Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms

Pharmacological Research

Volumn 85, Issue , 2014, Pages 45-54

  Pye, Chelsey ^a   Elsherbiny, Nehal M ^c   Ibrahim, Ahmed S ^a,c   Liou, Gregory I ^b   Chadli, Ahmed ^b   Al Shabrawey, Mohamed ^a   Elmarakby, Ahmed A ^a,c  

^a AUGUSTA UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c MANSOURA UNIVERSITY   (Egypt)

Author keywords

Adenosine kinase inhibition; Albuminuria; Diabetes; Macrophage infiltration; Nitric oxide; Oxidative stress; Renal injury

Indexed keywords

4 AMINO 5 (3 BROMOPHENYL) 7 (6 MORPHOLINO 3 PYRIDINYL)PYRIDO[2,3 D]PYRIMIDINE; ADENOSINE KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRITE; PODOCALYXIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STREPTOZOCIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GLUCOSE BLOOD LEVEL; MITOGEN ACTIVATED PROTEIN KINASE; MORPHOLINE DERIVATIVE; NITRIC ACID DERIVATIVE; NOS3 PROTEIN, MOUSE; PYRIMIDINE DERIVATIVE; TRANSCRIPTION FACTOR RELA;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GLOMERULOPATHY; GLOMERULUS FILTRATION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; KIDNEY INJURY; MACROPHAGE; MALE; MOUSE; NEPHRITIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENAL PROTECTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TREATMENT DURATION; ANALOGS AND DERIVATIVES; ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ENDOTHELIUM CELL; HUMAN; KIDNEY; METABOLISM; PATHOLOGY; PROTEINURIA;

ADENOSINE KINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BLOOD GLUCOSE; CELL LINE; DEXTRANS; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; KIDNEY; MALE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NADPH OXIDASE; NITRATES; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; PROTEINURIA; PYRIMIDINES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRANSCRIPTION FACTOR RELA;

EID: 84902551007     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.05.004     Document Type: Article

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