Urinary Metabolic Biomarker and Pathway Study of Hepatitis B Virus Infected Patients Based on UPLC-MS System

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Zhang, Aihua ^a   Sun, Hui ^a   Han, Ying ^a   Yan, Guangli ^a   Wang, Xijun ^a  

^a HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOSUGAR; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CYTOCHROME P450; PHENYLALANINE;

ARTICLE; AUTOMATED PATTERN RECOGNITION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; FEMALE; HEPATITIS B; HUMAN; LIVER BIOPSY; LIVER CIRRHOSIS; MALE; METABOLITE; METABOLOMICS; SENSITIVITY AND SPECIFICITY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; MALE; METABOLOMICS; MIDDLE AGED; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84877816058     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064381     Document Type: Article

References (26)

1. Wedemeyer H, Yurdaydìn C, Dalekos GN, Erhardt A, Çakaloǧlu Y, et al. (2011) Peginterferon plus adefovir versus either drug alone for hepatitis delta. N Engl J Med 364: 322-331.
2. Zheng D, Zhang S, Zhou X, Wang C, Xiang P, et al. (2012) The FgHOG1 Pathway Regulates Hyphal Growth, Stress Responses, and Plant Infection in Fusarium graminearum. PLoS One 7: e49495.
3. Amantonico A, Urban PL, Zenobi R, (2010) Analytical techniques for single-cell metabolomics: state of the art and trends. Anal Bioanal Chem 398: 2493-2504.
4. Zhang A, Sun H, Yan G, Han Y, Ye Y, et al. (2013) Urinary metabolic profiling identifies a key role for glycocholic acid in human liver cancer by ultra-performance liquid-chromatography coupled with high-definition mass spectrometry. Clin Chim Acta 418C: 86-90.
5. Zhang A, Sun H, Wang P, Han Y, Wang X, (2012) Recent and potential developments of biofluid analyses in metabolomics. J Proteomics 75: 1079-1088.
6. Zhang A, Sun H, Wang X (2012) Power of metabolomics in biomarker discovery and mining mechanisms of obesity. Obes Rev. doi: 10.1111/obr.12011.
7. Zhang A, Sun H, Wu X, Wang X, (2012) Urine metabolomics. Clin Chim Acta 414: 65-69.
8. Zhang A, Sun H, Han Y, Yuan Y, Wang P, et al. (2012) Exploratory urinary metabolic biomarkers and pathways using UPLC-Q-TOF-HDMS coupled with pattern recognition approach. Analyst 137: 4200-4208.
9. Wang X, Zhang A, Wang P, Sun H, Wu G, et al. (2013) Metabolomics coupled with proteomics advancing drug discovery towards more agile development of targeted combination therapies. Mol Cell Proteomics. doi: 10.1074/mcp.M112.021683.
10. Walsh BH, Broadhurst DI, Mandal R, Wishart DS, Boylan GB, et al. (2012) The metabolomic profile of umbilical cord blood in neonatal hypoxic ischaemic encephalopathy. PLoS One 7: e50520.
11. Wang X, Zhang A, Sun H, (2012) Future perspectives of Chinese medical formulae: chinmedomics as an effector. OMICS 16: 414-21.
12. Wang X, Wang Q, Zhang A, Zhang F, Zhang H, et al. (2013) Metabolomics study of intervention effects of Wen-Xin-Formula using ultra high-performance liquid chromatography/mass spectrometry coupled with pattern recognition approach. J Pharm Biomed Anal 74: 22-30.
13. Hall JA, Jewell DE, (2012) Feeding healthy beagles medium-chain triglycerides, fish oil, and carnitine offsets age-related changes in serum Fatty acids and carnitine metabolites. PLoS One 7: e49510.
14. Zhang A, Sun H, Wang X (2012) Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma. Hepatology doi: 10.1002/hep.26130.
15. Zhang A, Sun H, Wang X, (2012) Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment. Appl Biochem Biotechnol 168: 1718-1727.
16. Dove AD, Leisen J, Zhou M, Byrne JJ, Lim-Hing K, et al. (2012) Biomarkers of whale shark health: a metabolomic approach. PLoS One 7: e49379.
17. Wang X, Yang B, Zhang A, Sun H, Yan G, (2012) Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach. J Proteomics 75: 1411-1427.
18. van Wietmarschen HA, Dai W, van der Kooij AJ, Reijmers TH, Schroën Y, et al. (2012) Characterization of rheumatoid arthritis subtypes using symptom profiles, clinical chemistry and metabolomics measurements. PLoS One 7: e44331.
19. Wong VW, Wong GL, Chu WC, Chim AM, Ong A, et al. (2012) Hepatitis B virus infection and fatty liver in the general population. J Hepatol 56: 533-540.
20. Lee SA, Kim K, Kim H, Kim BJ, (2012) Nucleotide change of codon 182 in the surface gene of hepatitis B virus genotype C leading to truncated surface protein is associated with progression of liver diseases. J Hepatol 56: 63-69.
21. Chen J, Wen H, Liu J, Yu C, Zhao X, et al. (2012) Metabonomics study of the acute graft rejection in rat renal transplantation using reversed-phase liquid chromatography and hydrophilic interaction chromatography coupled with mass spectrometry. Mol Biosyst 8: 871-8878.
22. McMahon MA, Jilek BL, Brennan TP, Shen L, Zhou Y, et al. (2007) The HBV drug entecavir- effects on HIV-1 replication and resistance. N Engl J Med 356: 2614-2621.
23. Fabris C, Falleti E, Cussigh A, Bitetto D, Fontanini E, et al. (2011) IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: role in the course of chronic viral hepatitis and the development of HCC. J Hepatol 54: 716-722.
24. Zhang A, Sun H, Dou S, Sun W, Wu X, et al. (2013) Metabolomics study on the hepatoprotective effect of scoparone using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. Analyst 138: 353-361.
25. Wang X, Zhang A, Han Y, Wang P, Sun H, et al. (2012) Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease. Mol Cell Proteomics 11: 370-80.
26. Meissen JK, Yuen BT, Kind T, Riggs JW, Barupal DK, et al. (2012) Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism. PLoS One 7: e46770.