Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex

BioMetals

Volumn 27, Issue 3, 2014, Pages 445-458

  Wu, Jieyuan ^a   Chen, Wei ^a   Yin, Yan ^a   Zheng, Zhongliang ^a   Zou, Guolin ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Apoptosis; ER stress; Mitotic arrest

Indexed keywords

1,10 PHENANTHROLINE COPPER; CALCIUM; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN A; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; DNA; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN P21; PROTEIN P53; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; COPPER-1,10-PHENANTHROLINE; ORGANOMETALLIC COMPOUND; PHENANTHROLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL NUCLEUS; CELL STRUCTURE; CONTROLLED STUDY; CYTOLOGY; DNA DAMAGE; DNA FRAGMENTATION ASSAY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; M PHASE CELL CYCLE CHECKPOINT; MALE; MICROTUBULE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS INHIBITION; PROTEIN EXPRESSION; UPREGULATION; CALCIUM SIGNALING; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; IC50; METABOLISM; NUCLEAR SHAPE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CALCIUM SIGNALING; CELL NUCLEUS SHAPE; CELL PROLIFERATION; CELL SURVIVAL; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOPLASMIC RETICULUM STRESS; G2 PHASE CELL CYCLE CHECKPOINTS; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; M PHASE CELL CYCLE CHECKPOINTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; ORGANOMETALLIC COMPOUNDS; PHENANTHROLINES; REACTIVE OXYGEN SPECIES;

EID: 84902553841     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-014-9710-2     Document Type: Article

References (51)

1. Agarwal ML, Agarwal A, Taylor WR, Stark GR (1995) p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci 92(18):8493
2. Albarran G, Schuler RH (2005) Concerted effects of substituents in the reaction of ·OH radicals with aromatics: the cresols. J Phys Chem A 109(41):9363-9370 (Pubitemid 41541187)
3. Allen JB, Zhou Z, Siede W, Friedberg EC, Elledge SJ (1994) The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Gene Dev 8(20):2401-2415 (Pubitemid 24323819)
4. Benadiba M, dos Santos RRP, Silva DD, Colquhoun A (2010) Inhibition of C6 rat glioma proliferation by Ru2Cl(Ibp)(4) depends on changes in p21, p27, Bax/Bcl2 ratio and mitochondrial membrane potential. J Inorg Biochem 104(9):928-935. doi:10.1016/j.jinorgbio.2010.04.011
5. Boatright KM, Salvesen GS (2003) Mechanisms of caspase activation. Curr Opin Cell Biol 15(6):725-731 (Pubitemid 37492933)
6. Burkitt MJ, Milne L, Nicotera P, Orrenius S (1996) 1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions. Biochem J 313(1):163
7. Cadenas E, Davies KJA (2000) Mitochondrial free radical generation, oxidative stress, and aging. Free Radical Biol Med 29(3-4):222-230
8. Cai XQ, Pan N, Zou G (2007) Copper-1,10-phenanthroline-induced apoptosis in liver carcinoma Bel-7402 cells associates with copper overload, reactive oxygen species production, glutathione depletion and oxidative DNA damage. Biometals 20(1):1-11. doi:10.1007/s10534-006-9008-0 (Pubitemid 46292023)
9. Chen TF, Wong YS (2009) Selenocystine induces reactive oxygen species-mediated apoptosis in human cancer cells. Biomed Pharmacother 63(2):105-113. doi:10.1016/j.biopha.2008.03.009
10. Chen CH, Chang YJ, Ku MSB, Chung KT, Yang JT (2011) Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation. J Mol Med 89(3):303-315. doi:10.1007/s00109-010-0707-1
11. Choi EJ, Kim GH (2009) Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells. J Nutr Biochem 20(4):285-290. doi:10.1016/j.jnutbio.2008.03.005
12. Choi JH, Lee HW, Park HJ, Kim SH, Lee KT (2008) Kalopanaxsaponin A induces apoptosis in human leukemia U937 cells through extracellular Ca2 + influx and caspase-8 dependent pathways. Food Chem Toxicol 46(11):3486-3492. doi:10.1016/j.fct.2008.08.026
13. Cory S, Huang DCS, Adams JM (2003) The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22(53):8590-8607 (Pubitemid 38028528)
14. Da Silveira VC, Luz JS, Oliveira CC, Graziani I, Ciriolo MR, Ferreira A (2008) Double-strand DNA cleavage induced by oxindole-Schiff base copper(II) complexes with potential antitumor activity. J Inorg Biochem 102(5-6):1090-1103. doi:10.1016/j.jinorgbio.2007.12.033
15. D'Andrea AD, Haseltine WA (1978) Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin. Proc Natl Acad Sci 75(8):3608-3612 (Pubitemid 8399895)
16. Deegan C, Coyle B, McCann M, Devereux M, Egan D (2006) In vitro anti-tumour effect of 1,10-phenanthroline-5,6-dione (phendione), [Cu(phendione)3](ClO4)2·4H2O and [Ag(phendione)2]ClO4 using human epithelial cell lines. Chem Biol Interact 164:115-125 (Pubitemid 44712050)
17. Desoize B (2004) Metals and metal compounds in cancer treatment. Anticancer Res 24(3a):1529-1544
18. Garibal J, Hollville E, Renouf B, Tetaud C, Wiels J (2010) Caspase-8-mediated cleavage of Bid and protein phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells. Cell Signal 22(3):467-475. doi:10.1016/j.cellsig.2009.10.018
19. Ghosh S, Barve AC, Kumbhar AA, Kumbhar AS, Puranik VG, Datar PA, Sonawane UB, Joshi RR (2006) Synthesis, characterization, X-ray structure and DNA photocleavage by cis-dichloro bis(diimine) Co(III) complexes. J Inorg Biochem 100(3):331-343 (Pubitemid 43276084)
20. Huang HL, Liu YJ, Zeng CH, Yao JH, Liang ZH, Li ZZ, Wu FH (2010) Studies of ruthenium(II) polypyridyl complexes on cytotoxicity in vitro, apoptosis, DNA-binding and antioxidant activity. J Mol Struct 966(1-3):136-143. doi:10.1016/j.molstruc.2009.12.026
21. Katsarou ME, Efthimiadou EK, Psomas G, Karaliota A, Vourloumis D (2008) Novel copper(II) complex of N-propylnorfloxacin and 1,10-phenanthroline with enhanced antileukemic and DNA nuclease activities. J Med Chem 51(3):470-478. doi:10.1021/jm7013259 (Pubitemid 351252275)
22. Le X, Liao S, Liu X, Feng X (2006) Synthesis, structure and SOD-like activity of a ternary Cu(II) complex with 1,10-phenanthroline and L-valinate. J Coord Chem 59(9):985-995
23. Lee AH, Iwakoshi NN, Glimcher LH (2003) XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23(21):7448-7459 (Pubitemid 37271447)
24. Lee JW, Moon MJ, Min HY, Chung HJ, Park EJ, Park HJ, Hong JY, Kim YC, Lee SK (2005) Induction of apoptosis by a novel indirubin-5-nitro-3′- monoxime, a CDK inhibitor, in human lung cancer cells. Bioorg Med Chem Lett 15(17):3948-3952 (Pubitemid 41095500)
25. Lee MJ, Kee KH, Suh CH, Lim SC, Oh SH (2009) Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways. Toxicology 264(3):205-214. doi:10.1016/j.tox.2009.08.012
26. Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC, Altieri DC (1998) Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396(6711):580-583
27. Liu Q, Guntuku S, Cui X-S, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A (2000) Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Gene Dev 14(12):1448-1459 (Pubitemid 30421838)
28. Ma LN, Song B, Jin H, Pi J, Liu L, Jiang JH, Cai JY (2012) Cinobufacini induced MDA-MB-231 cell apoptosis-associated cell cycle arrest and cytoskeleton function. Bioorg Med Chem Lett 22(3):1459-1463. doi:10.1016/j.bmcl.2011.11.095
29. Manchado E, Guillamot M, Malumbres M (2012) Killing cells by targeting mitosis. Cell Death Differ 19:369-377
30. Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci 97(19):10389-10394
31. Meijler MM, Zelenko O, Sigman DS (1997) Chemical mechanism of DNA scission by (1,10-Phenanthroline)copper. Carbonyl oxygen of 5-methylenefuranone is derived from water. J Am Chem Soc 119:1135-1136 (Pubitemid 27107244)
32. Morla AO, Draetta G, Beach D, Wang J (1989) Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell 58(1):193
33. Nemmiche S, Chabane-Sari D, Kadri M, Guiraud P (2011) Cadmium chloride-induced oxidative stress and DNA damage in the human Jurkat T cell line is not linked to intracellular trace elements depletion. Toxicol In Vitro 25(1):191-198. doi:10.1016/j.tiv.2010.10.018
34. Nilsson J (2011) Cdc20 control of cell fate during prolonged mitotic arrest. BioEssays 33:903-909
35. Oyadomari S, Araki E, Mori M (2002) Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells. Apoptosis 7(4):335-345 (Pubitemid 34832258)
36. Prestayko A, d'Aoust J, Issell B, Crooke S (1979) Cisplatin (cis-diamminedichloroplatinum II). Cancer Treat Reviews 6(1):17-39 (Pubitemid 9189580)
37. Risinger AL, Giles FJ, Mooberry SL (2009) Microtubule dynamics as a target in oncology. Cancer Treat Reviews 35(3):255
38. Rudner AD, Murray AW (1996) The spindle assembly checkpoint. Curr Opin Cell Biol 8(6):773-780 (Pubitemid 26399936)
39. Simon H-U, Haj-Yehia A, Levi-Schaffer F (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5(5):415-418 (Pubitemid 32162623)
40. Theodore B, Thederahn MDK, Larsen T, Sigman D (1989) Nuclease activity of 1,10-Phenanthroline-copper: kinetic mechanism. J Am Chem Soc 111:4941-4946
41. Theophanides T, Anastassopoulou J (2002) Copper and carcinogenesis. Crit Rev Oncol Hemat 42(1):57-64 (Pubitemid 34232301)
42. Tsujimoto Y (1998) Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells 3(11):697-707
43. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160(1):1-40. doi:10.1016/j.cbi.2005.12.009 (Pubitemid 43227479)
44. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44-84. doi:10.1016/j.biocel.07.001.2006.07.001 (Pubitemid 44566469)
45. van Vugt MATM, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J (2010) A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G2/M DNA damage checkpoint. PLoS Biol 8(1):e1000287
46. Wali VB, Bachawal SV, Sylvester PW (2009) Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis inmammary tumor cells. Apoptosis 14(11):1366-1377. doi:10.1007/s10495-009-0406-y
47. Wang HC, Yang JH, Hsieh SC, Sheen LY (2010) Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G(2)/M arrest and apoptosis. JAgric Food Chem 58(11):7096-7103. doi:10.1021/jf100613x
48. Yang JH, Wong RNS, Yang MS (2000) Protective mechanism of metallothionein against copper-1,10-phenanthroline induced DNA cleavage. Chem Biol Interact 125(3):221-232 (Pubitemid 30145630)
49. Zeng Y, Forbes KC, Wu Z, Moreno S, Piwnica-Worms H, Enoch T (1998) Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature 395(6701):507-510 (Pubitemid 28462446)
50. Zhang K, Kaufman RJ (2004) Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem 279(25):25935
51. Zhou H, Zheng CY, Zou GL, Tao DD, Gong JP (2002) G(1)-phase specific apoptosis in liver carcinoma cell line induced by copper-1,10-phenanthroline. Int J Biochem Cell Biol 34(6):678-684 (Pubitemid 34270720)