Adenosine A 2A agonists as therapy for glomerulonephritis

Kidney International

Volumn 80, Issue 4, 2011, Pages 329-331

  Ferenbach, David A ^a   Hughes, Jeremy ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; COLLAGEN TYPE 3; COLLAGEN TYPE 4; CREATININE; MACROPHAGE DERIVED CHEMOKINE; OSTEOPONTIN; THROMBOSPONDIN; TRANSFORMING GROWTH FACTOR BETA;

ANTIINFLAMMATORY ACTIVITY; CELL INFILTRATION; CHRONIC INFLAMMATION; CREATININE BLOOD LEVEL; GLOMERULONEPHRITIS; GLOMERULUS BASEMENT MEMBRANE; HUMAN; IMMUNOMODULATION; KIDNEY FIBROSIS; KIDNEY SCAR; MACROPHAGE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RECEPTOR BLOCKING; REVIEW; URETER OBSTRUCTION;

EID: 80052251434     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.167     Document Type: Note

References (16)

1. Ferenbach D, Kluth DC, Hughes J. Inflammatory cells in renal injury and repair. Semin Nephrol 2007; 27: 250-259. (Pubitemid 46802913)
2. Garcia GE, Truong LD, Chen J-F et al. Adenosine A2 A receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. Kidney Int 2011;80: 378-388.
3. Garcia GE, Truong LD, Li P et al. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. FASEB J 2008; 22: 445-454. (Pubitemid 351225581)
4. Hasko G, Pacher P. A2A receptors in inflammation and injury: lessons learned from transgenic animals. J Leukoc Biol 2008; 83: 447-455. (Pubitemid 351966849)
5. Hasko G, Pacher P, Deitch EA, Vizi ES. Shaping of monocyte and macrophage function by adenosine receptors. P harmacol Ther 2007; 113: 264-275. (Pubitemid 46149045)
6. Awad AS, Huang L, Ye H et al. Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy. Am J Physiol Renal Physiol 2006;290: F828-F837. (Pubitemid 43724943)
7. Awad AS, Rouse M, Huang L et al. Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury. Kidney Int 2009;75: 689-698.
8. Lange-Sperandio B, Forbes MS, Thornhill B et al. A2A adenosine receptor agonist and PDE4 inhibition delays inflammation but fails to reduce injury in experimental obstructive nephropathy. Nephron Exp Nephrol 2005;100: e 113-e 123. (Pubitemid 40868956)
9. Carlstrom M, Wilcox CS, Welch WJ. Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol 2011;300: F 457-F 464.
10. Awad AS, Rouse M, Liu L et al. Activation of adenosine 2A receptors preserves structure and function of podocytes. J Am Soc Nephrol 2008; 19: 59-68.
11. Kim MG, Boo CS, Ko YS et al. Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury. N ephrol Dial Transplant 2010; 25: 2908-2921.
12. Duffield JS, Forbes SJ, Constandinou CM et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 2005;115: 56-65. (Pubitemid 40385505)
13. Nahrendorf M, Swirski FK, Aikawa E et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007; 204: 3037-3047. (Pubitemid 350179569)
14. Lee S, Huen S, Nishio H et al. Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol 2011;22: 317-326.
15. Nemeth ZH, Csoka B, Wilmanski J et al. Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis. J Immunol 2006; 176: 5616-5626.
16. Müller CE, Jacobson KA. Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta 2011; 1808: 1290-1308.