Increased testicular 8-hydroxy-2′-deoxyguanosine (8-OHdG) and inducible nitric oxide synthetase (iNOS) and nuclear factor kappa B (NF-κB) expressions in experimental rat varicocele

Archivio Italiano di Urologia e Andrologia

Volumn 82, Issue 4, 2010, Pages 148-153

  Tuǧcu, Volkan ^a   Gedikbaşi, Asuman ^a   Mutlu, Bircan ^a   Güner, Ekrem ^a   Uhri, Mehmet ^a   Andican, Gülnur ^b   Özbek, Emin ^c   Taşçi, Ali I ^a  

^a BAKIRKOY DR SADI KONUK TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c VAKIF GUREBA TRAINING AND RESEARCH HOSPITAL   (Turkey)

Author keywords

iNOS; Testicular 8 OHdG; Varicocele

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; KIDNEY VEIN; LIGATION; MALE; MALE FERTILITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SHAM PROCEDURE; SPERMATIC VEIN; TESTIS; VARICOCELE;

ANIMALS; DEOXYGUANOSINE; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; TESTIS; VARICOCELE;

EID: 79951607485     PISSN: 11243562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Sigman M, Howards SS. Male infertility, in Walsh PC, Gittes RF, Pelmutter AD, et al. (Eds): Campbell's Urology, 7th ed. Philadelphia, WB Saunders, 1998; pp. 1287-1330.
2. Naughton CK, Nangia AK, Agarwal A. Pathophysiology of varicoceles in male infertility. Hum Reprod Update 2001; 7:473-81. (Pubitemid 32827547)
3. Benoff S, Marmar JL, Hurley IR. Molecular and other predictors for infertility in patients with varicoceles. Front Biosci 2009; 14:3641-72.
4. Agarwal A, Said TM. Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod 2003; 331-45. (Pubitemid 36987282)
5. Sakamoto Y, Ishikawa T, Kondo Y, et al. The assessment of oxidative stress in infertile patients with varicocele. BJU Int 2008; 101:1547-52. (Pubitemid 351704024)
6. Mitropoulos D, Deliconstantinos G, Zervas A, et al. Nitric oxide synthase and xanthine oxidase activities in the spermatic vein of patients with varicocele: a potential role for nitric oxide and peroxynitrite in sperm dysfunction. J Urol 1996; 156:1952-1958. (Pubitemid 26378025)
7. Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J 1991; 10:2247-58. (Pubitemid 21905698)
8. Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 1994; 269:4705-8. (Pubitemid 24239438)
9. Markewitz BA, Michael JR, Kohan DE. Cytokine-induced expression of a nitric oxide synthase in rat renal tubule cells. J Clin Invest 1993; 91:2138-43. (Pubitemid 23141489)
10. Fischer PA, Dominguez GN, Cuniberti LA, et al. Hyperhomocysteinemia induces renal hemodynamic dysfunction: is nitric oxide involved? J Am Soc Nephrol 2003; 14 653-60.
11. Huie RE, Padmaja S. The reaction of NO with superoxide. Free Radic Res Commun 1993; 18:195-9.
12. Tugcu V, Ozbek E, Tasci AI, et al. Selective nuclear factor kappa-B inhibitors, pyrolidium dithiocarbamate and sulfasalazine, prevent the nephrotoxicity induced by gentamicin. BJU M 2006; 98:680-6.
13. Tugcu V, Kemahli E, Ozbek E, et al. Protective effect of a potent antioxidant, pomegranate juice, in the kidney of rats with nephrolithiasis induced by ethylene glycol. J Endourol 2008; 22:2723-31.
14. Koksal T, Erdogru T, Toptas B, et al. Effect of experimental varicocele in rats on testicular oxidative stress status. Andrologia 2002; 34:242-7 (Pubitemid 35013806)
15. Türker Köksal I, Erdoǧru T, Gülkesen H, et al. The potential role of inducible nitric oxide synthase (iNOS) activity in the testicular dysfunction associated with varicocele: an experimental study. Int Urol Nephrol. 2004; 36: 67-72.
16. De Stefani, et al. Experimental varicocele in the rat: early evaluation of the nitric oxide levels and histological alterations in the testicular tissue. Andrologia 2005; 37:115-118.
17. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90:7915-22. (Pubitemid 23260825)
18. Ishikawa T, Fujioka H, Ishimura T, Tet al. Increased testicular 8-hydroxy-2′-deoxyguanosine in patients with varicocele. BJU Int 2007; 100:863-6.
19. Li H, Dubocq F, Jiang Y, et al. Effect of surgically induced varicocele on testicular blood flow and Sertoli cell function. Urology 1999; 53:1258-1262. (Pubitemid 29264765)
20. Chehval MJ, Martin SA, Alexander NJ, et al. The effect of unilateral injury to the vas deferens on the contralateral testis in immature and adult rats. J Urol 1995; 153:1313-1315.
21. Hendin BN, Kolettis PN, Sharma RK, et al. Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. J Urol 1999; 161:1831-4. (Pubitemid 29420743)
22. Kao SH, Chao HT, Chen HW, et al. Increase of oxidative stress in human sperm with lower motility. Fertil Steril 2008; 89:1183-90.
23. Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation, and human sperm function. Biol Reprod 1989; 41:183-97. (Pubitemid 19246344)
24. Davis KL, Martin E, Turko IV, et al. Novel effects of nitric oxide. Annu Rev Pharmacol Toxicol 2001; 41:203-36. (Pubitemid 32385888)
25. Sherman MP, Aeberhard EE, Wong VZ, et al. Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem Biophys Res Commun 1993; 191:1301-8. (Pubitemid 23231632)
26. Mülsch A, Schray-Utz B, Mordvintcev PI, et al. Diethyldithiocarbamate inhibits induction of macrophage NO synthase. FEBS Lett. 1993; 321:215-8. (Pubitemid 23114080)
27. O'Bryan MK, Schlatt S, Gerdprasert O, et al. Inducible nitric oxide synthase in the rat testis: evidence for potential roles in both normal function and inflammation-mediated infertility. Biol Reprod 2000; 63:1285-93.
28. Santoro G, Romeo C, Impellizzeri P, et al. Nitric oxide synthase patterns in normal and varicocele testis in adolescents. BJU Int 2001; 88:967-73. (Pubitemid 34099028)
29. Nathan C. Inducible nitric oxide synthase: what difference does it make? J Clin Invest 1997; 100:2417-2423.
30. Leung JC, Marphis T, Craver RD, et al. Altered NMDA receptor expression in renal toxicity: Protection with a receptor antagonist. Kidney Int 2004; 66:167-76. (Pubitemid 38870092)
31. Nallella KP, Allamaneni SS, Pasqualotto FF, et al. Relationship of interleukin-6 with semen characteristics and oxidative stress in patients with varicocele. Urology 2004; 64:1010-3. (Pubitemid 39469524)
32. Shen HM, Chia SE, Ong CN. Evaluation of oxidative DNA damage in human sperm and its association with male infertility. J Androl 1999; 20:718-23.
33. Fraga CG, Motchnik PA, Shigenaga MK, et al. Ascorbic add protects against endogenous oxidative DNA damage in human sperm.Proc Natl Acad Sci USA 1991; 88:11003-6.
34. Fraga CG, Motchnik PA, Wyrobek AJ, et al. Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutat Res 1996; 351:199-203. (Pubitemid 26134900)