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Volumn 126, Issue 2, 2013, Pages 303-306

Amyloid-β may be released from non-junctional varicosities of axons generated from abnormal tau-containing brainstem nuclei in sporadic Alzheimer's disease: A hypothesis

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; TAU PROTEIN;

EID: 84881085093     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-013-1153-2     Document Type: Letter
Times cited : (38)

References (52)
  • 1
    • 0028876904 scopus 로고
    • Volume versus wiring transmission in the brain: A new theoretical frame of neuropsychopharmacology
    • 7898168 10.1002/med.2610150104 1:STN:280:DyaK2M3gsF2ntA%3D%3D
    • Agnati LF, Bjelke B, Fuxe K (1995) Volume versus wiring transmission in the brain: a new theoretical frame of neuropsychopharmacology. Med Res Rev 15:33-45
    • (1995) Med Res Rev , vol.15 , pp. 33-45
    • Agnati, L.F.1    Bjelke, B.2    Fuxe, K.3
  • 2
    • 84858031332 scopus 로고    scopus 로고
    • Striatal amyloid plaque density predicts Braak neurofibrillary stage and clinicopathological Alzheimer's disease: Implications for amyloid imaging
    • 22112552 1:CAS:528:DC%2BC38XisFejtbc%3D
    • Beach TG, Sue LI, Walker DG et al (2012) Striatal amyloid plaque density predicts Braak neurofibrillary stage and clinicopathological Alzheimer's disease: implications for amyloid imaging. J Alzheimers Dis 28:869-876
    • (2012) J Alzheimers Dis , vol.28 , pp. 869-876
    • Beach, T.G.1    Sue, L.I.2    Walker, D.G.3
  • 4
    • 0025247775 scopus 로고
    • Alzheimer's disease: Amyloid deposits and neurofibrillary changes in the striatum
    • 1692337 10.1097/00005072-199005000-00003 1:STN:280:DyaK3c3ksVamuw%3D%3D
    • Braak H, Braak E (1990) Alzheimer's disease: amyloid deposits and neurofibrillary changes in the striatum. J Neuropathol Exp Neurol 49:215-224
    • (1990) J Neuropathol Exp Neurol , vol.49 , pp. 215-224
    • Braak, H.1    Braak, E.2
  • 5
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • 1759558 10.1007/BF00308809 1:STN:280:DyaK387gtFOiug%3D%3D
    • Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 6
    • 2542567240 scopus 로고    scopus 로고
    • Alzheimer's disease: Intraneuronal alterations precede insoluble amyloid-β formation
    • 15165692 10.1016/j.neurobiolaging.2003.12.015
    • Braak H, Del Tredici K (2004) Alzheimer's disease: intraneuronal alterations precede insoluble amyloid-β formation. Neurobiol Aging 25:713-718
    • (2004) Neurobiol Aging , vol.25 , pp. 713-718
    • Braak, H.1    Del Tredici, K.2
  • 7
    • 79451471618 scopus 로고    scopus 로고
    • The pathological process underlying Alzheimer's disease in individuals under thirty
    • 21170538 10.1007/s00401-010-0789-4
    • Braak H, Del Tredici K (2011) The pathological process underlying Alzheimer's disease in individuals under thirty. Acta Neuropathol 121:171-181
    • (2011) Acta Neuropathol , vol.121 , pp. 171-181
    • Braak, H.1    Del Tredici, K.2
  • 8
    • 84870004031 scopus 로고    scopus 로고
    • Where, when, and in what form does sporadic Alzheimer's disease begin?
    • 23160422 10.1097/WCO.0b013e32835a3432 1:CAS:528:DC%2BC38Xhs12mtL%2FE
    • Braak H, Del Tredici K (2012) Where, when, and in what form does sporadic Alzheimer's disease begin? Curr Opin Neurol 25:708-714
    • (2012) Curr Opin Neurol , vol.25 , pp. 708-714
    • Braak, H.1    Del Tredici, K.2
  • 9
    • 0024431974 scopus 로고
    • Alzheimer's disease: Amyloid plaques in the cerebellum
    • 2556503 10.1016/0022-510X(89)90197-4 1:STN:280:DyaK3c%2FnvFGiug%3D%3D
    • Braak H, Braak E, Bohl J et al (1989) Alzheimer's disease: amyloid plaques in the cerebellum. J Neurol Sci 93:277-287
    • (1989) J Neurol Sci , vol.93 , pp. 277-287
    • Braak, H.1    Braak, E.2    Bohl, J.3
  • 10
    • 80054904670 scopus 로고    scopus 로고
    • Stages of the pathological process in Alzheimer' disease
    • 22002422 10.1097/NEN.0b013e318232a379 1:CAS:528:DC%2BC3MXhtlChs7bJ
    • Braak H, Thal DR, Ghebremedhin E et al (2011) Stages of the pathological process in Alzheimer' disease. J Neuropathol Exp Neurol 70:960-969
    • (2011) J Neuropathol Exp Neurol , vol.70 , pp. 960-969
    • Braak, H.1    Thal, D.R.2    Ghebremedhin, E.3
  • 11
    • 84888205849 scopus 로고    scopus 로고
    • Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid
    • doi: 10.1007/s00401-013-1139-0
    • Braak H, Zetterberg H, Del Tredici K, Blennow K (2013) Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathol. doi: 10.1007/s00401-013-1139-0
    • (2013) Acta Neuropathol
    • Braak, H.1    Zetterberg, H.2    Del Tredici, K.3    Blennow, K.4
  • 12
    • 0030820317 scopus 로고    scopus 로고
    • Spatial, temporal and numeric analysis of Alzheimer changes in the nucleus coeruleus
    • 9330971 10.1016/S0197-4580(97)00035-3 1:STN:280:DyaK2svnt1Snug%3D%3D
    • Busch C, Bohl J, Ohm TG (1997) Spatial, temporal and numeric analysis of Alzheimer changes in the nucleus coeruleus. Neurobiol Aging 18:401-406
    • (1997) Neurobiol Aging , vol.18 , pp. 401-406
    • Busch, C.1    Bohl, J.2    Ohm, T.G.3
  • 13
    • 0030792733 scopus 로고    scopus 로고
    • Astroglial and vascular interactions of noradrenaline terminals in the rat cerebral cortex
    • 9290587 10.1097/00004647-199708000-00008 1:CAS:528:DyaK2sXmt1yjt7o%3D
    • Cohen Z, Molinatti G, Hamel E (1997) Astroglial and vascular interactions of noradrenaline terminals in the rat cerebral cortex. J Cereb Blood Flow Metab 17:894-904
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 894-904
    • Cohen, Z.1    Molinatti, G.2    Hamel, E.3
  • 14
    • 67349143998 scopus 로고    scopus 로고
    • Classification and basic pathology of Alzheimer's disease
    • 19381658 10.1007/s00401-009-0532-1 1:CAS:528:DC%2BD1MXmt1ahu70%3D
    • Duyckaerts C, Delatour B, Potier MC (2009) Classification and basic pathology of Alzheimer's disease. Acta Neuropathol 118:5-36
    • (2009) Acta Neuropathol , vol.118 , pp. 5-36
    • Duyckaerts, C.1    Delatour, B.2    Potier, M.C.3
  • 15
    • 84857029808 scopus 로고    scopus 로고
    • Hyperphosphorylated tau in young and middle-aged subjects
    • 22160320 10.1007/s00401-011-0906-z 1:CAS:528:DC%2BC38Xkt1equg%3D%3D
    • Elobeid A, Soininen H, Alafuzoff I (2012) Hyperphosphorylated tau in young and middle-aged subjects. Acta Neuropathol 123:97-104
    • (2012) Acta Neuropathol , vol.123 , pp. 97-104
    • Elobeid, A.1    Soininen, H.2    Alafuzoff, I.3
  • 16
    • 0023247155 scopus 로고
    • Alzheimer's disease: Neurofibrillary tangles in nuclei that project to the cerebral cortex
    • 10.1016/0306-4522(87)90123-0 1:STN:280:DyaL2s3oslOguw%3D%3D
    • German DC, White CL, Sparkman DR (1987) Alzheimer's disease: neurofibrillary tangles in nuclei that project to the cerebral cortex. Neurosci 21:305-312
    • (1987) Neurosci , vol.21 , pp. 305-312
    • German, D.C.1    White, C.L.2    Sparkman, D.R.3
  • 17
    • 84880187571 scopus 로고    scopus 로고
    • Tau protein, the paired helical filament and Alzheimer's disease
    • 16914859 1:CAS:528:DC%2BD28XotFKktb8%3D
    • Goedert M, Klug A, Crowther RA (2006) Tau protein, the paired helical filament and Alzheimer's disease. J Alzheimers Dis 9(Suppl):195-207
    • (2006) J Alzheimers Dis , vol.9 , Issue.SUPPL. , pp. 195-207
    • Goedert, M.1    Klug, A.2    Crowther, R.A.3
  • 18
    • 67649945522 scopus 로고    scopus 로고
    • The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?
    • 19508444 10.1111/j.1365-2990.2008.00997.x 1:CAS:528:DC%2BD1MXpsFGgtbc%3D
    • Grinberg LT, Rüb U, Ferretti REL et al (2009) The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset? Neuropathol Appl Neurobiol 35:406-416
    • (2009) Neuropathol Appl Neurobiol , vol.35 , pp. 406-416
    • Grinberg, L.T.1    Rüb, U.2    Ferretti, R.E.L.3
  • 19
    • 84867724581 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy impact on endothelium
    • 22944481 10.1016/j.exger.2012.08.005
    • Grinberg LT, Korczyn AD, Heinsen H (2012) Cerebral amyloid angiopathy impact on endothelium. Exp Gerontol 47:838-842
    • (2012) Exp Gerontol , vol.47 , pp. 838-842
    • Grinberg, L.T.1    Korczyn, A.D.2    Heinsen, H.3
  • 20
    • 33846583006 scopus 로고    scopus 로고
    • Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease
    • 16574280 10.1016/j.neurobiolaging.2006.02.007 1:CAS:528: DC%2BD2sXhtlantrg%3D
    • Grudzien A, Shaw P, Weintraub S et al (2007) Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiol Aging 28:327-335
    • (2007) Neurobiol Aging , vol.28 , pp. 327-335
    • Grudzien, A.1    Shaw, P.2    Weintraub, S.3
  • 21
    • 0022744803 scopus 로고
    • Abnormal phosphorylation of the microtubule-associated protein τ (tau) in Alzheimer cytoskeletal pathology
    • 3088567 10.1073/pnas.83.13.4913 1:CAS:528:DyaL28XksFyqtrg%3D
    • Grundke-Iqbal I, Iqbal K, Tung Y et al (1986) Abnormal phosphorylation of the microtubule-associated proteinτ (tau) in Alzheimer cytoskeletal pathology. Proc Nat Acad Sci USA 83:4913-4917
    • (1986) Proc Nat Acad Sci USA , vol.83 , pp. 4913-4917
    • Grundke-Iqbal, I.1    Iqbal, K.2    Tung, Y.3
  • 22
    • 84862633779 scopus 로고    scopus 로고
    • Trafficking and proteolytic processing of APP
    • 22553493 10.1101/cshperspect.a006270
    • Haass C, Kaether C, Thinakaran G et al (2012) Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med 2:a006270
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. 006270
    • Haass, C.1    Kaether, C.2    Thinakaran, G.3
  • 23
    • 33751270153 scopus 로고    scopus 로고
    • Locus ceruleus degeneration is ubiquitous in Alzheimer's disease: Possible implications for diagnosis and treatment
    • 17203588 10.1111/j.1440-1789.2006.00725.x
    • Haglund M, Sjöbeck M, Englund E (2006) Locus ceruleus degeneration is ubiquitous in Alzheimer's disease: possible implications for diagnosis and treatment. Neuropathology 26:528-532
    • (2006) Neuropathology , vol.26 , pp. 528-532
    • Haglund, M.1    Sjöbeck, M.2    Englund, E.3
  • 24
    • 84856002055 scopus 로고    scopus 로고
    • National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
    • 22265587 10.1016/j.jalz.2011.10.007
    • Hyman BT, Phelps CH, Beach TG et al (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement 8:1-13
    • (2012) Alzheimers Dement , vol.8 , pp. 1-13
    • Hyman, B.T.1    Phelps, C.H.2    Beach, T.G.3
  • 25
    • 41149156856 scopus 로고    scopus 로고
    • Alzheimer neurofibrillary degeneration: Significance, etiopathogenesis, therapeutics and prevention
    • 18194444 10.1111/j.1582-4934.2008.00225.x 1:CAS:528:DC%2BD1cXltlSru7Y%3D
    • Iqbal K, Grundke-Iqbal I (2008) Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention. J Cell Mol Med 12:38-55
    • (2008) J Cell Mol Med , vol.12 , pp. 38-55
    • Iqbal, K.1    Grundke-Iqbal, I.2
  • 26
    • 0028491607 scopus 로고
    • Mechanism of neurofibrillary degeneration in Alzheimer's disease
    • 7888088 10.1007/BF02816111 1:STN:280:DyaK2M7psVGrsQ%3D%3D
    • Iqbal K, Alonso AC, Gong CX et al (1994) Mechanism of neurofibrillary degeneration in Alzheimer's disease. Mol Neurobiol 9:119-123
    • (1994) Mol Neurobiol , vol.9 , pp. 119-123
    • Iqbal, K.1    Alonso, A.C.2    Gong, C.X.3
  • 27
    • 67349142329 scopus 로고    scopus 로고
    • Mechanisms of tau-induced neurodegeneration
    • 19184068 10.1007/s00401-009-0486-3 1:CAS:528:DC%2BD1MXmt1ahu7k%3D
    • Iqbal K, Liu F, Gong CX et al (2009) Mechanisms of tau-induced neurodegeneration. Acta Neuropathol 118:53-69
    • (2009) Acta Neuropathol , vol.118 , pp. 53-69
    • Iqbal, K.1    Liu, F.2    Gong, C.X.3
  • 28
    • 0024406465 scopus 로고
    • Distribution and morphology of brain stem plaques in Alzheimer's disease
    • 2546358 10.1007/BF00688200 1:STN:280:DyaL1MzhvFGksQ%3D%3D
    • Iseki E, Matsushita M, Kosaka K et al (1989) Distribution and morphology of brain stem plaques in Alzheimer's disease. Acta Neuropathol 78:131-136
    • (1989) Acta Neuropathol , vol.78 , pp. 131-136
    • Iseki, E.1    Matsushita, M.2    Kosaka, K.3
  • 29
    • 0033387397 scopus 로고    scopus 로고
    • β-amyloid deposition and neurofibrillary tangle formation in the olfactory bulb in ageing and Alzheimer's disease
    • 10632898 10.1046/j.1365-2990.1999.00208.x
    • Kovács T, Cairns NJ, Lantos PL (1999) β-amyloid deposition and neurofibrillary tangle formation in the olfactory bulb in ageing and Alzheimer's disease. Neuropathol Appl Neurobiol 25:481-491
    • (1999) Neuropathol Appl Neurobiol , vol.25 , pp. 481-491
    • Kovács, T.1    Cairns, N.J.2    Lantos, P.L.3
  • 30
    • 84868677556 scopus 로고    scopus 로고
    • Biochemistry and cell biology of tau protein in neurofibrillary degeneration
    • 22762014 10.1101/cshperspect.a006247
    • Mandelkow EM, Mandelkow E (2012) Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med 2:a006247
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. 006247
    • Mandelkow, E.M.1    Mandelkow, E.2
  • 31
    • 33847239940 scopus 로고    scopus 로고
    • Structural principles of tau and the paired helical filaments of Alzheimer's disease
    • 17493042 10.1111/j.1750-3639.2007.00053.x 1:CAS:528:DC%2BD2sXkvFShsr8%3D
    • Mandelkow E, von Bergen M, Biernat J et al (2007) Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain Pathol 17:83-90
    • (2007) Brain Pathol , vol.17 , pp. 83-90
    • Mandelkow, E.1    Von Bergen, M.2    Biernat, J.3
  • 32
    • 84881117256 scopus 로고    scopus 로고
    • Pathways to the discovery of the neuronal origin and proteolytic biogenesis of Aβ amyloid of Alzheimer's disease
    • Springer, Berlin
    • Masters CL, Beyreuther K (2006) Pathways to the discovery of the neuronal origin and proteolytic biogenesis of Aβ amyloid of Alzheimer's disease. In: Alzheimer: 100 years and beyond. Springer, Berlin, pp 143-149
    • (2006) Alzheimer: 100 Years and beyond , pp. 143-149
    • Masters, C.L.1    Beyreuther, K.2
  • 33
    • 84879829589 scopus 로고    scopus 로고
    • Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer's disease
    • 22675658 10.1101/cshperspect.a006262
    • Masters CL, Selkow DJ (2012) Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer's disease. Cold Spring Harb Perspect Med 2:a006262
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. 006262
    • Masters, C.L.1    Selkow, D.J.2
  • 34
    • 2542511697 scopus 로고    scopus 로고
    • Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum
    • 15174015 10.1002/ana.20100 1:CAS:528:DC%2BD2cXlsVCkur8%3D
    • Mesulam MM, Shaw P, Mash D et al (2004) Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol 55:815-828
    • (2004) Ann Neurol , vol.55 , pp. 815-828
    • Mesulam, M.M.1    Shaw, P.2    Mash, D.3
  • 35
    • 84857030932 scopus 로고    scopus 로고
    • National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach
    • 22101365 10.1007/s00401-011-0910-3 1:CAS:528:DC%2BC38Xkt1eqtQ%3D%3D
    • Montine TJ, Phelps CH, Beach TG et al (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol 123:1-11
    • (2012) Acta Neuropathol , vol.123 , pp. 1-11
    • Montine, T.J.1    Phelps, C.H.2    Beach, T.G.3
  • 36
    • 37349096335 scopus 로고    scopus 로고
    • Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: Neuritic plaques and neurofibrillary tangles "do count" when staging disease severity
    • 18090922 10.1097/nen.0b013e31815c5efb
    • Nelson PT, Jicha GA, Schmitt FA et al (2007) Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol 66:1136-1146
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 1136-1146
    • Nelson, P.T.1    Jicha, G.A.2    Schmitt, F.A.3
  • 37
    • 79958116172 scopus 로고    scopus 로고
    • Alzheimer's disease is not "brain aging": Neuropathological, genetic, and epidemiological human studies
    • 21516511 10.1007/s00401-011-0826-y
    • Nelson PT, Head E, Schmitt FA et al (2011) Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol 121:571-587
    • (2011) Acta Neuropathol , vol.121 , pp. 571-587
    • Nelson, P.T.1    Head, E.2    Schmitt, F.A.3
  • 38
    • 84871450029 scopus 로고    scopus 로고
    • Norepinephrine: A neuromodulator that boosts the function of multiple cell types to optimize CNS performance
    • 22717696 10.1007/s11064-012-0818-x
    • O'Donnell J, Zeppenfeld D, McConnell E et al (2012) Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance. Neurochem Res 37:2496-2512
    • (2012) Neurochem Res , vol.37 , pp. 2496-2512
    • O'Donnell, J.1    Zeppenfeld, D.2    McConnell, E.3
  • 39
    • 0035117748 scopus 로고    scopus 로고
    • The selective vulnerability of brainstem nuclei to Alzheimer's disease
    • 11198297 10.1002/1531-8249(200101)49:1<53: AID-ANA30>3.0.CO;2-Q 1:STN:280:DC%2BD3M7gslKktQ%3D%3D
    • Parvizi J, Van Hoesen GW, Damasio A (2001) The selective vulnerability of brainstem nuclei to Alzheimer's disease. Ann Neurol 49:53-66
    • (2001) Ann Neurol , vol.49 , pp. 53-66
    • Parvizi, J.1    Van Hoesen, G.W.2    Damasio, A.3
  • 40
    • 0034527347 scopus 로고    scopus 로고
    • The evolution of Alzheimer's disease-related cytoskeletal pathology in the human raphe nuclei
    • 11123722 10.1046/j.0305-1846.2000.00291.x
    • Rüb U, Del Tredici K, Schultz C et al (2000) The evolution of Alzheimer's disease-related cytoskeletal pathology in the human raphe nuclei. Neuropathol Appl Neurobiol 26:553-557
    • (2000) Neuropathol Appl Neurobiol , vol.26 , pp. 553-557
    • Rüb, U.1    Del Tredici, K.2    Schultz, C.3
  • 41
    • 0033922730 scopus 로고    scopus 로고
    • Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert
    • 10965795 10.1007/s004019900178 1:STN:280:DC%2BD3M%2FntVyisA%3D%3D
    • Sassin I, Schultz C, Thal DR et al (2000) Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert. Acta Neuropathol 100:259-269
    • (2000) Acta Neuropathol , vol.100 , pp. 259-269
    • Sassin, I.1    Schultz, C.2    Thal, D.R.3
  • 42
    • 2542558147 scopus 로고    scopus 로고
    • Spatial and temporal relationship between plaques and tangles in Alzheimer-pathology
    • 15165691 10.1016/j.neurobiolaging.2003.09.009
    • Schönheit B, Zarski R, Ohm TG (2004) Spatial and temporal relationship between plaques and tangles in Alzheimer-pathology. Neurobiol Aging 25:697-711
    • (2004) Neurobiol Aging , vol.25 , pp. 697-711
    • Schönheit, B.1    Zarski, R.2    Ohm, T.G.3
  • 43
    • 0028123071 scopus 로고
    • Alzheimer's disease: A central role for amyloid
    • 8083687 10.1097/00005072-199409000-00003 1:CAS:528:DyaK2cXmsFamsbk%3D
    • Selkoe DJ (1994) Alzheimer's disease: a central role for amyloid. J Neuropathol Exp Neurol 53:438-447
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 438-447
    • Selkoe, D.J.1
  • 44
    • 84858046578 scopus 로고    scopus 로고
    • Neuropathological alterations in Alzheimer disease
    • 22229116 10.1101/cshperspect.a006189
    • Serrano-Pozo A, Frosch M, Masliah E et al (2011) Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med 1:a006189
    • (2011) Cold Spring Harb Perspect Med , vol.1 , pp. 006189
    • Serrano-Pozo, A.1    Frosch, M.2    Masliah, E.3
  • 45
    • 70449703321 scopus 로고    scopus 로고
    • Does Alzheimer's disease begin in the brainstem?
    • 19682326 10.1111/j.1365-2990.2009.01038.x 1:CAS:528:DC%2BD1MXhs1Wisr7K
    • Simic G, Stanic G, Mladinov M et al (2009) Does Alzheimer's disease begin in the brainstem? Neuropathol Appl Neurobiol 35:532-554
    • (2009) Neuropathol Appl Neurobiol , vol.35 , pp. 532-554
    • Simic, G.1    Stanic, G.2    Mladinov, M.3
  • 46
    • 0033624303 scopus 로고    scopus 로고
    • Sequence of Aβ-protein deposition in the human medial temporal lobe
    • 10952063 1:CAS:528:DC%2BD3cXmtlekur8%3D
    • Thal DR, Rüb U, Schultz C et al (2000) Sequence of Aβ-protein deposition in the human medial temporal lobe. J Neuropathol Exp Neurol 59:733-748
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 733-748
    • Thal, D.R.1    Rüb, U.2    Schultz, C.3
  • 47
    • 0037172826 scopus 로고    scopus 로고
    • Phases of Aβ-deposition in the human brain and its relevance for the development of AD
    • 12084879 10.1212/WNL.58.12.1791
    • Thal DR, Rüb U, Orantes M et al (2002) Phases of Aβ-deposition in the human brain and its relevance for the development of AD. Neurology 58:1791-1800
    • (2002) Neurology , vol.58 , pp. 1791-1800
    • Thal, D.R.1    Rüb, U.2    Orantes, M.3
  • 48
    • 80055022386 scopus 로고    scopus 로고
    • Progression of tau pathology in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
    • 21945902 10.1016/j.ajpath.2011.07.044 1:CAS:528:DC%2BC3MXhsFCmu7jI
    • Vana L, Kanaan NM, Ugwu IC et al (2011) Progression of tau pathology in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. Am J Pathol 179:2533-2550
    • (2011) Am J Pathol , vol.179 , pp. 2533-2550
    • Vana, L.1    Kanaan, N.M.2    Ugwu, I.C.3
  • 49
    • 45249087489 scopus 로고    scopus 로고
    • Functional consequences of locus coeruleus degeneration in Alzheimer's disease
    • 18537547 10.2174/156720508784533286 1:CAS:528:DC%2BD1cXmtFakt70%3D
    • Weinshenker D (2008) Functional consequences of locus coeruleus degeneration in Alzheimer's disease. Curr Alzheimer Res 5:342-345
    • (2008) Curr Alzheimer Res , vol.5 , pp. 342-345
    • Weinshenker, D.1
  • 50
    • 84859571761 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy
    • 22482447 10.1016/B978-0-12-385883-2.00006-0 1:CAS:528:DC%2BC38Xht1Klsr3O
    • Yamada M, Naiki H (2012) Cerebral amyloid angiopathy. Prog Mol Biol Transl Sci 107:41-78
    • (2012) Prog Mol Biol Transl Sci , vol.107 , pp. 41-78
    • Yamada, M.1    Naiki, H.2
  • 51
  • 52
    • 0023684459 scopus 로고
    • The neuropathology of aminergic nuclei in Alzheimer's disease
    • 3178178 10.1002/ana.410240210 1:STN:280:DyaL1M%2FisVGhtA%3D%3D
    • Zweig RM, Ross CA, Hedreen JC et al (1988) The neuropathology of aminergic nuclei in Alzheimer's disease. Ann Neurol 24:233-242
    • (1988) Ann Neurol , vol.24 , pp. 233-242
    • Zweig, R.M.1    Ross, C.A.2    Hedreen, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.