Biomimetic in vitro oxidation of lapachol: A model to predict and analyse the in vivo phase i metabolism of bioactive compounds

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 804-812

  Niehues, Michael ^a   Barros, Valéria Priscila ^a   Emery, Flávio Da Silva ^a   Dias Baruffi, Marcelo ^a   Assis, Marilda Das Dores ^a   Lopes, Norberto Peporine ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Biomimetic oxidation; Drug metabolism; Jacobsen catalyst; Lapachol; Naphtoquinones; Phase I metabolism

Indexed keywords

10,11 EPOXY LAPACHOL; 2 NAPHTOQUINONE DERIVATIVE; 2(1 HYDROXY 1 METHYLETHYL) 2,3 DIHYDRONAPHTHO [1,2 B] FURAN 4,5 DIONE; 2(1 HYDROXY 1 METHYLETHYL) 2,3 DIHYDRONAPHTHO [2,3 B] FURAN 4,9 DIONE; 3,4 DIHYDRO 3 HYDROXY 2,2 DIMETHYL 2H NAPHTHO [2,3 B] PYRAN 5,10 DIONE; 4 NAPHTOQUINONE DERIVATIVE; ALPHA LAPACHONE; DEHYDROLAPACHONE; DRUG METABOLITE; IODOSOBENZENE; LAPACHOL; MANGANESE; MANGANESE SALEN; NAPHTHO [1,2 B] FURAN 4,5 DIONE; NAPHTHOQUINONE; NORLAPACHOL; PORPHYRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOCATALYST; BIOMIMETICS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG METABOLISM; FEMALE; MASS FRAGMENTOGRAPHY; NONHUMAN; OXIDATION; RAT;

ANIMALS; BIOMIMETICS; ETHYLENEDIAMINES; FEMALE; MODELS, BIOLOGICAL; NAPHTHOQUINONES; ORGANOMETALLIC COMPOUNDS; OXIDANTS; OXIDATION-REDUCTION; RATS; RATS, WISTAR;

EID: 84864408810     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.042     Document Type: Article

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