Novel LC-MS/MS method for analyzing imperialine in rat plasma: Development, validation, and application to pharmacokinetics

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 938, Issue , 2013, Pages 51-59

  Lin, Qing ^a   Zhang, Quan ^a   Song, Xu ^a   Gong, Tao ^a   Sun, Xun ^a   Zhang, Zhirong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Imperialine; LC MS MS; Pharmacokinetic study; Rat plasma; Validation

Indexed keywords

IMPERIALINE; LC-MS/MS; PHARMACOKINETIC STUDIES; RAT PLASMA; VALIDATION;

BIOCHEMISTRY; COLUMN CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

BODY FLUIDS;

ACETONITRILE; ALKALOID; FORMIC ACID; IMPERIALINE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; BULBUS FRITILLARIAE CIRRHOSAE; CALIBRATION; CAVA VEIN; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG BIOAVAILABILITY; DRUG ISOLATION; DRUG MONITORING; DRUG STABILITY; DRUG STRUCTURE; ELUTION; FREEZING; FRITILLARIA; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; THAWING; VALIDATION PROCESS;

IMPERIALINE; LC-MS/MS; PHARMACOKINETIC STUDY; RAT PLASMA; VALIDATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CEVANES; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; LIMIT OF DETECTION; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84884516920     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.08.033     Document Type: Article

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