC5AC protein expression through the activation of Sp1. J Biol Chem 287: 27948-27958.
5. Mebratu YA, Schwalm K, Smith KR, Schuyler M, Tesfaigzi Y (2011) Cigarette Smoke Suppresses Bik To Cause Epithelial Cell Hyperplasia and Mucous Cell Metaplasia. Am J Respir Crit Care Med 183: 1531-1538.
6. Nyunoya T, Mebratu Y, Contreras A, Delgado M, Chand HS, et al. (2013) Molecular Processes That Drive Cigarette Smoke-Induced Epithelial Cell Fate of the Lung. Am J Respir Cell Mol Biol.
7. Nguyen LP, Ozozoma O, Sergio P, Joanna MF, Cecilia C, et al. (2008) Chronic Exposure to Beta-Blockers Attenuates Inflammation and Mucin Content in a Murine Asthma Model. Am J Respir Cell Mol Biol.: 256-262. (Pubitemid 351567693)
8. 2-adrenoceptor agonists induces dysfunction of airway β2-adrenoceptors and exacerbates lung inflammation in mice. Br J Pharmacol 165: 2365-2377.
9. Nguyen LP, Lin R, Parra S, Omoluabi O, Hanania NA, et al. (2009) β2-Adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A 106: 2435-2440.
10. Stefan MS, Rothberg MB, Priya A, Pekow PS, Au DH, et al. (2012) Association between beta-blocker therapy and outcomes in patients hospitalised with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension. Thorax 67: 977-984.
11. Short PM, Lipworth SI, Elder DH, Schembri S, Lipworth BJ (2011) Effect of beta blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort study. BMJ 342: d2549.
12. Guo Y, Zhang Y, Shen N, Zhou Y, Zhang Y, et al. (2014) Effects of one month treatment with propranolol and metoprolol on the relaxant and contractile function of isolated trachea from rats exposed to cigarette smoke for four months. Inhal Toxicol 26: 271-277.
13. Hellermann GR, Nagy SB, Kong X, Lockey RF, Mohapatra SS (2002) Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells. Respir Res 3: 22.
14. Chen YH, Wu R, Geng B, Qi YF, Wang PP, et al. (2009) Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma. Cytokine 45: 117-123.
15. Cosio M, Ghezzo H, Hogg JC, Corbin R, Loveland M, et al. (1978) The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med 298: 1277-1281. (Pubitemid 8361451)
16. James AL, Hogg JC, Dunn LA, Pare PD (1988) The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening. Am Rev Respir Dis 138: 136-139.
17. Livak KJ, Schmittgen T (2001) Analysis Of real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods: 402-408.
18. Billington CK, Ojo OO, Penn RB, Ito S (2013) cAMP regulation of airway smooth muscle function. Pulm Pharmacol Ther 26: 112-120.
19. Por ED, Bierbower SM, Berg KA, Gomez R, Akopian AN, et al. (2012) β-Arrestin-2 Desensitizes the Transient Receptor Potential Vanilloid 1 (TRPV1) Channel*. J Biol Chem 287: 37552-37563.
20. 2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin. Sci Signal 4: a51.
21. DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, et al. (2008) β-Arrestin-mediated Signaling Regulates Protein Synthesis. J Biol Chem 283: 10611-10620.
22. Yang M, He RL, Benovic JL, Ye RD (2009) β-arrestin1 interacts with the G protein subunits 1β γ2 and promotes β1 γ2-dependent Akt signaling for NF-κB activation. Biochem J 417: 287-296.
23. Fujisawa T, Ide K, Holtzman MJ, Suda T, Suzuki K, et al. (2008) Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells. Respirology 13: 191-202. (Pubitemid 351388781)
24. Song JS, Cho KS, Yoon HK, Moon HS, Park SH (2005) Neutrophil elastase causes MUC5AC mucin synthesis via EGF receptor, ERK and NF-kB pathways in A549 cells. Korean J Intern Med 20: 275-283.
25. Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, et al. (2006) beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem 281: 1261-1273.
26. Kargin F, Takir HB, Salturk C, Goksenoglu NC, Karabay CY, et al. (2014) The safety of beta-blocker use in chronic obstructive pulmonary disease patients with respiratory failure in the intensive care unit. Multidiscip Respir Med 9: 8.
27. Foresi A, Cavigioli G, Signorelli G, Pozzoni MB, Olivieri D (2010) Is the use of beta-blockers in COPD still an unresolved dilemma? Respiration 80: 177-187.
28. Minor DS, Meyer AM, Long RC, Butler KJ (2013) beta-Blockers and chronic obstructive pulmonary disease: inappropriate avoidance? J Clin Hypertens (Greenwich) 15: 925-930.
29. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, et al. (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350: 2645-2653. (Pubitemid 38787999)
30. Tan KS, Nackley AG, Satterfield K, Maixner W, Diatchenko L, et al. (2007) Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. Cell Signal 19: 251-260. (Pubitemid 46017083)
31. Oldenburger A, Roscioni SS, Jansen E, Menzen MH, Halayko AJ, et al. (2012) Anti-Inflammatory Role of the cAMP Effectors Epac and PKA: Implications in Chronic Obstructive Pulmonary Disease. PLoS One 7.
32. Gjertsen BT, Mellgren G, Otten A, Maronde E, Genieser HG, et al. (1995) Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action. J Biol Chem 270: 20599-20607.
33. Dicpinigaitis PV (2003) Cough reflex sensitivity in cigarette smokers. Chest 123: 685-688.
34. Sarir H, Mortaz E, Karimi K, Kraneveld AD, Rahman I, et al. (2009) Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages. J Inflamm (Lond) 6: 12.
35. Clunes LA, Davies CM, Coakley RD, Aleksandrov AA, Henderson AG, et al. (2012) Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. FASEB J 26: 533-545.
36. Shukla AK, Xiao K, Lefkowitz RJ (2011) Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci 36: 457-469.
37. Vibhuti A, Gupta K, Subramanian H, Guo Q, Ali H (2011) Distinct and Shared Roles of β-Arrestin-1 and β-Arrestin-2 on the Regulation of C3a Receptor Signaling in Human Mast Cells. PLoS One 6.
38. Song KS, Choi JK, Ahn DW (2013) Src homology 2-containing protein tyrosine phosphatase-2 acts as a negative regulator for MUC5AC transcription via the inhibition of the ERK1/2 MAPK signalling pathway in the airway. Acta Physiol (Oxf) 208: 245-250.
39. Choi WI, Syrkina O, Kwon KY, Quinn DA, Hales CA (2010) JNK activation is responsible for mucus overproduction in smoke inhalation injury. Respir Res 11: 172.
40. 2 adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/Protein Kinase A-independent pathway. Glia 57: 1600-1609.
41. Kohout TA, Lin FS, Perry SJ, Conner DA, Lefkowitz RJ (2001) beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc Natl Acad Sci U S A 98: 1601-1606. (Pubitemid 32165545)
42. Quint JK, Herrett E, Bhaskaran K, Timmis A, Hemingway H, et al. (2013) Effect of beta blockers on mortality after myocardial infarction in adults with COPD: population based cohort study of UK electronic healthcare records. BMJ 347: f6650.
43. 2-adrenoceptor ligands on airway function in a murine model of asthma. Proc Natl Acad Sci U S A 101: 4948-4953.
44. Rutten FH, Zuithoff NP, Hak E, Grobbee DE, Hoes AW (2010) Beta-blockers may reduce mortality and risk of exacerbations in patients with chronic obstructive pulmonary disease. Arch Intern Med 170: 880-887.
45. Guo Y, Zhang Y, Shen N, Zhou Y, Zhang Y, et al. (2014) Effects of long-term treatment with propranolol on the relaxation function of trachea isolated from rats exposed to cigarette smoke. Ihalation Toxicology, in press.
46. Rogers DF (2001) Motor control of airway goblet cells and glands. Respir Physiol 125: 129-144.
47. McGraw DW, Forbes SL, Mak JC, Witte DP, Carrigan PE, et al. (2000) Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. Am J Physiol Lung Cell Mol Physiol 279: L379-L389.
48. 2-adrenoceptors in human airways. Br J Pharmacol 166: 1804-1814.
49. Paul-Clark MJ, McMaster SK, Sorrentino R, Sriskandan S, Bailey LK, et al. (2009) Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Am J Respir Crit Care Med 179: 299-306.
50. Mossman BT, Lounsbury KM, Reddy SP (2006) Oxidants and Signaling by Mitogen-Activated Protein Kinases in Lung Epithelium. Am J Respir Cell Mol Biol 34: 666-669. (Pubitemid 43825330)