Simvastatin treatment ameliorates injury of rat testes induced by cadmium toxicity

Biological Trace Element Research

Volumn 153, Issue 1-3, 2013, Pages 269-278

  Fouad, Amr A ^a   Albuali, Waleed H ^a   Jresat, Iyad ^a  

^a KING FAISAL UNIVERSITY   (Saudi Arabia)

Author keywords

Cadmium; Inflammation; Oxidative stress; Rats; Simvastatin; Testes

Indexed keywords

CADMIUM; CADMIUM CHLORIDE; CASPASE 3; CATALASE; CYCLOOXYGENASE 2; GLUTATHIONE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; NITRIC OXIDE; SIMVASTATIN; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CADMIUM TOXICITY; CONTROLLED STUDY; ENZYME ACTIVITY; HEAVY METAL POISONING; HISTOPATHOLOGY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; TESTIS; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL; TISSUE LEVEL; TREATMENT DURATION; TREATMENT OUTCOME; ANIMAL; IMMUNOHISTOCHEMISTRY; SPRAGUE DAWLEY RAT; TOXICITY;

RATTUS;

ANIMALS; CADMIUM; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; TESTIS;

EID: 84878392567     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-013-9667-y     Document Type: Article

References (36)

1. Goyer RA, Clarkson TW (2001) Toxic effects of metals. In: Klaassen CD (ed) Casarett and Doull's toxicology: the basic science of poisons. McGraw-Hill, New York, pp 811-867
2. World Health Organization (2010) Exposure to cadmium: a major public health concern. Geneva, Switzerland. Available at: http://www.who.int/ipcs/ features/cadmium. Accessed 8-17 June 2010
3. Waisberg M, Joseph P, Hale B, Beyersmann D (2003) Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192:95-117
4. Lauwerys R (1979) Cadmium in man. In: Webb M (ed) Chemistry, biochemistry and biology of cadmium. Elsevier, Biomedical Press, Amsterdam, pp 433-453
5. Ognjanović BI, Marković SD, Ethordević NZ, Trbojević IS, Stajn AS, Saicić ZS (2010) Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: protective role of coenzyme Q(10) and vitamin E. Reprod Toxicol 29:191-197
6. Yari A, Asadi MH, Bahadoran H, Dashtnavard H, Imani H, Naghii MR (2010) Cadmium toxicity in spermatogenesis and protective effects of L-carnitine in adult male rats. Biol Trace Elem Res 137:216-225
7. Chen J, Fok KL, Chen H, Zhang XH, Xu WM, Chan HC (2012) Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2. Hum Reprod 27:2585-2597
8. Tuǧcu V, Gedikbaşi A, Mutlu B, Güner E, Uhri M, Andican G, Ozbek E, Taşçi AI (2010) Increased testicular 8-hydroxy-2′-deoxyguanosine (8-OHdG) and inducible nitric oxide synthetase (iNOS) and nuclear factor κB (NF-κB) expressions in experimental rat varicocele. Arch Ital Urol Androl 82:148-153
9. Tu YP, Chuang SJ, Chen SC, Liu YH, Chen CF, Hour TC (2011) Simvastatin induces the expression of hemeoxygenase-1 against ischemia-reperfusion injury on the testes in rats. Toxicol Lett 207:242-250
10. Aktas C, Kanter M, Erboga M, Ozturk S (2012) Anti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testes. Toxicol Ind Health 28:122-130
11. Farombi EO, Adedara IA, Akinrinde SA, Ojo OO, Eboh AS (2012) Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats. Andrologia 44:273-284
12. Fouad AA, Jresat I (2013) Captopril and telmisartan treatments attenuate cadmium-induced testicular toxicity in rats. Fundam Clin Pharmacol. 27:152-160
13. Cumaoǧlu A, Ozansoy G, Irat AM, ArIcIoǧlu A, Karasu C, Ari N (2011) Effect of long term, non cholesterol lowering dose of fluvastatin treatment on oxidative stress in brain and peripheral tissues of streptozotocin-diabetic rats. Eur J Pharmacol 654:80-85
14. Deo SH, Fisher JP, Vianna LC, Kim A, Chockalingam A, Zimmerman MC, Zucker IH, Fadel PJ (2012) Statin therapy lowers muscle sympathetic nerve activity and oxidative stress in patients with heart failure. Am J Physiol Heart Circ Physiol 303:H377-H385
15. Iwata A, Shirai R, Ishii H, Kushima H, Otani S, Hashinaga K, Umeki K, Kishi K, Tokimatsu I, Hiramatsu K, Kadota J (2012) Inhibitory effect of statins on inflammatory cytokine production from human bronchial epithelial cells. Clin Exp Immunol 168:234-240
16. Heeba GH, Hassan MK, Amin RS (2009) Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins. Eur J Pharmacol 607:188-193
17. Mohamadin AM, Elberry AA, Abdel Gawad HS, Morsy GM, Al-Abbasi FA (2011) Protective effects of simvastatin, a lipid lowering agent, against oxidative damage in experimental diabetic rats. J Lipids 2011:167958
18. Yin H, Shi ZG, Yu YS, Hu J, Wang R, Luan ZP, Guo DH (2012) Protection against osteoporosis by statins is linked to a reduction of oxidative stress and restoration of nitric oxide formation in aged and ovariectomized rats. Eur J Pharmacol 674:200-206
19. Yang S, Shih HJ, Chow YC, Wang TY, Tsai PS, Huang CJ (2010) Simvastatin attenuates testicular injury induced by torsion-detorsion. J Urol 184:750-756
20. Gupta RS, Gupta ES, Dhakal BK, Thakur AR, Ahnn J (2004) Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species. Mol Cells 17:132-139
21. Institute for Laboratory Animal Research (2011) Guide for the care and use of laboratory animals, 8th edn. National Academies Press, Washington, DC
22. Rasmussen OF (2009) Controls. In: Kumar GL, Rudbeck L (eds) Immunohistochemical staining methods, 5th edn. Dako North America, Carpinteria, p 127
23. Gunnarsson D, Nordberg G, Lundgren P, Selstam G (2003) Cadmium-induced decrement of the LH receptor expression and c-AMP levels in the testis of rats. Toxicology 183:57-63
24. Fouad AA, Qureshi HA, Al-Sultan AI, Yacoubi MT, Ali AA (2009) Protective effect of hemin against cadmium-induced testicular damage in rats. Toxicology 257:153-160
25. Kobayashi Y (2010) The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation. J Leukoc Biol 88:1157-1162
26. Gunnarsson D, Svensson M, Selstam G, Nordberg G (2004) Pronounced induction of testicular PGF(2 alpha) and suppression of testosterone by cadmium-prevention by zinc. Toxicology 200:49-58
27. Piechota-Polanczyk A, Goraca A, Demyanets S, Mittlboeck M, Domenig C, Neumayer C, Wojta J, Nanobachvili J, Huk I, Klinger M (2012) Simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-κB. Eur J Vasc Endovasc Surg 44:133-137
28. Iliodromitis EK, Andreadou I, Prokovas E, Zoga A, Farmakis D, Fotopoulou T, Ioannidis K, Paraskevaidis IA, Kremastinos DT (2010) Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: possible role of oxidative/nitrosative stress attenuation. Basic Res Cardiol 105:193-203
29. Ji YL, Wang H, Meng C, Zhao XF, Zhang C, Zhang Y, Zhao M, Chen YH, Meng XH, Xu DX (2012) Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. J Pineal Res 52:71-79
30. Bulger EM, Garcia I, Maier RV (2003) Induction of heme-oxygenase 1 inhibits endothelial cell activation by endotoxin and oxidant stress. Surgery 134:146-152
31. Wen T, Wu ZM, Liu Y, Tan YF, Ren F, Wu H (2007) Upregulation of heme oxygenase-1 with hemin prevents D-galactosamine and lipopolysaccharide-induced acute hepatic injury in rats. Toxicology 237:184-193
32. Kusakabe T, Nakajima K, Nakazato K, Suzuki K, Takada H, Satoh T, Oikawa M, Arakawa K, Nagamine T (2008) Changes of heavy metal, metallothionein and heat shock proteins in Sertoli cells induced by cadmium exposure. Toxicol In Vitro 22:1469-1475
33. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235:1043-1045
34. Hill-Kapturczak N, Agarwal A (2006) Carbon monoxide: from silent killer to potential remedy. Am J Physiol Renal Physiol 290:F787-F788
35. Rooney JP (2007) The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 234:145-156
36. Satoh M, Shimada A, Zhang B, Tohyama C (2000) Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice. Biochem Pharmacol 60:1729-1734