Thymoquinone supplementation ameliorates acute endotoxemia-induced liver dysfunction in rats

Pakistan Journal of Pharmaceutical Sciences

Volumn 23, Issue 2, 2010, Pages 131-137

  Helal, Gouda K ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Endotoxemia; Inflammation; Liver dysfunction; Oxidative stress; Thymoquinone; TNF

Indexed keywords

ALKALINE PHOSPHATASE; BILIRUBIN; CASPASE 3; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; LIPOPOLYSACCHARIDE; MALONALDEHYDE; THYMOQUINONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIRUBIN BLOOD LEVEL; BLACK CUMIN; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; ENDOTOXEMIA; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER; LIVER DYSFUNCTION; LIVER TOXICITY; MALE; NONHUMAN; RAT; SUPPLEMENTATION;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOQUINONES; CASPASE 3; DRUG-INDUCED LIVER INJURY; ENDOTOXEMIA; GLUTATHIONE; LIPOPOLYSACCHARIDES; MALE; MALONDIALDEHYDE; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77951759812     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Aboul-Ela EI (2002). Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping. Mutat. Res., 516: 11-17.
2. Aboutabl EA, El-Azzouny A and Hammerschmidt FJ (1986). Aroma volatiles of Nigella sati6a seeds. In: Brunke EJ editors. Prog Essent Oil Res. Proceeding International Symposium. Essential Oils. DeGruyer., Berlin, pp. 49-55.
3. Al-Shabanah OA, Badary OA, Naagi MN, Al-Gharably NM, Al-Rikabi AC and al-Bekairi AM. (1998). Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity. J. Exp. Clin. Cancer Res., 17: 193-198.
4. Badary OA (1999).Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J. Ethnopharmacol., 67: 135-1342.
5. Badary OA, Abdel-Naim AB, Abdel-Wahab MH and Hamada FM (2000). The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology, 143: 219-2126.
6. Badary OA, Nagi MN, Al-Shabanah OA, Al-Sawaf HA and Al-Sohaibani MO and al-Bekairi AM (1997). Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can. J. Physiol. Pharmacol., 75: 1356-1361.
7. Beutler B and Cerami A (1988). Tumor necrosis, cachexia, shock, and inflammation: a common mediator. Annu. Rev. Biochem., 57: 505-518.
8. Burits M and Bucar F (2000). Antioxidant activity of Nigella sativa essential oil. Phytother. Res., 14: 323-328.
9. Chakravarty N (1993). Inhibition of histamine release from mast cells by nigellone. Ann. Allergy. 70: 237-242. (Pubitemid 23085939)
10. Daba MH and Abdel-Rahman MS (1998). Hepato-protective activity of thymoquinone in isolated rat hepatocytes. Toxicol. Lett., 95: 23-29.
11. Ellman GL (1959). Tissue sulfhydryl groups. Arch. Biochem. Biophys., 82: 70-77.
12. Enomoto S, Asano R, Iwahori Y, Narui T, Okada Y, Singab AN and Okuyama T (2001). Hematological studies on black cumin oil from the seeds of Nigella sativa. Biol. Pharm. Bul., 24: 307-310. (Pubitemid 32237174)
13. Hartung T and Wendel A (1991). Endotoxin-inducible cytotoxicity in liver cell cultures. J. Biochem. Pharmacol., 42: 1129-1135.
14. Hines IN and Wheeler MD (2004). Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis. Am. J. Physiol. Gastrointest. Liver Physiol., 287: G310-G314.
15. Ho CH, Hsu SP, Yang CC, Lee YH and Chien CT (2008). Sialic acid reduces acute endotoxemia-induced liver dysfunction in the rat. Shock., PMID: 19106816 "In press".
16. Jaeschke H, Farhood A, Bautista AP, Spolarics Z and Spitzer JJ (1993). Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia. Am. J. Physiol., 264: G801-G809. (Pubitemid 23124784)
17. Juhás S, Cikos S, Czikková S, Veselá J, Il'ková G, Hájek T, Domaracká K, Domaracký M, Bujnáková D, Rehák P and Koppel J (2008). Effects of borneol and thymoquinone on TNBS-induced colitis in mice. Folia Biol (Praha), 54: 1-7.
18. Kaur G, Tirkey N, Bharrhan S, Chanana V, Rishi P and Chopra K (2006). Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clin. Exp. Immunol., 145: 313-321. (Pubitemid 44060123)
19. Kono H, Asakawa M, Fujii H, Amemiya H, Yamamoto M, Matsuda M and Matsumoto Y (2003). Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J. Pharmacol. Exp. Ther., 307: 74-82. (Pubitemid 37151893)
20. Liu Q, Shu X, Wang L, Sun A, Liu J and Cao X (2008). Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappaB activation and enhancing SOCS1 expression. Cell Mol. Immunol., 5: 271-278.
21. Lowery OH, Rosenbrough NJ and Randall RJ (1951). Protein measurement with Folin phenol reagent. J. Biol. Chem., 195: 256-275.
22. Luster MI, Germolec DR, Yoshida T, Kayama F and Thompson M (1994). Endotoxin-induced cytokine gene expression and excretion in the liver. Hepatology, 19: 480-488. (Pubitemid 24046795)
23. Matsuda H, Ishikado A, Nishida N, Ninomiya K, Fujiwara H, Kobayashi Y and Yoshikawa M (1998). Hepatoprotective, superoxide scavenging, and antioxidative activities of aromatic constituents from the bark of Betula platyphylla var. japonica. Bioorg. Med. Chem. Lett., 8: 2939-2944. (Pubitemid 28513080)
24. McKillop IH and Schrum LW (2005). Alcohol and liver cancer. Alcohol., 35: 195-203.
25. Mohamed A, Afridi DM, Garani O and Tucci M (2005). Thymoquinone inhibits the activation of NF-kappa B in the brain and spinal cord of experimental autoimmune encephalomyelitis. Biomed. Sci. Instrum., 41: 388-393. (Pubitemid 40504302)
26. Nagai H, Matsumaru K, Feng G and Kaplowitz N (2002). Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology, 36: 55-64. (Pubitemid 34700762)
27. Ni H, Chen X, Shi YH, Liao Y, Beg AA, Fan J and Yin XM (2009). Genetic delineation of the pathways mediated by Bid and JNK in TNFalpha-induced liver injury in adult and embryonic mice. J. Biol. Chem., 284: 4373-4382.
28. Salem ML (2005). Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int. Immunopharmacol., 5: 1749-1770.
29. Sameto RP (1990). Preparation of highly purified populations of neurons, astrocytes and oligodendrocytes. In: Conn PM (editors). Methods in Neurosciences, Cell. Academic Press, New York, p.2.
30. Su GL (2002). Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am. J. Physiol., Gastrointes. Liver Physiol., 283: G256-G265. (Pubitemid 34791290)
31. Suboh SM. Bilto YY and Aburjai TA (2004). Protective effects of selected medicinal plants against protein degradation, lipid peroxidation and deformability loss of oxidatively stressed human erythrocytes. Phytother. Res., 18: 280-284.
32. Tekeoglu I, Dogan A and Demiralp L (2006). Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models. Phytother. Res., 20: 869-871. (Pubitemid 44606483)
33. Uchiyama M and Mihara M (1978). Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem., 86: 271-278.
34. Wang H, Wei W, Zhang SY, Shen YX, Yue L, Wang NP and Xu SY (2005). Melatonin-selenium nanoparticles inhibit oxidative stress and protect against hepatic injury induced by Bacillus Calmette-Guerin/lipopolysaccharide in mice. J. Pineal Res., 39: 156-1563. (Pubitemid 41140754)
35. Yoshikawa T, Takano H, Takahashi S, Ichikawa H and Kondo M (1994). Changes in tissue antioxidant enzyme activities and lipid peroxides in endotoxininduced multiple organ failure. Circ. Shock, 42: 53-58. (Pubitemid 24051743)