Thymoquinone therapy abrogates toxic effect of cadmium on rat testes

Andrologia

Volumn 47, Issue 4, 2015, Pages 417-426

  Fouad, A A ^a,b   Jresat, I ^a  

^a KING FAISAL UNIVERSITY   (Saudi Arabia)

^b Minia University   (Egypt)

Author keywords

Cadmium; Rats; Testes; Thymoquinone

Indexed keywords

CADMIUM; CADMIUM CHLORIDE; CASPASE 3; CYCLOOXYGENASE 2; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; TESTOSTERONE; THYMOQUINONE; TUMOR NECROSIS FACTOR ALPHA; BENZOQUINONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REPRODUCTIVE TOXICITY; SPERMATOGENESIS; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL; ANIMAL; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; SPRAGUE DAWLEY RAT; TESTICULAR DISEASES; TESTIS;

ANIMALS; BENZOQUINONES; CADMIUM CHLORIDE; CASPASE 3; CYCLOOXYGENASE 2; GLUTATHIONE; MALE; MALONDIALDEHYDE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TESTICULAR DISEASES; TESTIS; TESTOSTERONE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84902552412     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/and.12281     Document Type: Article

References (48)

1. Abarikwu SO, Iserhienrhien BO, Badejo TA (2013) Rutin- and selenium-attenuated cadmium-induced testicular pathophysiology in rats. Hum Exp Toxicol 32:395-406.
2. Abd El-Ghany RM, Sharaf NM, Kassem LA, Mahran LG, Heikal OA (2009) Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury. Drug Discov Ther 3:296-306.
3. Aktas C, Kanter M, Erboga M, Ozturk S (2012) Anti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testes. Toxicol Ind Health 28:122-130.
4. Al-Azemi M, Omu FE, Kehinde EO, Anim JT, Oriowo MA, Omu AE (2010) Lithium protects against toxic effects of cadmium in the rat testes. J Assist Reprod Genet 27:469-476.
5. Al-Zahrani S, Mohany M, Kandeal S, Badr G (2012) Thymoquinone and vitamin E supplementation improve the reproductive characteristics of heat stressed male mice. J Med Plant Res 6:493-499.
6. Ammar E-S, Gameil NM, Shawky NM, Nader MA (2011) Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model. Int Immunopharmacol 11:2232-2236.
7. Basarslan F, Yilmaz N, Ates S, Ozgur T, Tutanc M, Motor VK, Arica V, Yilmaz C, Inci M, Buyukbas S (2012) Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats. Hum Exp Toxicol 31:726-733.
8. Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA (2009) Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB (Oxford) 11:373-381.
9. Chen J, Fok KL, Chen H, Zhang XH, Xu WM, Chan HC (2012) Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2. Hum Reprod 27:2585-2597.
10. de Freitas ML, Dalmolin L, Oliveira LP, da Rosa Moreira L, Roman SS, Soares FA, Bresolin L, Duarte MM, Brandão R (2012) Effects of butane-2, 3-dione thiosemicarbazone oxime on testicular damage induced by cadmium in mice. J Toxicol Sci 37:899-910.
11. Ekici S, Doğan Ekici AI, Öztürk G, Benli Aksungar F, Sinanoğlu O, Turan G, Lüleci N (2012) Comparison of melatonin and ozone in the prevention of reperfusion injury following unilateral testicular torsion in rats. Urology 80:899-906.
12. El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H (2006) Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol Lett 106:72-81.
13. El-Khouly D, El-Bakly WM, Awad AS, El-Mesallamy HO, El-Demerdash E (2012) Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats. Toxicology 302:106-113.
14. Farombi EO, Adedara IA, Akinrinde SA, Ojo OO, Eboh AS (2012) Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats. Andrologia 44:273-284.
15. Fouad AA, Jresat I (2013) Captopril and telmisartan treatments attenuate cadmium-induced testicular toxicity in rats. Fundam Clin Pharmacol 27:152-160.
16. Fouad AA, Qureshi HA, Al-Sultan AI, Yacoubi MT, Ali AA (2009) Protective effect of hemin against cadmium-induced testicular damage in rats. Toxicology 257:153-160.
17. Fouad AA, Albuali WH, Jresat I (2013) Simvastatin treatment ameliorates injury of rat testes induced by cadmium toxicity. Biol Trace Elem Res 153:269-278.
18. Gökçe A, Oktar S, Koc A, Gonenci R, Yalcinkaya F, Yonden Z, Duru M (2010) Protective effect of thymoquinone in experimental testicular torsion. Urol Int 85:461-465.
19. Gökçe A, Oktar S, Koc A, Yonden Z (2011) Protective effects of thymoquinone against methotrexate-induced testicular injury. Hum Exp Toxicol 30:897-903.
20. Goyer RA, Clarkson TW (2001) Toxic effects of metals. In: Casarett and Doull's Toxicology: The Basic Science of Poisons. Klaassen CD (ed). McGraw-Hill, New York, NY, pp 811-867.
21. Gunnarsson D, Nordberg G, Lundgren P, Selstam G (2003) Cadmium-induced decrement of the LH receptor expression and c-AMP levels in the testis of rats. Toxicology 183:57-63.
22. Gupta RS, Gupta ES, Dhakal BK, Thakur AR, Ahnn J (2004) Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species. Mol Cells 17:132-139.
23. Helal GK (2010) Thymoquinone supplementation ameliorates acute endotoxemia-induced liver dysfunction in rats. Pak J Pharm Sci 23:131-137.
24. Institute for Laboratory Animal Research (2011) Guide for the Care and Use of Laboratory Animals, 8th edn. National Academies Press, Washington, DC.
25. Ji YL, Wang H, Meng C, Zhao XF, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX (2012) Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. J Pineal Res 52:71-79.
26. Johnsen SG (1970) Testicular biopsy score count - a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1:2-25.
27. Kanter M (2011) Thymoquinone reestablishes spermatogenesis after testicular injury caused by chronic toluene exposure in rats. Toxicol Ind Health 27:155-166.
28. Kobayashi Y (2010) The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation. J Leukoc Biol 88:1157-1162.
29. Lauwerys R (1979) Cadmium in man. In: Chemistry, Biochemistry and Biology of Cadmium. Webb M (ed). Elsevier, Biomedical Press, Amsterdam, North Holand, pp 433-453.
30. Lei X, Liu M, Yang Z, Ji M, Guo X, Dong W (2012) Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice. Dig Dis Sci 57:2296-2303.
31. Li Q, Verma IM (2002) NF-kappaB regulation in immune system. Nat Rev Immunol 2:725-734.
32. Ognjanović BI, Marković SD, Ethordević NZ, Trbojević IS, Stajn AS, Saicić ZS (2010) Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: protective role of coenzyme Q(10) and vitamin E. Reprod Toxicol 29:191-197.
33. Rasmussen OF (2009) Controls. In: Immunohistochemical Staining Methods. Kumar GL, Rudbeck L (eds.). Dako North America, Carpinteria, CA, p 127.
34. Rooney JP (2007) The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 234:145-156.
35. Sankaranarayanan C, Pari L (2011) Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats. Chem Biol Interact 190:148-154.
36. Satoh M, Shimada A, Zhang B, Tohyama C (2000) Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice. Biochem Pharmacol 60:1729-1734.
37. Shen YC, Yen JC, Liou KT (2013) Ameliorative effects of caffeic acid phenethyl ester on an eccentric exercise-induced skeletal muscle injury by down-regulating NF-κB mediated inflammation. Pharmacology 91:219-228.
38. Spiazzi CC, Manfredini V, Barcellos da Silva FE, Flores EM, Izaguirry AP, Vargas LM, Soares MB, Santos FW (2013) γ-Oryzanol protects against acute cadmium-induced oxidative damage in mice testes. Food Chem Toxicol 55:526-532.
39. Tuğcu V, Gedikbaşi A, Mutlu B, Güner E, Uhri M, Andican G, Ozbek E, Taşçi AI (2010) Increased testicular 8-hydroxy-2′-deoxyguanosine (8-OHdG) and inducible nitric oxide synthetase (iNOS) and nuclear factor κB (NF-κB) expressions in experimental rat varicocele. Arch Ital Urol Androl 82:148-153.
40. Ullah I, Ullah N, Naseer MI, Lee HY, Kim MO (2012) Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons. BMC Neurosci 13:11.
41. Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, Khan HA (2012) Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats. Chem Biol Interact 197:40-46.
42. Vaillancourt F, Silva P, Shi Q, Fahmi H, Fernandes JC, Benderdour M (2011) Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis. J Cell Biochem 112:107-117.
43. Waisberg M, Joseph P, Hale B, Beyersmann D (2003) Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192:95-117.
44. Woo CC, Kumar AP, Sethi G, Tan KHB (2012) Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol 83:443-451.
45. World Health Organization (2010) Exposure to cadmium: a major public health concern. Geneva, Switzerland. Available at: http://www.who.int/ipcs/features/cadmium.
46. Yari A, Asadi MH, Bahadoran H, Dashtnavard H, Imani H, Naghii MR (2010) Cadmium toxicity in spermatogenesis and protective effects of L-carnitine in adult male rats. Biol Trace Elem Res 137:216-225.
47. Zafeer MF, Waseem M, Chaudhary S, Parvez S (2012) Cadmium-induced hepatotoxicity and its abrogation by thymoquinone. J Biochem Mol Toxicol 26:199-205.
48. Zhang H, Cai C, Shi C, Cao H, Han Z, Jia X (2012) Cadmium-induced oxidative stress and apoptosis in the testes of frog Rana limnocharis. Aquat Toxicol 122-123:67-74.