The inflammasomes in autoinflammatory diseases with skin involvement

Journal of Investigative Dermatology

Volumn 134, Issue 7, 2014, Pages 1805-1810

  Beer, Hans Dietmar ^a   Contassot, Emmanuel ^a   French, Lars E ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMASOME; INTERLEUKIN 1BETA;

AUTOINFLAMMATORY DISEASE; CINCA SYNDROME; DISEASE ASSOCIATION; ENZYME ACTIVITY; HUMAN; INNATE IMMUNITY; INTERLEUKIN 1 RECEPTOR ANTAGONIST DEFICIENCY; KERATINOCYTE; NEUTROPHIL; PAPA SYNDROME; PRIORITY JOURNAL; REVIEW; SAPHO SYNDROME; SCHNITZLER SYNDROME; SIGNAL TRANSDUCTION; SKIN DISEASE; TISSUE INJURY;

ACNE VULGARIS; ACQUIRED HYPEROSTOSIS SYNDROME; ANIMALS; ARTHRITIS, INFECTIOUS; AUTOIMMUNE DISEASES; BIOLOGICAL THERAPY; HUMANS; INFLAMMASOMES; KERATINOCYTES; MICE; PYODERMA GANGRENOSUM; SCHNITZLER SYNDROME; SKIN DISEASES;

EID: 84902544430     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.76     Document Type: Article

References (50)

1. Afonina IS, Tynan GA, Logue SE et al. (2011) Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1alpha. Mol Cell 44: 265-78
2. Agostini L, Martinon F, Burns K et al. (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20: 319-25
3. Aksentijevich I, Masters SL, Ferguson PJ et al. (2009) An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med 360: 2426-37
4. Asahina A, Sakurai N, Suzuki Y et al. (2010) Schnitzler's syndrome with prominent neutrophil infiltration misdiagnosed as Sweet's syndrome: a typical example of urticarial neutrophilic dermatosis. Clin Exp Dermatol 35:e123-6
5. Bauernfeind FG, Horvath G, Stutz A et al. (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183: 787-787
6. Bergsbaken T, Fink SL, Cookson BT (2009) Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 7: 99-109
7. Beutler BA (2009) TLRs and innate immunity. Blood 113: 1399-407
8. Brenner M, Ruzicka T, Plewig G et al. (2009) Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. Br J Dermatol 161: 1199-1199
9. Brydges SD, Mueller JL, McGeough MD et al. (2009) Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30: 875-87
10. Burns K, Martinon F, Tschopp J (2003) New insights into the mechanism of IL-1beta maturation. Curr Opin Immunol 15: 26-30
11. Cortis E, De Benedetti F, Insalaco A et al. (2004) Abnormal production of tumor necrosis factor (TNF) - alpha and clinical efficacy of the TNF inhibitor etanercept in a patient with PAPA syndrome [corrected]. J Pediatr 145: 851-5
12. de Koning HD, Schalkwijk J, van der Meer JW et al. (2011) Successful canakinumab treatment identifies IL-1beta as a pivotal mediator in Schnitzler syndrome. J Allergy Clin Immunol 128: 1352-4
13. Dierselhuis MP, Frenkel J, Wulffraat NM et al. (2005) Anakinra for flares of pyogenic arthritis in PAPA syndrome. Rheumatology (Oxford) 44: 406-8
14. Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27: 519-50
15. Dombrowski Y, Peric M, Koglin S et al. (2011) Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci Transl Med 3:82ra38
16. Dombrowski Y, Peric M, Koglin S et al. (2012) Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes. Allergy 67: 1400-7
17. Feldmeyer L, Keller M, Niklaus G et al. (2007) The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 17: 1140-5
18. Fettelschoss A, Kistowska M, LeibundGut-Landmann S et al. (2011) Inflammasome activation and IL-1beta target IL-1alpha for secretion as opposed to surface expression. Proc Natl Acad Sci USA 108: 18055-60
19. Gross O, Yazdi AS, Thomas CJ et al. (2012) Inflammasome activators induce interleukin- 1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36: 388-400
20. Hoffman HM, Mueller JL, Broide DH et al. (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 29: 301-5
21. Hoffman HM, Rosengren S, Boyle DL et al. (2004) Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 364: 1779-85
22. Hoffman HM, Throne ML, Amar NJ et al. (2008) Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum 58: 2443-52
23. Kofoed EM, Vance RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477: 592-5
24. Kone-Paut I, Lachmann HJ, Kuemmerle-Deschner JB et al. (2011) Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study. Arthritis Res Ther 13:R202
25. Krause K, Weller K, Stefaniak R et al. (2012) Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: an open-label study. Allergy 67: 943-50
26. Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB et al. (2009) Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med 360: 2416-25
27. Launay D, Dutoit-Lefevre V, Faure E et al. (2013) Effect of in vitro and in vivo anakinra on cytokines production in Schnitzler syndrome. PLoS One 8:e59327
28. Lu B, Nakamura T, Inouye K et al. (2012) Novel role of PKR in inflammasome activation and HMGB1 release. Nature 488: 670-4
29. Lukens JR, Vogel P, Johnson GR et al. (2013) RIP1- driven autoinflammation targets IL-1alpha independently of inflammasomes and RIP3. Nature 498: 224-7
30. Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10: 417-26
31. Masters SL, Simon A, Aksentijevich I et al. (2009) Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Annu Rev Immunol 27: 621-68
32. Meng G, Zhang F, Fuss I et al. (2009) A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 celldominant immune responses. Immunity 30: 860-860
33. Miao EA, Warren SE (2010) Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome. J Clin Immunol 30: 502-6
34. Nakamura Y, Franchi L, Kambe N et al. (2012) Critical role for mast cells in interleukin- 1beta-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity 37: 85-95
35. Nakamura Y, Kambe N, Saito M et al. (2009) Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med 206: 1037-46
36. Nesterovitch AB, Hoffman MD, Simon M et al. (2011) Mutations in the PSTPIP1 gene and aberrant splicing variants in patients with pyoderma gangrenosum. Clin Exp Dermatol 36: 889-95
37. Nickel W, Rabouille C (2009) Mechanisms of regulated unconventional protein secretion. Nat Rev Mol Cell Biol 10: 148-55
38. Reddy S, Jia S, Geoffrey R et al. (2009) An autoinflammatory disease due to homozygous deletion of the IL1RN locus. N Engl J Med 360: 2438-44
39. Reinholz M, Kawakami Y, Salzer S et al. (2013) HPV16 activates the AIM2 inflammasome in keratinocytes. Arch Dermatol Res 305: 723-723
40. Schnellbacher C, Ciocca G, Menendez R et al. (2012) Deficiency of interleukin-1 receptor antagonist responsive to anakinra. Pediatr Dermatol 30: 758-60
41. Shoham NG, Centola M, Mansfield E et al. (2003) Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. Proc Natl Acad Sci USA 100: 13501-6
42. Sollberger G, Strittmatter GE, Kistowska M et al. (2012) Caspase-4 is required for activation of inflammasomes. J Immunol 188: 1992-2000
43. Strowig T, Henao-Mejia J, Elinav E et al. (2012) Inflammasomes in health and disease. Nature 481: 278-86
44. Volz T, Wolbing F, Fischer J et al. (2012) Dermal interleukin-1 expression and effective and long-lasting therapy with interleukin-1 receptor antagonist anakinra in Schnitzler syndrome. Acta Derm Venereol 92: 393-4
45. Wagner AD, Andresen J, Jendro MC et al. (2002) Sustained response to tumor necrosis factor alpha-blocking agents in two patients with SAPHO syndrome. Arthritis Rheum 46: 1965-1965
46. Wang D, Hoing S, Patterson HC et al. (2013) Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndromeassociated PSTPIP1 A230T mutant proteins. J Biol Chem 288: 4594-601
47. Watanabe H, Gaide O, Petrilli V et al. (2007) Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 127: 1956-63
48. Wendling D, Prati C, Aubin F (2012) Anakinra treatment of SAPHO syndrome: short-term results of an open study. Ann Rheum Dis 71: 1098-100
49. Wu J, Fernandes-Alnemri T, Alnemri ES (2010) Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes. J Clin Immunol 30: 693-702
50. Yu JW, Fernandes-Alnemri T, Datta P et al. (2007) Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol Cell 28: 214-27 (Pubitemid 47600003)