Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats

Andrologia

Volumn 44, Issue 4, 2012, Pages 273-284

  Farombi, E O ^a   Adedara, I A ^a   Akinrinde, S A ^a   Ojo, O O ^a   Eboh, A S ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Cadmium; Kolaviron; Oxidative stress; Quercetin; Testes

Indexed keywords

CADMIUM; CATALASE; FOLLITROPIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; KOLAVIRON; LUTEINIZING HORMONE; MALONALDEHYDE; PROTECTIVE AGENT; QUERCETIN; SUPEROXIDE DISMUTASE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; EPIDIDYMIS; FOLLITROPIN BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REPRODUCTIVE TOXICITY; SEMEN ABNORMALITY; SPERMATOGENESIS; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TESTIS INJURY; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; WEIGHT REDUCTION;

ANIMALS; CADMIUM; CATTLE; ENDOCRINE GLANDS; FLAVONOIDS; MALE; QUERCETIN; TESTIS;

EID: 84863209695     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2012.01279.x     Document Type: Article

References (68)

1. Adedara IA, Farombi EO (2010) Induction of oxidative damage in the testes and spermatozoa and hematotoxicity in rats exposed to multiple doses of ethylene glycol monoethyl ether. Hum Exp Toxicol 29:801-812.
2. Akinloye O, Arowojolu AO, Shittu OB, Anetor JI (2006) Cadmium toxicity: a possible cause of male infertility in Nigeria. Reprod Biol 6:17-30.
3. Amara S, Abdelmelek H, Garrel C, Guiraud P, Douk T, Ravanat JL, Favier A, Sakly M, Rhouma KB (2008) Preventive effect of zinc against cadmium-induced oxidative stress in the rat testis. J Reprod Dev 54:129-134.
4. Anetor JI (2002) Endocrine Disruption. The probable situation in the highly polluted Nigerian environment. Scientific committee on problems of the environment/International union of pure and applied chemistry. International symposium of endocrine active substances and supplementary workshop. Program and collective abstract. Yokohama, Japan. pp 67-68.
5. Bauman JW, Liu J, Klaassen CD (1993) Production of metallothionein and heat-shock proteins in response to metals. Fundam Appl Toxicol 21:15-22.
6. Benoff S, Hurley IR, Mandel FS, Paine T, Jacob A, Cooper GW, Hershlag A (1997) Use of mannose ligands in IVF screens to mimic zona pellucida-induced acrosome reactions and predict fertilization success. Mol Hum Reprod 3:839-846.
7. Biswas NM, Sengupta R, Chatopadhyay GR, Choudhury A, Sarkar M (2001) Effect of ethanol on cadmium-induced testicular toxicity in male rats. Reprod Toxicol 15:699-704.
8. Chmielnicka J, Sowa B (1996) Cadmium interaction with essential metals (Zn, Cu, Fe), metabolism metallothionein, and ceruloplasmin in pregnant rats and fetuses. Ecotoxicol Environ Saf 35:277-281.
9. Cho SY, Park SJ, Kwon MJ, Jeong TS, Bok SH, Choi WY, Jeong WI, Ryu SY, Do SH, Lee CS, Song JC, Jeong KS (2003) Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappaB pathway in lipopolysaccharide-stimulated macrophage. Mol Cell Biochem 243:153-160.
10. Clairborne A (1995) Catalase activity. In: Handbook of Methods for Oxygen Radical Research. Greewald AR (ed.). CRC Press, Boca Raton, FL, pp 237-242.
11. El-Demerdash FM, Yousef MI, Kedwany FS, Bahadadi HH (2004) Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene. Food Chem Toxicol 42:1563-1571.
12. Farombi EO, Nwaokeafor IA (2005) Anti-oxidant mechanisms of action of kolaviron: studies on serum lipoprotein oxidation, metal chelation and oxidative microsomal membrane damage in rats. Clin Exp Pharmacol Physiol 32:667-674.
13. Farombi EO, Tahnteng JG, Agboola AO, Nwankwo JO, Emerole GO (2000) Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron-a Garcinia kola seed extract. Food Chem Toxicol 38:535-541.
14. Farombi EO, Akanni OO, Emerole GO (2002) Antioxidative and scavenging activities of kolaviron in vitro. Pharm Biol 40:107-116.
15. Farombi EO, Moller P, Dragsted LO (2004) Ex-vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress in human lymphocytes and rat liver cells. Cell Biol Toxicol 20:71-82.
16. Farombi EO, Adepoju BF, Ola-Davies OE, Emerole GO (2005) Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seeds. Eur J Cancer Prev 14:207-214.
17. Farombi EO, Abarikwu SO, Adedara IA, Oyeyemi MO (2007) Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol 100:43-48.
18. Farombi EO, Shrotriya S, Surh YJ (2009) Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-κB and AP-1. Life Sci 84:149-155.
19. Farombi EO, Adedara IA, Ebokaiwe AP, Teberen R, Ehwerhemuepha T (2010) Nigerian bonny light crude oil disrupts antioxidant systems in the testes and sperm of rats. Arch Environ Contam Toxicol 59:166-174.
20. Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S- transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139.
21. Hartwig A, Asmuss M, Blessing H, Hoffmann S, Jahnke G, Khandelwal S, Pelzer A, Burkle A (2002) Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability. Food Chem Toxicol 40:1179-1184.
22. IARC (1993) Beryllium, Cadmium, Mercury, and Exposures in the Glass Manufacturing Industry. IARC Monograph 58. IARC, Lyon.
23. Ikegwuonu FI, Egbunike GN, Emerole GO, Aire TA (1980) The effects of Aflatoxin B1 on some testicular and kidney enzyme activity in rat. Toxicology 17:9-16.
24. Iwu MM (1985) Antihepatotoxic constituents of Garcina kola seeds. Experientia 41:699-700.
25. Jee JH, Kang JC (2005) Biochemical changes of enzymatic defense system after phenanthrene exposure in olive flounder, Paralichthys olivaceus. Physiol Res 54:585-591.
26. Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR (1974) Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3, 4 bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11:151-169.
27. Joyce KL, Porcelli J, Cooke PS (1993) Neonatal goitrogen treatment increases adult testes size and sperm production in the mouse. J Androl 14:448-455.
28. Kawai M, Swan KF, Green AE, Edwards DE, Anderson MB, Henson MC (2002) Placental endocrine disruption induced by cadmium: effects on P450 cholesterol sidechain cleavage and 3β-hydroxysteroid dehydrogenase enzymes in cultured human trophoblasts. Biol Reprod 67:178-183.
29. Kusakabe T, Nakajima K, Nakazato K, Suzuki K, Takada H, Satoh T, Oikawa M, Arakawa K, Nagamine T (2008) Changes of heavy metal, metallothionein and heat shock proteins in Sertoli cells induced by cadmium exposure. Toxicol In Vitro 22:1469-1475.
30. Lafuente A, Marquez N, Perez-Lorenzo M, Pazo D, Esquifino AI (2000) Pubertal and post-pubertal Cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat. Food Chem Toxicol 38:913-923.
31. Li JL, Gao R, Li S, Wang JT, Tang ZX, Xu SW (2010) Testicular toxicity induced by dietary cadmium in cocks and ameliorative effect by selenium. Biometals 23:695-705.
32. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with folin phenol reagent. J Biol Chem 193:265-275.
33. Maduabuchi JMU, Nzegwu CN, Adigba EO, Aloke RU, Ezomike CN, Okocha CE, Obi E, Orisakwe OE (2006) Lead and cadmium exposures from canned and non-canned beverages in Nigeria: a public health concern. Sci Total Environ 366:621-626.
34. Manca D, Ricard AC, Trottier B, Chevalier G (1991) Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride. Toxicology 67:303-323.
35. Manna P, Sinha M, Sil PC (2008) Cadmium induced testicular pathophysiology: prophylactic role of taurine. Reprod Toxicol 26:282-291.
36. Misra HP, Fridovich I (1972) The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170-3175.
37. Murakami A, Ashida H, Terao J (2008) Multitargeted cancer prevention by quercetin. Cancer Lett 269:315-325.
38. Nair MP, Kandaswami C, Mahajan S, Chadha KC, Chawda R, Nair H, Kumar N, Nair RE, Schwartz SA (2002) The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta 1593:29-36.
39. 1 genotoxicity in human liver-derived HepG2 cells by kolaviron biflavonoids and molecular mechanisms of action. Eur J Cancer Prev 9:351-361.
40. Okoye CO (1994) Lead and other metals in dried fish from Nigerian markets. Bull Environ Contam Toxicol 52:825-832.
41. Olaleye SB, Farombi EO, Adewoye EA, Owoyele BV, Onasanwo SA, Elegbe RA (2000) Analgesic and anti-inflammatory effects of kolaviron (a Garcinia kola seed extract). Afr J Biomed Res 3:171-174.
42. Orisakwe OE, Nduka JK (2009) Lead and cadmium levels of commonly administered pediatric syrups in Nigeria: a public health concern? Sci Total Environ 407:5993-5996.
43. Oteiza PI, Adonaylo VN, Keen CL (1999) Cadmium-induced testes oxidative damage in rats can be influenced by dietary zinc intake. Toxicology 137:13-22.
44. Oyagbemi AA, Adedara IA, Saba AB, Farombi EO (2010) Role of oxidative stress in reproductive toxicity induced by co-administration of chloramphenicol and multivitamin-haematinics complex in rats. Basic Clin Pharmcol Toxicol 107:703-708.
45. Paksy K, Varga B, Horváth E, Tátrai E, Ungváry G (1989) Acute effects of cadmium on preovulatory serum FSH, LH, and prolactin levels and on ovulation and ovarian hormone secretion in estrous rats. Reprod Toxicol 3:241-247.
46. Pant N, Srivastava SP (2003) Testicular and spermatotoxic effects of quinalphos in rats. J Appl Toxicol 23:271-274.
47. Public Health Service (PHS) (1996) Public Health Service Policy on Humane Care and Use of Laboratory Animals. US Department of Health and Human Services, Washington, DC. [PL 99-158. Health Research Extension Act, 1985].
48. Punithavathi VR, Prince PSM (2010) Protective effects of combination of quercetin and α-tocopherol on mitochondrial dysfunction and myocardial infarct size in isoproterenol-treated myocardial infarcted rats: biochemical, transmission electron microscopic, and macroscopic enzyme mapping evidences. J Biochem Mol Toxicol 24:303-312.
49. Rec Gscc (DGKC) (1972) Optimised standard colorimetric methods. J Clin Chem Clin Biochem 10:182.
50. Reitmann S, Frankel S (1957) Colorimetric method for the determination of serum transaminase activity. Am J Clin Pathol 28:56-68.
51. Sadik NAH (2008) Effects of diallyl sulfide and zinc on testicular steroidogenesis in cadmium-treated male rats. J Biochem Mol Toxicol 22:345-353.
52. Saradha B, Mathur PP (2006) Induction of oxidative stress by lindane in epididymis of adult male rats. Environ Toxicol Pharmacol 22:90-96.
53. Schwartz GG, Reis IM (2000) Is cadmium a cause of human pancreatic cancer? Cancer Epidemiol Biomarkers Prev 9:139-145.
54. Shaikh ZA, Tang W (1999) Protection against chronic cadmium toxicity by glycine. Toxicology 132:139-146.
55. Siu ER, Mruk DD, Porto CS, Cheng CY (2009) Cadmium-induced testicular injury. Toxicol Appl Pharmacol 238:240-249.
56. Szuster-Ciesielska A, Stachura A, Slotwinska M, Kaminska T, Sniezko R, Paduch R, Abramczyk D, Filar J, Kandefer-Szerszen M (2000) The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology 145:159-171.
57. Takiguchi M, Yoshihara S (2006) New aspects of cadmium as endocrine disruptor. Environ Sci 13:107-116.
58. Tanigawa S, Fujii M, Hou DX (2007) Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin. Free Radic Biol Med 42:1690-1703.
59. Terashima K, Takawa Y, Niwa M (2002) Powerful antioxidative agents based on Garcinoic acid from Garcinia kola. Bioorg Med Chem 10:1619-1625.
60. Thompson J, Bannigan J (2008) Cadmium: toxic effects on the reproductive system and the embryo. Reprod Toxicol 25:304-315.
61. Uzun FG, Kalender S, Durak D, Demir F, Kalender Y (2009) Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and E. Food Chem Toxicol 47:1903-1908.
62. Waalkes MP (2000) Cadmium carcinogenesis in review. J Inorg Biochem 79:241-244.
63. Webb M, Cain K (1982) Function of metallothionein. Biochem Pharmacol 31:137-142.
64. Wells ME, Awa OA (1970) New technique for assessing acrosomal characteristics of spermatozoa. J Dairy Sci 53:227.
65. Wolff SP (1994) Ferrous ion oxidation in the presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol 233:182-189.
66. Yao P, Nussler A, Liu L, Hao L, Song F, Schirmeier A, Nussler N (2007) Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J Hepatol 47:253-261.
67. Yao Y, Han DD, Zhang T, Yang Z (2010) Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons. Phytother Res 24:136-140.
68. Zemjanis R (1970) Collection and evaluation of semen. In: Diagnostic and Therapeutic Technique in Animal Reproduction, 2nd edn. Zemjanis R (ed.). The William and Wilkins Company, Waverly Press Inc., Baltimore, MD, pp 139-153.