-
1
-
-
84862803170
-
New perspectives on the biology of fragile X syndrome
-
Wang T, Bray SM, Warren ST,. New perspectives on the biology of fragile X syndrome. Curr Opin Genet Dev 2012; 22: 256-263.
-
(2012)
Curr Opin Genet Dev
, vol.22
, pp. 256-263
-
-
Wang, T.1
Bray, S.M.2
Warren, S.T.3
-
2
-
-
77951498581
-
Adult hippocampal neurogenesis, synaptic plasticity and memory: Facts and hypotheses
-
Deng W, Aimone JB, Gage FH,. Adult hippocampal neurogenesis, synaptic plasticity and memory: Facts and hypotheses. Nat Rev Neurosci 2010; 11: 339-350.
-
(2010)
Nat Rev Neurosci
, vol.11
, pp. 339-350
-
-
Deng, W.1
Aimone, J.B.2
Gage, F.H.3
-
3
-
-
2342635196
-
The fragile-X premutation: A maturing perspective
-
Hagerman PJ, Hagerman RJ,. The fragile-X premutation: A maturing perspective. Am J Hum Genet 2004; 74: 805-816.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 805-816
-
-
Hagerman, P.J.1
Hagerman, R.J.2
-
5
-
-
17444384228
-
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes
-
Darnell JC, Fraser CE, Mostovetsky O, et al. Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev 2005; 19: 903-918.
-
(2005)
Genes Dev
, vol.19
, pp. 903-918
-
-
Darnell, J.C.1
Fraser, C.E.2
Mostovetsky, O.3
-
6
-
-
0034618767
-
RNAs that interact with the Fragile X syndrome RNA binding protein FMRP
-
Sung YJ, Conti J, Currie JR, et al. RNAs that interact with the Fragile X syndrome RNA binding protein FMRP. Biochem Biophys Res Commun 2000; 275: 973-980.
-
(2000)
Biochem Biophys Res Commun
, vol.275
, pp. 973-980
-
-
Sung, Y.J.1
Conti, J.2
Currie, J.R.3
-
7
-
-
84871413198
-
FMRP targets distinct mRNA sequence elements to regulate protein expression
-
Ascano M, Jr., Mukherjee N, Bandaru P, et al. FMRP targets distinct mRNA sequence elements to regulate protein expression. Nature 2012; 492: 382-386.
-
(2012)
Nature
, vol.492
, pp. 382-386
-
-
Ascano, Jr.M.1
Mukherjee, N.2
Bandaru, P.3
-
8
-
-
41149153256
-
Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP
-
Reeve SP, Lin XD, Sahin HB, et al. Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. J Neurosci 2008; 28: 3221-3226.
-
(2008)
J Neurosci
, vol.28
, pp. 3221-3226
-
-
Reeve, S.P.1
Lin, X.D.2
Sahin, H.B.3
-
9
-
-
18044379515
-
Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome
-
Brown V, Jin P, Ceman S, et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 2001; 107: 477-487.
-
(2001)
Cell
, vol.107
, pp. 477-487
-
-
Brown, V.1
Jin, P.2
Ceman, S.3
-
10
-
-
79960779323
-
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
-
Darnell JC, Van Driesche SJ, Zhang CL, et al. FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell 2011; 146: 247-261.
-
(2011)
Cell
, vol.146
, pp. 247-261
-
-
Darnell, J.C.1
Van Driesche, S.J.2
Zhang, C.L.3
-
11
-
-
0347382502
-
Phosphorylation influences the translation state of FMRP-associated polyribosomes
-
Ceman S, O'Donnell WT, Reed M, et al. Phosphorylation influences the translation state of FMRP-associated polyribosomes. Hum Mol Genet 2003; 12: 3295-3305.
-
(2003)
Hum Mol Genet
, vol.12
, pp. 3295-3305
-
-
Ceman, S.1
O'Donnell, W.T.2
Reed, M.3
-
12
-
-
37549044298
-
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group i mGluR and mediated by PP2A
-
Narayanan U, Nalavadi V, Nakamoto M, et al. FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. J Neurosci 2007; 27: 14349-14357.
-
(2007)
J Neurosci
, vol.27
, pp. 14349-14357
-
-
Narayanan, U.1
Nalavadi, V.2
Nakamoto, M.3
-
13
-
-
60849094795
-
Phosphorylation of FMRP inhibits association with Dicer
-
Cheever A, Ceman S,. Phosphorylation of FMRP inhibits association with Dicer. RNA 2009; 15: 362-366.
-
(2009)
RNA
, vol.15
, pp. 362-366
-
-
Cheever, A.1
Ceman, S.2
-
14
-
-
79958045841
-
Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling
-
Muddashetty RS, Nalavadi VC, Gross C, et al. Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling. Mol Cell 2011; 42: 673-688.
-
(2011)
Mol Cell
, vol.42
, pp. 673-688
-
-
Muddashetty, R.S.1
Nalavadi, V.C.2
Gross, C.3
-
15
-
-
68749103452
-
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs
-
Darnell JC, Fraser CE, Mostovetsky O, et al. Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. Hum Mol Genet 2009; 18: 3164-3177.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 3164-3177
-
-
Darnell, J.C.1
Fraser, C.E.2
Mostovetsky, O.3
-
16
-
-
0029069223
-
FXR1, an autosomal homolog of the fragile X mental retardation gene
-
Siomi MC, Siomi H, Sauer WH, et al. FXR1, an autosomal homolog of the fragile X mental retardation gene. EMBO J 1995; 14: 2401-2408.
-
(1995)
EMBO J
, vol.14
, pp. 2401-2408
-
-
Siomi, M.C.1
Siomi, H.2
Sauer, W.H.3
-
17
-
-
3242659054
-
Fxr1 knockout mice show a striated muscle phenotype: Implications for Fxr1p function in vivo
-
Mientjes EJ, Willemsen R, Kirkpatrick LL, et al. Fxr1 knockout mice show a striated muscle phenotype: Implications for Fxr1p function in vivo. Hum Mol Genet 2004; 13: 1291-1302.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 1291-1302
-
-
Mientjes, E.J.1
Willemsen, R.2
Kirkpatrick, L.L.3
-
18
-
-
5344237464
-
Characterization of Fxr1 in Danio rerio; A simple vertebrate model to study costamere development
-
Engels B, van't Padje S, Blonden L, et al. Characterization of Fxr1 in Danio rerio; a simple vertebrate model to study costamere development. J Exp Biol 2004; 207: 3329-3338.
-
(2004)
J Exp Biol
, vol.207
, pp. 3329-3338
-
-
Engels, B.1
Van'T Padje, S.2
Blonden, L.3
-
19
-
-
0029972935
-
Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them
-
Siomi MC, Zhang Y, Siomi H, et al. Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. Molecular and Cellular Biology 1996; 16: 3825-3832.
-
(1996)
Molecular and Cellular Biology
, vol.16
, pp. 3825-3832
-
-
Siomi, M.C.1
Zhang, Y.2
Siomi, H.3
-
20
-
-
46149091254
-
Fragile X-related proteins regulate mammalian circadian behavioral rhythms
-
Zhang J, Fang Z, Jud C, et al. Fragile X-related proteins regulate mammalian circadian behavioral rhythms. Am J Hum Genet 2008; 83: 43-52.
-
(2008)
Am J Hum Genet
, vol.83
, pp. 43-52
-
-
Zhang, J.1
Fang, Z.2
Jud, C.3
-
21
-
-
77950875820
-
A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1
-
Say E, Tay HG, Zhao ZS, et al. A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1. Mol Cell 2010; 38: 236-249.
-
(2010)
Mol Cell
, vol.38
, pp. 236-249
-
-
Say, E.1
Tay, H.G.2
Zhao, Z.S.3
-
22
-
-
0036501460
-
Knockout mouse model for Fxr2: A model for mental retardation
-
Bontekoe CJ, McIlwain KL, Nieuwenhuizen IM, et al. Knockout mouse model for Fxr2: A model for mental retardation. Hum Mol Genet 2002; 11: 487-498.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 487-498
-
-
Bontekoe, C.J.1
McIlwain, K.L.2
Nieuwenhuizen, I.M.3
-
23
-
-
59649126241
-
The FXG: A presynaptic fragile X granule expressed in a subset of developing brain circuits
-
Christie SB, Akins MR, Schwob JE, et al. The FXG: A presynaptic fragile X granule expressed in a subset of developing brain circuits. J Neurosci 2009; 29: 1514-1524.
-
(2009)
J Neurosci
, vol.29
, pp. 1514-1524
-
-
Christie, S.B.1
Akins, M.R.2
Schwob, J.E.3
-
24
-
-
84865848777
-
Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions
-
Akins MR, Leblanc HF, Stackpole EE, et al. Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions. J Comp Neurol 2012; 520: 3687-3706.
-
(2012)
J Comp Neurol
, vol.520
, pp. 3687-3706
-
-
Akins, M.R.1
Leblanc, H.F.2
Stackpole, E.E.3
-
25
-
-
65649083055
-
Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models
-
Zhang J, Hou L, Klann E, et al. Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models. J Neurophysiol 2009; 101: 2572-2580.
-
(2009)
J Neurophysiol
, vol.101
, pp. 2572-2580
-
-
Zhang, J.1
Hou, L.2
Klann, E.3
-
26
-
-
51549108502
-
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP
-
Napoli I, Mercaldo V, Boyl PP, et al. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 2008; 134: 1042-1054.
-
(2008)
Cell
, vol.134
, pp. 1042-1054
-
-
Napoli, I.1
Mercaldo, V.2
Boyl, P.P.3
-
27
-
-
0036792769
-
Fragile X-related protein and VIG associate with the RNA interference machinery
-
Caudy AA, Myers M, Hannon GJ, et al. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev 2002; 16: 2491-2496.
-
(2002)
Genes Dev
, vol.16
, pp. 2491-2496
-
-
Caudy, A.A.1
Myers, M.2
Hannon, G.J.3
-
28
-
-
0036791671
-
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
-
Ishizuka A, Siomi MC, Siomi H,. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev 2002; 16: 2497-2508.
-
(2002)
Genes Dev
, vol.16
, pp. 2497-2508
-
-
Ishizuka, A.1
Siomi, M.C.2
Siomi, H.3
-
29
-
-
33746852731
-
Dicer-derived MicroRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs
-
Plante I, Davidovic L, Ouellet DL, et al. Dicer-derived MicroRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs. J Biomed Biotechnol 2006; 2006: 64347-64358.
-
(2006)
J Biomed Biotechnol
, vol.2006
, pp. 64347-64358
-
-
Plante, I.1
Davidovic, L.2
Ouellet, D.L.3
-
30
-
-
1642540373
-
Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway
-
Jin P, Zarnescu DC, Ceman S, et al. Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci 2004; 7: 113-117.
-
(2004)
Nat Neurosci
, vol.7
, pp. 113-117
-
-
Jin, P.1
Zarnescu, D.C.2
Ceman, S.3
-
31
-
-
75949101467
-
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132
-
Edbauer D, Neilson JR, Foster KA, et al. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron 2010; 65: 373-384.
-
(2010)
Neuron
, vol.65
, pp. 373-384
-
-
Edbauer, D.1
Neilson, J.R.2
Foster, K.A.3
-
32
-
-
27844479666
-
Macrocephaly and the control of brain growth in autistic disorders
-
McCaffery P, Deutsch CK,. Macrocephaly and the control of brain growth in autistic disorders. Prog Neurobiol 2005; 77: 38-56.
-
(2005)
Prog Neurobiol
, vol.77
, pp. 38-56
-
-
McCaffery, P.1
Deutsch, C.K.2
-
33
-
-
33645991941
-
The nuclear MicroSpherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons
-
Davidovic L, Bechara E, Gravel M, et al. The nuclear MicroSpherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons. Hum Mol Genet 2006; 15: 1525-1538.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1525-1538
-
-
Davidovic, L.1
Bechara, E.2
Gravel, M.3
-
34
-
-
36249016834
-
The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules
-
Davidovic L, Jaglin XH, Lepagnol-Bestel AM, et al. The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules. Hum Mol Genet 2007; 16: 3047-3058.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 3047-3058
-
-
Davidovic, L.1
Jaglin, X.H.2
Lepagnol-Bestel, A.M.3
-
35
-
-
84862667070
-
Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected]
-
El Fatimy R, Tremblay S, Dury AY, et al. Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected]. PLoS One 2012; 7: e39338.
-
(2012)
PLoS One
, vol.7
-
-
El Fatimy, R.1
Tremblay, S.2
Dury, A.Y.3
-
36
-
-
44449121279
-
A direct role for FMRP in activity dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome
-
Dictenberg JB, Antar LN, Singer RH, et al. A direct role for FMRP in activity dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev Cell 2008; 14: 926-939.
-
(2008)
Dev Cell
, vol.14
, pp. 926-939
-
-
Dictenberg, J.B.1
Antar, L.N.2
Singer, R.H.3
-
37
-
-
33744966575
-
Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses
-
Antar LN, Li CX, Zhang HL, et al. Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses. Mol Cell Neurosci 2006; 32: 37-48.
-
(2006)
Mol Cell Neurosci
, vol.32
, pp. 37-48
-
-
Antar, L.N.1
Li, C.X.2
Zhang, H.L.3
-
38
-
-
3042647610
-
The mGluR theory of fragile X mental retardation
-
Bear M,. The mGluR theory of fragile X mental retardation. Trends Neurosci 2004; 27: 370-377.
-
(2004)
Trends Neurosci
, vol.27
, pp. 370-377
-
-
Bear, M.1
-
39
-
-
77956132014
-
Epigenetic regulation of neuronal dendrite and dendritic spine development
-
Smrt RD, Zhao X,. Epigenetic regulation of neuronal dendrite and dendritic spine development. Front Biol 2010; 5: 304-323.
-
(2010)
Front Biol
, vol.5
, pp. 304-323
-
-
Smrt, R.D.1
Zhao, X.2
-
40
-
-
34247485947
-
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
-
Zalfa F, Eleuteri B, Dickson KS, et al. A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat Neurosci 2007; 10: 578-587.
-
(2007)
Nat Neurosci
, vol.10
, pp. 578-587
-
-
Zalfa, F.1
Eleuteri, B.2
Dickson, K.S.3
-
41
-
-
34547180501
-
Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells
-
Zhang MQ, Wang QQ, Huang YQ,. Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells. Proc Natl Acad Sci USA 2007; 104: 10057-10062.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10057-10062
-
-
Zhang, M.Q.1
Wang, Q.Q.2
Huang, Y.Q.3
-
42
-
-
84866417191
-
DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis
-
Wang W, Zhu JZ, Chang KT, et al. DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis. EMBO J 2012; 31: 3655-3666.
-
(2012)
EMBO J
, vol.31
, pp. 3655-3666
-
-
Wang, W.1
Zhu, J.Z.2
Chang, K.T.3
-
43
-
-
84862908964
-
Inhibition of GSK3beta improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome
-
Guo W, Murthy AC, Zhang L, et al. Inhibition of GSK3beta improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. Hum Mol Genet 2012; 21: 681-691.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 681-691
-
-
Guo, W.1
Murthy, A.C.2
Zhang, L.3
-
44
-
-
58849126410
-
Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential
-
Min WW, Yuskaitis CJ, Yan QJ, et al. Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential. Neuropharmacology 2009; 56: 463-472.
-
(2009)
Neuropharmacology
, vol.56
, pp. 463-472
-
-
Min, W.W.1
Yuskaitis, C.J.2
Yan, Q.J.3
-
45
-
-
77956209418
-
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
-
Gross C, Nakamoto M, Yao XD, et al. Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neurosci 2010; 30: 10624-10638.
-
(2010)
J Neurosci
, vol.30
, pp. 10624-10638
-
-
Gross, C.1
Nakamoto, M.2
Yao, X.D.3
-
46
-
-
84879434002
-
Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: A postmortem study in cerebellar vermis and superior frontal cortex
-
Fatemi SH, Folsom TD, Kneeland RE, et al. Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: A postmortem study in cerebellar vermis and superior frontal cortex. Mol Autism 2013; 4: 21-39.
-
(2013)
Mol Autism
, vol.4
, pp. 21-39
-
-
Fatemi, S.H.1
Folsom, T.D.2
Kneeland, R.E.3
-
47
-
-
84878004228
-
Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?
-
Lohith TG, Osterweil EK, Fujita M, et al. Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome? Mol Autism 2013; 4: 15-22.
-
(2013)
Mol Autism
, vol.4
, pp. 15-22
-
-
Lohith, T.G.1
Osterweil, E.K.2
Fujita, M.3
-
48
-
-
55349098271
-
Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome
-
Weng N, Weiler IJ, Sumis A, et al. Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome. Am J Med Genet Part B-Neuropsychiatr Genet 2008; 147B: 1253-1257.
-
(2008)
Am J Med Genet Part B-Neuropsychiatr Genet
, vol.147 B
, pp. 1253-1257
-
-
Weng, N.1
Weiler, I.J.2
Sumis, A.3
-
49
-
-
74949102875
-
Dysregulation of mTOR signaling in fragile X syndrome
-
Sharma A, Hoeffer CA, Takayasu Y, et al. Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci 2010; 30: 694-702.
-
(2010)
J Neurosci
, vol.30
, pp. 694-702
-
-
Sharma, A.1
Hoeffer, C.A.2
Takayasu, Y.3
-
50
-
-
84859628864
-
Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice
-
Michalon A, Sidorov M, Ballard TM, et al. Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. Neuron 2012; 74: 49-56.
-
(2012)
Neuron
, vol.74
, pp. 49-56
-
-
Michalon, A.1
Sidorov, M.2
Ballard, T.M.3
-
51
-
-
0034942216
-
Chemical induction of mGluR5- and protein synthesis - Dependent long-term depression in hippocampal area CA1
-
Huber KM, Roder JC, Bear MF,. Chemical induction of mGluR5- and protein synthesis-Dependent long-term depression in hippocampal area CA1. J Neurophysiol 2001; 86: 321-325.
-
(2001)
J Neurophysiol
, vol.86
, pp. 321-325
-
-
Huber, K.M.1
Roder, J.C.2
Bear, M.F.3
-
52
-
-
58849126410
-
Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential
-
Min WW, Yuskaitis CJ, Yan Q, et al. Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential. Neuropharmacology 2009; 56: 463-472.
-
(2009)
Neuropharmacology
, vol.56
, pp. 463-472
-
-
Min, W.W.1
Yuskaitis, C.J.2
Yan, Q.3
-
53
-
-
71549145629
-
Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome
-
Yuskaitis CJ, Mines MA, King MK, et al. Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome. Biochem Pharmacol 2010; 79: 632-646.
-
(2010)
Biochem Pharmacol
, vol.79
, pp. 632-646
-
-
Yuskaitis, C.J.1
Mines, M.A.2
King, M.K.3
-
54
-
-
84884988657
-
Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome
-
King MK, Jope RS,. Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome. Genes Brain Behavior 2013; 12: 723-731.
-
(2013)
Genes Brain Behavior
, vol.12
, pp. 723-731
-
-
King, M.K.1
Jope, R.S.2
-
55
-
-
84860568814
-
Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110 beta-selective inhibitor
-
Gross C, Bassell GJ,. Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110 beta-selective inhibitor. Mol Med 2012; 18: 336-345.
-
(2012)
Mol Med
, vol.18
, pp. 336-345
-
-
Gross, C.1
Bassell, G.J.2
-
56
-
-
57449099863
-
Epigenetic regulation of mammalian stem cells
-
Li X, Zhao X,. Epigenetic regulation of mammalian stem cells. Stem Cells Dev 2008; 17: 1043-1052.
-
(2008)
Stem Cells Dev
, vol.17
, pp. 1043-1052
-
-
Li, X.1
Zhao, X.2
-
57
-
-
84862208827
-
Crosstalk among epigenetic pathways regulates neurogenesis
-
Jobe EM, McQuate AL, Zhao X,. Crosstalk among epigenetic pathways regulates neurogenesis. Front Neurosci 2012; 6: 59-73.
-
(2012)
Front Neurosci
, vol.6
, pp. 59-73
-
-
Jobe, E.M.1
McQuate, A.L.2
Zhao, X.3
-
58
-
-
79958803251
-
Heads-up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells
-
Callan MA, Zarnescu DC,. Heads-up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells. Genesis 2011; 49: 424-440.
-
(2011)
Genesis
, vol.49
, pp. 424-440
-
-
Callan, M.A.1
Zarnescu, D.C.2
-
59
-
-
34547830405
-
Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila
-
Yang LL, Duan RH, Chen DS, et al. Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila. Hum Mol Genet 2007; 16: 1814-1820.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 1814-1820
-
-
Yang, L.L.1
Duan, R.H.2
Chen, D.S.3
-
60
-
-
66349134742
-
The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells
-
Yang YY, Xu SL, Xia LX, et al. The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genet 2009; 5: e1000444.
-
(2009)
PLoS Genet
, vol.5
-
-
Yang, Y.Y.1
Xu, S.L.2
Xia, L.X.3
-
61
-
-
67349278796
-
Drosophila fragile X protein controls cellular proliferation by regulating cbl levels in the ovary
-
Epstein AM, Bauer CR, Ho A, et al. Drosophila fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Dev Biol 2009; 330: 83-92.
-
(2009)
Dev Biol
, vol.330
, pp. 83-92
-
-
Epstein, A.M.1
Bauer, C.R.2
Ho, A.3
-
62
-
-
84859489702
-
Caprin controls follicle stem cell fate in the Drosophila ovary
-
Reich J, Papoulas O,. Caprin controls follicle stem cell fate in the Drosophila ovary. PLoS One 2012; 7: e35365.
-
(2012)
PLoS One
, vol.7
-
-
Reich, J.1
Papoulas, O.2
-
63
-
-
29144442862
-
Altered differentiation of neural stem cells in fragile X syndrome
-
Castren M, Tervonen T, Karkkainen V, et al. Altered differentiation of neural stem cells in fragile X syndrome. Proc Natl Acad Sci USA 2005; 102: 17834-17839.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17834-17839
-
-
Castren, M.1
Tervonen, T.2
Karkkainen, V.3
-
64
-
-
39449115088
-
Normal neurogenesis but abnormal gene expression in human fragile X cortical progenitor cells
-
Bhattacharyya A, McMillan E, Wallace K, et al. Normal neurogenesis but abnormal gene expression in human fragile X cortical progenitor cells. Stem Cells Dev 2008; 17: 107-117.
-
(2008)
Stem Cells Dev
, vol.17
, pp. 107-117
-
-
Bhattacharyya, A.1
McMillan, E.2
Wallace, K.3
-
65
-
-
58149488779
-
Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome
-
Tervonen TA, Louhivuori V, Sun X, et al. Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome. Neurobiol Dis 2009; 33: 250-259.
-
(2009)
Neurobiol Dis
, vol.33
, pp. 250-259
-
-
Tervonen, T.A.1
Louhivuori, V.2
Sun, X.3
-
66
-
-
79251547954
-
FMRP regulates the transition from radial glial cells to intermediate progenitor cells during neocortical development
-
Saffary R, Xie ZG,. FMRP regulates the transition from radial glial cells to intermediate progenitor cells during neocortical development. J Neurosci 2011; 31: 1427-1439.
-
(2011)
J Neurosci
, vol.31
, pp. 1427-1439
-
-
Saffary, R.1
Xie, Z.G.2
-
67
-
-
77958181092
-
Fragile X protein controls neural stem cell proliferation in the Drosophila brain
-
Callan MA, Cabernard C, Heck J, et al. Fragile X protein controls neural stem cell proliferation in the Drosophila brain. Hum Mol Genet 2010; 19: 3068-3079.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3068-3079
-
-
Callan, M.A.1
Cabernard, C.2
Heck, J.3
-
68
-
-
77952353946
-
Fragile X mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells
-
Luo Y, Shan G, Guo W, et al. Fragile X mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet 2010; 6: e1000898.
-
(2010)
PLoS Genet
, vol.6
-
-
Luo, Y.1
Shan, G.2
Guo, W.3
-
69
-
-
35848937244
-
Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos
-
Eiges R, Urbach A, Malcov M, et al. Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos. Cell Stem Cell 2007; 1: 568-577.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 568-577
-
-
Eiges, R.1
Urbach, A.2
Malcov, M.3
-
70
-
-
84872370488
-
Neural differentiation of Fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis
-
Telias M, Segal M, Ben-Yosef D,. Neural differentiation of Fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis. Dev Biol 2013; 374: 32-45.
-
(2013)
Dev Biol
, vol.374
, pp. 32-45
-
-
Telias, M.1
Segal, M.2
Ben-Yosef, D.3
-
71
-
-
80053948646
-
Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome
-
Sheridan SD, Theriault KM, Reis SA, et al. Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS One 2011; 6: e26203.
-
(2011)
PLoS One
, vol.6
-
-
Sheridan, S.D.1
Theriault, K.M.2
Reis, S.A.3
-
72
-
-
84865064735
-
Signaling defects in iPSC-derived fragile X premutation neurons
-
Liu J, Koscielska KA, Cao Z, et al. Signaling defects in iPSC-derived fragile X premutation neurons. Hum Mol Genet 2012; 21: 3795-3805.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 3795-3805
-
-
Liu, J.1
Koscielska, K.A.2
Cao, Z.3
-
74
-
-
14644412883
-
The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway
-
Costa A, Wang Y, Dockendorff TC, et al. The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev Cell 2005; 8: 331-342.
-
(2005)
Dev Cell
, vol.8
, pp. 331-342
-
-
Costa, A.1
Wang, Y.2
Dockendorff, T.C.3
-
75
-
-
70449574252
-
Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects
-
Pepper AS, Beerman RW, Bhogal B, et al. Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects. PLoS One 2009; 4: e7618.
-
(2009)
PLoS One
, vol.4
-
-
Pepper, A.S.1
Beerman, R.W.2
Bhogal, B.3
-
76
-
-
85011452600
-
Macroorchidism in FMR1 knockout mice is caused by increased Sertoli cell proliferation during testicular development
-
Slegtenhorst-Eegdeman KE, de Rooij DG, Verhoef-Post M, et al. Macroorchidism in FMR1 knockout mice is caused by increased Sertoli cell proliferation during testicular development. Endocrinology 1998; 139: 156-162.
-
(1998)
Endocrinology
, vol.139
, pp. 156-162
-
-
Slegtenhorst-Eegdeman, K.E.1
De Rooij, D.G.2
Verhoef-Post, M.3
-
77
-
-
79953272221
-
Sertoli cells dictate spermatogonial stem cell niches in the mouse testis
-
Oatley MJ, Racicot KE, Oatley JM,. Sertoli cells dictate spermatogonial stem cell niches in the mouse testis. Biology of reproduction 2011; 84: 639-645.
-
(2011)
Biology of Reproduction
, vol.84
, pp. 639-645
-
-
Oatley, M.J.1
Racicot, K.E.2
Oatley, J.M.3
-
78
-
-
67651036549
-
The glial nature of embryonic and adult neural stem cells
-
Kriegstein A, Alvarez-Buylla A,. The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 2009; 32: 149-184.
-
(2009)
Annu Rev Neurosci
, vol.32
, pp. 149-184
-
-
Kriegstein, A.1
Alvarez-Buylla, A.2
-
79
-
-
78650621664
-
BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse
-
Louhivuori V, Vicario A, Uutela M, et al. BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse. Neurobiol Dis 2011; 41: 469-480.
-
(2011)
Neurobiol Dis
, vol.41
, pp. 469-480
-
-
Louhivuori, V.1
Vicario, A.2
Uutela, M.3
-
80
-
-
74249093220
-
A mouse model of the human Fragile X syndrome I304N mutation
-
Zang JB, Nosyreva ED, Spencer CM, et al. A mouse model of the human Fragile X syndrome I304N mutation. PLoS Genet 2009; 5: e1000758.
-
(2009)
PLoS Genet
, vol.5
-
-
Zang, J.B.1
Nosyreva, E.D.2
Spencer, C.M.3
-
81
-
-
84870543150
-
Fragile X syndrome: Causes, diagnosis, mechanisms, and therapeutics
-
Bagni C, Tassone F, Neri G, et al. Fragile X syndrome: Causes, diagnosis, mechanisms, and therapeutics. J Clin Invest 2012; 122: 4314-4322.
-
(2012)
J Clin Invest
, vol.122
, pp. 4314-4322
-
-
Bagni, C.1
Tassone, F.2
Neri, G.3
-
82
-
-
70349762428
-
Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus
-
Eadie BD, Zhang WN, Boehme F, et al. Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus. Neurobiol Dis 2009; 36: 361-373.
-
(2009)
Neurobiol Dis
, vol.36
, pp. 361-373
-
-
Eadie, B.D.1
Zhang, W.N.2
Boehme, F.3
-
83
-
-
79955682738
-
Ablation of Fmrp in adult neural stem cells disrupts hippocampus- dependent learning
-
Guo WX, Allan AM, Zong RT, et al. Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning. Nat Med 2011; 17: 559-565.
-
(2011)
Nat Med
, vol.17
, pp. 559-565
-
-
Guo, W.X.1
Allan, A.M.2
Zong, R.T.3
-
84
-
-
84862124493
-
Fragile X protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain
-
Callan MA, Clements N, Ahrendt N, et al. Fragile X protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. Brain Res 2012; 1462: 151-161.
-
(2012)
Brain Res
, vol.1462
, pp. 151-161
-
-
Callan, M.A.1
Clements, N.2
Ahrendt, N.3
-
85
-
-
79958060210
-
RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression
-
Guo W, Zhang L, Christopher DM, et al. RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. Neuron 2011; 70: 924-938.
-
(2011)
Neuron
, vol.70
, pp. 924-938
-
-
Guo, W.1
Zhang, L.2
Christopher, D.M.3
-
86
-
-
0019826665
-
Establishment in culture of pluripotential cells from mouse embryos
-
Evans MJ, Kaufman MH,. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154-156.
-
(1981)
Nature
, vol.292
, pp. 154-156
-
-
Evans, M.J.1
Kaufman, M.H.2
-
87
-
-
0032491416
-
Embryonic stem cell lines derived from human blastocysts
-
Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 1145-1147.
-
(1998)
Science
, vol.282
, pp. 1145-1147
-
-
Thomson, J.A.1
Itskovitz-Eldor, J.2
Shapiro, S.S.3
-
88
-
-
65349090170
-
MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells
-
Ren J, Jin P, Wang E, et al. MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells. J Transl Med 2009; 7: 20-36.
-
(2009)
J Transl Med
, vol.7
, pp. 20-36
-
-
Ren, J.1
Jin, P.2
Wang, E.3
-
89
-
-
33748037728
-
Human embryonic stem cells as a powerful tool for studying human embryogenesis
-
Dvash T, Ben-Yosef D, Eiges R,. Human embryonic stem cells as a powerful tool for studying human embryogenesis. Pediatr Res 2006; 60: 111-117.
-
(2006)
Pediatr Res
, vol.60
, pp. 111-117
-
-
Dvash, T.1
Ben-Yosef, D.2
Eiges, R.3
-
90
-
-
84892178896
-
The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells
-
Gerhardt J, Tomishima MJ, Zaninovic N, et al. The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells. Mol Cell 2014; 53: 19-31.
-
(2014)
Mol Cell
, vol.53
, pp. 19-31
-
-
Gerhardt, J.1
Tomishima, M.J.2
Zaninovic, N.3
-
91
-
-
77956214743
-
Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells
-
Urbach A, Bar-Nur O, Daley GQ, et al. Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell 2010; 6: 407-411.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 407-411
-
-
Urbach, A.1
Bar-Nur, O.2
Daley, G.Q.3
-
92
-
-
84890439421
-
Derivation of novel human ground state naive pluripotent stem cells
-
Gafni O, Weinberger L, Mansour AA, et al. Derivation of novel human ground state naive pluripotent stem cells. Nature 2013; 504: 282-286.
-
(2013)
Nature
, vol.504
, pp. 282-286
-
-
Gafni, O.1
Weinberger, L.2
Mansour, A.A.3
-
94
-
-
77957678816
-
Open-label add-on treatment trial of minocycline in fragile X syndrome
-
Paribello C, Tao L, Folino A, et al. Open-label add-on treatment trial of minocycline in fragile X syndrome. BMC Neurol 2010; 10: 91-99.
-
(2010)
BMC Neurol
, vol.10
, pp. 91-99
-
-
Paribello, C.1
Tao, L.2
Folino, A.3
-
95
-
-
83055184199
-
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome
-
Olmos-Serrano JL, Corbin JG, Burns MP,. The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome. Dev Neurosci 2011; 33: 395-403.
-
(2011)
Dev Neurosci
, vol.33
, pp. 395-403
-
-
Olmos-Serrano, J.L.1
Corbin, J.G.2
Burns, M.P.3
-
96
-
-
84861427428
-
Group i mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome
-
Xu ZH, Yang Q, Feng B, et al. Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome. Mol Neurodegener 2012; 7: 24-37.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 24-37
-
-
Xu, Z.H.1
Yang, Q.2
Feng, B.3
-
97
-
-
84862783882
-
Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome
-
Liu ZH, Huang TJ, Smith CB,. Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome. Neurobiol Dis 2012; 45: 1145-1152.
-
(2012)
Neurobiol Dis
, vol.45
, pp. 1145-1152
-
-
Liu, Z.H.1
Huang, T.J.2
Smith, C.B.3
-
98
-
-
35048886071
-
Developmental expression of FMRP in the astrocyte lineage: Implications for fragile X syndrome
-
Pacey LK, Doering LC,. Developmental expression of FMRP in the astrocyte lineage: Implications for fragile X syndrome. Glia 2007; 55: 1601-1609.
-
(2007)
Glia
, vol.55
, pp. 1601-1609
-
-
Lk, P.1
Lc, D.2
|