Early failure of the default-mode network and the pathogenesis of Alzheimer's disease

CNS Neuroscience and Therapeutics

Volumn 20, Issue 7, 2014, Pages 692-698

  Simic, Goran ^a   Babic, Mirjana ^a   Borovecki, Fran ^a   Hof, Patrick R ^b  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PITTSBURGH COMPOUND B;

ALZHEIMER DISEASE; BASAL GANGLION; BRAIN CELL; BRAIN DYSFUNCTION; BRAIN FUNCTION; CELL DEATH; COGNITION; CONNECTOME; CORRELATIONAL STUDY; DEFAULT MODE NETWORK; DEMENTIA; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; ELECTROENCEPHALOGRAM; FAMILIAL ALZHEIMER DISEASE; GENE MUTATION; HUMAN; LETTER; NEUROIMAGING; NEUROPATHOLOGY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PYRAMIDAL NERVE CELL; SPORADIC ALZHEIMER DISEASE; ANIMAL; BRAIN; BRAIN MAPPING; METABOLISM; NERVE CELL NETWORK; PATHOLOGY; PROCEDURES;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; BRAIN MAPPING; HUMANS; NERVE NET;

EID: 84902543261     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12260     Document Type: Letter

References (82)

1. Biswal B, Yetkin FZ, Haughton VM, Hyde JS. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 1995;34:537-541.
2. Birn RM, Murphy K, Bandettini PA. The effect of respiration variations on independent component analysis results of resting state functional connectivity. Hum Brain Mapp 2008;29:740-750.
3. Murphy K, Birn RM, Handwerker DA, Jones TB, Bandettini PA. The impact of global signal regression on resting state correlations: Are anti-correlated networks introduced? Neuroimage 2009;44:893-905.
4. Beckmann CF, DeLuca M, Devlin JT, Smith SM. Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci 2005;360:1001-1013.
5. Greicius M. Resting-state functional connectivity in neuropsychiatric disorders. Curr Opin Neurol 2008;21:424-430.
6. Smith SM, Fox PT, Miller KL, et al. Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci USA 2009;106:13040-13045.
7. Deco G, Jirsa VK, McIntosh AR. Resting brains never rest: Computational insights into potential cognitive architectures. Trends Neurosci 2013;36:268-274.
8. Damoiseaux JS, Greicius MD. Greater than the sum of its parts: A review of studies combining structural connectivity and resting state functional connectivity. Brain Struct Funct 2009;213:525-533.
9. Greicius MD, Menon V. Default-mode activity during a passive sensory task: Uncoupled from deactivation but impacting activation. J Cogn Neurosci 2004;16:1484-1492.
10. Greicius MD, Supekar K, Menon V, Dougherty RF. Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex 2009;19:72-78.
11. Pengas G, Williams GB, Acosta-Cabronero J, et al. The relationship of topographical memory performance to regional neurodegeneration in Alzheimer's disease. Front Aging Neurosci 2012;4:17.
12. Supekar K, Uddin LQ, Prater K, Amin H, Greicius MD, Menon V. Development of functional and structural connectivity within the default mode network in young children. Neuroimage 2010;52:290-301.
13. Vanhaudenhuyse A, Noirhomme Q, Tshibanda LJ, et al. Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 2010;133:161-171.
14. Lu H, Zou Q, Gu H, Raichle ME, Stein EA, Yang Y. Rat brains also have a default mode network. Proc Natl Acad Sci USA 2012;109:3979-3984.
15. Liu CY, Krishnan AP, Yan L, et al. Complexity and synchronicity of resting state blood oxygenation level-dependent (BOLD) functional MRI in normal aging and cognitive decline. J Magn Reson Imaging 2013;38:36-45.
16. Brooks DJ. Positron emission tomography and single-photon emission computed tomography in central nervous system drug development. NeuroRx 2005;2:226-236.
17. Rykhlevskaia E, Gratton G, Fabiani M. Combining structural and functional neuroimaging data for studying brain connectivity: A review. Psychophysiology 2008;45:173-187.
18. Klunk WW, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 2004;55:306-319.
19. 18F-FDDNP binding. J Nucl Med 2009;50:1464-1470.
20. Jack CR Jr., Barrio JR, Kepe V. Cerebral amyloid PET imaging in Alzheimer's disease. Acta Neuropathol 2013;126:643-657.
21. Maruyama M, Shimada H, Suhara T, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron 2013;79:1094-1108.
22. Hatashita S, Yamasaki H, Suzuki Y, Tanaka K, Wakebe D, Hayakawa H. [(18)F]Flutemetamol amyloid-beta PET imaging compared with [(11)C]PIB across the spectrum of Alzheimer's disease. Eur J Nucl Med Mol Imaging 2014;41:290-300.
23. Andrade-Moraes CH, Oliveira-Pinto AV, Castro-Fonseca E, et al. Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles. Brain 2013;136:3738-3752.
24. Sanes JR, Jessell TM. The aging brain. In: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, editors. Principles of neural science, 5th edn. McGraw-Hill, NewYork, NY, 2012;1328-1346.
25. Bettens K, Sleegers K, Van Broeckhoven C. Genetic insights in Alzheimer's disease. Lancet Neurol 2013;12:92-104.
26. Bhatia N, Hall GF. Untangling the role of tau in Alzheimer's disease: A unifying hypothesis. Transl Neurosci 2013;4:115-133.
27. Diana A, Simic G, Sinforiani E, Orrù N, Pichiri G, Bono G. Mitochondria morphology and DNA content upon sublethal exposure to beta-amyloid1-42 peptide. Coll Antropol 2008;32:51-58.
28. Mawuenyega KG, Sigurdson W, Ovod V, et al. Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science 2010;330:1774.
29. Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Merkle RK, Gong CX. Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease. FEBS Lett 2002;512:101-106.
30. Salkovic-Petrisic M, Tribl F, Schmidt M, Hoyer S, Riederer P. Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signaling pathway. J Neurochem 2006;96:1005-1015.
31. Andrews-Hanna JR, Snyder AZ, Vincent JL, et al. Disruption of large-scale brain systems in advanced aging. Neuron 2007;56:924-935.
32. Hafkemeijer A, van der Grond J, Rombouts SA. Imaging the default mode network in aging and dementia. Biochim Biophys Acta 2012;1822:431-441.
33. Lustig C, Snyder AZ, Bhakta M, et al. Functional deactivations: Change with age and dementia of the Alzheimer type. Proc Natl Acad Sci USA 2003;100:14504-14509.
34. Grady CL, Springer MV, Hongwanishkul D, McIntosh AR, Winocur G. Age-related changes in brain activity across the adult lifespan. J Cogn Neurosci 2006;18:227-241.
35. Koch W, Teipel S, Mueller S, et al. Effects of aging on default mode network activity in resting state fMRI: Does the method of analysis matter? Neuroimage 2010;51:280-287.
36. Damoiseaux JS, Beckmann CF, Arigita EJ, et al. Reduced resting-state brain activity in the "default network" in normal aging. Cereb Cortex 2008;18:1856-1864.
37. He Y, Wang L, Zang Y, et al. Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study. Neuroimage 2007;35:488-500.
38. Allen G, Barnard H, McColl R, et al. Reduced hippocampal functional connectivity in Alzheimer's disease. Arch Neurol 2007;64:1482-1487.
39. Zhang HY, Wang SJ, Liu B, et al. Resting brain connectivity: Changes during the progress of Alzheimer disease. Radiology 2010;256:598-606.
40. Wu X, Li R, Fleisher AS, et al. Altered default mode network connectivity in Alzheimer's disease - a resting functional MRI and Bayesian network study. Hum Brain Mapp 2011;32:1868-1881.
41. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85-94.
42. Buckner RL, Sepulcre J, Talukdar T, et al. Cortical hubs revealed by intrinsic functional connectivity: Mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci 2009;29:1860-1873.
43. Wong DF, Rosenberg PB, Zhou Y, et al. In vivo imaging of amyloid deposition in Alzheimer's disease using the novel radioligand 8FAV-45 (Florbetapir F 18). J Nucl Med 2010;51:913-920.
44. Saint-Aubert L, Barbeau EJ, Péran P, et al. Cortical florbetapir-PET amyloid load in prodromal Alzheimer's disease patients. EJNMMI Res 2013;3:43.
45. Binnewijzend MA, Schoonheim MM, Sanz-Arigita E, et al. Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 2012;33:2018-2028.
46. Damoiseaux JS, Prater KE, Miller BL, Greicius MD. Functional connectivity tracks clinical deterioration in Alzheimer's disease. Neurobiol Aging 2012;33:19-30.
47. Lehmann M, Madison CM, Ghosh PM, et al. Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer's disease. Proc Natl Acad Sci USA 2013;110:11606-11611.
48. Fleisher AS, Sherzai A, Taylor C, Langbaum JB, Chen K, Buxton RB. Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer's disease risk groups. Neuroimage 2009;47:1678-1690.
49. Reiman EM, Quiroz YT, Fleisher AS, et al. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: A case-control study. Lancet Neurol 2012;11:1048-1056.
50. Chhatwal JP, Schultz AP, Johnson K, et al. Impaired default network functional connectivity in autosomal dominant Alzheimer disease. Neurology 2013;81:736-744.
51. Sheline YI, Raichle ME. Resting state functional connectivity in preclinical Alzheimer's disease. Biol Psychiatry 2013;74:340-347.
52. Vlassenko AG, Vaishnavi SN, Couture L, et al. Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition. Proc Natl Acad Sci USA 2010;107:17763-17767.
53. Hof PR, Morrison JH. The aging brain: Morphomolecular senescence of cortical circuits. Trends Neurosci 2004;27:607-613.
54. Morisson JH, Hof PR. Life and death of neurons in the aging brain. Science 1997;278:412-419.
55. Simic G, Kostovic I, Winblad B, Bogdanovic N. Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease. J Comp Neurol 1997;379:482-494.
56. Hof PR, Cox K, Morrison JH. Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex. J Comp Neurol 1990;301:44-54.
57. Hof PR, Morrison JH. Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: II. Primary and secondary visual cortex. J Comp Neurol 1990;301:55-64.
58. Bussière T, Giannakopoulos P, Bouras C, Perl DP, Morrison JH, Hof PR. Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: Stereologic analysis of prefrontal cortex area 9. J Comp Neurol 2003;463:281-302.
59. Bussière T, Gold G, Kövari E, et al. Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer's disease. Neuroscience 2003;117:577-592.
60. Simic G, Stanic G, Mladinov M, Jovanov-Milosevic N, Kostovic I, Hof PR. Does Alzheimer's disease begin in the brainstem? Neuropathol Appl Neurobiol 2009;35:532-554.
61. Braak H, Del Tredici K. Amyloid-β may be released from non-juctional varicosities of axons generated from abnormal tau-containing brainstem nuclei in sporadic Alzheimer's disease: A hypothesis. Acta Neuropathol 2013;126:303-306.
62. Braak H, Del Tredici K. Reply: The early pathological process in sporadic Alzheimer's disease. Acta Neuropathol 2013;126:615-618.
63. Mann DMA, Hardy J. Amyloid or tau: The chicken or the egg? Acta Neuropathol 2013;126:609-613.
64. Attems J, Jellinger KA. Amyloid and tau: Neither chicken nor egg but two partners in crime!. Acta Neuropathol 2013;126:619-621.
65. Hedden T, Van Dijk KR, Becker JA, et al. Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. J Neurosci 2009;29:12686-12694.
66. Wang L, Brier MR, Snyder AZ, et al. Cerebrospinal fluid Aβ42, phosphorylated tau181, and resting-state functional connectivity. JAMA Neurol 2013;70:1242-1248.
67. Sheline YI, Raichle ME, Snyder AZ, et al. Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly. Biol Psychiatry 2010;67:584-587.
68. Mormino EC, Smiljic A, Hayenga AO, et al. Relationship between β-amyloid and functional connectivity in different components of the default mode network in aging. Cereb Cortex 2011;21:2399-2407.
69. Cirrito JR, Yamada KA, Finn MB, et al. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 2005;48:913-922.
70. Handoko M, Grant M, Kuskowski M, et al. Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults. JAMA Neurol 2013;70:594-599.
71. Lesné SE, Sherman MA, Grant M, et al. Brain amyloid-β oligomers in ageing and Alzheimer's disease. Brain 2013;136:1383-1398.
72. Zahs KR, Ashe KH. β-Amyloid oligomers in aging and Alzheimer's disease. Front Aging Neurosci 2013;5:28.
73. Roh JH, Huang Y, Bero AW, et al. Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology. Sci Transl Med 2012;4:150ra122.
74. Monti JM. Serotonin control of sleep-wake behavior. Sleep Med Rev 2011;15:269-281.
75. Kang JE, Lim MM, Bateman RJ, et al. Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science 2009;326:1005-1007.
76. Ju YE, McLeland JS, Toedebusch CD, et al. Sleep quality and preclinical Alzheimer disease. JAMA Neurol 2013;70:587-593.
77. Horovitz SG, Braun AR, Carr WS, et al. Decoupling of the brain's default mode network during deep sleep. Proc Natl Acad Sci USA 2009;106:11376-11381.
78. Dang-Vu TT, Schabus M, Desseilles M, Sterpenich V, Bonjean M, Maquet P. Functional neuroimaging insights into the physiology of human sleep. Sleep 2010;33:1589-1603.
79. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-259.
80. Dickson TC, King CE, McCormack GH, Vickers JC. Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease. Exp Neurol 1999;156:100-110.
81. Vickers JC, Dickson TC, Adlard PA, Saunders HL, King CE, McCormack G. The cause of neuronal degeneration in Alzheimer's disease. Prog Neurobiol 2000;60:139-165.
82. Rijal Upadhaya A, Kosterin I, Kumar S, et al. Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease. Brain 2014;137:887-903.