Simultaneous determination of imperatorin and its metabolites in vitro and in vivo by a GC-MS method: Application to a bioavailability and protein binding ability study in rat plasma

Biomedical Chromatography

Volumn 28, Issue 7, 2014, Pages 947-956

  Zhao, Gang ^a   Peng, Cheng ^a   Du, Wei ^a   Wang, Sicen ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Bioavailability; Imperatorin; Metabolites; Plasma protein binding

Indexed keywords

BIOCHEMISTRY; BIOMOLECULES; BODY FLUIDS; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; PROTEINS; RATS;

BINDING ABILITIES; BIOAVAILABILITY; IMPERATORIN; IN-VITRO; ORAL ADMINISTRATION; PLASMA PROTEIN BINDING; PROTEIN-BINDING; RAT PLASMA; SIMULTANEOUS DETERMINATIONS; VITRO AND IN VIVO;

METABOLITES;

DRUG METABOLITE; HERACLENIN; PENTOSALEN; UNCLASSIFIED DRUG; XANTHOTOXOL; FUROCOUMARIN DERIVATIVE; PLASMA PROTEIN; PROTEIN BINDING;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BILE SAMPLE; BLOOD LEVEL; CONTROLLED STUDY; DEMETHYLATION; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG ELIMINATION; DRUG METABOLISM; EXTRACELLULAR SPACE; FECES ANALYSIS; GAS CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA PROTEIN BINDING; PLASMA SAMPLE; QUALITY CONTROL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; URINALYSIS; URINARY EXCRETION; ANIMAL; BILE; BIOAVAILABILITY; CHEMISTRY; FECES; MALE; MASS FRAGMENTOGRAPHY; METABOLISM; ORAL DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; SPRAGUE DAWLEY RAT;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BILE; BIOLOGICAL AVAILABILITY; BLOOD PROTEINS; FECES; FUROCOUMARINS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MICROSOMES, LIVER; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 84902540356     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3100     Document Type: Article

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